EP2125223A2 - Appareil pièce rapportée pour bouteille pour la manipulation de liquides - Google Patents

Appareil pièce rapportée pour bouteille pour la manipulation de liquides

Info

Publication number
EP2125223A2
EP2125223A2 EP07856393A EP07856393A EP2125223A2 EP 2125223 A2 EP2125223 A2 EP 2125223A2 EP 07856393 A EP07856393 A EP 07856393A EP 07856393 A EP07856393 A EP 07856393A EP 2125223 A2 EP2125223 A2 EP 2125223A2
Authority
EP
European Patent Office
Prior art keywords
bottle
piston rod
piston
sensor
cylinder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP07856393A
Other languages
German (de)
English (en)
Other versions
EP2125223B1 (fr
Inventor
Dieter Böhm
Wolfgang Ettig
Peter Mahler
Jürgen Schraut
Roland Wohner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brand GmbH and Co KG
Original Assignee
Brand GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brand GmbH and Co KG filed Critical Brand GmbH and Co KG
Priority to EP14002517.2A priority Critical patent/EP2799141B1/fr
Priority to EP19158248.5A priority patent/EP3508274B1/fr
Publication of EP2125223A2 publication Critical patent/EP2125223A2/fr
Application granted granted Critical
Publication of EP2125223B1 publication Critical patent/EP2125223B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02Burettes; Pipettes
    • B01L3/0203Burettes, i.e. for withdrawing and redistributing liquids through different conduits
    • B01L3/0206Burettes, i.e. for withdrawing and redistributing liquids through different conduits of the plunger pump type
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/08Ergonomic or safety aspects of handling devices
    • B01L2200/087Ergonomic aspects
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14Process control and prevention of errors
    • B01L2200/141Preventing contamination, tampering
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14Process control and prevention of errors
    • B01L2200/143Quality control, feedback systems
    • B01L2200/146Employing pressure sensors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/02Identification, exchange or storage of information
    • B01L2300/024Storing results with means integrated into the container
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/02Identification, exchange or storage of information
    • B01L2300/025Displaying results or values with integrated means
    • B01L2300/027Digital display, e.g. LCD, LED
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/04Closures and closing means
    • B01L2300/046Function or devices integrated in the closure
    • B01L2300/048Function or devices integrated in the closure enabling gas exchange, e.g. vents
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated

