EP0991356A1 - Dispositifs pour la mammographie avec projection - Google Patents
Dispositifs pour la mammographie avec projectionInfo
- Publication number
- EP0991356A1 EP0991356A1 EP98933626A EP98933626A EP0991356A1 EP 0991356 A1 EP0991356 A1 EP 0991356A1 EP 98933626 A EP98933626 A EP 98933626A EP 98933626 A EP98933626 A EP 98933626A EP 0991356 A1 EP0991356 A1 EP 0991356A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- contrast
- mammography
- projection
- projection mammography
- iodine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000009607 mammography Methods 0.000 title claims abstract description 35
- 230000005855 radiation Effects 0.000 claims description 15
- 238000003860 storage Methods 0.000 claims description 8
- 238000010521 absorption reaction Methods 0.000 claims description 3
- 239000002872 contrast media Substances 0.000 abstract description 52
- 238000000034 method Methods 0.000 abstract description 26
- 238000001990 intravenous administration Methods 0.000 abstract description 13
- 230000003902 lesion Effects 0.000 abstract description 10
- 230000035945 sensitivity Effects 0.000 abstract description 9
- 238000003325 tomography Methods 0.000 abstract description 3
- 239000000032 diagnostic agent Substances 0.000 abstract description 2
- 229940039227 diagnostic agent Drugs 0.000 abstract description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 18
- 229940039231 contrast media Drugs 0.000 description 18
- 229910052740 iodine Inorganic materials 0.000 description 18
- 239000011630 iodine Substances 0.000 description 18
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 11
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 11
- 229910052794 bromium Inorganic materials 0.000 description 11
- 210000000481 breast Anatomy 0.000 description 10
- 229920001817 Agar Polymers 0.000 description 8
- 208000026310 Breast neoplasm Diseases 0.000 description 8
- 239000008272 agar Substances 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 8
- 238000001514 detection method Methods 0.000 description 8
- 230000037396 body weight Effects 0.000 description 7
- 238000003384 imaging method Methods 0.000 description 7
- 206010028980 Neoplasm Diseases 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 4
- 238000002583 angiography Methods 0.000 description 3
- 229910052797 bismuth Inorganic materials 0.000 description 3
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 3
- 239000013522 chelant Substances 0.000 description 3
- -1 complexes Substances 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 238000002601 radiography Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 208000004434 Calcinosis Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 238000002083 X-ray spectrum Methods 0.000 description 2
- 238000001574 biopsy Methods 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 238000002591 computed tomography Methods 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000004807 localization Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 241000766026 Coregonus nasus Species 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- YVPYQUNUQOZFHG-UHFFFAOYSA-N amidotrizoic acid Chemical compound CC(=O)NC1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I YVPYQUNUQOZFHG-UHFFFAOYSA-N 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 229960005423 diatrizoate Drugs 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- NBQNWMBBSKPBAY-UHFFFAOYSA-N iodixanol Chemical compound IC=1C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C(I)C=1N(C(=O)C)CC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NBQNWMBBSKPBAY-UHFFFAOYSA-N 0.000 description 1
- 229960004359 iodixanol Drugs 0.000 description 1
- DGAIEPBNLOQYER-UHFFFAOYSA-N iopromide Chemical compound COCC(=O)NC1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)N(C)CC(O)CO)=C1I DGAIEPBNLOQYER-UHFFFAOYSA-N 0.000 description 1
- UUMLTINZBQPNGF-UHFFFAOYSA-N ioxilan Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCCO)=C(I)C(C(=O)NCC(O)CO)=C1I UUMLTINZBQPNGF-UHFFFAOYSA-N 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229960003194 meglumine Drugs 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0457—Semi-solid forms, ointments, gels, hydrogels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Definitions
- the invention relates to the use of intravenous contrast media for projection mammography and to new devices for projection mammography.
- Mammography is an X-ray technique that has been established and improved for decades for early detection, for X-ray detection, for the characterization and localization of breast tumors. It is unrivaled in its performance and availability for patients in several respects.
