EP0911048A3 - Verfahren und Vorrrichtung zur Verabreichung von einem Arzneimittel in Aerosolform - Google Patents

Verfahren und Vorrrichtung zur Verabreichung von einem Arzneimittel in Aerosolform Download PDF

Info

Publication number
EP0911048A3
EP0911048A3 EP98306113A EP98306113A EP0911048A3 EP 0911048 A3 EP0911048 A3 EP 0911048A3 EP 98306113 A EP98306113 A EP 98306113A EP 98306113 A EP98306113 A EP 98306113A EP 0911048 A3 EP0911048 A3 EP 0911048A3
Authority
EP
European Patent Office
Prior art keywords
conduit
air
canister
wall
air tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP98306113A
Other languages
English (en)
French (fr)
Other versions
EP0911048B1 (de
EP0911048A2 (de
Inventor
Thomas Alex Armer
Bryce Burwick Evans
Nahed Mohsen Mohsen
Richard Matthew Pavkov
Atul M. Sudhalkar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Systemic Pulmonary Development Ltd
Systemic Pulmonary Dev Ltd
Original Assignee
Systemic Pulmonary Development Ltd
Systemic Pulmonary Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Systemic Pulmonary Development Ltd, Systemic Pulmonary Dev Ltd filed Critical Systemic Pulmonary Development Ltd
Priority to DK05076801.9T priority Critical patent/DK1591137T3/da
Priority to EP05076801A priority patent/EP1591137B1/de
Priority to EP05076802.7A priority patent/EP1627655B1/de
Publication of EP0911048A2 publication Critical patent/EP0911048A2/de
Publication of EP0911048A3 publication Critical patent/EP0911048A3/de
Application granted granted Critical
Publication of EP0911048B1 publication Critical patent/EP0911048B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0086Inhalation chambers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0086Inhalation chambers
    • A61M15/0088Inhalation chambers with variable volume
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/009Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0091Inhalators mechanically breath-triggered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0091Inhalators mechanically breath-triggered
    • A61M15/0095Preventing manual activation in absence of inhalation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00Characteristics of a physical parameter; associated device therefor
    • A61M2206/10Flow characteristics
    • A61M2206/16Rotating swirling helical flow, e.g. by tangential inflows
EP98306113A 1997-10-17 1998-07-31 Vorrrichtung zur Verabreichung von einem Arzneimittel in Aerosolform Expired - Lifetime EP0911048B1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DK05076801.9T DK1591137T3 (da) 1997-10-17 1998-07-31 Apparat til udlevering af aerosolformet medikament
EP05076801A EP1591137B1 (de) 1997-10-17 1998-07-31 Vorrichtung zur Verabreichung von einem Arzneimittel in Aerosolform
EP05076802.7A EP1627655B1 (de) 1997-10-17 1998-07-31 Verfahren und Vorrrichtung zur Verabreichung von einem Arzneimittel in Aerosolform

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/954,352 US5954047A (en) 1997-10-17 1997-10-17 Methods and apparatus for delivering aerosolized medication
US954352 1997-10-17

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP05076801A Division EP1591137B1 (de) 1997-10-17 1998-07-31 Vorrichtung zur Verabreichung von einem Arzneimittel in Aerosolform
EP05076802.7A Division EP1627655B1 (de) 1997-10-17 1998-07-31 Verfahren und Vorrrichtung zur Verabreichung von einem Arzneimittel in Aerosolform

Publications (3)

Publication Number Publication Date
EP0911048A2 EP0911048A2 (de) 1999-04-28
EP0911048A3 true EP0911048A3 (de) 1999-06-02
EP0911048B1 EP0911048B1 (de) 2005-12-07

Family

ID=25495309

Family Applications (3)

Application Number Title Priority Date Filing Date
EP05076802.7A Expired - Lifetime EP1627655B1 (de) 1997-10-17 1998-07-31 Verfahren und Vorrrichtung zur Verabreichung von einem Arzneimittel in Aerosolform
EP05076801A Expired - Lifetime EP1591137B1 (de) 1997-10-17 1998-07-31 Vorrichtung zur Verabreichung von einem Arzneimittel in Aerosolform
EP98306113A Expired - Lifetime EP0911048B1 (de) 1997-10-17 1998-07-31 Vorrrichtung zur Verabreichung von einem Arzneimittel in Aerosolform

