EP1834623B1 - Multi-chamber container - Google Patents

Multi-chamber container Download PDF

Info

Publication number
EP1834623B1
EP1834623B1 EP20070004952 EP07004952A EP1834623B1 EP 1834623 B1 EP1834623 B1 EP 1834623B1 EP 20070004952 EP20070004952 EP 20070004952 EP 07004952 A EP07004952 A EP 07004952A EP 1834623 B1 EP1834623 B1 EP 1834623B1
Authority
EP
European Patent Office
Prior art keywords
cover
chamber
chamber container
filling chambers
rigid members
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
EP20070004952
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1834623A3 (en
EP1834623A2 (en
Inventor
Toshiya Okahisa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Original Assignee
Baylor College of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College of Medicine filed Critical Baylor College of Medicine
Publication of EP1834623A2 publication Critical patent/EP1834623A2/en
Publication of EP1834623A3 publication Critical patent/EP1834623A3/en
Application granted granted Critical
Publication of EP1834623B1 publication Critical patent/EP1834623B1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2024—Separating means having peelable seals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2034—Separating means having separation clips

Definitions

  • the present invention relates to a multi-chamber container, and more particularly, to a multi-chamber container which accommodates two or more solutions to enable the solutions to be mixed.
  • a method of releasing the barrier to mix solutions in such a multi-chamber container there are a method of pressing a filling chamber by hand or the like to decrease the volume of the chamber, and thereby releasing the barrier by pressure of the solution inside the chamber to mix the solutions, another method of providing an injection plug extending from a filling chamber to another filling chamber through the barrier, and opening the injection plug to mix the solutions, and the like.
  • opening operation pressing or opening of the plug
  • opening operation is necessary independently of mounting operation in mounting the container to a predetermined device to administer.
  • a possibility thereby arises that solutions are administered without performing the opening operation.
  • the opened plug is left in the chamber, resulting in a problem of intrusion of the foreign substance.
  • the EP 0 513 364 A1 discloses a multi-chamber vessel used in the medical field, in which the flexible plastic vessel is divided into a plurality of chambers with partitioning means permitting communication as required At least one of a plurality of chambers composing the vessel is not provided with a cover whereas at least one other chamber is provided with a cover which covers this chamber through a sealed space and is composed of a flexible film having water- and gas-barrier functions, and at least any of desiccant and deoxidizer is contained in said sealed space, whereby the vessel is low in price, excellent in quality and performance, and, further, easy to discard.
  • a multi-chamber container of the invention is a multi-chamber container according to claim 1, which accommodates a plurality of solutions, is divided into a plurality of filling chambers by an opening preventing portion, and has a container body with the filling chambers filled with the solutions respectively, and a covering member that covers at least one of the filling chambers of the container body, where the covering member has a pair of rigid members that sandwich the opening preventing portion from the outside, and seal portions provided to close the pair of rigid members.
  • FIG.1 is a front view showing a multi-chamber container according to an embodiment of the present invention.
  • FIG.2 is a side view of the multi-chamber container shown in FIG.1 .
  • FIG.3 is an enlarged view of a cover attaching portion of the multi-chamber container shown in FIG.1 .
  • the multi-chamber container as shown in FIG.1 has a container body 1.
  • the container body 1 has a plurality of (two in this embodiment) filling chambers 11, 12.
  • a seal portion 13 is provided between the filling chambers 11, 12 to prevent opening of communication of solutions respectively filled in the filling chambers 11, 12. Accordingly, the container body 1 is divided into two filling chambers 11, 12 by the seal portion 13.
