EP3508274B1 - Appareil posé sur bouteille destiné à la manipulation de liquides - Google Patents

Appareil posé sur bouteille destiné à la manipulation de liquides Download PDF

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Publication number
EP3508274B1
EP3508274B1 EP19158248.5A EP19158248A EP3508274B1 EP 3508274 B1 EP3508274 B1 EP 3508274B1 EP 19158248 A EP19158248 A EP 19158248A EP 3508274 B1 EP3508274 B1 EP 3508274B1
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EP
European Patent Office
Prior art keywords
piston
piston rod
sensor
bottle
cylinder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP19158248.5A
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German (de)
English (en)
Other versions
EP3508274A1 (fr
Inventor
Dieter Böhm
Wolfgang Ettig
Peter Mahler
Jürgen Schraut
Roland Wohner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brand GmbH and Co KG
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Brand GmbH and Co KG
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Publication date
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Publication of EP3508274A1 publication Critical patent/EP3508274A1/fr
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0203—Burettes, i.e. for withdrawing and redistributing liquids through different conduits
    • B01L3/0206—Burettes, i.e. for withdrawing and redistributing liquids through different conduits of the plunger pump type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/08—Ergonomic or safety aspects of handling devices
    • B01L2200/087—Ergonomic aspects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/146—Employing pressure sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/024—Storing results with means integrated into the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/025—Displaying results or values with integrated means
    • B01L2300/027—Digital display, e.g. LCD, LED
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/048—Function or devices integrated in the closure enabling gas exchange, e.g. vents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated

Definitions

  • the invention relates to a bottle top device for handling liquids. These devices are about the precise measuring and delivery of liquids from a storage bottle or other storage container, with the precise measuring when taking up a partial volume of liquid from the storage bottle or the like into the device and/or when dispensing a partial volume of liquid from the device to the outside into a container.
  • Bottle top devices of the type in question are, in particular, burettes and dispensers. Such bottle top devices are used extensively in chemistry, biology and pharmacy in the laboratory and in production.
  • liquid refers to liquids such as those used extensively in chemistry, biology, pharmacy, etc. in the laboratory and in production, in particular liquids with a relative viscosity of up to around 300 (viscosity based on the viscosity of water under normal conditions ). This is the liquid range from very thin to slightly thick.
  • a manually operated burette is used during titration to determine the unknown amount of a dissolved substance from the consumption of a reagent liquid with a known concentration.
  • a burette is required to quickly and accurately dispense and display the specific amount of liquid.
  • High demands are placed on the precision of liquid dispensing as well as on operator safety (General Catalog 600 "Laboratory Equipment from Brand” of BRAND GMBH + CO KG 09/01, No. 9963 00, "Bürette Digital III", pp. 27 to 34).
  • Comparable requirements can also be found in bottle-top dispensers, especially those with a digital display of the desired dosing volume ( DE 35 16 596 A1 ; General catalog 600 "Laboratory equipment from Brand” of BRAND GMBH + CO KG 09/01, No. 9963 00, "Dispensette", pages 9 to 18).
  • the bottle top device is described in its operating position, i.e. in its position attached to a storage bottle and essentially vertically aligned.
  • a suction valve in the valve block, which allows liquid to be sucked in from the storage bottle using a suction pipe.
  • An exhaust line with an exhaust valve located in it extends approximately horizontally from the valve block. Since the discharge line projects approximately horizontally from the valve block and often carries an additional switching valve, this is the side from which an operator works with the bottle top device. We will henceforth refer to this side as the “front” or “front”. The opposite side is the “back” or “back”.
  • a bottle top device usually has a display with appropriate controls at the front.
  • a well-known bottle attachment device for handling liquids (see the general catalog 600 "Burette Digital III", as stated above) is characterized by the fact that the cylinder-piston arrangement is covered from above by an outer housing that is closed at the top. This outer housing moves up together with the piston rod relative to the cylinder. To accomplish this, there is a vertical rack on the cylinder with which a pinion meshes on a drive shaft that is mounted in the outer housing.
  • the piston drive of this bottle top device is designed for manual operation and therefore the drive shaft carries a manual operation knob at both ends outside the outer housing.
  • this bottle-top device is that the outer housing is closed around the cylinder-piston arrangement. But this comes at the cost of moving the entire outer housing with all the components arranged within it. Particularly when the outer housing is in the fully raised position, such an arrangement of bottle top device and storage bottle has a considerable tendency to tip over.
  • a bottle-top device in the form of a piston burette with a digital display, in which a housing containing the piston drive, the display, a sensor arrangement and control electronics is in a fixed, unchangeable relative position to the valve block ( DE 35 01 909 C1 ).
  • the outer housing is not closed, but the piston rod passes through the housing from bottom to top when the piston is in the lowest position in the cylinder.
  • the piston rod moves out of the top of the housing.
  • a bellows connected at the top prevents dirt and dust from entering the housing via the opening for the piston rod.
  • All bottle top devices of the type in question have operating buttons on the front of the outer housing. Actuating the operating buttons requires the outer housing to be held against it, at least if you want to safely prevent the arrangement of the bottle top device and the storage bottle from tipping over. This is particularly important for storage bottles with a small volume.
  • the measuring strip is an optical scale and the sensor arrangement is an reflected light system.
  • the measuring strip is part of a capacitive system, which also includes the sensor. Electrodes facing one another are arranged in such a way that two pairs of measuring capacitances are formed for measuring the relative movement between the measuring strip and the sensor.
  • the third variant proposed for this device is that the piston rod carries a magnetic strip. Adjacent to the piston rod, a reading head is provided in a stationary manner in the housing, which is aligned with the magnetic measuring strip and separated from it by a gap. An electronic control circuit is coupled to the reading head, which reads the measurement information on the magnetic measuring strip and feeds corresponding pulses into the control circuit. This converts the impulses and controls a digital display, which in turn shows the volume of liquid dispensed based on the relative movement between the piston and cylinder.
