EP2329829A3 - Verwendung von Uridin in Kombination mit Cholin zur Behandlung von Gedächtnisstörungen - Google Patents

Verwendung von Uridin in Kombination mit Cholin zur Behandlung von Gedächtnisstörungen Download PDF

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Publication number
EP2329829A3
EP2329829A3 EP10075661A EP10075661A EP2329829A3 EP 2329829 A3 EP2329829 A3 EP 2329829A3 EP 10075661 A EP10075661 A EP 10075661A EP 10075661 A EP10075661 A EP 10075661A EP 2329829 A3 EP2329829 A3 EP 2329829A3
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EP
European Patent Office
Prior art keywords
choline
uridine
treatment
combination
memory disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP10075661A
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English (en)
French (fr)
Other versions
EP2329829A2 (de
EP2329829B1 (de
Inventor
Carol Watkins
Richard J. Wurtman
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Massachusetts Institute of Technology
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Massachusetts Institute of Technology
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Filing date
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Publication of EP2329829A2 publication Critical patent/EP2329829A2/de
Publication of EP2329829A3 publication Critical patent/EP2329829A3/de
Application granted granted Critical
Publication of EP2329829B1 publication Critical patent/EP2329829B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP10075661.8A 1998-07-31 1999-07-30 Verwendung von Uridin in Kombination mit Cholin zur Behandlung neurologischer Erkrankungen Expired - Lifetime EP2329829B1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9500298P 1998-07-31 1998-07-31
EP07116909A EP1870103B1 (de) 1998-07-31 1999-07-30 Verwendung von Uridin in Kombination mit Cholin zur Behandlung von Gedächtnisstörungen
EP99937631A EP1140104B1 (de) 1998-07-31 1999-07-30 Behandlung der alzheimer-krankheit durch erhöhung des cytidin-spiegels in vivo
EP09173495.4A EP2145627B1 (de) 1998-07-31 1999-07-30 Verwendung von Uridin in Kombination mit Cholin zur Behandlung von Gemüts und Emotionalen Störungen

Related Parent Applications (7)

Application Number Title Priority Date Filing Date
EP09173495.4A Division EP2145627B1 (de) 1998-07-31 1999-07-30 Verwendung von Uridin in Kombination mit Cholin zur Behandlung von Gemüts und Emotionalen Störungen
EP09173495.4A Division-Into EP2145627B1 (de) 1998-07-31 1999-07-30 Verwendung von Uridin in Kombination mit Cholin zur Behandlung von Gemüts und Emotionalen Störungen
EP99937631.2 Division 1999-07-30
EP99937631A Division EP1140104B1 (de) 1998-07-31 1999-07-30 Behandlung der alzheimer-krankheit durch erhöhung des cytidin-spiegels in vivo
EP07116909A Division EP1870103B1 (de) 1998-07-31 1999-07-30 Verwendung von Uridin in Kombination mit Cholin zur Behandlung von Gedächtnisstörungen
EP07116909.8 Division 2007-09-21
EP09173495.4 Division 2009-10-20

Publications (3)

Publication Number Publication Date
EP2329829A2 EP2329829A2 (de) 2011-06-08
EP2329829A3 true EP2329829A3 (de) 2011-07-20
EP2329829B1 EP2329829B1 (de) 2014-04-16

Family

ID=22248474

Family Applications (5)

Application Number Title Priority Date Filing Date
EP07116909A Expired - Lifetime EP1870103B1 (de) 1998-07-31 1999-07-30 Verwendung von Uridin in Kombination mit Cholin zur Behandlung von Gedächtnisstörungen
EP99937631A Expired - Lifetime EP1140104B1 (de) 1998-07-31 1999-07-30 Behandlung der alzheimer-krankheit durch erhöhung des cytidin-spiegels in vivo
EP10075661.8A Expired - Lifetime EP2329829B1 (de) 1998-07-31 1999-07-30 Verwendung von Uridin in Kombination mit Cholin zur Behandlung neurologischer Erkrankungen
EP09173495.4A Expired - Lifetime EP2145627B1 (de) 1998-07-31 1999-07-30 Verwendung von Uridin in Kombination mit Cholin zur Behandlung von Gemüts und Emotionalen Störungen
EP10075660.0A Expired - Lifetime EP2322187B1 (de) 1998-07-31 1999-07-30 Verwendung von Uridin in Kombination mit Cholin zur Behandlung von Gedächtnisstörungen

