EP1032587A4 - Nouveaux composes agonistes de l'exendine - Google Patents
Nouveaux composes agonistes de l'exendineInfo
- Publication number
- EP1032587A4 EP1032587A4 EP98958573A EP98958573A EP1032587A4 EP 1032587 A4 EP1032587 A4 EP 1032587A4 EP 98958573 A EP98958573 A EP 98958573A EP 98958573 A EP98958573 A EP 98958573A EP 1032587 A4 EP1032587 A4 EP 1032587A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- exendin agonist
- agonist compounds
- novel exendin
- compounds
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE69839021T DE69839021T3 (de) | 1997-11-14 | 1998-11-13 | Neuartige exendin agonisten |
| EP07020413A EP1938830A1 (fr) | 1997-11-14 | 1998-11-13 | Nouveaux composants d'agoniste d'exendine |
| CY20081100159T CY1107883T1 (el) | 1997-11-14 | 2008-02-11 | Καινοφανεις ενωσεις αγωνιστες εξενδινης |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6602997P | 1997-11-14 | 1997-11-14 | |
| US66029P | 1997-11-14 | ||
| PCT/US1998/024273 WO1999025728A1 (fr) | 1997-11-14 | 1998-11-13 | Nouveaux composes agonistes de l'exendine |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP07020413A Division EP1938830A1 (fr) | 1997-11-14 | 1998-11-13 | Nouveaux composants d'agoniste d'exendine |
| EP07020413.6 Division-Into | 2007-10-18 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| EP1032587A1 EP1032587A1 (fr) | 2000-09-06 |
| EP1032587A4 true EP1032587A4 (fr) | 2002-04-10 |
| EP1032587B1 EP1032587B1 (fr) | 2008-01-16 |
| EP1032587B2 EP1032587B2 (fr) | 2013-03-13 |
Family
ID=22066811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP98958573A Expired - Lifetime EP1032587B2 (fr) | 1997-11-14 | 1998-11-13 | Nouveaux composes agonistes de l'exendine |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1032587B2 (fr) |
| JP (1) | JP2001523688A (fr) |
| AT (1) | ATE383867T1 (fr) |
| AU (1) | AU756836B2 (fr) |
| BR (1) | BR9814189A (fr) |
| CA (1) | CA2309356C (fr) |
| CY (1) | CY1107883T1 (fr) |
| DE (1) | DE69839021T3 (fr) |
| DK (1) | DK1032587T4 (fr) |
| ES (1) | ES2297902T5 (fr) |
| HK (1) | HK1031120A1 (fr) |
| NZ (1) | NZ504256A (fr) |
| PT (1) | PT1032587E (fr) |
| WO (1) | WO1999025728A1 (fr) |
Families Citing this family (136)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6872700B1 (en) | 1999-01-14 | 2005-03-29 | Amylin Pharmaceuticals, Inc. | Methods for glucagon suppression |
| NZ512663A (en) | 1999-01-14 | 2004-05-28 | Amylin Pharmaceuticals Inc | Novel exendin agonist formulations and methods of administration thereof |
| US7399489B2 (en) | 1999-01-14 | 2008-07-15 | Amylin Pharmaceuticals, Inc. | Exendin analog formulations |
| US20050272652A1 (en) | 1999-03-29 | 2005-12-08 | Gault Victor A | Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity |
| US6924264B1 (en) | 1999-04-30 | 2005-08-02 | Amylin Pharmaceuticals, Inc. | Modified exendins and exendin agonists |
| CA2501421A1 (fr) | 1999-05-17 | 2000-11-23 | Conjuchem Inc. | Exendin-4 a longue duree d'action |
| US6506724B1 (en) | 1999-06-01 | 2003-01-14 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for the treatment of gestational diabetes mellitus |
| EP1076066A1 (fr) * | 1999-07-12 | 2001-02-14 | Zealand Pharmaceuticals A/S | Peptides abaissant le taux de glucose sanguin |
| US6528486B1 (en) | 1999-07-12 | 2003-03-04 | Zealand Pharma A/S | Peptide agonists of GLP-1 activity |
| EP1695983B1 (fr) | 2000-06-16 | 2009-03-04 | Eli Lilly & Company | Analogues de peptide 1 du type glucagon |
