EP0649678B1 - Pipette à piston - Google Patents

Pipette à piston Download PDF

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Publication number
EP0649678B1
EP0649678B1 EP94115063A EP94115063A EP0649678B1 EP 0649678 B1 EP0649678 B1 EP 0649678B1 EP 94115063 A EP94115063 A EP 94115063A EP 94115063 A EP94115063 A EP 94115063A EP 0649678 B1 EP0649678 B1 EP 0649678B1
Authority
EP
European Patent Office
Prior art keywords
coupling
pipette
plunger
adjusting
spur gear
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP94115063A
Other languages
German (de)
English (en)
Other versions
EP0649678A1 (fr
Inventor
Horst Sabloewski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eppendorf SE
Original Assignee
Eppendorf SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eppendorf SE filed Critical Eppendorf SE
Publication of EP0649678A1 publication Critical patent/EP0649678A1/fr
Application granted granted Critical
Publication of EP0649678B1 publication Critical patent/EP0649678B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0224—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type having mechanical means to set stroke length, e.g. movable stops
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/025—Displaying results or values with integrated means
    • B01L2300/026—Drum counters

Definitions

  • the invention relates to a piston stroke pipette according to the preamble of claim 1.
  • Piston stroke pipettes of the type mentioned have one Cone on which a pipette tip can be plugged.
  • the plugged on Pipette tip communicates with a cylinder, in which a piston is arranged to be actuated from the outside.
  • the Piston stroke can be changed by means of adjusting devices, wherein display devices provide information about the respective Specify the volume of liquid pipetted. That from the However, the volume of liquid taken up by the pipette tip gives way mostly from the displayed.
  • the difference between recorded and displayed volume of liquid will also referred to as the error of accuracy.
  • the error of accuracy is usually over the setting range of Piston stroke pipette changeable.
  • a system has one Piston stroke pipette and a pipette tip at each set Liquid volume a defined accuracy deviation (see also DE 42 09 620 C1).
  • it changes with the liquid to be pipetted the liquid density, this also changes the weight with which the liquid column depends on the air cushion and the accuracy deviation every set volume of liquid changes yourself.
  • An adjustment of the errors in accuracy can be made by changing a pipette correction factor. This determines the ratio of the set piston stroke to the displayed one Volume of liquid.
  • a pipette correction factor In some known piston stroke pipettes is already an adjustment device for the pipette correction factor is available.
  • the adjusting device has an adjusting nut for setting a stop firmly connected to this for the piston diving device, the adjusting nut via a grain screw with a threaded rod and this is coupled with a volume display.
  • the zero setting of the volume display can be the grain screw loosened and the stop using the adjusting nut be adjusted.
  • US 4 165 646 discloses a pipetting device, in which the setting devices have an actuating bushing, the the upper end of a stop bushing of a piston rod take up. Thus the piston stroke is by turning the actuating bush adjustable.
  • This carries at the same time a cover sleeve which the stop bush and the upper Section of a cylindrical housing surrounds.
  • the housing carries a volume scale and the cover sleeve has a window, to make a set volume value visible.
  • the cover sleeve is used for calibration adjustable fixed to the upper socket.
  • US 4,501,163 describes a pipetting device, in the one button for axial piston displacement and adjustment the piston stroke by turning a stop bush is also coupled to a counter in a rotationally fixed manner.
  • This device can be calibrated by turning a sleeve, which is the stop bush for the piston rod in an internal thread.
  • US 4 023 716 discloses a micropipette which is in a axially displaceable piston rod one from the lower End protruding displacement piston.
  • the piston is fixed in the rod by means of a screw and can be moved axially after loosening the screw and on a other position. This is an attitude the amount of liquid to be dosed possible.
  • EP-A1-0 286 676 describes a pipette with a quickly changeable one Dosage volume. With this facility there is one Regulating bush for constantly adjusting the piston stroke coupled with a display device. The location of the jack is adjustable using an adjusting nut. The mother can, however, lead out of their interlocking with the socket be what the socket by means of an operating button is adjustable for the piston stroke. This favors a quick adjustment of the dosage volumes of very different Size.
  • the object of the invention is a piston stroke pipette with a simple and safe Adjustability of the accuracy deviation to create.
  • Opposite one Slip clutch has the advantage that none is special tight manufacturing tolerances must be observed and that a simplified adjustment is possible for the user is. As long as the coupling devices are engaged the volume setting can be compared to the display devices cannot be adjusted. An error in accuracy is therefore precisely and safely adjustable. Moreover there are switching devices that easily turn on Allow complete release of the coupling devices. Are the display devices from the coupling devices uncoupled, the pipette correction factor easily changed by adjusting the adjustment devices become.
  • the one coupled with the adjustment devices Part of the coupling devices can namely through Actuation of the setting devices compared to that with the Display devices coupled part of the coupling devices adjust.
  • the pipette correction factor can thus be operated reliably to adjust.
  • the setting spur gear on the casing is preferred formed out of the housing adjustment sleeve.
  • the display spur gear can be a drive wheel of a gear counter his.
  • Clutch spur gears, adjustment spur gear and display spur gear can with parallel axes on a common body be stored. This enables pre-assembly and facilitates assembly of the pipette.
  • the basic body can also carry the counter.
  • the axes of the clutch spur gears and the display spur gear can in the body be anchored.