  • the measuring strip is also moved into the cylinder.
  • the inner wall of the cylinder is wetted with the liquid to be dosed.
  • the interior is encapsulated by sealing measures, so that the sensor arrangement may also be intensively exposed to the resulting vapors.
  • the DE 35 34 550 A1 shows a precision dosing device for precisely dosing liquid media from a storage container into a template with a piston slide dosing pump.
  • the well-known precision dosing device consists of a dosing cylinder made of glass, a dosing piston that can be closed in this and a valve head containing a suction valve and a drain valve, which holds the dosing cylinder and can be connected to the storage container, with a sleeve connected to the dosing piston and extending telescopically over the dosing cylinder and with a digital display device for the stroke volume and/or the differential stroke volume of the piston slide metering pump.
  • a graduated measuring rod and a sensor that scans this measuring rod without contact are provided.
  • the sensor generates signals that represent the metering piston stroke, which, after evaluation in an electronic evaluation circuit, are displayed on the digital display device.
  • the measuring rod is stationary on the dosing cylinder and the sensor is stationary on the sleeve or vice versa.
  • the sensor, the evaluation circuit and an LCD element as a digital display device can be combined with a power source in a modular manner in a single building block, whereby the components mentioned in this building block can be encapsulated in a hermetically and corrosion-resistant manner in order to protect the components from corrosive vapors.
  • This building block is then arranged on the sleeve. Accordingly, the measuring rod is provided in a stationary manner on the dosing cylinder.
  • the teaching of the present invention is based on the problem that emerges from the document DE 35 34 550 A1 to improve the known precision dosing device with regard to distance measurement.
  • the sensor arrangement can optionally be cast on the back of the receiving pocket with casting compound in order to ensure an optimal protective effect for the sensor arrangement. Of course, this only works with a matching measuring strip.
  • a non-optical sensor arrangement in particular a sensor arrangement that is sensitive to magnetic fields, involves a correspondingly magnetized measuring strip.
  • An optical sensor arrangement uses an optical scale. The gas volume in the interior surrounding the piston rod, which is displaced during suction, now only flows past the sensor arrangement protected by the receiving pocket. It can no longer occupy the sensor as condensate and impair its function.
  • a useful alternative has a wall section of the receiving pocket that is designed as a film.
  • This film should be extremely thin and have low permeability to the gases that occur.
  • Such a thin film can even be made of transparent material so that the sensor of the sensor arrangement can work optically.
  • the senor is arranged in the receiving pocket on the side facing the measuring strip behind a thin-layer wall section of the receiving pocket.
  • the sensor has been brought as close as possible to the measuring strip without actually touching it, and while maintaining a gas-tight seal between the sensor arrangement and the interior of the device.
  • the senor is designed as a magnetoresistive sensor system, in particular based on the AMR effect, and that the evaluation circuit has a largely highly integrated, cost-effective mixed-signal controller, which converts the analog sensor signals evaluated directly via interpolation software.
  • Mixed-signal controllers are microcontrollers that combine various electronic processing functions, also suitable for evaluating sensor signals via interpolation software, with the functions of an A/D converter.
  • a mixed-signal microcontroller thus replaces a three-stage arrangement consisting of an A/D converter, a processing stage with processing software and an output stage.
  • Such a mixed-signal microcontroller is generally much more cost-effective to use at the signal level of AMR sensors than a three-stage arrangement.
  • Microcontrollers are offered by different providers with different performance spectrums (see e.g. B. the data sheet "MSP 430 x 33 x MIXED SIGNAL MICROCONTROLLER", February 1998, Texas Instruments ).
  • a mixed-signal microcontroller not only creates a simple solution for signal processing, but also very low power consumption both during operation and in idle state. (For detailed information, please refer to the relevant data sheets, in particular the data sheet mentioned above.)
  • Mixed-signal controllers can be implemented in different versions, for example as PSoC (Programmable System on a Chip), as DSP (Digital Signal Processor) or as FPGA (Field Programmable Gate Array).
  • PSoC Programmable System on a Chip
  • DSP Digital Signal Processor
  • FPGA Field Programmable Gate Array
  • the latter has a purely digital input converter, so that a discrete upstream A/D converter turns the entire arrangement into a mixed-signal controller of the type described.
  • the evaluation is carried out using the evaluation circuit with an ON/OFF duty cycle of approximately 0.1 to approximately 0.02, preferably between about 0.05 and about 0.03, in particular with an ON time of about 0.6 ms to about 0.1 ms, in particular between about 0.3 ms and about 0.15 ms.
  • the interpolation software works with an interpolation rate between 200 and 1,000, in particular between approximately 400 and approximately 600, preferably approximately 500.
  • the measuring system based on magnetic field measurement can be significantly optimized in a device of the type in question.
  • the device according to the invention With the device according to the invention, a structure can be realized which ensures safe operation and at the same time easy handling.
  • the power consumption of the measuring system is low and the manufacturing costs are also lower than with classic bottle top devices.
  • the bottle top device As has already been mentioned, it is advantageous to make the bottle top device largely chemical-resistant. However, it's not just about the surfaces that come into contact with the liquid. Surrendered indeed Corrosive or otherwise damaging liquids also produce corresponding vapors, which can cause problems in the interior of the outer housing of the bottle top device.
  • At least one actuation button can be relocated from the display on the front of the outer housing to its top side.
  • two or even more actuation buttons can be arranged on the top of the outer housing.
  • the outer housing is closed on the top and includes the cylinder-piston arrangement from above.
  • the solution takes advantage of this fact, which has been known for decades, to optimize the possibility of operating the bottle top device.
  • An operating button which is often used when working with the bottle top device, can be activated here by pressing it from above. This enables quick and error-free operation without exerting a serious tilting moment on the bottle top device and the storage bottle underneath.