| UA81897C2 (uk) | 2000-12-07 | 2008-02-25 | Эли Лилли Энд Компани | Гетерологічний пептидильований глюкагон-1-подібний білок та його застосування для для виготовлення лікарського засобу для лікування пацієнтів, що страждають на ожиріння та/або інсулінонезалежний діабет |
| EP1349563B1 (fr) | 2000-12-14 | 2009-12-02 | Amylin Pharmaceuticals, Inc. | Peptide pyy[3-36] destines au traitement des troubles du metabolisme |
| US7112567B2 (en) | 2001-02-16 | 2006-09-26 | Conjuchem Inc. | Long lasting glucagon-like peptide 2 (glp-2) for the treatment of gastrointestinal diseases and disorders |
| CN1162446C (zh) * | 2001-05-10 | 2004-08-18 | 上海华谊生物技术有限公司 | 促胰岛素分泌肽衍生物 |
| MXPA04001560A (es) | 2001-08-28 | 2004-05-17 | Lilly Co Eli | Premezclas de glp-1 e insulina basal. |
| CA2463803A1 (fr) | 2001-10-19 | 2003-05-01 | Eli Lilly And Company | Melanges biphasiques de glp-1 et d'insuline |
| RU2332229C2 (ru) | 2002-02-20 | 2008-08-27 | Эмисфире Текнолоджис Инк. | Способ введения молекул glp-1 |
| ATE432289T1 (de) | 2002-07-04 | 2009-06-15 | Zealand Pharma As | Glp-1 und behandlungsmethode für diabetes |
| EP1546200A2 (fr) | 2002-10-02 | 2005-06-29 | Zealand Pharma A/S | Composes d'exendine-4 stabilises |
| US7790681B2 (en) | 2002-12-17 | 2010-09-07 | Amylin Pharmaceuticals, Inc. | Treatment of cardiac arrhythmias with GLP-1 receptor ligands |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| US8008255B2 (en) | 2003-05-30 | 2011-08-30 | Amylin Pharmaceuticals, Inc. | Methods and compositions for enhanced transmucosal delivery of peptides and proteins |
| US20060286129A1 (en) | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
| US8076288B2 (en) | 2004-02-11 | 2011-12-13 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides having glucose lowering activity |
| WO2006083254A1 (fr) | 2004-02-11 | 2006-08-10 | Amylin Pharmaceuticals, Inc. | Peptides de la famille amyline et procedes de production et d'utilisation desdits peptides |
| JP5638177B2 (ja) | 2004-02-11 | 2014-12-10 | アミリン・ファーマシューティカルズ, リミテッド・ライアビリティ・カンパニーAmylin Pharmaceuticals, Llc | 膵臓ポリペプチドファミリーモチーフおよびそのモチーフを含むポリペプチド |
| EP2422807A3 (fr) | 2004-02-11 | 2012-05-30 | Amylin Pharmaceuticals Inc. | Polypeptides hybrides présentant des propriétés pouvant être choisies |
| EP2314615A3 (fr) | 2004-10-08 | 2011-07-20 | Amylin Pharmaceuticals, Inc. | Analogues de la famille de l'amyline polypeptide-6 (afp-6) et procedes de leurs fabrication et d'utilisation |
| BRPI0518241A (pt) | 2004-11-01 | 2008-04-22 | Amylin Pharmaceuticals Inc | métodos para tratar obesidade e doenças e distúrbios relacionados à obesidade |
| CN101128487B (zh) * | 2004-12-02 | 2012-10-10 | 杜门蒂斯有限公司 | 靶向血清白蛋白和glp-1或pyy的双特异性结构域抗体 |
| SG158141A1 (en) | 2004-12-13 | 2010-01-29 | Amylin Pharmaceuticals Inc | Pancreatic polypeptide family motifs, polypeptides and methods comprising the same |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| WO2006083761A2 (fr) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solutions de solvant/polymere utilisees comme vehicules de suspension |
| SG159551A1 (en) | 2005-02-11 | 2010-03-30 | Amylin Pharmaceuticals Inc | Gip analog and hybrid polypeptides with selectable properties |
| US8263545B2 (en) | 2005-02-11 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | GIP analog and hybrid polypeptides with selectable properties |
| DK1888103T3 (da) | 2005-04-11 | 2012-04-23 | Amylin Pharmaceuticals Inc | Anvendelse af glp-1, exendin og agonister deraf til forsinkelse eller forhindring af kardial remodellering |
