EP1028689B1 - Reservoir zum verabreichen von fliessfähigen substanzen - Google Patents

Reservoir zum verabreichen von fliessfähigen substanzen Download PDF

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Publication number
EP1028689B1
EP1028689B1 EP98956915A EP98956915A EP1028689B1 EP 1028689 B1 EP1028689 B1 EP 1028689B1 EP 98956915 A EP98956915 A EP 98956915A EP 98956915 A EP98956915 A EP 98956915A EP 1028689 B1 EP1028689 B1 EP 1028689B1
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EP
European Patent Office
Prior art keywords
reservoir
walls
laminate
reservoir according
previous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP98956915A
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German (de)
English (en)
French (fr)
Other versions
EP1028689A1 (de
Inventor
Norbert Witowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19751406A external-priority patent/DE19751406A1/de
Application filed by Schering AG filed Critical Schering AG
Publication of EP1028689A1 publication Critical patent/EP1028689A1/de
Application granted granted Critical
Publication of EP1028689B1 publication Critical patent/EP1028689B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers

Definitions

  • the invention relates to a reservoir for the administration of flowable substances.
  • these are bags in which pharmaceutical Substances, preferably contrast agents, are filled. They serve as a reservoir for infusions.
  • a reservoir which is used to administer infusion liquids suitable is.
  • Such a reservoir has flexible reservoir walls on, which are welded together in the edge areas. Thereby the reservoir walls form a closed container in the lower area has two openings. One of these openings is with the Infusion set connected. The opening that merges into the infusion set can be found at the bottom of the reservoir.
  • the reservoir can be suspended, whereby in the upper area of the reservoir the front and back wall of the reservoir are welded together and one in the welding area Perforation, which hangs the entire reservoir allows.
  • the reservoir has a scale that varies from top to bottom extends below and which is printed on the reservoir.
  • Reservoirs are also known from the detergent industry in which there is liquid detergent.
  • Such bags have an opening which, in contrast to before, is in the upper area of the reservoir are located.
  • Such bags have a front and a rear reservoir wall, a front wall and a rear wall, all of which are flexible.
  • You are in the Edge areas welded together.
  • the reservoir walls are from Stand elements surrounded by the reservoir walls in the stand area are separated.
  • the stand elements are also in the side and the upper areas welded together so that they form a bag. Only in the floor area, i.e. So in the lower area, they have Stand elements in the filled state of the bag no contact. In this The two stand elements over the reservoir walls, which are in in this case form bottom parts of the reservoir, connected to one another.
  • Such bags are usually printed with colors and symbols. The The disadvantage of these bags is that the corresponding materials are not are compatible with pharmaceutical and diagnostic substances. Also Imprinting process turns out to be problematic.
  • EP 0 102 302 A describes a reservoir according to the preamble of the claim 1 can be seen.
  • the aluminum laminate covers the entire container.
  • the reservoir has sufficient stability to filled or partially empty in a relatively small area to be able to. Furthermore, the reservoir for pharmaceuticals and diagnostics be compatible and can be easily emptied.
  • the invention has several advantages. Flexible reservoirs are very desirable, they are easy to handle, their storage and handling are easy. If the reservoir walls are sufficiently stable, the reservoirs cannot be torn open. It is also advantageous to be able to use materials that are already widely used in the pharmaceutical industry. Infusion bags have long been used in blood transfusions. However, they consist of the material PVC, which is very controversial from an ecological point of view. It is advantageous that the bags and reservoirs according to the invention can be set up without any problems. Because they take up little space when set up. Significantly more reservoirs can be safely placed on the same surface than would be possible with flat bags. If at least parts of the reservoir walls or stand elements consist of composite material with aluminum, printing on the corresponding reservoirs is possible without any problems.
  • An aluminum laminate successfully prevents the dyes from penetrating. This also ensures that the reservoirs can be printed in an irreparable manner. It is advantageous that in addition to the planar printing, the letters or characters can also be pressed in. This enables a clear assignment of the reservoir content and the reservoir outer surface. This prevents the reservoirs from being mixed up. This results in a significantly higher level of security in using such reservoirs in the field of medicines and in the diagnostic field.