Definitions

  • the invention relates to a bottle attachment for handling liquids. These devices involve the accurate metering and delivery of fluids from a storage bottle or other storage container, with accurate metering in picking up a partial fluid volume from the storage bottle or the like into the device and / or dispensing a partial fluid volume out of the device to the outside into a container.
  • Bottle attachments of the type in question are in particular burettes and dispensers.
  • Such bottle top devices are widely used in chemistry, biology and pharmacy in the laboratory and in production.
  • liquid in the present context denotes liquids such as are widely used in the laboratory and in production in chemistry, biology, pharmacy, etc., in particular liquids having a relative viscosity of up to about 300 (viscosity with respect to the viscosity of water under normal conditions). It is therefore the fluid range from very fluid to slightly viscous.
  • a manually operated burette is used in titration to determine the unknown amount of a solute from the consumption of a reagent liquid of known concentration. To ensure proper and economic analysis work, a burette is required to quickly and accurately dispense and display the particular amount of fluid. High demands are placed on the precision of the liquid dispensing and on the operator safety (General Catalog 600 "Laboratory Equipment from Brand" of BRAND GMBH + CO KG 09/01, No. 9963 00, "Burette Digital III", pages 27 to 34).
  • the bottle top device is described in its operating position, that is mounted in its position on a storage bottle and aligned substantially vertically.
  • valve block In the valve block is regularly a suction valve, which allows to suck liquid from the storage bottle by means of a suction pipe.
  • a suction valve Approximately horizontally from the valve block from an ejection line extends with a discharge valve therein. Since the discharge line protrudes approximately horizontally from the valve block and often still carries an additional switching valve, this is the side from which an operator works with the bottle top unit. This page will be referred to below as “front” or “front”. The opposite side is the “back” or “back”.
  • a display with corresponding operating elements is regularly at the front.
  • the known bottle top apparatus for handling liquids, from which the invention proceeds is characterized in that the cylinder-piston assembly is covered by a closed top outer housing from above , This outer housing moves together with the piston rod relative to the cylinder upwards.
  • a vertically extending rack located on the cylinder a vertically extending rack, with a pinion on a drive shaft which is mounted in the outer housing, meshes.
  • the piston drive of this bottle attachment device is designed for manual actuation and therefore carries the drive shaft there at both ends outside the outer housing each have a manual control knob.
  • the teaching of the present invention is based on the problem of specifying a bottle attachment for handling liquids, which achieves a particularly high level of user-friendliness and operator safety.
  • the present invention solves the above-indicated problem with a bottle attachment device having the features of claim 1.
  • the solution of claim 1 has a displacement of at least one operating button of the display on the front of the outer housing on the top of the subject. It can be arranged on the top of the outer housing depending on the space and requirements but also two or even more buttons.
  • the outer housing is closed on the upper side and encompasses the cylinder-piston arrangement from above.
  • the solution according to the invention makes itself known to this fact known for decades Use for an optimized operation possibility of the bottle top unit.
  • An operating button which is often used when working with the bottle top unit, can be actuated here by pressure from above. As a result, a quick and error-free operation is possible without a serious tilting moment is exerted on the bottle attachment and the storage bottle underneath.
  • operating buttons thus no holding back the outer housing is required.
  • Preferred embodiments and further developments of this variant are subject matter of claims 2 to 6.
  • a large-scale actuating button on the top of the outer housing can finally be used in a dual function according to claim 8 to hide ventilation openings at this point. Further preferred variants are the subject matter of claims 9 to 18.
  • the measuring strip is an optical scale and the sensor array is an incident light system.
  • the measuring strip is part of a capacitive system, which also includes the sensor. Opposing electrodes are arranged so that two pairs of Meßkapazticianen for measurement the relative movement between the measuring strip and the sensor are formed.
  • the piston rod carries a magnetic strip. Adjacent to the piston rod is here fixed in the housing a read head provided which is aligned with the magnetic measuring strip and separated from it by a gap.
  • An electronic control circuit is coupled to the read head, which reads the measurement information on the magnetic strip and injects corresponding pulses in the control circuit. This converts the pulses and controls a digital display, which in turn indicates the volume of liquid dispensed based on the relative movement between the piston and cylinder.
  • the above-indicated problem of optimizing the measuring system in devices of the type in question is solved in that the sensor arrangement is arranged in a fully enclosed to the measuring strip Aumahmetasche.
  • the sensor arrangement may optionally be cast in the receiving pocket backward with potting compound to ensure optimum protection for the sensor assembly. Of course, this only works with a suitable measuring strip.
  • a magnetic field-sensitive sensor arrangement is concerned with a correspondingly magnetized measuring strip.
  • An optical sensor arrangement uses an optical scale.
  • a suitable alternative has a wall portion of the receiving pocket, which is designed as a film.
  • This film should be extremely thin and have a low permeability to the gases occurring.
  • Such a thin film can even consist of transparent material, so that the sensor of the sensor arrangement can work optically.
  • the receiving pocket is provided with slot connections, which allow an exact alignment of the receiving pocket on the measuring strip when installed in the device.
  • the senor is arranged in the receiving pocket at the side facing the measuring strip behind a thin-walled wall portion of the receiving pocket.
  • the sensor has been brought as close as possible to the measuring strip, without actually touching it, and while maintaining a gas-tight seal of the sensor assembly to the interior of the device out.
  • the above-mentioned problem is solved in that the sensor is designed as a magnetoresistive sensor system, in particular based on the AMR effect, and that the evaluation circuit is a largely highly integrated, cost-effective mixed signal Controller, which evaluates the converted analog sensor signals directly via an interpolation software.
  • Mixed-signal controllers are microcontrollers which connect various electronic processing functions, which are also suitable for evaluating the sensor signals via interpolation software, with the functions of an A / D converter.
  • a mixed-signal microcontroller replaces a three-stage arrangement of A / D converter, processing stage with processing software and output stage.
  • Such a mixed-signal microcontroller is regularly far cheaper to use at the signal level of AMR sensors than a three-stage arrangement.
  • Microcontrollers are offered by different suppliers with different power spectra (see, for example, the data sheet "MSP 430 x 33 x MIXED SIGNAL MICROCONTROLLERS", February 1998, Texas Instruments). With a mixed-signal microcontoller, you not only create a simple signal processing solution, but in particular a very low power consumption both during operation and at rest. (For detailed information, please refer to relevant data sheets, especially the data sheet mentioned above.)
  • Mixed signal controllers can be realized in different versions, for example as PSoC (Programmable System on a Chip), as DSP (Digital Signal Processor) or as FPGA (Field Programmable Gate Array).
  • PSoC Programmable System on a Chip
  • DSP Digital Signal Processor
  • FPGA Field Programmable Gate Array
  • the latter has a purely digital input transducer, so that a discrete upstream A / D converter can be the overall arrangement to a mixed-signal controller of the type described.
  • the evaluation takes place by means of the evaluation circuit with an ON / OFF duty cycle of about 0, 1 to about 0.02, preferably between about 0.05 and about 0.03, in particular with an ON Time from about 0.6 ms to about 0.1 ms, in particular between about 0.3 ms and about 0.15 ms. It also appears to be particularly advantageous for the interpolation software to operate at an interpolation rate of between 200 and 1000, in particular between approximately 400 and approximately 600, preferably approximately 500.
  • the device according to the invention a structure can be realized, which ensures safe operation and at the same time easy handling.
  • the power consumption of the measuring system is low and the cost of the production are also lower than in classic bottle top devices.
  • FIG. 1 is a perspective view of a bottle top device in the form of a digital burette on a storage bottle
  • FIG. 8 is a schematic diagram of an AMR sensor that can be used as a magnetoresistive sensor in the measuring system according to the invention.