- the main disadvantage is an imperfect detection sensitivity for tumors of smaller size and without recognizable micro-lime.
- Contrast-mammography Brit. J. Radiol. 38, 947-951, 1965.
- the technique is also known as galactography.
- the contrast is achieved with concentrated iodine-containing contrast agents (> 100 mg iodine / ml). Contrast agents were also injected directly into suspicious or tumorous breast lesions in order to either characterize them (e.g. Lehto M.
- Mathiesen TI Adenography: An ancillary diagnostic method of circumscribed lesions of the breast with a positive contrast agent, Breast Dis, 6, 259-268, 1993) or to be marked (e.g. Raininko R., Linna MI, Rasanen 0 .: Preoperative localization of nonpalpable breast tumors. Acta Chir Scand, 142, 575-578, 1976). In both cases, undiluted, commercially available contrast media are displayed directly.
- the intravenous administration of X-ray contrast media to display parenchymatous processes in projection radiography is the very rare exception. It only works if a tissue or organ actively enriches the contrast medium. So far there are two examples of this: the representation of the healthy kidney parenchyma by the Urographica commonly used today and the representation of the healthy liver and spleen parenchyma by emulsions or suspensions of radiopaque substances. Both methods are no longer used (liver, spleen) or only in exceptional cases (kidney). It has never been possible to use intravenous X-ray contrast media for direct contrasting of tumors of relevant size in projection radiography.
- DSA digital subtraction angiography
- the invention therefore relates to the use of intravenous contrast media for producing a diagnostic agent for projection mammography.
- projection mammography achieves a sensitivity comparable to that of the most modern methods such as magnetic resonance tomography (MRI) with a significantly more versatile application and avoiding the costs of MRI.
- MRI magnetic resonance tomography
- the new procedure is simple and can be carried out without any particular stress on the patient and results in a significant improvement a) in the sensitivity for the detection of focal lesions in the breast and b) in additional information about the character of previously recognized lesions.
- the use according to the invention can be done with devices and means available today, e.g. B. be carried out as follows, provided the devices are operated at low radiation energy - as is customary in projection mammography.
- the measuring method is preferably carried out as follows:
- the patient receives a common urographic X-ray contrast medium in a dose of approximately 0.5 g to
- 1.5 g iodine / kg body weight is rapidly injected or infused intravenously.
- Suitable for the use according to the invention are all compounds which are normally used for the production of water-soluble urographic contrast media. Examples include: meglumine or lysine diatrizoate, lothalamate, loxithalamate, lopromid, lohexol, lomeprol, lopamidol, loversol, lobitridol, lopentol, lotrolan, iodixanol and loxilan (INN).
- iodine-free connections can also be used, such as:
- contrast media which contain bromine as an imaging element
- Contrast agents which contain chelate compounds of elements of atomic numbers 56-60, 62-79, 82 or 83 as an imaging element.
- the invention therefore also relates to the use of such iodine-free compounds.
- the urographic X-ray contrast media in use today are extremely suitable for the described method. It has surprisingly been found that, unlike almost any other X-ray method in projection mammography, the element iodine can be exchanged in whole or in part for the element bromine. Although this has also been discussed in the past, it has not proven itself in any X-ray procedure because of the significantly lower radiation absorption of bromine compared to iodine. In this respect, projection mammography is an exception. It is a new, surprising application for e.g. compounds described in EP 0 118 348 A1.
- contrast media based on other contrasting elements, molecular and supramolecular structures are also suitable for the use according to the invention.
- Contrasting elements are primarily those with atomic numbers 34, 42, 44 - 60, 62 - 79, 82 or 83.
- the contrasting elements can be covalently bound to organic molecules or be present as complexes or integrated in macromolecular structures. Substances with a molecular weight of 10,000 to 80,000 D are particularly advantageous.
- the individual contrast agent molecules can be components of larger structures such as associates, liposomes, emulsion droplets and micro- or nanoparticles (Parvez Z., Moncada R., Sovak M., edts .: Contrast Media: Biological Effects and clinical application. Vol. III, CRC Press, Boca Raton, Florida 1987, 73-130).