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EP07116909A Expired - Lifetime EP1870103B1 (de) 1998-07-31 1999-07-30 Verwendung von Uridin in Kombination mit Cholin zur Behandlung von Gedächtnisstörungen
EP99937631A Expired - Lifetime EP1140104B1 (de) 1998-07-31 1999-07-30 Behandlung der alzheimer-krankheit durch erhöhung des cytidin-spiegels in vivo

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP09173495.4A Expired - Lifetime EP2145627B1 (de) 1998-07-31 1999-07-30 Verwendung von Uridin in Kombination mit Cholin zur Behandlung von Gemüts und Emotionalen Störungen
EP10075660.0A Expired - Lifetime EP2322187B1 (de) 1998-07-31 1999-07-30 Verwendung von Uridin in Kombination mit Cholin zur Behandlung von Gedächtnisstörungen

Country Status (11)

Country Link
US (1) US6989376B2 (de)
EP (5) EP1870103B1 (de)
JP (1) JP2003517437A (de)
AT (2) ATE446097T1 (de)
CA (1) CA2339008C (de)
CY (1) CY1110570T1 (de)
DE (2) DE69937198T2 (de)
DK (5) DK2145627T3 (de)
ES (5) ES2476940T3 (de)
PT (5) PT2329829E (de)
WO (1) WO2000006174A1 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8314064B2 (en) * 1998-07-31 2012-11-20 Massachusetts Institute Of Technology Uridine administration stimulates membrane production
US8518882B2 (en) * 1998-07-31 2013-08-27 Massachusetts Institute Of Technology Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same
US20050203053A1 (en) * 1999-07-30 2005-09-15 Wurtman Richard J. Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function
US20070004670A1 (en) * 1998-07-31 2007-01-04 Richard Wurtman Compositions containing citicoline, and methods of use thereof
US8143234B2 (en) * 1998-07-31 2012-03-27 Massachusetts Institute Of Technology Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function
US20060069061A1 (en) * 1998-07-31 2006-03-30 Dick Wurtman Compositions containing uridine and choline, and methods utilizing same
US7915233B1 (en) 1998-08-31 2011-03-29 Wellstat Therapeutics Corporation Compositions and methods for treatment of mitochondrial diseases
US6472378B2 (en) * 1998-08-31 2002-10-29 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
US7807654B2 (en) * 1998-08-31 2010-10-05 Wellstat Therapeutics Corporation Compositions and methods for treatment of mitochondrial diseases
ES2425114T3 (es) * 2000-03-16 2013-10-11 The Mclean Hospital Corporation CDP-colina y uridina para el tratamiento del abuso del acohol
US6727231B1 (en) * 2000-10-12 2004-04-27 Repligen Corporation Uridine therapy for patients with elevated purine levels
NL1019368C2 (nl) * 2001-11-14 2003-05-20 Nutricia Nv Preparaat voor het verbeteren van receptorwerking.
CA2492725A1 (en) * 2002-07-11 2004-01-22 Yamasa Corporation Medicinal composition for drug-induced neuropathy
PT1565055E (pt) 2002-11-08 2013-09-16 Mclean Hospital Corp Compostos para o tratamento da dependência e da privação de tabaco
AU2003299715A1 (en) * 2002-12-20 2004-07-22 The Mclean Hospital Corporation Compounds for the normalization of the sleep/wake cycle
WO2005034874A2 (en) * 2003-10-08 2005-04-21 The Mclean Hospital Corporation Enhanced efficacy of omega-3 fatty acid therapy in the treatment of psychiatric disorders and other indications
WO2005086619A2 (en) * 2003-10-08 2005-09-22 The Mclean Hospital Corporation Methods of treating psychiatric, substance abuse, and other disorders using combinations containing omega-3 fatty acids
JP5523669B2 (ja) * 2004-05-13 2014-06-18 マサチューセッツ インスティテュート オブ テクノロジー ドーパミン放出に対するウリジンの効果
EP1765075A4 (de) * 2004-06-10 2010-11-10 Mclean Hospital Corp Pyrimidine, wie z.b. uridin; bei der behandlung von patienten mit manisch-depressiver psychose
US20090215714A1 (en) * 2004-06-10 2009-08-27 Perry Renshaw Pyrimidines, such as cytidine, in treatments for patients with biopolar disorder
EP1784199A4 (de) * 2004-08-11 2010-06-23 Mclean Hospital Corp Verbindungen zur behandlung von marihuana-abhängigkeit, entzug und konsum
EP1802314A4 (de) * 2004-09-15 2011-02-23 Massachusetts Inst Technology Zusammensetzung mit uridin und anwendungsverfahren dafür
AU2011253660B2 (en) * 2004-09-15 2013-12-19 Massachusetts Institute Of Technology Compositions containing uridine, and methods utilizing same