  • no counter-holding of the outer housing is required.
  • the present bottle attachment device is particularly preferably a burette, i.e. designed as a burette.
  • Fig. 1 shows a preferred embodiment of a bottle attachment device according to the invention for handling liquids, here in the form of a burette.
  • liquid handling devices for handling liquids, so-called “liquid handling devices”, reference may be made to the applicant's general catalog "600 General Catalog - Laboratory Devices from BRAND” 09/01, pages 9 to 34. There, bottle-top dispensers and burettes are explained in terms of construction and application.
  • Bottle top dispensers result from the DE 88 00 844 U1 and especially that EP 0 542 241 A1 , which will be discussed further below.
  • top and bottom as well as front and back that were given at the beginning of the description apply to the bottle top device, which is described below.
  • the bottle top device is always in the in Fig. 1 shown position on a storage bottle, even if it is not shown in this position.
  • the bottle attachment device shown is located on a storage bottle 1 during operation. It has an outer housing 2 and is overall equipped with a fastening arrangement 3, here a cap, on a bottle neck Storage bottle 1 attached, screwed on here.
  • a display 4 At the top of the outer housing 2, facing forward, there is a display 4 with a display field 5, in particular for a digital display, preferably with LCD elements, as well as with actuating elements, in particular actuating buttons 6.
  • An ejection line 7 projects forward from the outer housing 2, which in the exemplary embodiment shown is arranged in an angular holder 8 and is closed at the end by means of a closure cap 9 for closure and as drip protection.
  • the bottle attachment device shown initially has a valve block 10 in the outer housing 2. Attached to this or integrally formed is the already mentioned fastening arrangement 3, with which the valve block 10 is actually fastened to the storage bottle 1. At the same time, the outer housing 2 is then attached to the storage bottle 1.
  • valve block 10 shows the valve block 10 as a component made in one piece from plastic, in particular from chemical-resistant plastic, which is provided with a large number of channels and internals.
  • the construction largely corresponds to the valve block of the bottle top dispenser, which consists of the EP 0 542 241 A1 is known and is part of the state of the art.
  • the fastening arrangement 3 is designed as a cap that can rotate freely relative to the valve block 10.
  • a suction valve insert 11 to which a suction line 12, which is shown shortened here for simplicity, connects downwards into the storage bottle 1.
  • an intake channel 13 adjoins the intake valve insert 11 in the valve block 10, from which approximately half height an in Fig. 2 ejection channel 14 branches off to the right.
  • An exhaust valve insert 15 is located in a recess in the valve block 10 on the discharge channel 14.
  • this is part of a valve body 16 of a changeover valve 17 attached to the valve block 10.
  • the changeover valve 17 is connected to the discharge line 7 in the holder 8.
  • the holder 8 runs in an arc and guides the ejection line 7 in the same arc, so that the ejection opening points downwards. There it is closed with the closure cap 9.
  • the changeover valve 17 has in the valve body 16 a valve body 18 which can be rotated about a vertical axis of rotation and which also has an in Fig. 1 recognizable toggle 19 can be adjusted by hand.
  • a return channel 20 runs in the valve body 16, which continues in the valve block 10 up to a downward return line 21.
  • the switching valve 17 is switched to passage, so that the discharge channel 14 is connected to the discharge line 7.
  • the ejection channel 14 is connected to the return channel 20, so that liquid is conveyed in the circuit from the storage bottle 1 and back into the storage bottle 1 via the return line 21.
  • redosing please refer to the detailed explanations in the EP 0 542 241 A1 to get expelled.
  • the valve block 10 also contains a bottle ventilation line 22 near the rear, which opens into a rear-facing, radially open plug receptacle 23.
  • a stopper 24 or a similar closure element that closes it, but which has a small passage opening, so that the interior of the storage bottle 1 is connected to the ambient atmosphere via the bottle ventilation line 22 and this passage in the stopper 24. This makes it possible to equalize the pressure in the storage bottle 1.
  • valve block 10 which is made here in one piece from chemical-resistant plastic material, for example PFA, a cylinder 26, which is preferably made of glass and is also made of glass, is firmly attached in a cylinder receptacle 25 and sealed against the valve block 10. Specifically, the cylinder 26 is pressed into the cylinder receptacle 25.
  • a supporting frame 30 is provided which surrounds the cylinder 26 and extends upwards beyond the cylinder 26.
  • This frame 30 is firmly connected at the lower end to the valve block 10 in an axially precisely determined position, but is fundamentally detachable from the valve block 10.
  • the detachability of the frame 30 from the valve block 10 is achieved here by the fact that an external thread is provided at the upper edge of the valve block 10 and that the frame 30 has a flange at the bottom which is provided with a cap 31 with an internal thread.
  • the frame 30 It is also essential for the frame 30 that it also accommodates or carries the piston drive 29.
  • the piston drive 29 does not have to be part of the frame 30, but in any case the frame 30 represents the supporting component for the piston drive 29 and determines its position relative to the valve block 10.
  • the frame 30 is expanded or extended in a block-like manner towards the top and has various recesses there for receiving various parts of the piston drive 29. This will be discussed later.
  • an outer housing 2 which is detachably connected to the valve block 10 is finally provided.
  • This encloses the frame 30 on the outside, thus forming the outer shell of the bottle top device and protecting the internal components. In any case, it extends slightly upwards beyond the piston drive 29 on the frame 30 and is closed at the top in the illustrated and preferred exemplary embodiment.
  • Fig. 2 in connection with the Fig. 3 and 4 also recognize that the cap 31 cannot be easily operated here. Rather, for safety reasons and for reasons of accessibility in the outer housing 2, it is provided that the cap 31 can only be operated with a special tool 32.
  • This tool 32 can be seen in Fig. 2 Top left in a suspension on the back of the outer housing 2.