  • FIG. 10 is a diagram showing the keying in the preferred measuring system according to the invention by way of example,
  • FIG. 1a a preferred embodiment of a cylinder-piston arrangement with a measured value detection according to the invention for a magnetoresistive measurement with a piston rod located in the desired position
  • FIG. 1b the system of FIG. 1a, now the piston rod is deflected relative to the desired position due to the play
  • Fig. 12 in an enlarged view in Fig. 3 similar orientation a piston with piston rod with a measuring strip in a particularly convenient arrangement.
  • Fig. 1 shows a preferred exemplary embodiment of a bottle attachment according to the invention for handling liquids, here in the form of a burette.
  • Bottle-top dispensers result, for example, from DE-U-88 00 844 and in particular EP-A-0 542 241, which will be discussed in more detail below.
  • a display 4 with a display fei d 5, in particular for a digital display, preferably with LCD elements, as well as with actuators, in particular operation buttons. 6 - -
  • a discharge line 7 which is arranged in the illustrated embodiment in an angle-shaped holder 8 and closed at the end by means of a closure cap 9 for sealing and as drip protection.
  • the illustrated bottle top unit has in the outer housing 2, first a valve block 10. At this is attached or integrally formed the already mentioned mounting assembly 3, with the fact of the valve block 10 is mounted on the storage bottle 1. At the same time then also the outer housing 2 is mounted on the storage bottle 1.
  • valve block 10 as a one-piece made of plastic, in particular made of chemical resistant plastic component, which is provided with a plurality of channels and internals.
  • the construction is similar to the valve block of the bottle top dispenser known from EP-A-0 542 241 and belongs to the prior art.
  • the mounting assembly 3 is designed as compared to the valve block 10 freely rotatable cap.
  • a suction valve insert 11 to which an intake line 12, which is shown shortened here for simplicity, is connected to the bottom of the storage bottle 1 into it.
  • the intake valve insert 11 in the valve block 10 is adjoined by an intake passage 13, from which an ejection channel 14 directed to the right in FIG. 2 branches off at approximately half the height.
  • An ejection valve insert 15 is located in a recess of the valve block 10 on the ejection channel 14. This is part of a valve body 16 of a changeover valve 17 attached to the valve block 10.
  • the ejection line 7 adjoins the changeover valve 17 in the holder 8.
  • the holder 8 extends in an arc shape and guides the discharge line 7 in the same arc, so that the discharge opening faces downwards. There she is closed with the cap 9.
  • the switching valve 17 has in the valve body 16 a rotatable about a vertical axis of rotation valve body 18 which can be adjusted with a recognizable also in Fig. 1 knob 19 by hand.
  • Below the exhaust valve insert 15 extends in the valve body 16, a return passage 20, which continues in the valve block 10 to a downwardly outgoing return line 21.
  • the valve block 10 further includes near the rear side a bottle ventilation line 22, which opens into a rearwardly open, radially open stopper receptacle 23.
  • a bottle ventilation line 22 which opens into a rearwardly open, radially open stopper receptacle 23.
  • the plug receptacle 23 is a closing this plug 24 or a similar closure element, but having a small passage opening, so that the interior of the storage bottle 1 is connected via the bottle venting line 22 and this passage in the plug 24 with the ambient atmosphere.
  • a pressure equalization in the storage bottle 1 is possible.
  • existing valve block 10 is in a Zylinderauf- take 25 a preferably and also made of glass existing cylinder 26 fixed and sealed against the valve block 10. Specifically, the cylinder 26 is compressed in the cylinder receptacle 25.
  • Fig. 2 in conjunction with Fig. 3 and Fig. 4 makes it clear that initially a cylinder 26 surrounding, upwardly beyond the cylinder 26 also extending, supporting frame 30 is provided.
  • This frame 30 is connected at the lower end with the valve block 10 fixed in an axially precisely determined position, but in principle detachable from the valve block 10.
  • the solubility of the frame 30 from the valve block 10 is hereby realized in that at the upper edge of the valve block 10, an external thread is provided and that the frame 30 has a flange below, which is provided with a cap 31 with internal thread.
  • FIGS. 3 and 4 makes it clear that the throw-over cap 31 is guided on the frame 30 and can move upwards.
  • the frame 30 can thus be brought first with its lower edge in the desired position on the valve block 10. Then, while maintaining this position, the cap 31 can be screwed onto the external thread on the valve block 10 and the frame 30 can be fixed relative to the valve block 10.
  • Essential for the frame 30 is further that this also receives the piston drive 29 or carries.
  • the piston drive 29 may not be part of the frame 30, but in any case the frame 30 is the supporting member for the piston drive 29 and determines its position relative to the valve block 10.
  • the frame 30 is enlarged or extended in the manner of a block and has various recesses there for receiving various parts of the piston drive 29. This will be discussed later.
  • a releasably connected to the valve block 10 outer housing 2 is provided. This encloses the frame 30 on the outside, thus forming the outer shell of the bottle top unit and protects the internal components. It extends beyond the piston drive 29 on the frame 30 in any case slightly upwards and is closed in the illustrated and preferred embodiment above.
  • Fig. 2 The illustrated and preferred embodiment can be seen in Fig. 2 in conjunction with Figs. 3 and 4 further that the cap 31 can not be operated here easily. Rather, it is provided for safety reasons and for reasons of accessibility in the outer housing 2, that the cap 31 can be operated only with a special tool 32.
  • This tool 32 can be seen in Fig. 2 top left in a suspension at the back of the outer housing. 2
  • the small stroke of the piston 27 in the bottle attachment device according to the invention facilitates the closed design of the outer housing 2, because the complete stroke of the piston rod 28 can be handled within the outer housing 2.
  • the outer housing 2 still does not have to be made excessively high. Also, it does not have to ride along with the piston rod 28 in whole or in part.
  • the construction according to the invention thus increases the operating safety of the bottle top unit.
  • the lower the bottle top unit the higher the stability of a stock bottle 1 equipped with such a bottle top unit.
  • the stroke quotient has a value of just under 2.0 for the nominal volume of 25 ml and a nominal volume of 50 ml in the illustrated embodiment Value of about 1.4. With a nominal volume of 100 ml, which would represent a rather unusually large arrangement, one would come to a value of about 1.0, which would mean an effective diameter of the piston 27 of about 50 mm.
  • the execution of the cylinder 26 as a calibrated glass tube with extremely high precision further increases the accuracy of the bottle top unit in total.
  • the use of a calibrated glass tube as a cylinder 26 is useful and expedient here because of the measures taken otherwise.
  • FIGS. 3 and 4 show that a drive shaft 33 of the piston drive 29 is mounted in the upper part of the frame 30.
  • the primary objective of the invention is a manually actuated bottle attachment device with an electronic, in particular digital measured value acquisition and display.
  • Figs. 1, 3 and 4 that the piston drive 29 is designed for manual operation and the drive shaft 33 at one end or at each end outside of the outer housing 2 carries a manual operation knob 38. It can be seen the two hand control knobs 38 left and right on the outer housing 2 in Fig. 1st
  • the geared connection between the drive shaft 33 and the pinion 35 is designed so that a rotation of the manual operation knob 38 causes a downward movement of the piston 27 forward and downward.
  • Ergonomic studies have shown that one can combine a good dosing accuracy with a quick recording or dispensing large amounts of liquid optimally, if the maximum Stroke of the piston 27 five to ten of the manual operation knob 38 corresponds.
  • the design of the piston 27 in the cylinder 26 is important.
  • the piston 27 is made in one piece with the piston rod 28, or designed as a separate part and fixedly attached to the piston rod 28, in particular screwed.
  • the illustrated embodiment shows the piston rod 28, and screwed thereto by means of a central fastening screw 39, the piston 27, which here carries him a bottom side and circumferentially comprehensive slide piece 40 of a very good sliding material, in particular of PTFE.
  • the sliding piece 40 forms a pressure ring on the cylinder 26 under pressure 40a, which is stored for generating pressure with a piston 27 supported on the spring ring 42 from a preferably also chemically resistant material.
  • the spring ring 42 is shown in the drawing as a hollow chamber ring, for example made of chemical-resistant elastomer material. It is essential that the sliding ring 40 a itself does not have to apply the force to achieve the sealing effect of the sliding nozzle 40 on the inner surface of the cylinder 26. This is taken over by the spring ring 42, which is adapted for it. Incidentally, it can hardly be recognized in the drawing that the outer peripheral surface of the sliding ring 40a can still be structured in order, for example, to realize a multi-start scraper ring.