EP3090740A1 (de) 2005-05-23 2016-11-09 Massachusetts Institute of Technology Zusammensetzungen enthaltend eicosapentaensäure zur verbesserung des kognitiven funktion
AU2012203650B2 (en) * 2005-05-23 2014-09-18 Massachusetts Institute Of Technology Compositions containing PUFA and methods of use thereof
NZ566842A (en) * 2005-09-22 2011-12-22 Megmilk Snow Brand Co Ltd Use of sphingomyelin for preventing or reducing alcohol intoxication and/or hangover
EP1951308B1 (de) * 2005-11-25 2013-02-20 Gisela Susilo Kombinationspräparate enthaltend physiologische zellmembran-bestandteile, einschliesslich phosphatidylserin, cholin und ein pyrimidinnukleos/tid
PT1800675E (pt) 2005-12-23 2011-08-30 Nutricia Nv COMPOSIÇÃO CONTENDO ÁCIDOS GORDOS POLI-INSATURADOS, PROTEÍNAS E MANGANjS E/OU MOLIBDÉNIO PARA O MELHORAMENTO DA COMPOSIÇÃO DA MEMBRANA
EP2033647A4 (de) * 2006-06-27 2010-07-28 Yamasa Corp Mittel gegen psychosozialen stress
US7972633B2 (en) * 2007-02-07 2011-07-05 Applied Cognitive Sciences, LLC Nutritional supplements for healthy memory and mental function
CN101896119A (zh) * 2007-11-02 2010-11-24 麻省理工学院 尿苷饮食添加顺应性方法及其用途
WO2009152430A2 (en) * 2008-06-12 2009-12-17 Repligen Corporation Methods of treatment of bipolar disorder
US20100041621A1 (en) * 2008-08-15 2010-02-18 Perry Renshaw Methods and compositions for improving cognitive performance
CN107353316B (zh) 2011-09-30 2020-08-18 塔夫斯大学 用于治疗神经变性疾病的尿苷二磷酸衍生物、组合物和方法
WO2013066152A1 (en) 2011-10-31 2013-05-10 N.V. Nutricia Method for improving executive function
WO2014027882A1 (en) 2012-08-13 2014-02-20 N.V. Nutricia Product and method for supporting uridine homeostasis
JP6523958B2 (ja) 2012-09-28 2019-06-05 タフツ・ユニバーシティ ウリジン二リン酸誘導体、プロドラッグ、組成物およびそれらの使用
US10138265B2 (en) 2013-03-13 2018-11-27 Tufts University Uridine nucleoside derivatives, compositions and methods of use
JP6591957B2 (ja) 2013-03-13 2019-10-16 タフツ・ユニバーシティ ウリジンヌクレオシド誘導体、組成物および使用方法
WO2015115885A1 (en) 2014-01-31 2015-08-06 N.V. Nutricia Method for reducing white matter lesions, white matter hyperintensities (wmh), leukoaraiosis or periventricular white matter disease in elderly
WO2016053085A1 (en) * 2014-09-30 2016-04-07 N.V. Nutricia Composition comprising a uridine source and butyrate producing fibres for preventing gastrointestinal disorders
WO2016072842A1 (en) * 2014-11-05 2016-05-12 N.V. Nutricia Method for preventing, reducing the risk of, or treating behavioral frontotemporal dementia
WO2017069613A1 (en) 2015-10-23 2017-04-27 N.V. Nutricia Method for improving recognition and/or working memory in hyperphenylalanimenia and phenylketonuria patients
WO2017176109A1 (en) 2016-04-04 2017-10-12 N.V. Nutricia Method for reducing or preventing global developmental delay in children
CA3088213A1 (en) * 2018-02-01 2019-08-08 Wellstat Therapeutics Corporation Compositions and devices for systemic delivery of uridine
CN114990176A (zh) * 2022-05-26 2022-09-02 宁夏华吉生物有限公司 一种生产尿嘧啶核苷的方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2508474A1 (de) * 1975-02-27 1976-09-02 Boehringer Mannheim Gmbh Infusions- und spuelfluessigkeiten zur behandlung von hirnoedemen
DE2629845A1 (de) * 1976-07-02 1978-01-05 Geb Graze Erika Graze Infusions- bzw. injektionsloesungen bzw. waessrige konzentrate zu deren bereitung zur therapeutischen restituion des zellulaeren energiestoffwechsels und der koerpereigenen regelfunktion
US4221784A (en) * 1979-04-05 1980-09-09 Massachusetts Institute Of Technology Process and composition for treating disorders by administering lecithin
US4609647A (en) * 1985-05-28 1986-09-02 Massachusetts Institute Of Technology Cytidyl diphosphocholine-drug composition and process
US4960759A (en) * 1988-06-21 1990-10-02 Polifarma S.P.A. Pharmacological use of uridine in the treatment of nervous disorders
US5567689A (en) * 1993-08-13 1996-10-22 The Uab Research Foundation Methods for increasing uridine levels with L-nucleosides
WO1997045127A1 (en) * 1996-05-28 1997-12-04 Polifarma S.P.A. Uridine-comprising therapeutic active agent for treatment of neurodegenerative disorders