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EP05076802.7A Expired - Lifetime EP1627655B1 (de) 1997-10-17 1998-07-31 Verfahren und Vorrrichtung zur Verabreichung von einem Arzneimittel in Aerosolform
EP05076801A Expired - Lifetime EP1591137B1 (de) 1997-10-17 1998-07-31 Vorrichtung zur Verabreichung von einem Arzneimittel in Aerosolform

Country Status (16)

Country Link
US (3) US5954047A (de)
EP (3) EP1627655B1 (de)
JP (5) JP2001520088A (de)
KR (1) KR20010031187A (de)
CN (1) CN1285759A (de)
AT (2) ATE311913T1 (de)
AU (1) AU750459B2 (de)
CA (3) CA2243175C (de)
DE (2) DE69832679T2 (de)
DK (2) DK1591137T3 (de)
ES (2) ES2348495T3 (de)
MX (1) MXPA00003766A (de)
NO (1) NO983631L (de)
NZ (1) NZ504021A (de)
TR (1) TR200001033T2 (de)
WO (1) WO1999020331A1 (de)

Families Citing this family (238)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010031244A1 (en) * 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
US6703050B1 (en) * 1998-09-04 2004-03-09 The Regents Of The University Of Michigan Methods and compositions for the prevention or treatment of cancer
DZ2947A1 (fr) * 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
US6257231B1 (en) * 1998-12-03 2001-07-10 Ferraris Medical, Inc. Aerosol enhancement
ZA9811257B (en) * 1998-12-09 2001-01-31 App Sub Cipla Ltd 8 8 2000 Inhalation device.
EP1183060B1 (de) * 1999-05-20 2006-05-03 Kos Life Sciences, Inc. Zerstäubungssystem mit niedriger spraykraft und retention
US6315985B1 (en) * 1999-06-18 2001-11-13 3M Innovative Properties Company C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
IT1313553B1 (it) 1999-07-23 2002-09-09 Chiesi Farma Spa Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione.
TR200200647T2 (tr) * 1999-09-13 2002-11-21 Sheffield Pharmaceuticals, Inc. Aerosol hava akımı kontrol sistemi ve yöntemi
US6367471B1 (en) * 1999-11-01 2002-04-09 Sheffield Pharmaceuticals, Inc. Internal vortex mechanism for inhaler device
IT1317720B1 (it) * 2000-01-07 2003-07-15 Chiesi Farma Spa Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani.
GB0002798D0 (en) * 2000-02-09 2000-03-29 Glaxo Group Ltd Actuator nozzle for metered dose inhaler
IT1317846B1 (it) 2000-02-22 2003-07-15 Chiesi Farma Spa Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
ES2305057T3 (es) 2000-02-28 2008-11-01 Pharmakodex Limited Dispositivo para la administracion de farmacos orales.
US6443151B1 (en) 2000-03-08 2002-09-03 Aradigm Corporation Fluid velocity-sensitive trigger mechanism
GB2360216A (en) * 2000-03-18 2001-09-19 Astrazeneca Uk Ltd Inhaler
ES2257996T3 (es) * 2000-04-07 2006-08-16 Andi-Ventis Limited Boquilla para inhalador de particulas.
CA2733850C (en) 2000-04-11 2013-10-22 Trudell Medical International Aerosol delivery apparatus with positive expiratory pressure capacity
US6328035B1 (en) * 2000-05-09 2001-12-11 Iep Pharmaceutical Devices Inc. Pneumatic breath actuated inhaler
IT1318514B1 (it) * 2000-05-12 2003-08-27 Chiesi Farma Spa Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari.
UA73986C2 (uk) 2000-05-22 2005-10-17 К'Єзі Фармачеутічі С.П.А. АЕРОЗОЛЬНА КОМПОЗИЦІЯ, ЩО МІСТИТЬ <font face="Symbol">b</font>2-АДРЕНЕРГІЧНИЙ АГОНІСТ ТРИВАЛОЇ ДІЇ, ДОЗУЮЧИЙ ІНГАЛЯТОР ПІД ТИСКОМ ТА СПОСІБ ЙОГО ЗАПОВНЕННЯ
PE20020067A1 (es) * 2000-06-23 2002-02-05 Norton Healthcare Ltd Desaglomerador para inhalador de polvo seco accionado por la respiracion