  • the aluminum laminate also protects the contents of the bag from the environment.
  • the visual Check immediately after filling at the pharmaceutical manufacturer and possible before use by the doctor. It should also be emphasized that the opening of the reservoir is protected several times. The opening is including the screw valve closure of a protective film surrounded, which is part of the reservoir walls or is connected to them.
  • a reservoir is a vessel in which flowable substances can be received. It is essential for the reservoir that it can permanently shield the flowable substances from the outside world. It is also important that the reservoir avoid a change in the enclosed flowable substances. For example, pharmaceuticals or diagnostic substances must not change chemically. It is also to be avoided that substances penetrate into the reservoir and are either dissolved in the flowable substance or can mix with it. In principle, the shape of the reservoir is not fixed, but there are practical reasons such as storage and discharge. This ensures during emptying that the entire flowable substance can escape from the reservoir. Avoid forming cavities and angles from which the flowable substance cannot escape. It should also be noted with the reservoir that the same can be easily produced and can easily be filled with the flowable substance.
  • the function of the reservoir walls is to separate the flowable substance from the environment and to prevent the flowable substance from escaping. Conversely, it must also be avoided that substances from the environment can penetrate into the flowable substance.
  • the reservoir walls are flexible in the use of force by the operating personnel. Only when the reservoir is placed on the stand elements, the stand elements have to be rigid with respect to the static forces of the reservoir. Desirably, the reservoir walls are impermeable to both liquids and gases. It can also be seen that the diffusion of gases takes place through almost every material. It is essential that the diffusion of gases is so low that there is no impairment of the flowable substance in the interior of the reservoir. This should not occur even if the flowable substance is stored in the reservoir over a longer period of time, such as one to two years. It is essential that the reservoir walls have substances which increase flexibility, but which cannot penetrate into the flowable substance. For example, plastics also contain plasticizers. These plasticizers should be able to penetrate the flowable substance in an insignificant manner and amount.
  • Flowable substances are understood to mean all pharmaceutical and diagnostic substances. These are drugs, including their pharmaceutically acceptable excipients and carriers. It is often the case that in addition to a liquid there are also gases in the form of a gas bubble in the reservoirs. In addition to liquids, flowable substances also include solid and gaseous substances. Such mixtures are shown in W. Schröter et al .: Chemistry, Facts and Laws, Leipzig 1987, 14th edition, p. 24. Suspensions, emulsions and micelle solutions such as liposomes are also of interest.
  • the reservoir can be filled and emptied.
  • a filling opening and a separate discharge opening can be attached to the reservoir.
  • the openings are preferably welded to the entire reservoir, in particular to the reservoir walls.
  • the openings are intended to enable the infusion set including a pump device to be connected to the reservoir without any problems.
  • the openings must be large enough to allow flow rates of 2 - 10 ml / sec through the openings.
  • Such openings are preferably sterilized and are protected from contamination by sealing caps. Only after removing these caps is it possible to connect the infusion set or the pump connection to the opening. Attention must be paid to extreme sterility, since it must be expected that once opened reservoirs must remain free of contamination for several hours, even up to several days.
  • the stand elements have the task of giving the reservoir, which preferably consists of two reservoir walls welded to one another, such stability that this reservoir can also stand securely in the erected form.
  • the shape set up is defined by the fact that the bag comes to rest on an edge, the edge preferably being selected. which has the smallest length and which is opposite the opening.
  • the stand elements expediently have a perforation which does not endanger the tightness of the reservoir, but which makes it possible to hang up the entire reservoir. This makes it possible to allow the reservoir to flow out through the opening. This shows that the opening of the suspension device is as far as possible.
  • the stand elements are preferably less flexible than the reservoir walls. They must be connected to the reservoir walls at least in small areas in order to have a corresponding strength.
