EP2707694A1 - Tête de capteur à usage unique et récipient à usage unique - Google Patents

Tête de capteur à usage unique et récipient à usage unique

Info

Publication number
EP2707694A1
EP2707694A1 EP12719599.8A EP12719599A EP2707694A1 EP 2707694 A1 EP2707694 A1 EP 2707694A1 EP 12719599 A EP12719599 A EP 12719599A EP 2707694 A1 EP2707694 A1 EP 2707694A1
Authority
EP
European Patent Office
Prior art keywords
sensor head
disposable
container
wall
viewing window
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12719599.8A
Other languages
German (de)
English (en)
Inventor
Daniel Riechers
Christian Grimm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sartorius Stedim Biotech GmbH
Original Assignee
Sartorius Stedim Biotech GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sartorius Stedim Biotech GmbH filed Critical Sartorius Stedim Biotech GmbH
Publication of EP2707694A1 publication Critical patent/EP2707694A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/54—Inspection openings or windows
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/031—Multipass arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G01N21/8507—Probe photometers, i.e. with optical measuring part dipped into fluid sample
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G01N21/8507—Probe photometers, i.e. with optical measuring part dipped into fluid sample
    • G01N2021/8514—Probe photometers, i.e. with optical measuring part dipped into fluid sample with immersed mirror

Definitions

  • the flow chamber has at least two lateral, arranged between the lens and the reflector disc openings.
  • the openings are chosen as large as possible.
  • they occupy the predominant wall part of the through-channel between the viewing window and the reflector disk and are separated from each other only by narrow webs.
  • the central body on the side facing away from the reflector disc of the lens has a coupling device for the reversible coupling of an optoelectronic sensor module.
  • An optoelectronic sensor module is here understood to mean a structural unit which has a light source, a detector unit and suitable light-conducting elements.
  • the light-guiding elements may be fiber-optic, but preferably of a beam-optical nature.
  • fiber-optic light-conducting elements can have problems with regard to transparency, Dispersion, aperture, loss of fiber bends, etc. raise.
  • the optoelectronic sensor module therefore preferably comprises an NIR light source, a purely or at least predominantly beam-optical illumination beam path comprising mirrors and optionally lenses, a likewise purely or at least predominantly radiolucent detection beam path, and an NIR detector, in particular an NIR spectrometer whose spectrometer input is definitely fiber-optic elements may contain. Due to the optical radiation supply and discharge of light, a positionally stable coupling between the sensor head and the optoelectronic sensor module is required. This requirement is met by said development of the invention due to the direct coupling with the central body. Corresponding coupling standards are known to the person skilled in the art, for example from microscopy.
  • the central body does not necessarily have to be constructed in one piece. Rather, it is quite possible and often advantageous if the central body is constructed in several parts and has a main body and at least one other central body component. This can for example be realized so that the lens is sealingly supported between the main body and an end face of a clamping ring.
  • the clamping ring can be fixed, for example, as a threaded ring, like a snap ring, by a latching or in a similar manner to the main body. Its object is to press the lens against a preferably provided with a seal projection of the passage channel to hold them on the one hand and on the other hand to seal.
  • the clamping ring on its side facing away from the lens end face
  • Coupling device for reversible coupling of the optoelectronic sensor module has.
  • the clamping ring is thus assigned a dual function, namely on the one hand for holding and sealing the lens, as described above, and on the other hand as an adapter for the optoelectronic sensor module.
  • a further realization of a multipart center body which may alternatively or preferably be implemented in addition to the aforementioned, is that the reflector disk is fixed on an adjusting plate, which is fixed at an adjustable distance from the lens on the main body.
  • the adjusting plate may be formed as a body with external thread, which can be screwed into an internal thread at the outlet of the through-channel. Under cost aspects favorable and in the majority of practice-relevant cases probably sufficient will be a variant in which the adjustment plate and the main body have corresponding locking grooves and bulges.
  • the adjusting plate may be provided with a circumferential detent groove or a peripheral detent bead which snaps into one of a plurality of mutually parallel, corresponding detent grooves or latching beads in the outlet-near inner wall of the through-channel.
  • the sensor head geometry specifies several fixed positions for the adjustment plate, from which one can be chosen during assembly of the sensor head.
  • this type of fixation of the adjusting plate is basically possible even with only one predetermined position.
  • FIG. 2 shows a top view of the sensor head according to the invention along the line of sight arrow II in FIG. 1,
  • clamping ring 24 and / or the main body 18 ahead is, if one or both of said elements, as preferably provided, are formed from a corresponding plastic.
  • the clamping ring could for example also be provided with an external thread which can be screwed into an internal thread of the main body.
  • the inner region of the through-channel 20 or the main body 18 can be subdivided into two subregions.
  • the partial area next to the viewing window 14 is designed as a flow chamber 34.
  • the main body 18 passing through openings 36 are provided which allow ontageendschreib a fluid exchange between the flow chamber 34 and the container interior.
  • the flow chamber is closed by the reflector disc 14 opposite and substantially parallel to this reflector disc, which in turn is attached to an adjustment plate 26, for example, glued to this.
  • the adjusting plate 26 has in the illustrated
  • Embodiment a circumferential locking bead 38 which in one of two corresponding with him locking grooves 39 in the inner wall of the passageway 20 formed by the main body 18 is engaged.
  • embodiments with only one latching groove 39, with more than two latching grooves 39 and with other fastening means are possible, for example an external thread on the adjusting plate 26, which can be screwed into an internal thread of the main body 18.
  • the reflector disk 16 permanently fixed to the main body 18 in a non-adjustable manner.
  • Figure 2 shows a plan view of the sensor head of Figure 1 according to the sighting arrow II, with reference to the above explained for explanation.
  • FIG 3 shows a highly schematic sectional view of an optoelectronic sensor module, which forms an optical sensor together with the sensor head of Figures 1 and 2.
  • the reflector disk 16 of the sensor head 10 is shown in addition to the optoelectronic sensor module 40.
  • the optoelectronic sensor module 40 has a preferably dust and liquid-tight housing 42.
  • an optical window 44 is embedded, which has sufficient for the intended measurement transparency in the respective required spectral range.
  • NIR near Infrared Area
  • a reflection flap 58 is provided in FIG. 3, which can be folded into the illumination beam path for calibration purposes, so that the light from the light source 48 is thrown onto the reflection flap via the mirror 50 and mirrored from there to the input 54 of the spectrometer 56 can be scattered.
  • This direct measurement of the illumination light can be used to create a reference with which subsequently measured detection light of a transflection measurement can be compared.
  • FIG. 4 shows the final assembly state of a disposable container 60 according to the invention.
  • the container consists of a flexible bag 62 which is filled with a fluid 64.
  • an agitator 66 projecting into the interior of the bag 64 is additionally provided, which maintains a permanent flow within the medium 64.
  • the sensor head is used in the manner already described above. In particular, in the embodiment shown, it is welded to the outside of its mounting flange 22 against the inner wall of the bag 62.
  • the flow chamber 34 is flowed through its openings 36 by the fluid 64, wherein the agitator 66 conveys the flow of "fresh" fluid, so that a measurement made on the volume of the flow chamber 34 can be taken as representative of the total bag contents of the sensor head 10 is the optoelectronic sensor module 40 coupled with the tri-clamp coupling structures 25/45 are held together by a clamp 70 in a standard manner.
  • the coupling structures 25/45 are designed so that the optical window 44 is not parallel to the viewing window 14, but at a low angle, preferably between 1 degree and 3 degrees, particularly preferably 2 degrees lies, takes. As a result, errors are avoided, which can be caused by a reflection of the illumination light on the lens 14.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Mechanical Engineering (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