US6339107B1 (en) 2000-08-02 2002-01-15 Syntex (U.S.A.) Llc Methods for treatment of Emphysema using 13-cis retinoic acid
SE517226C2 (sv) * 2000-09-25 2002-05-14 Microdrug Ag Inhalator med luftbroms för torrt pulver
CA2422129A1 (en) * 2000-09-29 2002-04-04 Daniel Godfrey Dosing device
GB0023845D0 (en) * 2000-09-29 2000-11-15 Pa Knowledge Ltd Dosing device
EP1935869A1 (de) 2000-10-02 2008-06-25 F. Hoffmann-La Roche Ag Retinoide zur Behandlung von Emphysem
US6964647B1 (en) * 2000-10-06 2005-11-15 Ellaz Babaev Nozzle for ultrasound wound treatment
US6601581B1 (en) 2000-11-01 2003-08-05 Advanced Medical Applications, Inc. Method and device for ultrasound drug delivery
US6533803B2 (en) 2000-12-22 2003-03-18 Advanced Medical Applications, Inc. Wound treatment method and device with combination of ultrasound and laser energy
US6761729B2 (en) 2000-12-22 2004-07-13 Advanced Medicalapplications, Inc. Wound treatment method and device with combination of ultrasound and laser energy
US7914470B2 (en) * 2001-01-12 2011-03-29 Celleration, Inc. Ultrasonic method and device for wound treatment
US8235919B2 (en) 2001-01-12 2012-08-07 Celleration, Inc. Ultrasonic method and device for wound treatment
US6960173B2 (en) * 2001-01-30 2005-11-01 Eilaz Babaev Ultrasound wound treatment method and device using standing waves
US6623444B2 (en) 2001-03-21 2003-09-23 Advanced Medical Applications, Inc. Ultrasonic catheter drug delivery method and device
SE0101233L (sv) * 2001-04-05 2002-10-01 Microdrug Ag Förfarande och anordning för frigörande av pulver och inhalatoranordning för administrering av medicinskt pulver
US6478754B1 (en) 2001-04-23 2002-11-12 Advanced Medical Applications, Inc. Ultrasonic method and device for wound treatment
US7118227B2 (en) 2001-04-25 2006-10-10 Matsushita Electric Industrial Co., Ltd. Projection display device
EG24184A (en) * 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
US6681768B2 (en) * 2001-06-22 2004-01-27 Sofotec Gmbh & Co. Kg Powder formulation disintegrating system and method for dry powder inhalers
ATE267591T1 (de) * 2001-07-02 2004-06-15 Chiesi Farma Spa Optimierte tobramycin-formulierung zur aerosolbildung
DE60236011D1 (de) * 2001-09-06 2010-05-27 Microdose Therapeutx Inc Inhalator Typ DPI
EP1450885B1 (de) 2001-09-28 2015-04-22 Kurve Technology, Inc. Nasaler vernebler
US6701922B2 (en) * 2001-12-20 2004-03-09 Chrysalis Technologies Incorporated Mouthpiece entrainment airflow control for aerosol generators
DK3536344T3 (da) * 2002-03-01 2020-03-16 Chiesi Farm Spa Superfin formoterolformulering
AU2003220125B2 (en) 2002-03-20 2006-06-15 Mannkind Corporation Inhalation apparatus
GB0209494D0 (en) * 2002-04-25 2002-06-05 Optinose As Nasal devices
US20030205226A1 (en) * 2002-05-02 2003-11-06 Pre Holding, Inc. Aerosol medication inhalation system
AU2003225071A1 (en) * 2002-05-03 2003-11-17 Trudell Medical International Aerosol medication delivery apparatus with narrow orifice
US8122881B2 (en) * 2002-05-09 2012-02-28 Kurve Technology, Inc. Particle dispersion device for nasal delivery
US6889690B2 (en) * 2002-05-10 2005-05-10 Oriel Therapeutics, Inc. Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages
US7677411B2 (en) 2002-05-10 2010-03-16 Oriel Therapeutics, Inc. Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders
US6904908B2 (en) 2002-05-21 2005-06-14 Trudell Medical International Visual indicator for an aerosol medication delivery apparatus and system