  • the short stroke of the piston 27 in the bottle top device according to the invention facilitates the closed design of the outer housing 2 because the entire stroke of the piston rod 28 can be carried out within the outer housing 2.
  • the outer housing 2 does not have to be made excessively high. It also does not have to travel completely or partially with the piston rod 28.
  • the construction according to the invention thus increases the operational safety of the bottle top device.
  • the lower the bottle top device the higher the stability of a storage bottle 1 equipped with such a bottle top device.
  • the stroke quotient has a value of just under 2.0 for the nominal volume of 25 ml and a value of approximately 2.0 for the nominal volume of 50 ml 1.4.
  • With a nominal volume of 100 ml which would represent a rather unusually large arrangement, you would get a value of about 1.0, which would mean an effective diameter of the piston 27 of about 50 mm.
  • the design of the cylinder 26 as a calibrated glass tube with extremely high precision further increases the overall accuracy of the bottle top device.
  • the use of a calibrated glass tube as a cylinder 26 is sensible and effective here because of the other measures taken.
  • Fig. 3 and 4 also show that a drive shaft 33 of the piston drive 29 is mounted in the upper part of the frame 30.
  • the piston drive 29 could be designed as a motor. To do this, an electric drive motor would have to be integrated into the outer housing 2. This is associated with considerable costs and leads to a much more complex bottle top device.
  • the primary aim of the invention is a manually operated bottle top device with electronic, in particular digital, measurement recording and display. To that extent show Fig. 1 , 3 and 4 that the piston drive 29 is designed for manual operation and the drive shaft 33 carries a manual operation knob 38 at one end or at each end outside the outer housing 2. You can see the two manual control knobs 38 on the left and right of the outer housing 2 in Fig. 1 .
  • the gear connection between the drive shaft 33 and the pinion 35 is designed such that a rotation of the manual control knob 38 forward and downward causes a downward movement of the piston 27.
  • Ergonomic studies have shown that good dosing accuracy can be optimally combined with the rapid absorption or dispensing of large quantities of liquid if the maximum stroke of the piston 27 corresponds to five to ten of the manual control knob 38.
  • the design of the piston 27 in the cylinder 26 is also important for the desired accuracy of the bottle top device, which, as explained in the general part of the description, is considerably better than all bottle top devices known from the prior art.
  • the piston 27 is designed in one piece with the piston rod 28, or is designed as a separate part and is firmly attached, in particular screwed, to the piston rod 28.
  • the exemplary embodiment shown shows the piston rod 28, and the piston 27 is screwed to it by means of a central fastening screw 39, which here carries a sliding socket 40 which surrounds it on the bottom and on the circumference and is made of a very slippery material, in particular made of PTFE.
  • the sliding connector 40 forms a sliding ring 40a which rests under pressure on the cylinder 26 and is backed with a spring ring 42, which is supported on the piston 27 and made of a material which is preferably also chemically resistant, in order to generate pressure.
  • the spring ring 42 is shown in the drawing as a hollow chamber ring, for example made of chemical-resistant elastomer material. It is important that the sliding ring 40a itself does not have to apply the force in order to achieve the sealing effect of the sliding connector 40 on the inner surface of the cylinder 26. This is done by the spring ring 42, which is adapted for this purpose. Incidentally, it can hardly be seen in the drawing that the outer peripheral surface of the slide ring 40a can still be structured, for example to realize a multi-start wiper ring.
  • the piston 27 is not moved at the bottom against the valve block 10, but rather the piston rod 28 or the piston 27 is moved at the top against a stop 43.
  • the stop 43 can be adjustable and should in any case be removable in order to be able to pull out the piston 27 together with the piston rod 28, for example for cleaning or sterilization measures. This measure makes it possible to leave a small gap to the valve block 10 or to the bottom of the cylinder 26 even in the lowest position of the piston 27. Unevenness here cannot be a problem.
  • the arrangement shown is particularly advantageous, in which the stop 43 engages near the piston drive 29 on the piston rod 28 which is firmly connected to the piston 27. As a result, the stop 43 and the force application point of the piston drive 29 on the piston rod 28 are close to one another.
  • the frame 30 is not designed as an open framework, but as an essentially closed housing, which is the case in the present exemplary embodiment (see in particular Fig. 2 and Fig. 4 ), it is recommended to provide the frame 30 with a front viewing cutout 44 or a corresponding window and, as provided here ( Fig. 5 ), with a rear viewing cutout 45 or a corresponding window. This means you can look into the glass cylinder 26 from the front or back.
  • a viewing cutout or a window in the frame would be of no use unless the outer housing 2 overlaps the viewing cutout 44; 45 or window of the frame 30 would have a corresponding viewing window 46 or 47.
  • Such a viewing window can, if necessary, be colored to protect against UV rays, for example in brown.
  • the front viewing window 46 in the outer housing 2 is also in Fig. 1 to recognize.
  • Ventilation openings 48 are recommended, which are expediently located in the middle to achieve convection, e.g. B. hidden under the manual control knobs 38, or are arranged at the bottom near the valve block 10 and at the top near the upper end of the outer housing 2.
  • the illustrated and preferred exemplary embodiment shows that the top ventilation openings 48 are arranged at the head of the outer housing 2, preferably under an actuation button 49 arranged on the top.
  • actuation button 49 On top of the top of the outer housing 2 there is a large actuation button 49, which is labeled here with the word "Clear", i.e. represents a zero position button. This is often used when working with a burette.
  • the actuation button 49 on the top of the outer housing 2 is designed as a push button. They are actuated by pressure from above on the outer housing 2. This enables quick and error-free actuation without a serious tilting moment being exerted on the bottle top device and the storage bottle 1 underneath. Unlike the actuation buttons 6 arranged on the front of the outer housing 2, no counter-holding of the outer housing 2 is required.