- the preparation is carried out in the pharmaceutically customary form in physiologically compatible carrier media, preferably water, using customary auxiliaries such as stabilizers (e.g. complexes, complexing agents, antioxidants), buffers (e.g. tris, citrate, bicarbonate), emulsifiers and substances for Adjustment of the osmolality and the electrolyte content as required.
- customary auxiliaries such as stabilizers (e.g. complexes, complexing agents, antioxidants), buffers (e.g. tris, citrate, bicarbonate), emulsifiers and substances for Adjustment of the osmolality and the electrolyte content as required.
- Contrast agents with concentrations of 100 mg iodine / ml to 500 mg iodine / ml are preferred, non-ionic X-ray contrast media with 200 mg iodine / ml to 400 mg iodine / ml or a corresponding X-ray density are particularly preferred if another radiation-absorbing element is selected.
- the agent can be administered in a dose of 150 to 1500 mg iodine / kg body weight (KG).
- a concentration of 100 to 500 mg bromine / ml is preferred in the contrast medium.
- the dose that can be applied is 100 to 1500 mg bromine / kg body weight.
- a concentration of 10 mmol to 2 mol / l - based on the imaging element - is preferred in the contrast medium .
- the dose that can be applied is 0.1 to 2 mmol / kg of body weight (based on the imaging element).
- the range is preferably 0.2 to 0.6 mmol / kg body weight.
- a concentration of 10 mmol to 2 mol / l - based on the imaging element - preferred.
- the dose that can be applied is
- the range is preferably 0.2 to 0.6 mmol / kg body weight.
- a variant of intravenous contrast projection mammography which is very advantageous in the use according to the invention relates to the use of the subtraction technique which has not been introduced in projection mammography to date.
- Appropriate procedures have proven very successful in angiography. In angiography, however, much higher local iodine concentrations (in the blood) are required than can be achieved in breast tumors. In this respect, the possibility of using this technique to detect small lesions was not predictable.
- the method is therefore based on the use of digital image receivers in mammography, which must have a spatial resolution that is sufficiently good for this examination method.
- the invention therefore also relates to a device for projection mammography characterized by a spatial resolution sufficient for the mammographic examination.
- This sufficient spatial resolution is either achieved directly via the resolution of the digital image receiver or by linking the digital image receiver and the direct radiographic enlargement technique.
- the device contains at least one storage device for the pre-contrast recording, at least one storage device for the post-contrast recording, at least one computing unit for correlating (in particular subtraction) the different recordings and an output device for the calculated mammogram.
- the correlation of recordings that were made with different radiation energy is also advantageous.
- suppression of the normal tissue structures is also achieved in favor of the contrast-giving, intravenously supplied element, since the radiation absorption of the tissue differs from that of the contrast medium at the selected energies.
- the time course of the contrast agent concentration can also be recorded and evaluated by means of such a device.
- Another object of the invention is therefore a device for projection mammography characterized by at least one storage device for recording with a radiation energy ⁇ - ] , at least one storage device for recording with a radiation energy ⁇ , at least one computing unit for correlating the different recordings and an output device for the calculated mammogram.
- a device for projection mammography characterized by at least one storage device for recording with a radiation energy ⁇ - ] , at least one storage device for recording with a radiation energy ⁇ , at least one computing unit for correlating the different recordings and an output device for the calculated mammogram.
- classic projection mammography only one breast is examined at a time. To limit the amount of contrast agent required, it is advantageous in the use according to the invention to examine both breasts simultaneously. Devices that allow such an investigation are not yet known.
- the invention therefore also relates to devices which are characterized in that they enable the simultaneous examination of both breasts.
- the entire phantom is X-rayed at 28 kV and 63 mA in accordance with a mammogram, with the X-rays each having to pass approximately 4 cm to 5 cm of contrast medium-free agar and 3 mm to 10 mm of contrast medium-containing agar.