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1178044B (it) * 1984-10-09 1987-09-03 Polifarma Spa Agente attivo farmaceutico per il trattamento di patologie cerebrali a base di uridina
ES2007350A6 (es) * 1987-05-29 1989-06-16 Ganadera Union Ind Agro Productos alimenticios enriquecidos con nucleosidos yno nucleotidos para la nutricion infantil y de adultos, y procedimiento para su preparacion.
DE3883374T2 (de) * 1987-10-28 1993-12-09 Pro Neuron Inc Acylatiertes uridin und cytidin und deren verwendungen.
US5470838A (en) 1987-10-28 1995-11-28 Pro-Neuron, Inc. Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine
RU2003332C1 (ru) 1989-06-09 1993-11-30 Борис Витальевич Страдомский Средство дл лечени депрессий
JPH0722495B2 (ja) * 1990-01-30 1995-03-15 美穂 田中 クロレラ含有油脂食品
US5141943A (en) 1990-04-12 1992-08-25 Brown University Research Foundation 5-benzyl barbiturate derivatives
US5700590A (en) * 1994-01-10 1997-12-23 Abbott Laboratories Nutritional formula with ribo-nucleotides
JPH07215879A (ja) * 1994-02-02 1995-08-15 Otsuka Pharmaceut Factory Inc 抗ストレス組成物
DE9412374U1 (de) * 1994-08-01 1994-09-22 Rauch-Petz, Gisela G., Dr., 80803 München Nahrungsergänzungsmittel
JPH0930976A (ja) * 1995-07-17 1997-02-04 Otsuka Pharmaceut Factory Inc 記憶低下改善剤
US5843024A (en) * 1996-05-17 1998-12-01 Breonics, Inc. Solution and process for resuscitation and preparation of ischemically damaged tissue
US5962459A (en) * 1996-05-28 1999-10-05 Polifarma S.P.A. Therapeutic active agent for treatment of neuron degenerative diseases
US6472378B2 (en) * 1998-08-31 2002-10-29 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
MXPA01008549A (es) * 1999-02-23 2003-06-06 Pro Neuron Inc Metodos de tratamiento de desordenes mitocondriales.
JP2001233776A (ja) * 2000-02-25 2001-08-28 Yamasa Shoyu Co Ltd 学習・記憶能低下改善剤およびその用途
US20030114415A1 (en) * 2001-12-14 2003-06-19 Wurtman Richard J. Compositions and methods for treating and preventing memory impairment using citicoline

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2508474A1 (de) * 1975-02-27 1976-09-02 Boehringer Mannheim Gmbh Infusions- und spuelfluessigkeiten zur behandlung von hirnoedemen
DE2629845A1 (de) * 1976-07-02 1978-01-05 Geb Graze Erika Graze Infusions- bzw. injektionsloesungen bzw. waessrige konzentrate zu deren bereitung zur therapeutischen restituion des zellulaeren energiestoffwechsels und der koerpereigenen regelfunktion
US4221784A (en) * 1979-04-05 1980-09-09 Massachusetts Institute Of Technology Process and composition for treating disorders by administering lecithin
US4609647A (en) * 1985-05-28 1986-09-02 Massachusetts Institute Of Technology Cytidyl diphosphocholine-drug composition and process
US4960759A (en) * 1988-06-21 1990-10-02 Polifarma S.P.A. Pharmacological use of uridine in the treatment of nervous disorders
US5567689A (en) * 1993-08-13 1996-10-22 The Uab Research Foundation Methods for increasing uridine levels with L-nucleosides
WO1997045127A1 (en) * 1996-05-28 1997-12-04 Polifarma S.P.A. Uridine-comprising therapeutic active agent for treatment of neurodegenerative disorders