  • the piston 27 is not driven down against the valve block 10 but the piston rod 28 or the piston 27 up against a stop 43. It recognizes the stop 43 in FIG. 4. It interacts with a counterpart 43 'on the piston rod 28.
  • the stop 43 can be adjustable and should in any case be removable in order to be able to pull out the piston 27 together with the piston rod 28, for example for cleaning or sterilization measures.
  • the frame 30 is not designed as an open frame, but as a substantially closed housing, which is the case in the present embodiment (see in particular Fig. 2 and Fig. 4), it is recommended that the frame 30 in any case with a front view cutout 44 or a corresponding window and, as provided here ( Figure 5), to be provided with a rear view cutout 45 or a corresponding window. This allows you to look into the cylinder 26 from the front or the back.
  • a viewing cutout or a window in the frame would not be of any use if the outer casing 2 were not covered by the viewing cutout 44; 45 or window of the frame 30 would have a corresponding window 46 and 47, respectively.
  • a viewing window may optionally be UV-protective colored, for example in brown color.
  • the front window 46 in the outer housing 2 can also be seen in Fig. 1.
  • Ventilation openings 48 which expediently to achieve convection in the middle, z. B. concealed under the manual operation knob 38, or below near the valve block 10 and above the upper end of the outer housing 2 are arranged.
  • the illustrated and preferred exemplary embodiment shows that the ventilation openings 48 on the top are arranged on the head of the outer housing 2, preferably under an actuating button 49 arranged on the upper side.
  • a large-area actuator button 49 which is labeled here with the word "Clear”, that is, represents a zeroing button. Such is often used when working with a burette.
  • the actuating button 49 on the upper side of the outer housing 2 is designed as a pushbutton. Their operation is thus carried out by pressure from the top of the outer housing 2. This makes a quick and error-free operation possible without a serious tilting moment is exerted on the bottle top unit and the storage bottle 1 underneath. Unlike the arranged on the front of the outer housing 2 th actuating buttons 6 thus no holding the outer housing 2 is required.
  • the large-area actuation button 49 also offers the option of hiding the ventilation opening 48 there. This is shown in FIG. 2.
  • the outer housing 2 has a front housing shell 51 and a rear housing shell 52 releasably connected thereto.
  • the front housing shell 51 is hooked behind the valve block 10 and centered (or top) on the frame 30 firmly anchored. She's screwed on there.
  • the rear housing shell 52 is suspended at the top of the front housing shell 51.
  • FIG. 2 and Fig. 5 show further features of the interior design of the outer housing 2.
  • the outer housing 2 here in the front housing shell 51, more precisely attached to this, one from behind (as here), from This (2004)hahmefach 53 serves to accommodate electronic devices, in particular a populated circuit board 54.
  • Aufhahmefach 53 is also the electronics of the display 4 including the Display field 5.
  • the receiving compartment 53 continues under the actuating button 49 angularly into the rear housing shell 52.
  • the electronic devices can also be protected under the operating button 49 in this Aufhahmefach 53.
  • this is another board 55, which carries a pushbutton 56, which is actuated by the actuating button 49.
  • This further board 55 is connected in the illustrated and preferred embodiment with the circuit board 54 via a film hinge 57 and sits even in a slide-58 of Aufhahmefaches 53.
  • the film hinge 57 is formed in the illustrated and preferred embodiment of a circuit film web.
  • the receptacle 53 could be completed to the front by a possibly also the display 4 and the operation buttons 6 carrying compartment cover 59. _ _
  • an external connection 60 can also be seen on the receiving compartment 53 in the upper region extending up to the rear housing shell 52 in FIG. 2 and FIG. 5. The latter is also sealed to the rear housing shell 52.
  • the terminal 60 represents an external interface of the electronic devices that can be used in any conventional manner.
  • the ventilation opening 48 below the actuating button 49 is the ventilation of the Aufhahmefaches 53, are indicated in Fig. 5, laterally below the actuating button 49 ventilation openings for the ventilation of the interior of the outer housing 2 in the rest responsible. It can be seen in Fig. 5 in this context that the Aufiiahmefach 53 at least in the rearwardly extending portion is narrower than the outer housing 2 and is arranged centrally.
  • Fig. 5 in conjunction with Fig. 2, that in the outer housing 2, and here in the front housing shell 51, d. H. attached to this, two battery compartments 61, namely right and left of Aufhahmefaches 53, are arranged. Each battery compartment 61 is closed by a cover 62 to the interior of the outer housing 2 in the rest.
  • the lid 62 can be seen in Fig. 2, it has a handling tab 63.
  • Fig. 5 shows the battery compartments 61 without the lid 62 and without batteries. Of course, the battery compartments 61 are sealed by the lid 62 against the vapors occurring in the outer housing 2.
  • the apparent design of the outer housing 2 with the substantially fixed front housing shell 51 and the easily removable rear housing shell 52 is a simple way for the user to disassemble the cylinder-piston assembly, the piston 27 together with the piston rod 28 on the one hand and to clean the cylinder 26 on the other hand and also to change the piston 27 or the slide neck 40, if necessary.
  • the piston rod 28, preferably on the side opposite the row of teeth 34 carries a measuring strip 64 extending axially on the piston rod 28 and adjacent to the piston rod 28, preferably in the upper part of the frame 30 , a sensor arrangement 65 is arranged with a sensor 66 oriented on the measuring strip 64.
  • a direct measured value space is provided on the piston rod 28, as is generally known from the prior art explained in the introduction. Play in translation devices, as occurs in electromechanical data acquisition, is systematically excluded here. This is particularly useful here if the other measures for stiffening the mechanical arrangement and for increasing the accuracy are also taken.
  • the illustrated embodiment shows that the measuring strip 64 is aligned here on one side form-fitting manner on the piston rod 28.
  • the measuring strip 64 is inserted with a one-sided axial stop 67 in a pocket on the piston rod 28 and potted with a preferably chemical-resistant potting compound 68.
  • the potting compound 68 on the one hand down the stop 67 in a small amount, on the other hand, top of the upper end of the piston rod 28.
  • a potting compound 68 is easier to perform chemical resistant than normal glue. She has -
  • Fig. 12 the assembly with piston 27, piston rod 28 and measuring strip 64 is shown.
  • the measuring strip 64 is arranged in the piston rod 28 near the central axis of the piston 27, as in the embodiment according to FIG. 11a / 1b.
  • the measuring strip 64 is also not held as in the embodiment of FIG. 2.
  • the measuring strip 64 sits vertically near the piston 27 on the stop 67.
  • the upper opposite end of the measuring strip 64 is moved by a spring element 28a vertically downward on the stop 67. Both abutment surfaces are inclined, so that the measuring strip 64 is held in the direction of its lateral abutment against the piston rod 28.
  • the measuring strip 64 is not connected over its vertical length with the piston rod 28.
  • the embodiment according to FIG. 12 keeps the measuring strip 64 flexibly fixed to the piston rod 28 by the spring element 28a. Temperature changes and different elongations have no influence on the attachment. In addition, the assembly of the measuring strip 64 without aids and / or a curing time is positive in terms of costs for production and repair.
  • the spring element 28a and the piston rod 28 are made in one piece.
  • the spring element 28a could also be a separate component, which is fastened to the piston rod 28 and consists of another material with good elastic properties.
  • the spring element 28a could be designed so that it the measuring strip 64th in the direction of its lateral abutment on the piston rod 28 positively, for example by means of a molded bracket holds.
  • the distance measuring strip 64 (measuring strip 64) is magnetized in sections spaced apart or partially magnetized in opposite directions, with a pitch between 0.3 mm and 2.0 mm, preferably and as a compromise between resolution and cost about 1 , 0 mm.
  • the illustrated and so far preferred embodiment shows a particularly expedient embodiment of a non-optical, in particular a magnetic field-sensitive sensor assembly 65.
  • This is located in a measuring strip 64 and the interior of the outer housing 2 out completely closed receiving pocket 69.
  • This is in the illustrated embodiment in the Used frame 30, namely screwed to this with slot connections 70.
  • the slot connections 70 allow the exact alignment of the receiving pocket 69 on the measuring strip 64.
  • the sensor 66 of the sensor assembly 65 in the receiving pocket 69 on its side facing the measuring strip 64 behind a thin-walled wall portion 71 is.
  • the purpose of the arrangement is to bring the sensor 66 as close as possible to the measuring strip 64, without actually touching it, and while maintaining a gas-tight seal of the sensor assembly 65 to the interior of the outer housing 2.