  • the stand element does not need to touch the floor over the entire length, but it should be ensured that sufficient stability of the reservoir is ensured even with a few contact points with the floor.
  • the stand elements can also be constructed in such a way that they practically replace the reservoir walls as a whole. Only in the stand area, that is to say in the lower area of the reservoir, do reservoir walls then appear, which are no longer connected directly to the stand element, but rather via a weld seam or an adhesive seam. Rather, the reservoir walls between the stand elements in the stand area are constructed such that they extend sealingly between the stand elements.
  • the surface formed by the reservoir walls in the lower region of the reservoir behaves like a fold which, when folded, points upwards towards the opening.
  • this fold which consists of the reservoir walls, folds down and then forms the bottom of the reservoir.
  • the stand elements and reservoir walls can be exchanged in many areas. It is essential that the functions are guaranteed.
  • the reservoir walls have the function of preventing gas and liquid penetration.
  • the stand elements have the function of giving the reservoir sufficient stability so that it can stand securely on the stand elements in the upright state.
  • the extent to which stand elements and reservoir walls extend can be varied from shape to shape. However, it is essential that the stand elements in the lower area, pointing towards the floor, are spatially separable. They should limit and include a footprint in the contact area with the floor.
  • Plastic laminates are flat plastics, which are described in detail in Römpp-Chemie-Lexikon, editors Jürgen Falbe and Manfred Regitz, 9th edition Stuttgart 1990, p. 2398 ff. Plastics also necessarily include plasticizers and additives. The plastics must have the property of being flexible in the forces that occur with the operating personnel. In the case of static forces which are present in the case of an individually installed reservoir, the stand element should be essentially rigid with respect to the stand area. At the same time, the plastics should absolutely have a sealing function, so that liquid and gases can only penetrate this plastic laminate in a non-noteworthy manner.
  • the plastic laminates can be transparent in different ways, preferably completely transparent laminates. The plastic laminates should preferably be weldable or glueable, so that wall parts can be connected to one another without problems in the edge regions of the reservoirs.
  • At least part of the reservoir walls should be covered with an aluminum laminate.
  • This is an additional laminate on the plastic laminate.
  • This has the advantage that the gas permeability in this part of the reservoir is prevented.
  • the aluminum laminate enables the aluminum laminate to be printed on the side facing away from the flowable substance. Printer ink and solvents cannot penetrate the aluminum laminate, so there is no risk to the flowable substance. This also guarantees that the lettering is firmly connected to the reservoir afterwards. The label can no longer be detached from the reservoir without destroying the reservoir itself. This ensures that the reservoirs and the imprints cannot be mixed up.
  • the aluminum laminates show imprints that would otherwise have made the pasted labels illegible or would have caused them to become detached in the event of weather or drenching.
  • Aluminum Since aluminum is relatively rigid and embossable, the letters and characters can also be stamped during printing so that the print can still be read even after the color has been lost. Aluminum also has the advantage that a mirror effect occurs in the region which faces the flowable substance. As a result, the viewer can immediately critically examine the contents of the reservoir if the wall opposite the aluminum laminate consists of completely transparent material. The consistency, any contamination or problems with the reservoir can thus be discovered immediately.
  • a reservoir according to the invention in which the reservoir walls are advantageous is advantageous include a front wall and a rear wall. This is particularly re making a very simple method. Two walls, namely the front and the back wall, are placed on top of each other and in the outside areas welded together, with a recess provided for the opening is. In addition to welding, the walls can also be glued. Such folded bags hardly take up any space when empty Claim. Due to the stand elements, however, is in the filled state such reservoir well able to stand securely on a flat surface to be able to. Thus stability functions and a minimization of the Space requirements linked together when empty. Because of the flexibility sensible storage of the filled reservoirs is still possible. Different reservoirs can easily be stacked on top of each other become.
  • a reservoir in which the rear wall is covered with an aluminum laminate is preferred is provided, the front wall is transparent.
