ES2063820T3 - Metodo para el analisis de componentes celulares de un fluido. - Google Patents
Metodo para el analisis de componentes celulares de un fluido.Info
- Publication number
- ES2063820T3 ES2063820T3 ES89306036T ES89306036T ES2063820T3 ES 2063820 T3 ES2063820 T3 ES 2063820T3 ES 89306036 T ES89306036 T ES 89306036T ES 89306036 T ES89306036 T ES 89306036T ES 2063820 T3 ES2063820 T3 ES 2063820T3
- Authority
- ES
- Spain
- Prior art keywords
- analysis
- fluid
- cell components
- nucleic acid
- dyes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000003850 cellular structure Anatomy 0.000 title 1
- 239000012530 fluid Substances 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 239000000980 acid dye Substances 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000002458 cell surface marker Substances 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N15/1456—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56977—HLA or MHC typing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N2015/1402—Data analysis by thresholding or gating operations performed on the acquired signals or stored data
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/973—Simultaneous determination of more than one analyte
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/80—Fluorescent dyes, e.g. rhodamine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Abstract
SE DESCRIBE UN METODO PARA ANALISIS MULTIPARAMETRICO DE CELULAS EN UNA MUESTRA DE FLUIDO CORPORAL, QUE HACE USO DE VARIAS MEDIDAS FLUORESCENTES, QUE TIENEN POR LO MENOS DOS COLORANTES ACIDO NUCLEICO Y POR LO MENOS UN MARCADOR DE SUPERFICIE CELULAR MARCADO FLUORESCENTEMENTE, Y VARIAS MEDIDAS DE DISPERSION DE LA LUZ. TAMBIEN SE DESCRIBE UN KIT QUE CONTIENE LOS COLORANTES DE ACIDO NUCLEICO Y EL MARCADOR DE SUPERFICIE CELULAR.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/207,099 US5047321A (en) | 1988-06-15 | 1988-06-15 | Method for analysis of cellular components of a fluid |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2063820T3 true ES2063820T3 (es) | 1995-01-16 |
Family
ID=22769201
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89306036T Expired - Lifetime ES2063820T3 (es) | 1988-06-15 | 1989-06-14 | Metodo para el analisis de componentes celulares de un fluido. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5047321A (es) |
EP (1) | EP0347210B1 (es) |
JP (1) | JPH0726954B2 (es) |
AT (1) | ATE111227T1 (es) |
AU (1) | AU613197B2 (es) |
CA (1) | CA1340170C (es) |
DE (1) | DE68918004T2 (es) |
DK (1) | DK296889A (es) |
ES (1) | ES2063820T3 (es) |
FI (1) | FI94180C (es) |
NO (1) | NO175506C (es) |
Families Citing this family (96)
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US4963478A (en) * | 1988-07-05 | 1990-10-16 | Immucor, Inc. | Article for preforming immunological assays utilizing organic dyes and method for producing and utilizing same |
FR2638848B1 (fr) * | 1988-11-04 | 1993-01-22 | Chemunex Sa | Procede de detection et/ou de dosage dans un milieu liquide ou semi-liquide d'au moins une substance organique, biologique ou medicamenteuse soluble, par une methode d'agglutination |
FR2653447B1 (fr) * | 1989-10-20 | 1991-12-27 | Bio Merieux | Procede et reactifs pour la detection de micro-organismes. |
DE69118429T2 (de) * | 1990-01-26 | 1996-09-12 | Canon Kk | Verfahren zur Messung einer Spezies unter Verwendung von Fluoreszenzlicht |
US5229265A (en) * | 1990-03-13 | 1993-07-20 | Litron Laboratories | Process for analyzing clastogenic agents |
US5401847A (en) * | 1990-03-14 | 1995-03-28 | Regents Of The University Of California | DNA complexes with dyes designed for energy transfer as fluorescent markers |