  • the adjustment spur gear can be on the outside a hollow cylindrical approach to the base body be an internal thread for a spindle for stroke adjustment of the piston. Then there are the adjustment devices also a basic body for the piston stroke pre-assembled.
  • the hollow cylindrical approach can each have an internal step for a lower and upper end stop or one each Face for an upper and lower end stop of the Have spindle. Radial projections of the upper end stop the spindle can be used for a rotary coupling in axial Engage the inner grooves of the adjusting sleeve.
  • a switching lever of the switching devices from is preferred can be actuated from the outside of a housing of the piston stroke pipette.
  • the switching devices can one on the Axle for the clutch spur gears and laterally have on this slider.
  • the pipette correction factor and the setting devices can be used to achieve predetermined values on an adjusting sleeve protruding from the housing a mark and the case an orderly Have a mark, scale or memo scale.
  • the piston pipette has a housing 1, which is at the bottom At the end of a cone 2 carries a pipette tip 3.
  • an operating button 4 attached, which is connected to a piston rod 5, which extends through a spindle 6.
  • a piston 7 is attached, the opposite the action of a spring 8 displaceable in a cylinder 9 is.
  • the piston rod 5 is provided with a flange 11 which in the starting position of the rod at the bottom of the Spindle 6 is applied.
  • This flange 11 defines the upper one Stop for the piston 7.
  • the upper stop is adjustable.
  • Adjustment sleeve 12 stored.
  • the spindle 6, which the Piston rod 5 surrounds, is rotationally fixed with the adjusting sleeve 12 connected.
  • the spindle 6 has a rotationally fixed its connected upper stop 13, which has radial projections 14 guided in axial grooves 15 of the adjusting sleeve 12 is.
  • the adjusting sleeve 12 is rotated, the Screwed into the internal thread 16 fixed to the housing, its stop for the flange 11 axially displaced becomes. Since the piston rod 5 by the spring 8 with her Flange 11 pressed against the lower stop of the spindle 6 is, the starting position of the piston 7 is through defines the setting of the adjusting sleeve 12.
  • the piston stroke until reaching the lower end of the cylinder 9 is therefore adjustable by means of the adjusting sleeve 12.
  • the striking of the piston 7 at the lower end of the cylinder 9 becomes by the effect of a lower stop 17 prevented from being supported by an overtravel spring 18 in the housing is.
  • the flange 11 lies on the lower stop 17 in the form of a spring plate before the piston 7 against the lower limit of the cylinder 9 abuts.
  • Coupling devices 19 adjusts a counter 20.
  • the Coupling devices 19 are guided to the outside Switching device 21 connected, the coupling and disengagement allowed. Details of the coupling devices 19, the counter 20 and the switching devices 21 are best seen in FIGS. 3 to 5.
  • the coupling devices 19 have two clutch spur gears 22, 23, which are mounted on a common axis 24 and are non-rotatably connected.
  • the upper clutch spur gear 22 combs in the unactuated state of the switching devices 21 with a setting spur gear 25, which is at the bottom End of the adjusting sleeve 12 is formed.
  • the lower Clutch spur gear 23 always meshes with a display spur gear 26, the bottom on an axis 27 of the counter 20 is arranged.
  • the axes 24 and 27 of the coupling devices 19 and the counter 20 are in parallel on one anchored plate-shaped base body 28.
  • the base body 28 carries one which extends on both sides hollow cylindrical projection 29 on an upper part 30 a storage for the adjusting sleeve 12 and that Has internal thread 16 for the spindle 6.
  • the approach 29 has a further internal thread 32 for receiving an abutment 33 for the overtravel spring 18 (see Fig. 1).
  • the clutch spur gears 22, 23 are on the one Coil spring 34 guided on axis 24 on base body 28 supported. At the top they are secured by a circlip 34 ' held on the axis 24. Between circlip 34 'and upper clutch spur gear 22 have the switching devices 21 a slide 35 guided on the axis 24 Slider 35 has a shift lever 36 attached to the side, the in an externally accessible opening 37 of the housing 1 protrudes (see Fig. 7). By moving the Shift lever 36 down the upper clutch spur gear 22 brought out of engagement with the adjustment spur gear 25 become. If you let go of the shift lever 36, the upper one Clutch spur gear 22 automatically engages again brought the adjustment spur gear 25.
  • the counter 20 has staggered one above the other on the axis 27 arranged counter wheels 38 with digits from 0 to 9.
  • the lower counter gear 39 is non-rotatable with the display spur gear 26 connected.
  • switching wheels 41 are arranged on a further axis 40, which is parallel to the axis 27 in Base body 28 is anchored.
  • Each switching wheel 41 intervenes with a toothing two adjacent counter wheels 38.
  • the lower one Counter wheel has at least one driver and the upper counter wheel is there with a revolving one Provide teeth. If the driver of the lower Counter wheel 39 executed a certain angle of rotation has, he actuates the associated switching wheel 41, whereby the counter wheel 38 arranged above it by one position is rotated further. So is a carryover to each parent counter wheel 38 realized.
  • a ratchet wheel 42 that rotatably with the two aforementioned wheels is connected.
  • the ratchet 42 assigns each number of the assigned counter wheel 38 one Deepening its scope.
  • a locking element 43 engages in at least one recess of the ratchet wheel 42 if the lower counter wheel 39 displays a full number. there is the locking element 43 on the further axis 40 of the Counter 20 stored. This will ensure an exact alignment the counter wheels 38 and 39 and the reading guaranteed.
  • the parts shown in Figs. 4 and 5 are preferred mainly made of plastic. For both Axles as well as the circlip and the coil spring 34 metallic materials are preferred.
  • the basic body 28 enables the coupling devices to be preassembled 19, switching devices 21 and the counter 20.
  • At the Base body 28 can also be the piston rod 5 with the Spindle 6 and the adjusting sleeve 12 are preassembled. Pre-assembly can take place until the abutment 33 is attached and the piston 7 go.
  • the pre-assembled unit is from inserted into the top of the housing 1 and therein by means of a Union nut 44 secured (see. Fig. 1).
  • the adjusting sleeve 12 can on her a section X led out the housing 1 have, with a marking, scale 45 or memo scale of the housing interacts.