  • the seal portion 13 has sufficient pressure resistance to a pressure in the normal direction (direction of the arrow A) to the sheet. In other words, the pressure from the direction of the arrow A is dispersed over the entire container body 1, and the seal portion 13 is thereby not peeled. Meanwhile, the seal portion 13 has a property of easily peeling against the force in the vertical direction (direction of the arrow B) of the sheet.
  • a seal portion 13 as an opening preventing portion, when the pressure in the direction of the arrow B is applied to the seal portion 13 by applying the pressure to at least one of the filling chambers 11, 12, the seal portion 13 is peeled to open the communication between the filling chambers 11, 12, and the solutions filled into the chambers 11, 12 are mixed.
  • the container body 1 has a hole 14 to be hanged in a stand during administration of the solutions at its one end (upper position in the figure). Further, the container body 1 has a cock 15 at the other end (lower position in the figure) . The cock 15 is sealed by a rubber stopper until a hollow needle is inserted.
  • the multi-chamber container as shown in FIG.1 has a cover 2 that covers at least one of the filling chambers 11, 12 (the chamber 12 in FIG.1 ).
  • the cover 2 is only required to cover at least an end portion (for example, the cock 15 or hole 14).
  • the cover 2 includes a pair of rigid members 21 that sandwich the seal portion 13 from the outside, and seal portions 22 provided to close the pair of rigid members 21.
  • a film, sheet and the like may be used which are formed of paper, plastic or the like.
  • the rigid members 21 have sufficient ridigity to hold the seal portion 13 from the outside to enable the cover 2 to be attached to the container body 1.
  • the rigid members 21 plates and the like may be used which can pinch the seal portion 13 (thin portion of the container body 1) along the seal portion 13. It is preferable that the rigid members 21 are light in weight as possible. Accordingly, as a material for the rigid members, for example, paper, plastic and the like may be used.
  • the rigid members 21 are attached to the internal side of the cover 2 by adhesive or the like to come into contact with the seal portion 13. Further, as in an aspect as shown in FIG.1 , since the cover 2 is closed by the seal portions 22, the length L of the rigid member 21 is set shorter than the width D of the cover 2.
  • the seal portions 22 are provided in regions outside the rigid members 21 in the cover 2.
  • the seal portions 22 have adhesion of the extent to which the seal portions 22 peel by an increase in thickness of the seal portion 13 when the seal portion 13 peels to cause the filling chambers 11, 12 to be opened in therebetween and increases its thickness.
  • the adhesion and shape of the seal portions 22, and positions of the seal portions 22 in the cover 2 are set so as to hold the cover when the filling chambers 11, 12 are not opened in therebetween, while causing the cover 2 to easily drop when the filling chambers 11, 12 are opened in therebetween and the thickness of the seal portion 13 increases.
  • the seal portions 22 may be formed of a double-faced tape, the cover 2 may be melted to form the seal portions 22, or engaging portions may be provided at contact portions (end portions) of the cover 2 and engaged to form the seal portions 22.
  • cover 2 for example, film or sheet
  • Rigid members 21 for example, plates
  • FIG.4B the cover 2 is bent so that the rigid members 21 are opposed to each other.
  • the bent cover 2 is put on the container body 1 so as to cover one (the chamber 12) of the filling chambers of the container body 1 so that positions of the rigid members 21 are in accordance with the position of the seal portion 13.
  • regions outside the rigid members 21 are sealed to form the seal portions 22.
  • the aforementioned multi-chamber container is configured so that the filling chamber 12 is covered with the cover 2 when the filling chambers 11, 12 are not opened in therebetween, and that the cover 2 drops when the filling chambers 11, 12 are opened in therebetween and the seal portion 13 increases its thickness. Therefore, when the filling chambers 11, 12 are not opened in therebetween, the cock 15 of the container body 1 is covered with the cover 2. Hence, in this state, since the cock 15 is covered with the cover 2, it is logically not possible to inject a hollow needle into the cock 15 to use the container. In other words, the container cannot be used with the filling chambers 11, 12 not opened in therebetween. It is thus possible to reliably avoid an occurrence of forgetting to mix the solutions. Further, according to this configuration, it is possible to prevent intrusion of a foreign substance.