L'invention concerne une tête de capteur pour un capteur optique, comprenant un corps central (12) qui comporte un conduit traversant axial (10) fermée par une plaque optique (14) transparente disposée perpendiculairement à son axe longitudinal, et une collerette de fixation périphérique (22) au moyen de laquelle il peut se fixer de manière étanche sur la paroi d'un récipient flexible (62) de telle manière que le conduit traversant (20) traverse la paroi. L'invention est caractérisée en ce que le conduit traversant (20) forme, dans une zone, une chambre ouverte d'écoulement traversant (34) qui est délimitée d'un côté par la plaque de visualisation (14) et de l'autre côté par une plaque réflectrice (16) opposée à la plaque de visualisation (14).
EP12719599.8A 2011-05-10 2012-05-05 Tête de capteur à usage unique et récipient à usage unique Withdrawn EP2707694A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011101107A DE102011101107B4 (de) 2011-05-10 2011-05-10 Einweg-Sensorkopf und Einwegbehälter
PCT/EP2012/001942 WO2012152423A1 (fr) 2011-05-10 2012-05-05 Tête de capteur à usage unique et récipient à usage unique

Publications (1)

Publication Number Publication Date
EP2707694A1 true EP2707694A1 (fr) 2014-03-19

Family

ID=46046119

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12719599.8A Withdrawn EP2707694A1 (fr) 2011-05-10 2012-05-05 Tête de capteur à usage unique et récipient à usage unique