- FIG. 1 shows an X-ray image at 28 kV, 63 mA
- the blocks in the upper row contain 3.8 mg bromine / ml, those in the middle row 6 mg iodine / ml, those in the lower row 9.8 mg Bi / ml.
- Example 2 Intravenous contrast medium mammography
- a 1.5 cm x 0.8 cm breast cancer was detected on the basis of structures, microcalcifications and biopsy. Preoperative testing should be carried out for multifocality; the patient is placed a 1-patient indwelling cannula in the left arm vein (V. cubitalis). The projection mammography is repeated before the contrast medium is administered. Immediately after the native exposure, the infusion of 3 ml / kg Ultravist®-300 (Schering AG, Berlin; active ingredient: lopromid (INN)) begins at a rate of 3 ml / sec. using an automatic injector. The first exposure after contrast agent administration is 1 minute after the end of the infusion. The position of patient and recording device remains completely unchanged during this time, as do the recording conditions with 28 kV tube voltage and 63 mAs.
- the images after contrast agent injection show a significantly enlarged area of the contrast agent uptake compared to the tissue defined as the tumor area before contrast agent administration, but no further separate enriching foci in the breast.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Detergent Compositions (AREA)
- Medicinal Preparation (AREA)
- Holo Graphy (AREA)
- Video Image Reproduction Devices For Color Tv Systems (AREA)
- Liquid Crystal (AREA)
- Percussion Or Vibration Massage (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Abstract
L'invention concerne l'utilisation de produits de contraste intraveineux pour la mammographie avec projection ainsi que de nouveaux dispositifs pour la mammographie avec projection. L'invention concerne donc l'utilisation de produits de contraste intraveineux pour produire un agent diagnostique pour la mammographie avec projection. Par l'administration supplémentaire de produit de contraste en intraveineuse, la mammographie avec projection atteint une sensibilité comparable aux procédés les plus modernes comme la tomographie par résonance magnétique (TRM), mais présente des usages plus nombreux et évite le coût de la TRM. Le nouveau procédé est simple; on peut le mettre en oeuvre, sans contrainte particulière pour les patientes. Il a) améliore considérablement la sensibilité pour la mise en évidence de lésions dans le sein et b) fournit des informations supplémentaires sur le caractère de lésions détectées auparavant.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98933626A EP0991356A1 (fr) | 1997-06-20 | 1998-06-19 | Dispositifs pour la mammographie avec projection |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97250190 | 1997-06-20 | ||
EP97250190A EP0885616A1 (fr) | 1997-06-20 | 1997-06-20 | Utilisation d'agents de contraste à administration intraveneuse, et appareil pour la mammographie |
PCT/EP1998/003659 WO1998058585A1 (fr) | 1997-06-20 | 1998-06-19 | Dispositifs pour la mammographie avec projection |
EP98933626A EP0991356A1 (fr) | 1997-06-20 | 1998-06-19 | Dispositifs pour la mammographie avec projection |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0991356A1 true EP0991356A1 (fr) | 2000-04-12 |
Family
ID=8229158
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97250190A Withdrawn EP0885616A1 (fr) | 1997-06-20 | 1997-06-20 | Utilisation d'agents de contraste à administration intraveneuse, et appareil pour la mammographie |