  • the sensor 66 of the sensor arrangement 65 is seated on a board 74 inserted into the receiving pocket 69 in a slide-in guide 73, specifically on its front edge, which in FIG. 3 and FIG on the thin wall portion 71 abuts.
  • the wall section 71 here has, for example, only a thickness of about 0.1 to 0.2 mm. If the pitch of the measuring strip 64 is selected to be larger, the distance between the sensor 66 and the measuring strip 64 can also increase. Then easier to produce, in particular injection-moldable wall sections can be designed, which will regularly have a slightly larger wall thickness of about 0.5 mm.
  • the Aufhahmetasche 69 here consists of a total of a chemical-resistant and pourable temperature-stable plastic material, in particular PEEK. Length and width of the receiving pocket 69 are about 20 mm, the thickness of about 8 to 10 mm.
  • the wall portion 71 of the receiving pocket 69 can not be made in one piece with the Aufhahmetasche 69, but separately. It would then be attached to the receiving pocket 69.
  • the receiving pocket 69 can have an opening in the region of the wall section 71.
  • a gas-tight film may be welded to such an opening or otherwise fixed with and without auxiliaries, the opening closing on the Aufhahmetasche 69.
  • Such a gas-tight film usually has a thickness of about 10 microns to about 500 microns.
  • This film now forms the wall section 71, which separates the sensor 66 from the measuring strip 64 in a gastight manner. In this way you can come to a very small distance of 0, 1 mm or less.
  • the sensor arrangement 65 also has on the board 74 the evaluation circuit 72 for evaluating the output signals of the sensor 66 and for controlling the display 4.
  • the evaluation circuit 72 is constructed as a system solution with individual or multiple discrete components.
  • a space-saving, energy-saving and cost-effective evaluation circuit 72 is achieved with the use of a mixed-signal controller, which evaluates the converted analog sensor signals directly via an interpolation software.
  • the evaluation circuit 72 can also be used with a software solution that is in the extreme case pure by means of a microprocessor or microcontroller. Realize computers without departing from the spirit of the teachings of the present invention.
  • FIG. 7 shows a perspective view of the receiving pocket 69 with inserted board 74 obliquely from behind.
  • the board 74 is not yet shed.
  • the soldered to the board 74 and not shown with molded interface cable It can be provided to completely shed the board 74 in the receiving pocket 69, and indeed with a chemical-resistant potting compound.
  • FIG 8 shows an arrangement of a particularly expedient sensor 66 for a sensor arrangement 65 of a device according to the invention.
  • the sensor 66 is designed as a magnetoresistive sensor system based on the AMR effect.
  • this operating principle may be on the publication of Dr. med. Erik Lins, SENSITEC GmbH "Magnetoresistive with Optical Precision", of August 1, 2005, the disclosure of which is incorporated by reference into the disclosure content of the present application. This publication has been freely available on the Internet since August 2005.
  • Fig. 8 briefly shows two Wheatstone bridge circuits offset by 45 ° from each other to produce a cosine signal (C) and a sine signal (S), taps at + C / -C and + S / -S , Operating voltage at Ub, against ground.
  • the magnetization direction of the measuring strip 64 is defined by H, the angle between H and the direction of the current flow is indicated by ⁇ .
  • the angle information becomes independent of the amplitude of the signals.
  • the working distance between the sensor 66 and measuring strip 64 is not particularly critical.
  • the separate evaluation of the sine and cosine signals provides some redundancy and allows due to the fact that the Sum of squares is equal to 1, a self-monitoring of the sensor 66 and an offset amplitude correction.
  • a circuit arrangement 72 as shown in FIG. 9 as a block diagram is recommended.
  • the sensor 66 is supplied with a clocked supply voltage 80, which is adjustable via an amplitude setting 81 on the sensor 66.
  • the designated outputs (cos, sin) of the sensor 66 are connected to amplifiers 82, each with offset trim 82 '. After the amplifiers 82 there is a branch on the one hand to comparators 83 for comparison with a reference voltage 84, on the other hand to analog / digital converters 75 with downstream modules 85 and normalization stages 86.
  • the assemblies 75, 85, 86, 87, 88 and 89 are in the present, so far preferred solution implemented in a mixed-signal controller.
  • a mixed-signal controller see the related notes and quotation point included in the general part of the description.
  • a magnetoresistive measuring system is already quite expedient anyway, at least much cheaper than an optoelectronic measuring system.
  • the evaluation by means of the interpolation software takes place with an ON / OFF duty cycle of approximately 0.1 to approximately 0.02, preferably between approximately 0.05 and approximately 0.03, in particular with an ON / OFF duty cycle. Time of about 0.6 ms to about 0.1 ms, in particular between about 0.3 ms and about 0.15 ms. It is particularly recommended that the interpolation software with an interpolation between 200 and 1,000, in particular between about 400 and about 600, preferably from about 500 works.
  • the adjustment speed of the piston 27 will not be greater than about 50 mm / s. Then the interpolation rate is adjusted. This gives a resolution of the measuring path of about 2 microns and an accuracy of the measured value over the full range of about 10 microns, the whole in a temperature range of + 10 0 C to about + 40 ° C.
  • FIG. 11 Another teaching that is independent of itself is explained on the basis of the exemplary embodiment of FIG. 11 (FIG. 11a, FIG. 1b).
  • this construction is for a magnetic Field-sensitive sensor system, in particular a magnetoresistive sensor system.
  • Fig. Ia shows a precise alignment of the piston rod 28 on a side guide 90. It is provided here that on the same side on which the sensor assembly 65 is located, a side guide 90 is provided for the piston rod 28 and the sensor 26 is close to , Preferably, approximately at the height of the side guide 90 is arranged. This ensures that in the target position of the piston rod 28 in abutment against the side guide 90 and the sensor 66 is aligned relative to the positioned on the piston rod 28 measuring strip 64 exactly. The parallelism of the measuring strip 64 with the sensor 66 is optimal over the full displacement of the piston rod 28.
  • Fig. 1 Ib shows in connection with Fig. 1 Ia, that a measurement error in terms of distance measurement in the axial direction could also result from an inclination of the piston rod 28 in the cylinder 26, in particular relative to the piston 27.
  • This measurement error occurs in a device of the type in question because of the otherwise achieved high precision. It is caused by the fact that the piston rod 28 in the region of the piston drive 29 has a certain lateral play, for example of 0.3 mm. This leads to a minimal, but disturbing in the context of the present measurement accuracy inclination of the piston rod 28, which causes a Wegmeßcons.
  • Sensor 66 facing surface of the measuring strip 64 forms a plane which is closest possible to or on the longitudinal central axis of the piston rod 28.
  • This arrangement rule for the measuring strip 64 on the piston rod 28 is based on the recognition that in a incident light system, the surface of the
  • Measuring strip 64 is the interface between measuring strip 64 and sensor 66.
  • the sensor 66 which detects the magnetic field of the measuring strip 64 is located next to or on the longitudinal central axis of the piston rod 28 as soon as possible. This is shown in Fig. I Ia, b.
  • the interface in the magnetoresistive measuring system is the sensor 66, which is penetrated by the field lines of the periodically magnetized measuring strip 64. If the measuring strip 64 tilts to the left as shown in FIG.
  • the interface is somewhere between the two previously described orientations.
  • Fig. 12 shows a particularly interesting constructive solution for fixing the measuring strip 64 in the piston rod 28, taking into account the boundary conditions explained above. This has already been explained above.
  • the illustrated embodiments show that the sensor arrangement 65 is not arranged on the outer housing 2, but on the dimensionally stable frame 30.
  • the entire metrological chain is completely concentrated on the frame 30, so that its dimensional stability leads to the excellent accuracy of the bottle attachment device according to the invention.
  • the measuring strip 64 is an optical scale and the sensor arrangement 65 is a high-resolution incident-light system, in particular with four incident-light diodes. Then, the construction in the area of the sensor arrangement 65 is of course different from what has been described above.
  • the accuracy of measurements in the bottle-top device according to the invention can be increased to an accuracy R of approximately +/- 0.06% and a coefficient of variation VK of approximately 0.02% at nominal volumes of 25 ml and 50 ml. These are values that otherwise would otherwise be achieved by high-precision motorized bottle top units.
  • the high accuracy of the bottle attachment device according to the invention is also due to the fact that all mechanically moving parts are axially fixed relative to the valve block 10 precisely and dimensionally stable. This, in conjunction with the direct measurement acquisition directly on the piston rod 28 makes a backlash in reversing the Betrelifactsrich- direction superfluous. _ _