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Sampling And Sample Adjustment (AREA)
  • A Measuring Device Byusing Mechanical Method (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Claims (13)

  1. Pipette à course de piston pour une pointe de pipette emboítable (3), comprenant des dispositifs de réglage (12) pour modifier la course du piston, des dispositifs indicateurs (20) pour le volume de liquide contenu respectivement dans la pipette, des dispositifs d'accouplement débrayables (19, 25, 26) entre les dispositifs de réglage et les dispositifs indicateurs pour modifier un facteur de correction de pipette déterminant le rapport de la course du piston au volume de liquide indiqué, caractérisée en ce que les dispositifs d'accouplement sont des dispositifs d'accouplement par conjugaison de formes (19, 25, 26), qui comportent une partie d'accouplement (25) accouplée aux dispositifs de réglage (12), une partie d'accouplement (26) accouplée aux dispositifs indicateurs et des dispositifs de manoeuvre (21) pour débrayer complètement les deux parties d'accouplement l'une de l'autre et modifier le facteur de correction de pipette par ajustement des dispositifs de réglage, un levier de manoeuvre (36) des dispositifs de manoeuvre (21) pouvant être actionné de l'extérieur du bâti de pipette (1).
  2. Pipette à course de piston selon la revendication 1, caractérisée en ce que les dispositifs d'accouplement par conjugaison de formes (19, 25, 26) comportent deux engrenages droits (22, 23) solidaires en rotation l'un à l'autre (roues droites d'accouplement), les dispositifs de réglage (12) sont reliés à un engrenage droit (25) (roue droite de réglage) dont la rotation correspond à la course de piston réglée et les dispositifs indicateurs (20) sont reliés à un engrenage droit (26) dont la rotation correspond au volume de liquide indiqué, l'une des roues droites d'accouplement (22) engrenant avec la roue droite de réglage (25) et l'autre roue droite d'accouplement (23) engrenant avec la roue droite d'indication (26), et en ce que les roues droites d'accouplement (22, 23) sont placées sur un axe (24) et s'appuient sur un dispositif à ressort (34) et peuvent être déplacées par le dispositif de manoeuvre (21) sur l'axe contre l'action du ressort par le débrayage d'au moins une roue droite d'accouplement (22, 23).
  3. Pipette à course de piston selon la revendication 2 ou 3, caractérisée en ce que la roue droite de réglage (25) est formée sur l'enveloppe d'une douille de réglage (12) en saillie sur le bâti.
  4. Pipette à course de piston selon la revendication 2 ou 3, caractérisée en ce que la roue droite d'indication (26) est une roue d'entraínement d'un compteur (20).
  5. Pipette à course de piston selon les revendications 2 à 4, caractérisée en ce que les roues droites d'accouplement (22, 23), la roue droite de réglage (25) et la roue droite d'indication (26) sont placées avec des axes parallèles (24, 27) sur un corps de base commun (28).
  6. Pipette à course de piston selon la revendication 5, caractérisée en ce que les axes (24, 27, 40) des roues droites d'accouplement (22, 23) et du compteur (20) sont ancrées dans le corps de base commun (28).
  7. Pipette à course de piston selon la revendication 5 ou 6, caractérisée en ce qu'une douille de réglage (12) est placée à l'extérieur sur un appendice cylindrique creux (29) du corps de base (28) et que l'appendice comporte un filetage intérieur (16), dans lequel une broche (6) accouplée en rotation avec la douille de réglage peut être vissée pour régler la course du piston (7).