  • the combination of printability and the transparency of the opposite reservoir wall most advantageous. It ensures that the reservoir is unique Marking must be provided. Confusing the substances and the reservoirs is no longer possible if the usual precautions to get voted.
  • the aluminum laminate can be large enough to to carry a corresponding label and other coding systems. On the inside of the aluminum laminate, pointing towards the flowable substance, there can be a scale on which you can see which volumes are are still in the reservoir.
  • Another very advantageous embodiment consists of a reservoir, with the front wall made of polyester propylene and the back made of polyester - Aluminum - polypropylene. These are different Layers that are connected by welding. It is formed so-called composite films.
  • Reservoirs according to the invention are preferred in which the aluminum has a Plastic laminate is provided on the side facing away from the container interior points away. This provides protection against tearing.
  • the reservoir gets a significantly higher tear resistance on the surface.
  • thin Aluminum laminates which have the advantages mentioned above, can easily be torn by mechanical action. To prevent this and not giving up the aforementioned advantages are the reservoirs with the additional protective layer made of plastic. Furthermore, this has Reservoir a considerable advantage during manufacture. such Exterior surfaces can be easily welded or glued without that high temperatures have to be applied. It is advantageous if the reservoirs at least in the areas of the sealed seams with the outer Plastic laminate are provided.
  • the inner laminate for Container interior pointing
  • the middle laminate made of aluminum
  • the outer laminate made of transparent plastic.
  • This three-layer structure is functional. It corresponds to plastic, aluminum and plastic again.
  • reservoirs where the outer laminate is made of Is polyester or polyamide. These are particularly suitable Materials.
  • Reservoirs according to the invention in which the reservoir walls are advantageous are advantageous are more flexible than the stand elements. This ensures that the same the filling status of the reservoirs in an upright form can.
  • two filling stages are preferred; on the one hand the completely emptied condition and secondly the completely filled reservoir. In these In both conditions, the reservoirs are usually operated by the operator handled. The partially present filling states only occur when the corresponding amount of flowable substance is removed from the reservoirs what occurs when the reservoirs are usually hanging Form to be emptied. The opening at the bottom always comes Of the reservoir.
  • Reservoirs in which the reservoir walls are resistant to expansion are advantageous are. This successfully avoids that even at higher pressures, such as they can occur during stacking or short-term loads. it is ensured that the reservoirs are not in relation to the reservoir walls can tear down. This is a desired form of security that guarantees that the reservoir walls open in a controlled manner be prevented.
  • the stretch resistance also ensures that the Reservoirs can also be stored stacked in certain deposits. This also avoids problems during filling.
  • Reservoirs according to the invention in which the reservoirs are more preferred have at least one hanger opposite the opening. hereby ensures that the contents of a reservoir are completely removed can.
  • a suspension can be designed differently, it can are just an eye or a hole that is in the wide weld seam of the reservoir walls. However, it can also act as an additional material, which is flat with at least one of the reservoir walls is connected.
  • the suspension can also be made from a Bayonet or adapter lock exist with a corresponding complementary suspension can be connected to a frame. In the In practice, it makes sense to diagonally opposite the suspension and the opening to arrange.
  • a reservoir according to the invention is advantageous, in which the closure is a Screw cap with tamper evident closure and / or one by one Adapter is openable closure. This ensures that, on the one hand the withdrawal can only take place once and on the other hand guarantees sterility can be. The issue of sterility is very serious and appropriate solutions for this very advantageous.
  • the Opening including the closure is surrounded by a protective film that Is part of the reservoir walls, or is connected to them. This ensures that after a sterilization process, which after filling takes place, a sterile closure also remains in this sterile form. hereby will ensure in the best way that contamination of the connector, which is with the pump or with the infusion set is connected, is avoided.
  • a reservoir in which the reservoir can be thermally sterilized is advantageous. This should be a sterilization, both before filling as well as after filling.
  • sterilization processes radiation sterilization or chemical sterilization processes.