  • the large operating button 49 also offers the possibility of hiding the ventilation opening 48 underneath. This shows Fig. 2 .
  • the outer housing 2 has a front housing shell 51 and a rear housing shell 52 which is detachably connected thereto.
  • the front housing shell 51 is suspended at the rear of the valve block 10 and firmly anchored in the middle (or top) of the frame 30. It's screwed on there.
  • the rear housing shell 52 is suspended at the top of the front housing shell 51. Below it is on the valve block 10 of the stopper 24, which sits in the stopper receptacle 23 and belongs to the bottle ventilation line 22. Other fixation options are also available, for example here using a screw. It is expedient to use the stopper 24 at the same time, also because it is particularly easily accessible from the back of the bottle top device. In Fig. 5 the rear housing shell 52 has been removed and accordingly the plug 24 is also missing.
  • FIG. 2 and Fig. 5 show further special features of the interior design of the outer housing 2.
  • the outer housing 2 here in the front housing shell 51, more precisely attached to it, there is an area accessible from the back (as here), from the front and / or from above, to the interior of the Outer housing 2, however, is otherwise a closed receiving compartment 53.
  • This receiving compartment 53 is used to accommodate electronic devices, in particular an equipped circuit board 54.
  • the electronics of the display 4, including the display panel 5, are also located in the receiving compartment 53.
  • the receiving compartment 53 continues under the actuation button 49 at an angle into the rear housing shell 52.
  • this is another circuit board 55 that carries a push button 56 that is actuated by the actuation button 49.
  • this further circuit board 55 is connected to the circuit board 54 via a film hinge 57 and itself sits in an insertion socket 58 of the receiving compartment 53.
  • the film hinge 57 is formed by a circuit film web.
  • the receiving compartment 53 could be closed at the front by a compartment cover 59 which may also carry the display 4 and the operating buttons 6. Then The receiving compartment 53 could be equipped from the outside with the compartment cover 59 removed.
  • connection 60 represents an external interface of the electronic devices, which can be used in any usual way.
  • the ventilation opening 48 below the actuation button 49 serves to ventilate the receiving compartment 53
  • Fig. 5 indicated ventilation openings located on the side under the actuation button 49 are also responsible for ventilation of the interior of the outer housing 2.
  • the receiving compartment 53 is narrower than the outer housing 2, at least in the area extending backwards, and is arranged centrally.
  • Fig. 5 in the outer housing 2, namely here in the front housing shell 51, ie attached to it, two battery compartments 61, namely to the right and left of the receiving compartment 53, are arranged.
  • Each battery compartment 61 is otherwise closed to the interior of the outer housing 2 by a cover 62.
  • the lid 62 is in Fig. 2 recognizable, it has a handling tab 63.
  • Fig. 5 You can see the battery compartments 61 without the covers 62 and without batteries. Of course, the battery compartments 61 are also sealed by the covers 62 against the vapors occurring in the outer housing 2.
  • the two in Fig. 5 recognizable battery compartments 61 leave a space between them in which the piston rod 28 can move upwards. Accordingly, the wall of the receiving compartment 53 also has a corresponding course here, which gives the piston rod 28 the necessary clearance.
  • the openable design of the outer housing 2 with the essentially fixed front housing shell 51 and the easily removable rear housing shell 52 gives the user an easy way to disassemble the cylinder-piston arrangement, the piston 27 together with the piston rod 28 on the one hand and the cylinder 26 on the other hand to clean and also to change the piston 27 or the sliding connector 40 if necessary.
  • the piston rod 28, preferably on the side opposite the row of teeth 34 carries a measuring strip 64 which extends axially on the piston rod 28 and that adjacent to the piston rod 28, preferably in the upper part of the frame 30, one Sensor arrangement 65 is arranged with a sensor 66 aligned with the measuring strip 64.
  • a direct measured value recording is provided on the piston rod 28, as is basically known from the prior art explained at the beginning. Backlash in translation devices, as occurs with electromechanical measurement recordings, is systematically excluded here. This is particularly useful here if the other measures to stiffen the mechanical arrangement and increase accuracy are also taken.
  • the exemplary embodiment shown shows that the measuring strip 64 is aligned on one side in a form-fitting manner on the piston rod 28.
  • the measuring strip 64 with a one-sided axial stop 67 is inserted into a pocket on the piston rod 28 and is potted with a preferably chemical-resistant potting compound 68.
  • a casting compound 68 is easier to make chemical-resistant than normal adhesives. It also has sufficient inherent elasticity to accommodate the minimal displacements of the measuring strip 64 relative to the piston rod 28.
  • measuring strips 64 made of plastic and containing magnetic powder can be used.
  • Fig. 12 the assembly with piston 27, piston rod 28 and measuring strip 64 is shown.
  • the measuring strip 64 in contrast to the execution according to Fig. 2 is the measuring strip 64 as in the version Fig. 11 a/11b arranged in the piston rod 28 near the central axis of the piston 27.
  • the measuring strip 64 is also not as in the version Fig. 2 held.
  • the measuring strip 64 sits vertically near the piston 27 on the stop 67.
  • the upper, opposite end of the measuring strip 64 is moved vertically downward onto the stop 67 by a spring element 28a. Both contact surfaces are inclined so that the measuring strip 64 is held in the direction of its lateral contact with the piston rod 28.
  • Fig. 12 holds the measuring strip 64 flexibly on the piston rod 28 by the spring element 28a. Temperature changes and different linear expansions have no influence on the fastening. In addition, the assembly of the measuring strip 64 without any aids and/or a curing time has a positive effect in terms of production and repair costs.
  • the spring element 28a and the piston rod 28 are made in one piece.
  • the spring element 28a could also be a separate component that is attached to the piston rod 28 and consists of another material with good elastic properties.