  8. Pipette à course de piston selon la revendication 7, caractérisée en ce que l'appendice (29) reçoit sur le côté tourné vers le piston (7) une cuvette de ressort (17) pour une butée de fin de course inférieure de la tige (5) de piston.
  9. Pipette à course de piston selon la revendication 7 ou 8, caractérisée en ce que l'extrémité de l'appendice (29) opposée au piston (7) sert de surface de butée pour une butée de fin de course supérieure (13) de la broche (6).
  10. Pipette à course de piston selon l'une des revendications 3 à 9, caractérisée en ce que des parties en saillie radiales (14) de la butée de fin de course supérieure (13) de la broche (6) viennent en prise pour un accouplement en rotation dans des rainures intérieures axiales (15) de la douille de réglage (12).
  11. Pipette à course de piston selon l'une des revendications 2 à 10, caractérisée en ce que les dispositifs de manoeuvre (19) comportent un coulisseau (35) guidé sur l'axe (24) pour les roues droites d'accouplement (22, 23) et adjacent latéralement à celles-ci.
  12. Pipette à course de piston selon l'une des revendications 1 à 11, caractérisée en ce que le compteur (20) comporte une roue à encoches (42) avec une position d'encliquetage pour chaque valeur indiquée entière et un élément d'encliquetage (43).
  13. Pipette à course de piston selon l'une des revendications 1 à 12, caractérisée en ce que les dispositifs de réglage comportent sur une douille de réglage (12) faisant saillie sur le bâti (1) un marquage et le boítier comporte un marquage, une échelle ou une échelle de repères ou inversement.
EP94115063A 1993-10-21 1994-09-23 Pipette à piston Expired - Lifetime EP0649678B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4335863 1993-10-21
DE4335863A DE4335863C1 (de) 1993-10-21 1993-10-21 Kolbenhubpipette

Publications (2)

Publication Number Publication Date
EP0649678A1 EP0649678A1 (fr) 1995-04-26
EP0649678B1 true EP0649678B1 (fr) 2001-06-13

Family

ID=6500635

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94115063A Expired - Lifetime EP0649678B1 (fr) 1993-10-21 1994-09-23 Pipette à piston

Country Status (6)

Country Link
US (1) US5531131A (fr)
EP (1) EP0649678B1 (fr)
JP (1) JP2709573B2 (fr)
AT (1) ATE202011T1 (fr)
DE (2) DE4335863C1 (fr)
ES (1) ES2157940T3 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3915682A1 (fr) 2020-05-25 2021-12-01 Eppendorf AG Pipette à volume de dosage réglable

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PL2659978T3 (pl) 2012-05-02 2017-11-30 Eppendorf Ag Pipeta z systemem blokowania
US10016755B2 (en) 2015-01-08 2018-07-10 Integra Biosciences Ag Manual pipette with selectable plunger force
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EP3778028B1 (fr) 2019-08-15 2021-10-06 Eppendorf AG Pipette à volume de dosage réglable
WO2021033213A1 (fr) * 2019-08-16 2021-02-25 株式会社 ニチリョー Mécanisme d'étalonnage de volume d'admission de pipette, pipette et procédé d'étalonnage de celui-ci
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DE102021117128B4 (de) 2021-07-02 2023-03-30 Brand Gmbh + Co Kg Pipettiervorrichtung
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3915682A1 (fr) 2020-05-25 2021-12-01 Eppendorf AG Pipette à volume de dosage réglable

Also Published As

Publication number Publication date
EP0649678A1 (fr) 1995-04-26
ATE202011T1 (de) 2001-06-15
DE59409783D1 (de) 2001-07-19
US5531131A (en) 1996-07-02
DE4335863C1 (de) 1995-02-02
JPH07185361A (ja) 1995-07-25
JP2709573B2 (ja) 1998-02-04
ES2157940T3 (es) 2001-09-01

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