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Loading And Unloading Of Fuel Tanks Or Ships (AREA)
  • Measurement Of Length, Angles, Or The Like Using Electric Or Magnetic Means (AREA)

Abstract

L'invention a pour objet un appareil pièce rapportée pour bouteille pour la manipulation de liquides. Un tel appareil pièce rapportée pour bouteille est généralement une burette ou un distributeur. L'appareil pièce rapportée pour bouteille présente généralement un ensemble cylindre-piston dans un boîtier externe. L'invention est caractérisée en ce que, sur la face supérieure du boîtier externe, est placé au moins un bouton d'actionnement (49) à enfoncer vers le bas. Le boîtier externe (2) peut être doté d'orifices d'aération (48) que l'on peut cacher sous le bouton d'actionnement (49). L'appareil pièce rapportée pour bouteille est également caractérisé par un agencement particulier d'un système de détection (65) par rapport à une bande de mesure (64) sur une tige de piston (28). L'évaluation du signal de mesure de trajet peut être assurée par un système de détection magnétoresistant, notamment un de type sur la base de l'effet AMR. L'agencement de la bande de mesure (64) par rapport à l'axe central longitudinal de la tige de piston (28) joue un rôle important.
EP07856393.9A 2006-12-07 2007-12-06 Appareil pièce rapportée pour bouteille pour la manipulation de liquides Active EP2125223B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP14002517.2A EP2799141B1 (fr) 2006-12-07 2007-12-06 Dispositif pour la manipulation de liquides à attaché à une bouteille
EP19158248.5A EP3508274B1 (fr) 2006-12-07 2007-12-06 Appareil posé sur bouteille destiné à la manipulation de liquides

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE202006018526 2006-12-07
DE202006018527 2006-12-07
PCT/EP2007/010580 WO2008068013A2 (fr) 2006-12-07 2007-12-06 Appareil pièce rapportée pour bouteille pour la manipulation de liquides

Related Child Applications (3)

Application Number Title Priority Date Filing Date
EP19158248.5A Division EP3508274B1 (fr) 2006-12-07 2007-12-06 Appareil posé sur bouteille destiné à la manipulation de liquides
EP14002517.2A Division EP2799141B1 (fr) 2006-12-07 2007-12-06 Dispositif pour la manipulation de liquides à attaché à une bouteille
EP14002517.2A Division-Into EP2799141B1 (fr) 2006-12-07 2007-12-06 Dispositif pour la manipulation de liquides à attaché à une bouteille