  • the cover 2 may be configured so that the side portions of the cover 2 are closed by perforations to be torn off, and the perforations are torn to cause the cover 2 to drop when the thickness of the seal portion 13 increases with the filling chambers 11, 12 opened in therebetween.
  • the seal portions 22 may be provided or not provided.
  • FIG.5 is a front view showing another example of the multi-chamber container according to this embodiment of the present invention.
  • the filling chamber 11 is covered with the cover 2.
  • a configuration of the cover 2 is the same as that in the multi-chamber container as shown in FIG.1 .
  • the multi-chamber container as shown in FIG.5 is configured so that the filling chamber 11 is covered with the cover 2 when the filling chambers 11, 12 are not opened in therebetween, and that the cover 2 drops when the filling chambers 11, 12 are opened in therebetween and the seal portion 13 increases its thickness. Therefore, when the filling chambers 11, 12 are not opened in therebetween, the hole 14 of the container body 1 is covered with the cover 2. Hence, in this state, since the hole 14 is covered with the cover 2, the container cannot be hung in a stand logically nor cannot be used. In other words, the container cannot be used with the filling chambers 11, 12 not opened in therebetween. It is thus possible to reliably avoid an occurrence of forgetting to mix the solutions. Further, according to this configuration, it is possible to prevent intrusion of a foreign substance.
  • FIG.6 is a front view showing still another example of the multi-chamber container according to this embodiment of the present invention.
  • the cover 2 is sealed to form the seal portions 22.
  • the rigid members 21 are sealed to form the seal portions 22. Accordingly, in an aspect as shown in FIG.6 , since the cover 2 is closed by the rigid members 21, the length L of the rigid members 21 is set longer than the width D of the cover 2. In addition, the rigid members 21 are the same as those in the multi-chamber containers as shown in FIG.1 and FIG.5 .
  • the multi-chamber container as shown in FIG.6 is configured so that the filling chamber 12 is covered with the cover 2 when the filling chambers 11, 12 are not opened in therebetween, and that the cover 2 drops when the filling chambers 11, 12 are opened in therebetween and the seal portion 13 increases its thickness. Therefore, when the filling chambers 11, 12 are not opened in therebetween, the cock 15 of the container body 1 is covered with the cover 2. Hence, in this state, since the cock 15 is covered with the cover 2, it is logically not possible to inject a hollow needle into the cock 15 to use the container. In other words, the container cannot be used with the filling chambers 11, 12 not opened in therebetween. It is thus possible to reliably avoid an occurrence of forgetting to mix the solutions. Further, according to this configuration, it is possible to prevent intrusion of a foreign substance.
  • the filling chamber 12 is covered with the cover 2.
  • the filling chamber 11 may be covered with the cover 2 as in the multi-chamber container as shown in FIG.5 , using the same cover 2 as shown in FIG.6 .
  • the present invention is not limited to the above-mentioned embodiment, and is capable of being carried into practice with various modifications thereof.
  • the above-mentioned embodiment describes the case of two filling chambers
  • the present invention is applicable to cases of three or more filling chambers.
  • the above-mentioned embodiment describes the case of filling solutions into filling chambers
  • the present invention is applicable to cases of filling powdery substances into filling chambers.
  • materials, sizes, shapes and the like in the above-mentioned embodiment are of examples, and the invention is not limited thereto.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Bag Frames (AREA)
  • Package Specialized In Special Use (AREA)
EP20070004952 2006-03-13 2007-03-09 Multi-chamber container Expired - Fee Related EP1834623B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/375,188 US20070209951A1 (en) 2006-03-13 2006-03-13 Multi-chamber container