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CACABELOS R ET AL: "THERAPEUTIC EFFECTS OF CDP-CHOLINE IN ALZHEIMER'S DISEASE COGNITION, BRAIN MAPPING, CEREBROVASCULAR HEMODYNAMICS, AND IMMUNE FACTORS", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, NEW YORK, NY, US, 1 January 1996 (1996-01-01), pages 399 - 403, XP008065562, ISSN: 0077-8923 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1986, MERLINI G ET AL: "EFFECTS OF LARGE DOSES OF PYRIMIDINE NUCLEOSIDES CYTIDINE AND URIDINE IN ELDERLY PATIENTS WITH NEUROPSYCHOLOGICAL DISTURBANCES CAUSED BY VASCULAR AND CEREBRAL METABOLIC INSUFFICIENCY", XP002640124, Database accession no. PREV198783027367 *
D'ORLANDO K J ET AL: "Citicoline (CDP-choline): mechanisms of action and effects in ischemic brain injury.", NEUROLOGICAL RESEARCH AUG 1995 LNKD- PUBMED:7477743, vol. 17, no. 4, August 1995 (1995-08-01), pages 281 - 284, XP009149054, ISSN: 0161-6412 *
GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE, vol. 145, no. 6, 1986, pages 379 - 390, ISSN: 0393-3660 *
KARKISHCHENKO N N; MAKLYAKOV YU S; STRADOMSKII B V: "Use of uridine as antidepressant - shows its reduced toxicity and elimination of several harmful side effects", DERWENT, 30 November 1993 (1993-11-30), XP002302971 *
PICCOLI F ET AL: "CDP-choline in the treatment of chronic cerebrovasculopathies", ARCHIVES OF GERONTOLOGY AND GERIATRICS, ELSEVIER, AMSTERDAM, NL, vol. 18, no. 3, 1 May 1994 (1994-05-01), pages 161 - 168, XP023512323, ISSN: 0167-4943, [retrieved on 19940501], DOI: 10.1016/0167-4943(94)90010-8 *
SPIERS P A ET AL: "CITICOLINE IMPROVES VERBAL MEMORY IN AGING", ARCHIVES OF NEUROLOGY, AMERICAN MEDICAL ASSOCIATION, CHICAGO, IL, US, vol. 53, no. 5, 1 May 1996 (1996-05-01), pages 441 - 448, XP008028412, ISSN: 0003-9942 *
WEISS G B: "Metabolism and actions of CDP-choline as an endogenous compound and administered exogenously as citicoline.", LIFE SCIENCES 1995 LNKD- PUBMED:7869846, vol. 56, no. 9, 1995, pages 637 - 660, XP002640081, ISSN: 0024-3205 *

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EP2322187A2 (de) 2011-05-18
DE69937198T2 (de) 2008-07-03
PT1140104E (pt) 2007-12-26
ES2478044T3 (es) 2014-07-18
ES2332669T3 (es) 2010-02-10
DK1140104T3 (da) 2008-01-21
US6989376B2 (en) 2006-01-24
EP2322187A3 (de) 2011-07-20
ES2294850T3 (es) 2008-04-01
EP2329829A2 (de) 2011-06-08
EP1140104A4 (de) 2004-12-22
EP1870103A3 (de) 2008-08-06
JP2003517437A (ja) 2003-05-27
EP2329829B1 (de) 2014-04-16
EP1140104B1 (de) 2007-09-26
PT2322187E (pt) 2014-07-24
EP1870103B1 (de) 2009-10-21
DE69941586D1 (de) 2009-12-03
DK2322187T3 (da) 2014-07-21
CY1110570T1 (el) 2015-04-29
PT2329829E (pt) 2014-07-24
ATE374029T1 (de) 2007-10-15
CA2339008A1 (en) 2000-02-10
CA2339008C (en) 2009-12-15
ES2477568T3 (es) 2014-07-17
US20020028787A1 (en) 2002-03-07
EP1870103A2 (de) 2007-12-26
EP2145627B1 (de) 2014-04-16
DE69937198D1 (de) 2007-11-08
ES2476940T3 (es) 2014-07-15
PT1870103E (pt) 2010-02-23
EP1140104A1 (de) 2001-10-10
ATE446097T1 (de) 2009-11-15
DK2145627T3 (da) 2014-07-21
EP2145627A1 (de) 2010-01-20
WO2000006174A1 (en) 2000-02-10
EP2322187B1 (de) 2014-05-14
PT2145627E (pt) 2014-07-24
DK2329829T3 (da) 2014-07-21

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