Publications (2)

Publication Number Publication Date
EP2125223A2 true EP2125223A2 (fr) 2009-12-02
EP2125223B1 EP2125223B1 (fr) 2015-12-02

Family

ID=39301515

Family Applications (3)

Application Number Title Priority Date Filing Date
EP07856393.9A Active EP2125223B1 (fr) 2006-12-07 2007-12-06 Appareil pièce rapportée pour bouteille pour la manipulation de liquides
EP14002517.2A Active EP2799141B1 (fr) 2006-12-07 2007-12-06 Dispositif pour la manipulation de liquides à attaché à une bouteille
EP19158248.5A Active EP3508274B1 (fr) 2006-12-07 2007-12-06 Appareil posé sur bouteille destiné à la manipulation de liquides

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP14002517.2A Active EP2799141B1 (fr) 2006-12-07 2007-12-06 Dispositif pour la manipulation de liquides à attaché à une bouteille
EP19158248.5A Active EP3508274B1 (fr) 2006-12-07 2007-12-06 Appareil posé sur bouteille destiné à la manipulation de liquides

Country Status (4)

Country Link
US (1) US8142738B2 (fr)
EP (3) EP2125223B1 (fr)
CN (1) CN103285951B (fr)
WO (1) WO2008068013A2 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2098588B1 (fr) * 2006-11-22 2013-01-02 Altair Corporation Élément de noyau de pipette, pipette et dispositif de pipette
DE202009012054U1 (de) 2009-09-07 2011-02-10 Brand Gmbh + Co Kg Dosiergerät für Flüssigkeiten
WO2012103870A1 (fr) * 2011-01-31 2012-08-09 Witeg Labortechnik Gmbh Distributeur pour flacons pourvu d'un affichage numérique de volume
US9568406B2 (en) * 2011-08-31 2017-02-14 King Tester Corporation Portable brinell hardness tester with stented through bore pumping chamber
US9131811B2 (en) * 2011-09-22 2015-09-15 Gojo Industries, Inc. Hygiene compliance monitor for a dispensing container
EP2657661A1 (fr) 2012-04-24 2013-10-30 Socorex Isba S.A. Distributeur à volume variable pour distribuer avec précision une quantité de liquide
US20140002642A1 (en) 2012-06-15 2014-01-02 Elmar SWIEGOT Absolute position detection
DE102015000905A1 (de) 2015-01-23 2016-07-28 Brand Gmbh + Co Kg Zylinder-Kolben-Anordnung für ein Flaschenaufsatzgerät
DE102015000904A1 (de) 2015-01-23 2016-07-28 Brand Gmbh + Co Kg Ventilblockanordnung für ein Flaschenaufsatzgerät
DE102015017471B3 (de) 2015-01-23 2023-07-20 Brand Gmbh + Co Kg Aussstoßleitungsanordnung für ein Flaschenaufsatzgerät
DE202015000520U1 (de) 2015-01-23 2016-04-28 Brand Gmbh + Co Kg Ventilblockanordnung für ein Flaschenaufsatzgerät
DE102015000906A1 (de) 2015-01-23 2016-07-28 Brand Gmbh + Co Kg Ausstoßventilanordnung für ein Flaschenaufsatzgerät
DE202015000519U1 (de) 2015-01-23 2016-04-27 Brand Gmbh + Co Kg Ausstoßleitungsanordnung für ein Flaschenaufsatzgerät
DE102015000903B4 (de) 2015-01-23 2023-05-17 Brand Gmbh + Co Kg Ausstoßleitungsanordnungen für ein Flaschenaufsatzgerät
DE202015000523U1 (de) 2015-01-23 2016-04-27 Brand Gmbh + Co Kg Ausstoßleitungsanordnung für ein Flaschenaufsatzgerät
DE102015000902B4 (de) 2015-01-23 2023-06-15 Brand Gmbh + Co Kg Ausstoßleitungsanordnung für ein Flaschenaufsatzgerät
DE202015000522U1 (de) * 2015-01-23 2016-04-26 Brand Gmbh + Co Kg Zylinder-Kolben-Anordnung für ein Flaschenaufsatzgerät
DE202015000521U1 (de) 2015-01-23 2016-04-28 Brand Gmbh + Co Kg Ausstoßventilanordnung für ein Flaschenaufsatzgerät
USD799717S1 (en) * 2015-02-11 2017-10-10 Brand Gmbh + Co Kg Bottle top dispenser for laboratory use
DE202015001781U1 (de) 2015-03-09 2016-06-10 Brand Gmbh + Co Kg Zylinder-Kolben-Anordnung für ein Flaschenaufsatzgerät
KR102621896B1 (ko) * 2017-07-04 2024-01-08 주식회사 엘지생활건강 타이머 및 이를 구비하는 용기
DE102018200219B4 (de) * 2018-01-09 2020-10-08 Festo Se & Co. Kg Vorrichtung zur Erfassung der Stellung eines Ventilglieds, Ventilbaueinheit, Abfüllanlage und Verfahren zur Inbetriebnahme einer Abfüllanlage
US11376589B2 (en) * 2018-04-30 2022-07-05 Protein Fluidics, Inc. Valveless fluidic switching flowchip and uses thereof
CN111921576A (zh) * 2020-08-18 2020-11-13 北京沄汇智能科技有限公司 快速装拆多功能物料瓶
CN114889964B (zh) * 2022-05-17 2023-09-19 江南大学 一种多用途气液混合增压瓶