  • the spring element 28a could be designed so that it holds the measuring strip 64 in a form-fitting manner in the direction of its lateral contact with the piston rod 28, for example by means of a molded-on bracket.
  • the distance measuring strip 64 (measuring strip 64) is magnetized in sections at a distance or magnetized in opposite directions in sections, with a pitch between 0.3 mm and 2.0 mm, preferably and as a compromise between resolution and costs approximately 1 .0mm.
  • the illustrated and preferred exemplary embodiment shows a particularly useful embodiment of a non-optical, in particular a magnetic field-sensitive, sensor arrangement 65.
  • This is located in a receiving pocket 69 that is completely closed towards the measuring strip 64 or towards the interior of the outer housing 2.
  • this is in the Frame 30 inserted, namely on this with elongated hole connections 70 screwed.
  • the elongated hole connections 70 allow the receiving pocket 69 to be precisely aligned with the measuring strip 64.
  • the sensor 66 of the sensor arrangement 65 is arranged in the receiving pocket 69 on the side facing the measuring strip 64 behind a thin-layer wall section 71. The purpose of the arrangement is to bring the sensor 66 as close as possible to the measuring strip 64 without actually touching it, and while maintaining a gas-tight seal of the sensor arrangement 65 towards the interior of the outer housing 2.
  • the sensor 66 of the sensor arrangement 65 sits on a circuit board 74 inserted into the receiving pocket 69 in an insertion guide 73, namely on its front edge, which is in Fig. 3 and Fig. 6 on the left directly rests against the thin wall section 71.
  • the wall section 71 here, for example, only has a thickness of approximately 0.1 to 0.2 mm. If the pitch of the measuring strip 64 is chosen to be larger, the distance between the sensor 66 and the measuring strip 64 can also become larger. Wall sections that are easier to produce, in particular injection moldable ones, can then be designed, which will generally have a slightly larger wall thickness of around 0.5 mm.
  • the receiving pocket 69 here consists overall of a chemical-resistant and temperature-stable plastic material, in particular PEEK.
  • the length and width of the receiving pocket 69 are approximately 20 mm, the thickness is approximately 8 to 10 mm.
  • the wall section 71 of the receiving pocket 69 can also not be made in one piece with the receiving pocket 69, but separately. It would then be attached to the receiving pocket 69.
  • the can do this Receiving pocket 69 has an opening in the area of the wall section 71.
  • a gas-tight film can be welded onto such an opening or fixed to the receiving pocket 69 in another way with or without auxiliary materials to close the opening.
  • Such a gas-tight film usually has a thickness of approx. 10 ⁇ m to approx. 500 ⁇ m.
  • This film now forms the wall section 71, which separates the sensor 66 from the measuring strip 64 in a gas-tight manner. In this way you can get to a very small distance of 0.1 mm or less.
  • the sensor arrangement 65 also has the evaluation circuit 72 on the circuit board 74 for evaluating the output signals of the sensor 66 and for controlling the display 4.
  • the evaluation circuit 72 can be built as a system solution with individual or several discrete components.
  • a space- and energy-saving and cost-effective evaluation circuit 72 can be achieved by using a mixed-signal controller, which evaluates the converted analog sensor signals directly via interpolation software.
  • the evaluation circuit 72 can also be implemented with an extreme case pure software solution using a microprocessor or microcomputer, without departing from the spirit of the teaching of the present invention.
  • Fig. 7 shows a perspective view of the receiving pocket 69 with the inserted circuit board 74 diagonally from behind.
  • the circuit board 74 has not yet been cast.
  • the interface cable soldered to the circuit board 74 and cast in is not shown. You can plan to completely cast the circuit board 74 in the receiving pocket 69, also with a chemical-resistant casting compound.
  • Fig. 8 shows an arrangement of a particularly useful sensor 66 for a sensor arrangement 65 of a device according to the invention.
  • the sensor 66 is designed as a magnetoresistive sensor system based on the AMR effect is executed.
  • this operating principle please refer to the publication by Dr. Erik Lins, SENSITEC GmbH "Magnetoresistive with optical precision", dated August 1, 2005 , are referred to, the disclosure content of which is also made part of the disclosure content of the present application by reference. This publication has been freely accessible on the Internet since August 2005.
  • Fig. 8 Briefly shows two Wheatstone bridge circuits, offset by 45° from each other, so that a cosine signal (C) and a sine signal (S) are generated, taps at +C/-C and +S/-S.
  • the magnetization direction of the measuring strip 64 is defined by H, the angle between H and the direction of the current flow is given by ⁇ .
  • the angle information becomes independent of the amplitude of the signals. On the one hand, this minimizes the influence of temperature, but on the other hand, the working distance between sensor 66 and measuring strip 64 is not particularly critical.
  • the separate evaluation of the sine and cosine signals offers a certain redundancy and, due to the fact that the sum of the squares is equal to 1, allows self-monitoring of the sensor 66 or an offset amplitude correction.
  • a circuit arrangement 72 as shown in Fig. 9 is shown as a block diagram.
  • the sensor 66 is fed with a clocked supply voltage 80, which can be adjusted via an amplitude setting 81 on the sensor 66.
  • the designated outputs (cos, sin) of the sensor 66 are connected to amplifiers 82, each with offset adjustment 82 '.
  • the amplifiers 82 there is a branch, on the one hand, to comparators 83 for comparison with a reference voltage 84, and on the other hand to analog/digital converters 75 with downstream modules 85 and normalization stages 86.
  • the modules 75, 85, 86, 87, 88 and 89 are in The present, preferred solution is implemented in a mixed-signal controller.
  • a mixed-signal controller please refer to the relevant statements and the citation contained in the general part of the description.