EP98933626A Withdrawn EP0991356A1 (fr) | 1997-06-20 | 1998-06-19 | Dispositifs pour la mammographie avec projection |
EP98937494A Expired - Lifetime EP0994729B1 (fr) | 1997-06-20 | 1998-06-19 | Utilisation d'agents de contraste intraveineux pour mammographie avec projection |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97250190A Withdrawn EP0885616A1 (fr) | 1997-06-20 | 1997-06-20 | Utilisation d'agents de contraste à administration intraveneuse, et appareil pour la mammographie |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98937494A Expired - Lifetime EP0994729B1 (fr) | 1997-06-20 | 1998-06-19 | Utilisation d'agents de contraste intraveineux pour mammographie avec projection |
Country Status (28)
Country | Link |
---|---|
US (2) | US20020031475A1 (fr) |
EP (3) | EP0885616A1 (fr) |
JP (3) | JP4664449B2 (fr) |
KR (2) | KR20010013980A (fr) |
CN (2) | CN1263449A (fr) |
AT (1) | ATE229820T1 (fr) |
AU (2) | AU747033B2 (fr) |
BG (2) | BG64895B1 (fr) |
BR (2) | BR9810205A (fr) |
CA (2) | CA2294187A1 (fr) |
CZ (1) | CZ298462B6 (fr) |
DE (1) | DE59806743D1 (fr) |
DK (1) | DK0994729T3 (fr) |
HK (1) | HK1029759A1 (fr) |
HU (2) | HU225522B1 (fr) |
IL (2) | IL133574A (fr) |
NO (2) | NO315638B1 (fr) |
NZ (2) | NZ501603A (fr) |
PL (2) | PL337286A1 (fr) |
RS (1) | RS49734B (fr) |
RU (1) | RU2194533C2 (fr) |
SI (2) | SI20152A (fr) |
SK (2) | SK181199A3 (fr) |
TR (2) | TR199903144T2 (fr) |
UA (1) | UA71895C2 (fr) |
WO (2) | WO1998058679A1 (fr) |
YU (1) | YU66299A (fr) |
ZA (1) | ZA985395B (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10118792B4 (de) * | 2001-04-05 | 2005-12-22 | Schering Ag | Anordnung zur Aufnahme von Projektionsmammogrammen und Verwendung der Anordnung für die Projektionsmammographie |
FR2823969B1 (fr) * | 2001-04-30 | 2003-12-26 | Ge Med Sys Global Tech Co Llc | Procede de prelevement d'un tissu au cours d'un examen par rayons x et dispositif de mise en oeuvre |
DE102005033235A1 (de) * | 2005-07-15 | 2007-01-18 | Siemens Ag | Verfahren zur Visualisierung eines vaskulären Einsatzstücks |
US20080167552A1 (en) * | 2007-01-04 | 2008-07-10 | General Electric Company | System and method of generating an image of a contrast agent injected into an imaged subject |
FR2927719B1 (fr) | 2008-02-19 | 2010-03-26 | Gen Electric | Procede de traitement d'images obtenues par tomosynthese et dispositif associe |
US8315449B2 (en) * | 2008-06-24 | 2012-11-20 | Medrad, Inc. | Identification of regions of interest and extraction of time value curves in imaging procedures |
JP2012055549A (ja) * | 2010-09-10 | 2012-03-22 | Fujifilm Corp | バイオプシ用ファントム |
FR2967888B1 (fr) * | 2010-11-26 | 2012-12-21 | Gen Electric | Procede de galactographie et mammographe pour l'execution dudit procede |
US9651138B2 (en) | 2011-09-30 | 2017-05-16 | Mtd Products Inc. | Speed control assembly for a self-propelled walk-behind lawn mower |
DE102012217301B4 (de) | 2012-09-25 | 2021-10-14 | Bayer Pharma Aktiengesellschaft | Kombination aus Kontrastmittel und Mammographie-CT-System mit vorgegebenem Energiebereich und Verfahren zur Erzeugung tomographischer Mammographie-CT-Aufnahmen durch diese Kombination |
EA036245B1 (ru) * | 2017-10-26 | 2020-10-16 | Казахский научно-исследовательский институт онкологии и радиологии | Способ диагностики рака молочной железы |
EP3498306A1 (fr) * | 2017-12-16 | 2019-06-19 | Bionorica SE | Extraits de vitex agnus castus destinés au traitement et au diagnostic du cancer du sein |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4192859A (en) * | 1978-09-29 | 1980-03-11 | E. R. Squibb & Sons, Inc. | Contrast media containing liposomes as carriers |