| AU2006279680B2 (en) | 2005-08-11 | 2012-12-06 | Amylin Pharmaceuticals, Llc | Hybrid polypeptides with selectable properties |
| BRPI0614649A2 (pt) | 2005-08-11 | 2011-04-12 | Amylin Pharmaceuticals Inc | polipeptìdeos hìbridos com propriedades selecionáveis |
| CN101291662A (zh) | 2005-10-21 | 2008-10-22 | 诺瓦提斯公司 | 肾素抑制剂和抗血脂异常剂和/或抗肥胖剂的组合 |
| CN101453982B (zh) | 2006-05-30 | 2011-05-04 | 精达制药公司 | 两件式内部通道渗透递送系统流动调节器 |
| WO2008021133A2 (fr) | 2006-08-09 | 2008-02-21 | Intarcia Therapeutics, Inc. | systèmes d'administration osmotiques et ensembles pistons |
| US8497240B2 (en) | 2006-08-17 | 2013-07-30 | Amylin Pharmaceuticals, Llc | DPP-IV resistant GIP hybrid polypeptides with selectable properties |
| EP2114437A2 (fr) | 2006-10-16 | 2009-11-11 | ConjuChem Biotechnologies Inc. | Peptides du facteur libérateur de corticotrophine modifiés et leurs utilisations |
| RU2413528C2 (ru) | 2007-01-18 | 2011-03-10 | Открытое Акционерное Общество "Валента Фармацевтика" | Лекарственный препарат для лечения сахарного диабета на основе экзенатида и даларгина, применение и способ лечения |
| EP2157967B1 (fr) | 2007-04-23 | 2013-01-16 | Intarcia Therapeutics, Inc | Formulations en suspension de peptides insulinotropes et leurs utilisations |
| US9353170B2 (en) | 2007-06-08 | 2016-05-31 | Sanofi-Aventis Deutschland Gmbh | Long-acting transient polymer conjugates of exendin |
| WO2009035540A2 (fr) * | 2007-09-07 | 2009-03-19 | Ipsen Pharma S.A.S. | Analogues d'exendine-4 et exendine-3 |
| EP2240155B1 (fr) | 2008-02-13 | 2012-06-06 | Intarcia Therapeutics, Inc | Dispositifs, formulations et méthodes d administration de plusieurs agents bénéfiques |
| CN102046207B (zh) | 2008-03-31 | 2013-08-28 | 葛兰素集团有限公司 | 药物融合物和缀合物 |
| WO2009143285A2 (fr) | 2008-05-21 | 2009-11-26 | Amylin Pharmaceuticals, Inc. | Exendines pour diminuer le cholestérol et les triglycérides |
| DE102009038210A1 (de) | 2009-08-20 | 2011-03-03 | Sanofi-Aventis Deutschland Gmbh | Kombination von einem Insulin und einem GLP-1-Agonisten |
| DE102008053048A1 (de) | 2008-10-24 | 2010-04-29 | Sanofi-Aventis Deutschland Gmbh | Kombination von einem Insulin und einem GLP-1-Agonisten |
| DE102008051834A1 (de) | 2008-10-17 | 2010-04-22 | Sanofi-Aventis Deutschland Gmbh | Kombination von einem Insulin und einem GLP-1-Agonisten |
| DK2349324T3 (en) | 2008-10-17 | 2017-12-11 | Sanofi Aventis Deutschland | COMBINATION OF AN INSULIN AND A GLP-1 AGONIST |
| US8779103B2 (en) | 2009-03-27 | 2014-07-15 | Glaxo Group Limited | Drug fusions and conjugates |
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| JP5973918B2 (ja) | 2009-11-13 | 2016-08-23 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Ｇｌｐ−１アゴニスト及びメチオニンを含む薬学的組成物 |
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| EP2438930A1 (fr) | 2010-09-17 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Promédicaments comprenant un conjugué de liaison d'exendine |
| BR112013007442A2 (pt) | 2010-09-28 | 2019-09-24 | Amylin Pharmaceuticals Llc | polipeptídeos construídos tendo duração de ação realçada |
| US9161953B2 (en) | 2010-12-22 | 2015-10-20 | Amylin Pharmaceuticals, Llc | GLP-1 receptor agonists for islet cell transplantation |
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| EP3080152A1 (fr) | 2013-12-13 | 2016-10-19 | Sanofi | Analogues peptidiques de l'exendine 4 non acylés |