  • the evaluation is carried out using the interpolation software with an ON/OFF duty cycle of approximately 0.1 to approximately 0.02, preferably between approximately 0.05 and approximately 0.03, in particular with an ON Time from about 0.6 ms to about 0.1 ms, in particular between about 0.3 ms and about 0.15 ms. It is particularly recommended that the interpolation software works with an interpolation rate between 200 and 1,000, in particular between around 400 and around 600, preferably around 500.
  • the time for recording measured values is an ON time of 200 ⁇ s marked by vertical blackened lines shown. In the gaps between the lines, the OFF time is 5.6 ms.
  • the duty cycle is therefore approximately 0.036 in this exemplary embodiment.
  • the current consumption can be reduced to approximately 130 to 160 ⁇ A during operation.
  • Mixed-signal controllers often have the option of selecting different power-saving modes in which different components or connections of the controller are de-energized or switched to trickle current.
  • the mixed-signal controller mentioned as an example in the introduction to the description has, for example, five different power-saving modes (page 6 of the data sheet there), all of which are characterized by the fact that the central processing unit (CPU) is switched off.
  • CPU central processing unit
  • such a mixed-signal controller with different power-saving modes is to be preferred because it can be optimally tailored to the special features of a device according to the invention.
  • the adjustment speed of the piston 27 will not be greater than approximately 50 mm/s.
  • the interpolation rate is tailored to this. This gives you a resolution of the measuring path of around 2 ⁇ m and an accuracy of the measured value over the full measuring range of around 10 ⁇ m, all in a temperature range of + 10 °C to around + 40 °C.
  • FIG. 11 Another and independent teaching is based on the exemplary embodiment of Fig. 11 (Fig. 11a, Fig. 11b ) explained.
  • this construction applies to a magnetic field-sensitive sensor system, in particular a magnetoresistive sensor system.
  • Fig. 11a shows an exact alignment of the piston rod 28 on a side guide 90.
  • a side guide 90 is provided for the piston rod 28 and the sensor 26 is arranged close to, preferably approximately at the height of, the side guide 90. This ensures that when the piston rod 28 is in the desired position in contact with the side guide 90, the sensor 66 is also exactly aligned relative to the measuring strip 64 positioned on the piston rod 28. The parallelism of the measuring strip 64 with the sensor 66 is optimal over the full adjustment path of the piston rod 28.
  • Fig. 11b shows in connection with Fig. 11a that a measurement error with regard to the distance measurement in the axial direction could also result from an inclination of the piston rod 28 in the cylinder 26, in particular relative to the piston 27.
  • This measurement error is noticeable in a device of the type in question because of the high precision achieved. It is caused by the fact that the piston rod 28 has a certain lateral play in the area of the piston drive 29, for example 0.3 mm. This leads to a minimal but disturbing inclination of the piston rod 28 within the scope of the present measurement accuracy, which causes a position measurement error.
  • the sensor 66 which detects the magnetic field of the measuring strip 64 applies lies as close as possible to or on the longitudinal central axis of the piston rod 28. This is in Fig. 11a, b shown.
  • the interface in the magnetoresistive measuring system is the sensor 66, which is penetrated by the field lines of the periodically magnetized measuring strip 64. If the measuring strip 64 tilts as in Fig. 11b shown to the left, the starting area of the field lines moves slightly downwards, but at the same time the direction of the field lines is also tilted due to the tilting, these run from the measuring strip 64 slightly upwards in the direction of the sensor 66. At the interface, namely at the sensor 66, only the amplitude changes slightly, which can be corrected, but not the phase position, which is crucial for the distance measurement.
  • the interface lies somewhere between the two orientations described above.
  • the sensor 66 in the sensor arrangement 65 is no longer next to the piston rod 28, but in its clear profile. Accordingly, it is recommended that the piston rod 28 has a recess or flattening that allows the corresponding position of the sensor 66.
  • Fig. 12 shows a particularly interesting design solution for fixing the measuring strip 64 in the piston rod 28, taking into account the previously explained boundary conditions. This has already been explained above.
  • the exemplary embodiments shown show that the sensor arrangement 65 is not arranged on the outer housing 2, but on the dimensionally stable frame 30. This means that the entire measurement chain is completely concentrated on the frame 30, so that its dimensional stability leads to the excellent accuracy of the bottle top device according to the invention.
  • the measuring strip 64 is an optical scale and the sensor arrangement 65 is a high-resolution reflected light system, in particular with four reflected light diodes. Then the construction in the area of the sensor arrangement 65 is of course different than previously described.
  • the accuracy of measurements in the bottle top device according to the invention can be increased to an accuracy R of approximately +/- 0.06% and a coefficient of variation VK of approximately 0.02% for nominal volumes of 25 ml and 50 ml. These are values that are otherwise only achieved by high-precision motorized bottle top devices.
  • the high accuracy of the bottle top device according to the invention also stems from the fact that all mechanically moving parts are fixed axially with respect to the valve block 10 precisely and dimensionally stable. This, in conjunction with the direct measurement measurement directly on the piston rod 28, makes it unnecessary to compensate for play when reversing the actuation direction.
  • the occurrence of tilting moments on the bottle top device is systematically avoided or reduced to a minimum.
  • the comparatively low height of the outer housing 2 is also important, which is possible despite the fixed outer housing 2 because a comparatively small stroke of the piston 27 is achieved.

Claims (6)

  1. Appareil pièce rapportée pour bouteille pour la manipulation de liquides avec
    - d'un agencement cylindre-piston pour recevoir et distribuer avec précision des volumes partiels de liquide, avec un cylindre (26) et un piston (27) se déplaçant de manière étanche dans le cylindre (26),
    - une bande de mesure de déplacement (64),
    - un agencement de capteurs (65) avec un capteur (66) orienté vers la bande de mesure (64) et séparé de la bande de mesure (64) uniquement par une fente étroite, l'agencement de capteurs (65) étant disposé dans une poche de réception (69) complètement fermée en direction de la bande de mesure (64),
    - un indicateur (4) de la quantité de liquide manipulée ou à manipuler, et
    - un circuit d'évaluation électronique (72) pour évaluer les signaux de sortie du capteur (66),
    caractérisé
    en ce que le piston (27) présente une tige de piston (28) sortant vers le haut du cylindre (26),
    en ce que la bande de mesure de déplacement (64) est disposée directement sur la tige de piston (28) et s'étend axialement dans la direction de déplacement de la tige de piston (28), et
    que l'agencement de capteurs (65) est disposé de manière fixe dans l'appareil au voisinage de la tige de piston (28).