Publications (3)

Publication Number Publication Date
EP1834623A2 EP1834623A2 (en) 2007-09-19
EP1834623A3 EP1834623A3 (en) 2009-02-11
EP1834623B1 true EP1834623B1 (en) 2012-04-18

Family

ID=38134138

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20070004952 Expired - Fee Related EP1834623B1 (en) 2006-03-13 2007-03-09 Multi-chamber container

Country Status (5)

Country Link
US (1) US20070209951A1 (ja)
EP (1) EP1834623B1 (ja)
JP (1) JP5361138B2 (ja)
AU (1) AU2007200955B2 (ja)
HK (1) HK1102541A1 (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9358135B2 (en) * 2007-04-17 2016-06-07 Warsaw Orthopedic, Inc. Devices, methods and systems for hydrating a medical implant material
JP2009142414A (ja) * 2007-12-13 2009-07-02 Fuji Seal International Inc 複槽薬剤バッグ封緘体
EP2382052B1 (en) * 2009-01-23 2013-01-16 Akzo Nobel Coatings International B.V. Packaging for two or more fluids
JP6626264B2 (ja) * 2015-03-31 2019-12-25 株式会社大塚製薬工場 輸液バッグ用の誤投与防止具及びこれを備えた輸液バッグ

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3830630A1 (de) * 1988-09-09 1990-03-15 Fresenius Ag Mehrkammerbeutelsystem
US4994056A (en) * 1989-11-09 1991-02-19 Ikeda Daniel P Unit dose medicament storing and mixing system
US5257985A (en) * 1989-12-04 1993-11-02 Richard Puhl Multi-chamber intravenous bag apparatus
ATE125147T1 (de) * 1990-11-07 1995-08-15 Otsuka Pharma Co Ltd Mehrere kammern aufweisender behälter.
JPH105313A (ja) * 1996-06-21 1998-01-13 Material Eng Tech Lab Inc 医療用容器の包装方法
US20010047162A1 (en) * 2000-02-17 2001-11-29 Yasumi Yugari Injection kit and injection device
JP2002136570A (ja) * 2000-08-24 2002-05-14 Otsuka Pharmaceut Factory Inc 医療用複室容器
CN1688274A (zh) * 2002-10-23 2005-10-26 株式会社Jms 2液分割用夹子
JP4178917B2 (ja) * 2002-11-11 2008-11-12 ニプロ株式会社 複室容器
US7243787B2 (en) * 2003-03-26 2007-07-17 Nipro Corporation Medicine bag
JP2004305722A (ja) * 2003-03-26 2004-11-04 Nipro Corp 薬剤バッグ
US7207970B2 (en) * 2003-06-27 2007-04-24 Nipro Corporation Displaceable-plug-containing filling/discharging port and medical container having the same
KR20060104988A (ko) * 2003-09-30 2006-10-09 니프로 가부시키가이샤 의료용 용기 및 그 사용방법
JP4179218B2 (ja) * 2003-09-30 2008-11-12 ニプロ株式会社 医療用容器
WO2005053598A1 (ja) * 2003-12-02 2005-06-16 Fuso Pharmaceutical Industries, Ltd. 複室容器
JP4600725B2 (ja) * 2004-02-02 2010-12-15 有限会社ケーアールビジネス 未開封使用防止機構つき医療用複室容器
JP4587096B2 (ja) * 2004-03-03 2010-11-24 有限会社ケーアールビジネス 未混合防止機構つき医療用複室容器
JP4609791B2 (ja) * 2004-08-10 2011-01-12 有限会社ケーアールビジネス 複室容器
JP3118291U (ja) * 2005-09-30 2006-01-26 株式会社大塚製薬工場 吊具カバー

Also Published As

Publication number Publication date
AU2007200955A1 (en) 2007-09-27
AU2007200955B2 (en) 2012-10-25
JP5361138B2 (ja) 2013-12-04
JP2007244864A (ja) 2007-09-27
EP1834623A3 (en) 2009-02-11
US20070209951A1 (en) 2007-09-13
EP1834623A2 (en) 2007-09-19
HK1102541A1 (en) 2007-11-30

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