  • Treatment with ethylene oxide, propan-3-olide and diethyl dicarbonate, hydrogen peroxide and an ozone / steam mixture are known as chemical sterilization processes.
  • Sterilization with high-energy radiation is also possible.
  • Gamma rays and X-rays are known here.
  • Manufacturing in a clean room is an alternative. This means that these first sterilization steps can be dispensed with If necessary, the reservoirs are sterile packed in bacteria-proof but gas-permeable film or aluminum.
  • the sterilization is carried out with the aid of thermal and / or chemical sterilization, with gamma rays or x-rays, neutron rays or beta rays or a mixture of the aforementioned rays. Treatment with hydrogen peroxide or ozone / steam mixture is preferred.
  • the reservoir is then filled. Then the filling opening closed by the closure.
  • the reservoir is thermally sterilized in the autoclave or sterilizer with hot air or using a microwave. If necessary, it is possible to build up a support pressure in the sterilization space of the autoclave or the sterile chamber by a gas in the sterilization space, the pressure on the outer surface of the reservoir being greater than, equal to or less than the pressure on the inner surface of the reservoir.
  • the support pressure is to be defined as the pressure which corresponds to the sum of the partial pressures in the sterilization room minus the partial pressure of the steam.
  • Reservoirs in which the flowable substance is very preferred Drug or diagnostic is, most preferred is a reservoir, at for whom the diagnostic is an imaging diagnostic. This is what it is about the following contrast agents with the generic names: Amidotrizoic acid, gadopentetic acid, gadobutrol, gadolinium EOB-DTPA, lopamidol, lopromid, lotrolan and lotroxinic acid.
  • the invention is exemplified in the drawing.
  • 1 represents a reservoir, which is shown in an upright, standing form.
  • 2 shows a reservoir in a hanging form, the reservoir being suitable for emptying the flowable substance.
  • a reservoir 100 can be seen in FIG. 1.
  • the viewer looks at the Front wall 2, which is transparent.
  • the front wall 2 only have a transparent longitudinal stripe, the remaining surface could be coated with aluminum.
  • the rear wall 3 possible, which over the entire width and over the length A is connected to an aluminum foil.
  • the aluminum foil is there outside on the plastic film of the rear wall 3.
  • the front wall 2 and the Rear wall 3 are connected to one another via a weld 4.
  • This Weld 4 has different thicknesses.
  • the weld seam is relatively large compared to the weld seam in the floor area 5.
  • the rear wall and front wall meet directly, there is no one here Aluminum before.
  • the Bottom also be made of aluminum, which means that the coated with aluminum Area is maximized and at the same time the visual control through the front wall is guaranteed.
  • the stand element 6 comprises a front stand element 8 and a backing element 9, both of which have a weld seam 7 are interconnected.
  • the front stand element 8 and that Backing element 9 is in the area of line 10 with the front wall 2 and the rear wall 3 connected.
  • the front stand element 8 occurs directly and the front wall 2 in contact and further the rear element 9 and the rear wall 3.
  • the front stand element 8 and the rear stand element 9 has a crescent-shaped recess 10. In this area the part of the idealized rectangular stand element through either the front wall 2 or the rear wall 3 replaced.
  • the reservoir has a suspension 11 which is opposite the opening 12.
  • the opening 12 is both with a valve and with a Surround closure 13, which must be removed before removal.
  • the Closure 13 is a screw cap.
  • the opening 12 and the closure 13 is surrounded by a protective film 14, which has a front and a back has.
  • the protective film also has a predetermined breaking point 15 with which the protective film 14 can be easily removed. It is intensely on it to ensure that the opening is not contaminated. Although it is possible remove the closure with non - sterile fingers, but the inside may be removed of the closure 13 and the opening 12 are not contaminated become.
  • FIG. 2 shows a reservoir 100 in a hanging form, the reservoir 100 being suspended from the suspension 11, so that the opening 12 forms the lowest point.
  • the deepest point of the reservoir should not be located at the bottom of the page, but in the lower right corner.
  • the protective portfolio 14 has already been removed. However, the closure 13 is still on the opening 12.
EP98956915A 1997-11-14 1998-11-16 Reservoir zum verabreichen von fliessfähigen substanzen Expired - Lifetime EP1028689B1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19751406 1997-11-14
DE19751406A DE19751406A1 (de) 1997-11-14 1997-11-14 Reservoir zum Verabreichen von fließfähigen Substanzen
US6734297P 1997-12-02 1997-12-02
US67342P 1997-12-02
PCT/EP1998/007292 WO1999025308A1 (de) 1997-11-14 1998-11-16 Reservoir zum verabreichen von fliessfähigen substanzen