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3067915A (en) * 1960-05-23 1962-12-11 Microchemical Specialties Co Liquid dispensing devices
US3805998A (en) * 1972-11-17 1974-04-23 M Croslin Dispensing pipette
DE3143600A1 (de) 1981-11-03 1983-05-11 Nichiryo Co., Ltd., Tokyo Fluessigkeitsausgabegeraet
DE8208367U1 (de) 1982-02-05 1982-12-09 Jencons (Scientific) Ltd., Leighton Buzzard, Bedfordshire Dosiergeraet zur abgabe von fluessigkeit aus einem behaelter
ATE32666T1 (de) 1982-06-04 1988-03-15 Brand Rudolf Gmbh & Co Flaschenaufsatzkolbenbuerette.
DE3417016C1 (de) 1984-05-09 1985-12-05 Preibisch, Herbert, Dr.-Ing., 8000 München Verfahren zur Ermittlung der Lage und Geschwindigkeit von Objekten
DE3501909C1 (de) 1985-01-22 1986-07-10 Witeg-Glasgeräte Helmut Antlinger KG, 6980 Wertheim Kolbenbürette
DE3534550A1 (de) 1985-04-02 1986-10-09 Walter Graf U. Co Gmbh & Co, 6980 Wertheim Praezisionsdosiergeraet mit digitaler anzeigevorrichtung
DE3516596A1 (de) 1985-04-02 1986-10-02 Walter Graf U. Co Gmbh & Co, 6980 Wertheim Praezisionsdosiergeraet mit digitaler anzeigevorrichtung
GB8614850D0 (en) * 1986-06-18 1986-07-23 Jencons Scient Ltd Liquid dispensers
DE8800844U1 (de) 1988-01-25 1988-06-23 Walter Graf U. Co Gmbh & Co, 6980 Wertheim Dispenser
DE4137351C2 (de) 1991-11-13 1997-01-16 Walu Apparatetechnik Gmbh Flaschendispenser
DE9202990U1 (de) 1992-03-06 1992-08-06 Walu-Apparatetechnik GmbH, 6980 Wertheim Aufsteckmodul für ein Flaschendosiergerät
US5862958A (en) * 1997-03-21 1999-01-26 Barnstead/Thermolyne Corporation Bottle top dispenser
DE10106463A1 (de) 2001-02-13 2002-08-14 Hirschmann Laborgeraete Gmbh Digitalbürette und Verfahren zum Anzeigen des Dosiervolumens einer solchen Digitalbürette
US20050194407A1 (en) * 2001-06-29 2005-09-08 Bach David T. Precision fluid dispensing system
DE10301343B4 (de) * 2003-01-16 2004-12-09 Eppendorf Ag Dosiervorrichtung
US6899254B1 (en) * 2004-01-20 2005-05-31 Plas-Pak Industries, Inc. Venting seal for dispenser
US20060143482A1 (en) 2004-12-23 2006-06-29 Lachapelle David R Methods and devices for controlling the distribution of power on a printed circuit board

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2008068013A2 *

Also Published As

Publication number Publication date
WO2008068013A3 (fr) 2008-09-18
US20100021349A1 (en) 2010-01-28
EP3508274A1 (fr) 2019-07-10
EP2799141B1 (fr) 2019-05-01
WO2008068013A2 (fr) 2008-06-12
EP2799141A3 (fr) 2015-01-21
CN103285951A (zh) 2013-09-11
US8142738B2 (en) 2012-03-27
CN103285951B (zh) 2015-01-14
EP3508274B1 (fr) 2024-02-28
EP2799141A2 (fr) 2014-11-05
EP2125223B1 (fr) 2015-12-02

Similar Documents

Publication Publication Date Title
EP2799141B1 (fr) Dispositif pour la manipulation de liquides à attaché à une bouteille
US8597593B2 (en) Bottle top dispenser for handling liquids
EP0649678B1 (fr) Pipette à piston
DE102005033378B4 (de) Kolbenhubpipette
WO2007131593A1 (fr) Bioréacteur à usage unique muni d'un système de détection
EP0619476A1 (fr) Dispositif pour la détection d'un interface fluidique dans un tube de mesure transparent
EP2060885A1 (fr) Appareil de laboratoire doté d'une salle de travail sécurisée
DE102011080956A1 (de) Verfahren und Messstelle zur Messung zumindest einer physikalischen und/oder chemischen Prozessgrößen eines in einem Einwegbehältnis enthaltenen Messmediums
DE2511322B2 (de) Kolorimeter
DE2051189B2 (de) Vorrichtung zum Messen der optischen Dichte von Mikrobenkulturen
DE202007017095U1 (de) Flaschenaufsatzgerät zur Handhabung von Flüssigkeiten
EP2671054A1 (fr) Distributeur pour flacons pourvu d'un affichage numérique de volume
DE69215394T2 (de) System zur Blutanalyse
DE2018068A1 (de) Flüssigkeitsanalysegerät
DE202007017094U1 (de) Gerät zur messenden Handhabung von kleinen Flüssigkeitsmengen
EP1950764A1 (fr) Cellule de fluide pour microscopie à sonde à balayage ou spectroscopie de force
DE3516596A1 (de) Praezisionsdosiergeraet mit digitaler anzeigevorrichtung
DE10239554A1 (de) Dispenser für eine Flüssigkeit, insbesondere Flaschenaufsatzdispenser
WO2001073374A1 (fr) Microscope de mesure
DE102011114688A1 (de) Handdosiervorrichtung
DE4305924C2 (de) Vorrichtung zur Detektion der Überfüllung eines Überlaufkanals für Flüssigkeiten
DE4334750C2 (de) Vorrichtung zum Dosieren von Flüssigkeiten aus einem Vorratsbehälter
DE1090449B (de) Vorrichtung zum schnellen und exakten Pipettieren kleiner Fluessigkeitsmengen
JPH01500971A (ja) ピペット
DE202016008012U1 (de) System zur Weglängenkalibrierung

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20090618

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
17Q First examination report despatched

Effective date: 20121112

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

INTG Intention to grant announced

Effective date: 20150710

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 763376

Country of ref document: AT

Kind code of ref document: T

Effective date: 20151215

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 9

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: LANGUAGE OF EP DOCUMENT: GERMAN

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 502007014446

Country of ref document: DE

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20160302

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151202

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151202

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151202

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20151231

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151202

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160303

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151202

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151202

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151202

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151202

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151202

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151202

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151202

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151202

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151202

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160402

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160404

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 502007014446

Country of ref document: DE

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151202

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20151206

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151202

26N No opposition filed

Effective date: 20160905

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151202

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 10

REG Reference to a national code

Ref country code: AT

Ref legal event code: MM01

Ref document number: 763376

Country of ref document: AT

Kind code of ref document: T

Effective date: 20151206

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20151206

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151202

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20071206

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151202

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151202

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151202

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20151206

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 11

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20231220

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20231221

Year of fee payment: 17

Ref country code: DE

Payment date: 20231212

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20240101

Year of fee payment: 17