Country Status (4)

Country Link
US (1) US9400243B2 (fr)
EP (1) EP2707694A1 (fr)
DE (2) DE102011101107B4 (fr)
WO (1) WO2012152423A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3650529A1 (fr) 2018-11-09 2020-05-13 Sartorius Stedim FMT SAS Récipient à usage unique comportant un élément fonctionnel imprimé en 3d, procédé d'impression correspondant et ensemble

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WO2014012584A1 (fr) * 2012-07-18 2014-01-23 Siemens Aktiengesellschaft Dispositif d'analyse permettant d'analyser un fluide dans une poche souple; et récipient de réaction comportant une paroi réalisée en un matériau souple
DE102012218901A1 (de) * 2012-10-17 2014-04-17 Robert Bosch Gmbh Sensorvorrichtung mit Positioniereinrichtung
DE102014005710A1 (de) * 2013-04-23 2014-10-23 Technische Hochschule Mittelhessen Erfindung betreffend eine Messmethode zur Detektion und quantitativen Bestimmung der Zellkonzentration
US10041896B2 (en) 2013-12-06 2018-08-07 Pendo TECH Sensor fitting for biotech process bag
US10557811B2 (en) 2013-12-06 2020-02-11 Pendotech Sensor fitting for biotech process bag
US11181496B2 (en) 2013-12-06 2021-11-23 Pendotech Sensor fitting for biotech process bag
DE102015110893B3 (de) * 2015-07-06 2016-03-24 Sartorius Stedim Biotech Gmbh Verfahren zum Messen einer Mehrzahl von Zustandsparametern eines in einem Behälter enthaltenen Fluids
DE102015122745B3 (de) * 2015-12-23 2017-01-19 Sartorius Stedim Biotech Gmbh Behälter
DE102016000997B3 (de) * 2016-01-29 2017-02-23 Sartorius Stedim Biotech Gmbh System zum Aufbewahren und/oder Kalibrieren eines Sensors
DE102016008826B4 (de) 2016-07-19 2024-04-25 Sartorius Stedim Biotech Gmbh Spektroskopische Messung für Behälter
FR3059770B1 (fr) * 2016-12-02 2020-10-02 Chene & Cie Dispositif de mesure de couleur d'un liquide sans prise d'echantillon
DE102017110671A1 (de) 2017-05-17 2018-11-22 Presens Precision Sensing Gmbh Sensorträger und diesen verwendende Verfahren
EP3435162A1 (fr) 2017-07-28 2019-01-30 ASML Netherlands B.V. Procédé et appareil de métrologie et programme informatique
DE102017010629A1 (de) * 2017-11-16 2019-05-16 Sartorius Stedim Biotech Gmbh Behälter mit Wandungsvorsprung und Sensorbereich
DE102018108325B4 (de) 2018-04-09 2020-07-09 Schott Ag Sensoraufnahme für einen Bioreaktor sowie Bioreaktor mit Sensoraufnahme und Verfahren zur Vermehrung oder Kultivierung biologischen Materials
DE102018108323B4 (de) 2018-04-09 2020-07-09 Schott Ag Vorrichtung zur Halterung einer bilderfassenden Einrichtung an einem Bioreaktor, Bioreaktor mit Vorrichtung zur Halterung einer bilderfassenden Einrichtung sowie Verfahren zur Vermehrung oder Kultivierung biologischen Materials
DE102019115147B4 (de) * 2019-06-05 2021-01-14 Schott Ag Biokompatibles Verbundelement und Verfahren zur Herstellung eines biokompatiblen Verbundelements
DE102022129251A1 (de) * 2022-11-04 2024-05-08 Watergenics GmbH Sonde zur Flüssigkeits-Analyse

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3650529A1 (fr) 2018-11-09 2020-05-13 Sartorius Stedim FMT SAS Récipient à usage unique comportant un élément fonctionnel imprimé en 3d, procédé d'impression correspondant et ensemble
WO2020094391A1 (fr) 2018-11-09 2020-05-14 Sartorius Stedim FMT S.A.S. Récipient à usage unique avec élément fonctionnel imprimé en 3d, procédé d'impression correspondant, et assemblage

Also Published As

Publication number Publication date
US9400243B2 (en) 2016-07-26
DE102011101107B4 (de) 2013-08-14
US20140054186A1 (en) 2014-02-27
DE102011101107A1 (de) 2012-11-15
WO2012152423A1 (fr) 2012-11-15
DE202012004503U1 (de) 2012-05-22

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