Publications (2)

Publication Number Publication Date
EP1028689A1 EP1028689A1 (de) 2000-08-23
EP1028689B1 true EP1028689B1 (de) 2003-05-07

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EP98956915A Expired - Lifetime EP1028689B1 (de) 1997-11-14 1998-11-16 Reservoir zum verabreichen von fliessfähigen substanzen

Country Status (19)

Country Link
EP (1) EP1028689B1 (no)
JP (1) JP2001522708A (no)
KR (1) KR100561583B1 (no)
AT (1) ATE239439T1 (no)
AU (1) AU741541B2 (no)
BR (1) BR9814193A (no)
CA (1) CA2309840C (no)
CZ (1) CZ296418B6 (no)
DK (1) DK1028689T3 (no)
ES (1) ES2193584T3 (no)
HU (1) HUP0100081A3 (no)
IL (1) IL136097A0 (no)
IS (1) IS2249B (no)
NO (1) NO320698B1 (no)
PL (1) PL189428B1 (no)
PT (1) PT1028689E (no)
SK (1) SK285462B6 (no)
TR (1) TR200001292T2 (no)
WO (1) WO1999025308A1 (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19948018A1 (de) * 1999-10-06 2001-04-12 Gabriele Mohr Medizinisches Gefäß und Schützhülle für ein medizinisches Gefäß
JP2002028220A (ja) * 2000-05-09 2002-01-29 Kanto Chem Co Inc 医療用液剤の収納容器
CN102928553A (zh) * 2011-08-09 2013-02-13 崔瑛 消毒效果实验中和剂套装

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2532550B1 (fr) * 1982-09-02 1986-01-17 Synthelabo Biomedical Poches a usage medical, et en particulier destinees a l'alimentation parenterale
US4484351A (en) * 1983-05-23 1984-11-20 Union Carbide Corporation Non-glass chemical container
JPS60153865A (ja) * 1984-01-24 1985-08-13 東洋製罐株式会社 栓体付スタンデイングパウチとその製造方法
JPS60225559A (ja) * 1984-04-20 1985-11-09 石塚硝子株式会社 輸液用バツグとその製造方法
JPS6139550U (ja) * 1984-08-14 1986-03-12 東洋製罐株式会社 栓体付パウチ
US5176634A (en) * 1990-08-02 1993-01-05 Mcgaw, Inc. Flexible multiple compartment drug container
JP2555254Y2 (ja) * 1991-07-12 1997-11-19 株式会社大塚製薬工場 輸液バッグ
US5295967A (en) 1992-09-23 1994-03-22 Becton, Dickinson And Company Syringe pump having continuous pressure monitoring and display
JP3135798B2 (ja) * 1994-09-28 2001-02-19 株式会社細川洋行 耐熱性容器
SE9502428D0 (sv) * 1995-07-04 1995-07-04 Pharmacia Ab Container for medical fluids
JPH09286462A (ja) * 1996-04-17 1997-11-04 Takeda Chem Ind Ltd 合成樹脂製容器

Also Published As

Publication number Publication date
JP2001522708A (ja) 2001-11-20
SK6692000A3 (en) 2000-09-12
ATE239439T1 (de) 2003-05-15
AU1338199A (en) 1999-06-07
BR9814193A (pt) 2000-09-26
NO20002485L (no) 2000-07-03
HUP0100081A2 (hu) 2001-05-28
CA2309840C (en) 2008-04-29
IL136097A0 (en) 2001-07-24
PL189428B1 (pl) 2005-08-31
IS2249B (is) 2007-06-15
NO20002485D0 (no) 2000-05-12
NO320698B1 (no) 2006-01-16
PL340377A1 (en) 2001-01-29
EP1028689A1 (de) 2000-08-23
SK285462B6 (sk) 2007-02-01
KR100561583B1 (ko) 2006-03-20
WO1999025308A1 (de) 1999-05-27
AU741541B2 (en) 2001-12-06
ES2193584T3 (es) 2003-11-01
IS5472A (is) 2000-04-26
TR200001292T2 (tr) 2000-10-23
CZ296418B6 (cs) 2006-03-15
HUP0100081A3 (en) 2001-07-30
CZ20001762A3 (cs) 2000-08-16
CA2309840A1 (en) 1999-05-27
KR20010032086A (ko) 2001-04-16
PT1028689E (pt) 2003-08-29
DK1028689T3 (da) 2003-09-01

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