FR2541272A1 (fr) * | 1983-02-23 | 1984-08-24 | Guerbet Sa | Composes bromes et produits opacifiants en contenant |
WO1987002893A1 (fr) * | 1985-11-18 | 1987-05-21 | Board Of Regents, The University Of Texas System | Agents polychelateurs pour l'amelioration de l'image et du spectre (et pour derive spectrale) |
US5260050A (en) * | 1988-09-29 | 1993-11-09 | Ranney David F | Methods and compositions for magnetic resonance imaging comprising superparamagnetic ferromagnetically coupled chromium complexes |
GB8906130D0 (en) * | 1989-03-17 | 1989-05-04 | Nycomed As | Compositions |
DE3938992A1 (de) * | 1989-11-21 | 1991-05-23 | Schering Ag | Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
US5844965A (en) * | 1989-11-24 | 1998-12-01 | Thomas Jefferson University | Method and apparatus for using film density measurements of a radiograph to monitor the reproducibility of X-ray exposure parameters of a mammography unit |
DE4232925A1 (de) * | 1992-09-28 | 1994-03-31 | Diagnostikforschung Inst | 3-,8-substituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel und Verfahren zu ihrer Herstellung |
US5411730A (en) * | 1993-07-20 | 1995-05-02 | Research Corporation Technologies, Inc. | Magnetic microparticles |
DE4417628C1 (de) * | 1994-05-19 | 1995-09-28 | Siemens Ag | Verfahren zur adaptiven Rauschverminderung für digitale Bildsequenzen |
AU4173896A (en) * | 1994-11-30 | 1996-06-19 | Schering Aktiengesellschaft | Use of chelate compounds as diagnostic agents in the x-ray examination of liver and bile ducts |
US5756066A (en) * | 1995-06-07 | 1998-05-26 | Schering Aktiengesellschaft | Iodine-containing peptides |
US5804164A (en) * | 1996-03-13 | 1998-09-08 | Research Corporation Technologies, Inc. | Water-soluble lipophilic contrast agents |
US6009342A (en) * | 1997-02-28 | 1999-12-28 | The Regents Of The University Of California | Imaging method for the grading of tumors |
-
1997
- 1997-06-20 EP EP97250190A patent/EP0885616A1/fr not_active Withdrawn
-
1998
- 1998-06-19 KR KR19997012006A patent/KR20010013980A/ko not_active Application Discontinuation
- 1998-06-19 SK SK1811-99A patent/SK181199A3/sk unknown
- 1998-06-19 RS YUP-661/99A patent/RS49734B/sr unknown
- 1998-06-19 PL PL98337286A patent/PL337286A1/xx unknown
- 1998-06-19 YU YU66299A patent/YU66299A/sh unknown
- 1998-06-19 CN CN98807066A patent/CN1263449A/zh active Pending
- 1998-06-19 US US09/446,328 patent/US20020031475A1/en not_active Abandoned
- 1998-06-19 CA CA002294187A patent/CA2294187A1/fr not_active Abandoned
- 1998-06-19 NZ NZ501603A patent/NZ501603A/en unknown
- 1998-06-19 TR TR1999/03144T patent/TR199903144T2/xx unknown
- 1998-06-19 EP EP98933626A patent/EP0991356A1/fr not_active Withdrawn
- 1998-06-19 BR BR9810205-2A patent/BR9810205A/pt not_active Application Discontinuation
- 1998-06-19 SK SK1712-99A patent/SK282716B6/sk not_active IP Right Cessation
- 1998-06-19 JP JP50374199A patent/JP4664449B2/ja not_active Expired - Fee Related
- 1998-06-19 WO PCT/EP1998/003658 patent/WO1998058679A1/fr active IP Right Grant
- 1998-06-19 AT AT98937494T patent/ATE229820T1/de not_active IP Right Cessation
- 1998-06-19 HU HU0003097A patent/HU225522B1/hu not_active IP Right Cessation
- 1998-06-19 WO PCT/EP1998/003659 patent/WO1998058585A1/fr not_active Application Discontinuation