  2. Appareil pièce rapportée pour bouteille selon la revendication 1, caractérisé en ce que l'agencement de capteurs (65) dans la poche de réception (69) est conçu comme un ensemble complètement séparé, en forme de bloc, à manipuler de manière autonome.
  3. Appareil pièce rapportée pour bouteille selon la revendication 1 ou 2, caractérisé en ce que
    - l'appareil pièce rapportée pour bouteille présente un boîtier extérieur (2) et peut être fixé avec un dispositif de fixation (3) sur un goulot d'une bouteille de stockage (1),
    - l'appareil pièce rapportée pour bouteille comprend dans le boîtier extérieur (2) un bloc de soupape (10) sur lequel est monté ou formé intégralement l'agencement de fixation (3) avec lequel le bloc de soupape (10) peut être fixé sur la bouteille de stockage (1),
    - le boîtier extérieur (2) est relié de manière amovible au bloc de soupapes (10),
    - l'appareil pièce rapportée pour bouteille présente un cadre porteur (30) entourant le cylindre (26) et s'étendant vers le haut au-delà du cylindre (26),
    - le cadre (30) est relié de manière fixe à l'extrémité inférieure au bloc de soupape (10) dans une position déterminée avec précision dans le sens axial, mais peut être détaché du bloc de soupape (10),
    - l'appareil pièce rapportée pour bouteille présente au-dessus du cylindre (26) un entraînement à piston (29) en liaison d'entraînement avec la tige de piston (28),
    - le cadre (30) reçoit ou supporte l'entraînement à piston (29),
    - le boîtier extérieur entoure le cadre (30) à l'extérieur, s'étend vers le haut au-delà de l'entraînement à piston (29) sur le cadre (30) et est fermé en haut et
    - l'ensemble de capteurs (65) est disposé dans la partie supérieure du cadre (30).
  4. Appareil pièce rapportée pour bouteille selon l'une des revendications précédentes, caractérisé en ce que le capteur (66) est disposé dans la poche de réception (69) sur son côté tourné vers la bande de mesure (64), derrière une section de paroi (71) à couche mince de la poche de réception (69), la section de paroi (71) présentant une épaisseur d'environ 0,1 mm à 0,5 mm.
  5. Appareil pièce rapportée pour bouteille selon l'une des revendications précédentes, caractérisé en ce que l'agencement de capteurs (65) est coulé à l'arrière dans la poche de réception (69) avec une masse de scellement.
  6. Appareil pièce rapportée pour bouteille selon l'une des revendications précédentes, caractérisé en ce que le capteur (66) de l'ensemble de capteurs (65) est placé sur une platine (74) insérée dans la poche de réception (66) dans un guide d'insertion (73) sur son bord avant.
EP19158248.5A 2006-12-07 2007-12-06 Appareil posé sur bouteille destiné à la manipulation de liquides Active EP3508274B1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE202006018527 2006-12-07
DE202006018526 2006-12-07
PCT/EP2007/010580 WO2008068013A2 (fr) 2006-12-07 2007-12-06 Appareil pièce rapportée pour bouteille pour la manipulation de liquides
EP07856393.9A EP2125223B1 (fr) 2006-12-07 2007-12-06 Appareil pièce rapportée pour bouteille pour la manipulation de liquides
EP14002517.2A EP2799141B1 (fr) 2006-12-07 2007-12-06 Dispositif pour la manipulation de liquides à attaché à une bouteille

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
EP07856393.9A Division EP2125223B1 (fr) 2006-12-07 2007-12-06 Appareil pièce rapportée pour bouteille pour la manipulation de liquides
EP14002517.2A Division EP2799141B1 (fr) 2006-12-07 2007-12-06 Dispositif pour la manipulation de liquides à attaché à une bouteille
EP14002517.2A Division-Into EP2799141B1 (fr) 2006-12-07 2007-12-06 Dispositif pour la manipulation de liquides à attaché à une bouteille

Publications (2)

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EP3508274A1 EP3508274A1 (fr) 2019-07-10
EP3508274B1 true EP3508274B1 (fr) 2024-02-28

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EP07856393.9A Active EP2125223B1 (fr) 2006-12-07 2007-12-06 Appareil pièce rapportée pour bouteille pour la manipulation de liquides
EP19158248.5A Active EP3508274B1 (fr) 2006-12-07 2007-12-06 Appareil posé sur bouteille destiné à la manipulation de liquides
EP14002517.2A Active EP2799141B1 (fr) 2006-12-07 2007-12-06 Dispositif pour la manipulation de liquides à attaché à une bouteille

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EP (3) EP2125223B1 (fr)
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Also Published As

Publication number Publication date
EP2125223A2 (fr) 2009-12-02
EP2799141A2 (fr) 2014-11-05
CN103285951B (zh) 2015-01-14
EP2799141B1 (fr) 2019-05-01
EP2125223B1 (fr) 2015-12-02
WO2008068013A2 (fr) 2008-06-12
EP2799141A3 (fr) 2015-01-21
CN103285951A (zh) 2013-09-11
US8142738B2 (en) 2012-03-27
WO2008068013A3 (fr) 2008-09-18
EP3508274A1 (fr) 2019-07-10
US20100021349A1 (en) 2010-01-28

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