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US5641629A (en) * | 1990-06-11 | 1997-06-24 | Nexstar Pharmacueticals Inc | Spectroscopically detectable nucleic acid ligands |
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JP2927979B2 (ja) * | 1991-02-22 | 1999-07-28 | シスメックス株式会社 | フローサイトメトリーによる赤芽球の分類方法 |
US5776709A (en) * | 1991-08-28 | 1998-07-07 | Becton Dickinson And Company | Method for preparation and analysis of leukocytes in whole blood |
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DE69428552T2 (de) * | 1993-01-26 | 2002-04-11 | Becton Dickinson Co | Verfahren zum Nachweis von seltenen Ereignissen |
US5294799A (en) * | 1993-02-01 | 1994-03-15 | Aslund Nils R D | Apparatus for quantitative imaging of multiple fluorophores |
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US5879900A (en) * | 1994-12-15 | 1999-03-09 | Abbott Laboratories | Method for simultaneous analysis of cell viability, nucleated red blood cells and white blood cell differentials |
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US4520110A (en) * | 1981-10-06 | 1985-05-28 | The Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing a phycobiliprotein labeled ligand or receptor |
CA1254134A (en) * | 1984-03-28 | 1989-05-16 | Mount Sinai School Of Medicine Of The City University Of New York | Specific binding flow cytometry method |
US4661913A (en) * | 1984-09-11 | 1987-04-28 | Becton, Dickinson And Company | Apparatus and method for the detection and classification of articles using flow cytometry techniques |
US4727020A (en) * | 1985-02-25 | 1988-02-23 | Becton, Dickinson And Company | Method for analysis of subpopulations of blood cells |
ZA867698B (en) * | 1985-10-11 | 1987-07-29 | Smithkline Beckman Corp | Methods and reagents for performing subset analysis |
CA1279008C (en) * | 1985-10-11 | 1991-01-15 | Smith Kline & French Canada Ltd. | Methods and reagents for performing subset analysis |
US4883867A (en) * | 1985-11-01 | 1989-11-28 | Becton, Dickinson And Company | Detection of reticulocytes, RNA or DNA |
US5016283A (en) * | 1985-11-04 | 1991-05-14 | Cell Analysis Systems, Inc. | Methods and apparatus for immunoploidy analysis |
-
1988
- 1988-06-15 US US07/207,099 patent/US5047321A/en not_active Expired - Lifetime
-
1989
- 1989-06-01 AU AU35961/89A patent/AU613197B2/en not_active Ceased
- 1989-06-01 CA CA000601444A patent/CA1340170C/en not_active Expired - Fee Related
- 1989-06-05 NO NO892302A patent/NO175506C/no unknown
- 1989-06-14 DE DE68918004T patent/DE68918004T2/de not_active Expired - Lifetime
- 1989-06-14 FI FI892926A patent/FI94180C/fi not_active IP Right Cessation
- 1989-06-14 AT AT89306036T patent/ATE111227T1/de not_active IP Right Cessation
- 1989-06-14 EP EP89306036A patent/EP0347210B1/en not_active Expired - Lifetime
- 1989-06-14 ES ES89306036T patent/ES2063820T3/es not_active Expired - Lifetime
- 1989-06-15 DK DK296889A patent/DK296889A/da not_active Application Discontinuation
- 1989-06-15 JP JP1153564A patent/JPH0726954B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
FI94180C (fi) | 1995-07-25 |
JPH0273157A (ja) | 1990-03-13 |
US5047321A (en) | 1991-09-10 |
NO175506B (no) | 1994-07-11 |
DK296889A (da) | 1989-12-16 |
CA1340170C (en) | 1998-12-08 |
DE68918004T2 (de) | 1995-01-05 |
FI94180B (fi) | 1995-04-13 |
FI892926A (fi) | 1989-12-16 |
DK296889D0 (da) | 1989-06-15 |
FI892926A0 (fi) | 1989-06-14 |
AU3596189A (en) | 1989-12-21 |
NO892302D0 (no) | 1989-06-05 |
EP0347210A2 (en) | 1989-12-20 |
ATE111227T1 (de) | 1994-09-15 |
AU613197B2 (en) | 1991-07-25 |
NO175506C (no) | 1994-10-19 |
EP0347210B1 (en) | 1994-09-07 |
JPH0726954B2 (ja) | 1995-03-29 |
EP0347210A3 (en) | 1990-10-17 |
DE68918004D1 (de) | 1994-10-13 |
NO892302L (no) | 1989-12-18 |
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