- 1998-06-19 IL IL13357498A patent/IL133574A/en not_active IP Right Cessation
- 1998-06-19 CA CA002294502A patent/CA2294502C/fr not_active Expired - Fee Related
- 1998-06-19 TR TR1999/03140T patent/TR199903140T2/xx unknown
- 1998-06-19 DE DE59806743T patent/DE59806743D1/de not_active Expired - Lifetime
- 1998-06-19 JP JP50374299A patent/JP2002504843A/ja active Pending
- 1998-06-19 SI SI9820041A patent/SI20152A/sl not_active IP Right Cessation
- 1998-06-19 IL IL13357398A patent/IL133573A0/xx unknown
- 1998-06-19 CN CNB988070677A patent/CN1212862C/zh not_active Expired - Fee Related
- 1998-06-19 HU HU0003096A patent/HUP0003096A1/hu unknown
- 1998-06-19 SI SI9820042A patent/SI20148A/sl unknown
- 1998-06-19 EP EP98937494A patent/EP0994729B1/fr not_active Expired - Lifetime
- 1998-06-19 ZA ZA985395A patent/ZA985395B/xx unknown
- 1998-06-19 NZ NZ501602A patent/NZ501602A/en unknown
- 1998-06-19 AU AU86271/98A patent/AU747033B2/en not_active Ceased
- 1998-06-19 PL PL337287A patent/PL191807B1/pl not_active IP Right Cessation
- 1998-06-19 DK DK98937494T patent/DK0994729T3/da active
- 1998-06-19 RU RU2000101332/14A patent/RU2194533C2/ru not_active IP Right Cessation
- 1998-06-19 KR KR1019997012005A patent/KR100582980B1/ko not_active IP Right Cessation
- 1998-06-19 UA UA2000010342A patent/UA71895C2/uk unknown
- 1998-06-19 CZ CZ0460999A patent/CZ298462B6/cs not_active IP Right Cessation
- 1998-06-19 BR BR9810215-0A patent/BR9810215A/pt not_active Application Discontinuation
- 1998-06-19 AU AU83379/98A patent/AU8337998A/en not_active Abandoned
-
1999
- 1999-12-15 BG BG104017A patent/BG64895B1/bg unknown
- 1999-12-15 BG BG104018A patent/BG104018A/xx unknown
- 1999-12-17 NO NO19996291A patent/NO315638B1/no not_active IP Right Cessation
- 1999-12-17 NO NO996292A patent/NO996292L/no not_active Application Discontinuation
-
2001
- 2001-01-29 HK HK01100622A patent/HK1029759A1/xx not_active IP Right Cessation
-
2004
- 2004-05-24 US US10/851,213 patent/US20050008574A1/en not_active Abandoned
-
2010
- 2010-10-01 JP JP2010223769A patent/JP2011012074A/ja active Pending
Non-Patent Citations (1)
Title |
---|
See references of WO9858585A1 * |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2007051739A2 (fr) | Systeme radiographique destine a la creation de representations radiographiques par application d'agents de contraste | |
JP2011012074A (ja) | 乳房投射撮影用静脈内造影剤の使用および装置 | |
DE10132778A1 (de) | Verfahren und Vorrichtung zur Radiologieuntersuchung durch Injektion eines Kontrastmittels | |
WO1999042139A2 (fr) | Conjugues d'amidon hydroxyethyle, leur procede de production et produits pharmaceutiques les contenant | |
DE60026743T2 (de) | Verwendung von Kontrastmitteln zur Herstellung eines Diagnostischen Mittels für die Darmlumenbildgebung | |
DE4426439C1 (de) | Kontrastmittel zur Darstellung der Leber | |
DE10118792B4 (de) | Anordnung zur Aufnahme von Projektionsmammogrammen und Verwendung der Anordnung für die Projektionsmammographie | |
DE4426438A1 (de) | Verwendung von Chelaten als Röntgenkontrastmittel | |
CZ461099A3 (cs) | Zařízení pro projekční mamografii | |
MXPA99011339A (en) | Device for projection mammography | |
MXPA99011508A (en) | Use of intravenous contrast agents and devices for projection mammography |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19991111 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
17Q | First examination report despatched |
Effective date: 20000918 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Withdrawal date: 20001129 |