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| CN114939156A (zh) | 2014-01-09 | 2022-08-26 | 赛诺菲 | 门冬胰岛素的稳定化药物制剂 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5424286A (en) * | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
| WO1998005351A1 (fr) * | 1996-08-08 | 1998-02-12 | Amylin Pharmaceuticals, Inc. | Methodes de regulation de la motilite gastro-intestinale |
| WO1998030231A1 (fr) * | 1997-01-07 | 1998-07-16 | Amylin Pharmaceuticals, Inc. | Utilisation d'exendines et de leurs agonistes pour reduire la consommation alimentaire |
| WO1999007404A1 (fr) * | 1997-08-08 | 1999-02-18 | Amylin Pharmaceuticals, Inc. | Nouveaux composes agonistes de l'exendine |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US694954A (en) † | 1901-09-20 | 1902-03-11 | Bion B Farnham | Couch-roll. |
| EP0915910B1 (fr) † | 1996-06-05 | 2006-01-18 | Roche Diagnostics GmbH | Analogues exendine, procedes permettant de les preparer et medicaments les contenant |
| DE69838916T2 (de) † | 1997-11-14 | 2008-12-18 | Amylin Pharmaceuticals, Inc., San Diego | Neuartige exendin agonisten |
-
1998
- 1998-11-13 JP JP2000521108A patent/JP2001523688A/ja active Pending
- 1998-11-13 DE DE69839021T patent/DE69839021T3/de not_active Expired - Lifetime
- 1998-11-13 ES ES98958573T patent/ES2297902T5/es not_active Expired - Lifetime
- 1998-11-13 AT AT98958573T patent/ATE383867T1/de active
- 1998-11-13 PT PT98958573T patent/PT1032587E/pt unknown
- 1998-11-13 DK DK98958573.2T patent/DK1032587T4/da active
- 1998-11-13 AU AU14588/99A patent/AU756836B2/en not_active Ceased
- 1998-11-13 CA CA2309356A patent/CA2309356C/fr not_active Expired - Fee Related
- 1998-11-13 NZ NZ504256A patent/NZ504256A/xx not_active IP Right Cessation
- 1998-11-13 EP EP98958573A patent/EP1032587B2/fr not_active Expired - Lifetime
- 1998-11-13 BR BR9814189-9A patent/BR9814189A/pt not_active Application Discontinuation
- 1998-11-13 WO PCT/US1998/024273 patent/WO1999025728A1/fr active IP Right Grant
-
2001
- 2001-03-06 HK HK01101595A patent/HK1031120A1/xx not_active IP Right Cessation
-
2008
- 2008-02-11 CY CY20081100159T patent/CY1107883T1/el unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5424286A (en) * | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
| WO1998005351A1 (fr) * | 1996-08-08 | 1998-02-12 | Amylin Pharmaceuticals, Inc. | Methodes de regulation de la motilite gastro-intestinale |
| WO1998030231A1 (fr) * | 1997-01-07 | 1998-07-16 | Amylin Pharmaceuticals, Inc. | Utilisation d'exendines et de leurs agonistes pour reduire la consommation alimentaire |
| WO1999007404A1 (fr) * | 1997-08-08 | 1999-02-18 | Amylin Pharmaceuticals, Inc. | Nouveaux composes agonistes de l'exendine |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999025728A1 (fr) | 1999-05-27 |
| CY1107883T1 (el) | 2013-06-19 |
| PT1032587E (pt) | 2008-04-21 |
| EP1032587B2 (fr) | 2013-03-13 |
| BR9814189A (pt) | 2000-10-03 |
| ES2297902T3 (es) | 2008-05-01 |
| HK1031120A1 (en) | 2001-06-01 |
| DK1032587T4 (da) | 2013-04-08 |
| JP2001523688A (ja) | 2001-11-27 |
| AU1458899A (en) | 1999-06-07 |
| DE69839021T2 (de) | 2009-01-15 |
| ATE383867T1 (de) | 2008-02-15 |
| EP1032587A1 (fr) | 2000-09-06 |
| NZ504256A (en) | 2003-01-31 |
| AU756836B2 (en) | 2003-01-23 |
| DE69839021T3 (de) | 2013-08-08 |
| CA2309356A1 (fr) | 1999-05-27 |
| DK1032587T3 (da) | 2008-03-25 |
| EP1032587B1 (fr) | 2008-01-16 |
| DE69839021D1 (de) | 2008-03-06 |
| ES2297902T5 (es) | 2013-07-09 |
| CA2309356C (fr) | 2010-09-21 |
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