JP4243499B2 (ja) * 2002-06-11 2009-03-25 富士通株式会社 貼合せ基板製造装置及び貼合せ基板製造方法
EP1535349B1 (de) * 2002-06-27 2014-06-25 Oriel Therapeutics, Inc. Geräte, systeme und relevante verfahren für die aufbereitung, ausgabe und/oder beurteilung von nichtpharmazeutischen trockenpulvern
CA2493341A1 (en) 2002-07-23 2004-01-29 The Regents Of The University Of Michigan Tetrapropylammonium tetrathiomolybdate and related compounds for anti-angiogenic therapies
US7189865B2 (en) * 2002-07-23 2007-03-13 Attenuon, Llc Thiomolybdate analogues and uses thereof
EP1556171B1 (de) * 2002-09-06 2010-12-15 Philip Morris USA Inc. Aerosolerzeugungsvorrichtungen und verfahren zur erzeugung von aerosolen mit gesteuerten teilchengrössen
CA2500360A1 (en) * 2002-09-27 2004-04-08 Bioenvision, Inc. Methods and compositions for the treatment of autoimmune disorders using clofarabine
WO2004028463A2 (en) * 2002-09-27 2004-04-08 Bioenvision, Inc. Methods and compositions for the treatment of lupus using clofarabine
US6834717B2 (en) 2002-10-04 2004-12-28 R&M Energy Systems, Inc. Tubing rotator
WO2004032864A2 (en) * 2002-10-07 2004-04-22 Radiorx, Inc. X-nitro compounds, pharmaceutical compositions thereof and uses therof
JP2006511257A (ja) * 2002-10-30 2006-04-06 グラクソ グループ リミテッド 医薬送達用システムに使用するための管状ノズル
EP1594521A4 (de) * 2002-11-25 2008-01-09 Attenuon Llc Peptide, die die angiogenese, zellwanderung, zellinvasion und zellproliferation hemmen, sowie deren zusammensetzungen und verwendungen
AU2003293361A1 (en) * 2002-12-18 2004-07-29 Glaxo Group Limited Drug delivery system with vented mouthpiece
WO2004064705A2 (en) * 2003-01-17 2004-08-05 Schering Corporation Training device for medicament inhalers
ZA200504940B (en) * 2003-01-28 2006-09-27 Xenoport Inc Amino acid derived prodrugs of propofol, compositions and uses thereof
CA2518584A1 (en) 2003-03-12 2004-09-23 Celgene Corporation 7-amino- isoindolyl compounds and their pharmaceutical uses
PL3103800T3 (pl) 2003-04-11 2018-11-30 Ptc Therapeutics, Inc. Związki kwasu 1,2,4-oksadiazolobenzoesowego i ich zastosowanie do supresji mutacji nonsensownych i leczenia choroby
US7360537B2 (en) * 2003-04-16 2008-04-22 Trudell Medical International Antistatic medication delivery apparatus
CN100558409C (zh) * 2003-05-27 2009-11-11 阿特努奥恩公司 硫代钨酸盐类似物及其用途
WO2005004882A1 (en) * 2003-07-09 2005-01-20 Monash University Antiviral charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and methods of use thereof
US8001963B2 (en) * 2003-09-05 2011-08-23 Kurve Technology, Inc. Integrated nebulizer and particle dispersion chamber for nasal delivery of medicament to deep nasal cavity and paranasal sinuses
WO2005023334A2 (en) * 2003-09-05 2005-03-17 Kurve Technology, Inc. Nasal adapter for the base of the nose
WO2005023204A2 (en) * 2003-09-09 2005-03-17 Xenoport, Inc. Aromatic prodrugs of propofol, compositions and uses thereof
WO2005025506A2 (en) * 2003-09-10 2005-03-24 Map Pharmaceuticals, Inc. Aerosol formulations for delivery of dihydroergotamine to the systemic circulation via pulmonary inhalation
GB2405799A (en) * 2003-09-15 2005-03-16 Vectura Ltd Dry powder inhaler incorporating a valve which is opened and closed by pressurized gas
US7342660B2 (en) * 2003-09-25 2008-03-11 Deka Products Limited Partnership Detection system and method for aerosol delivery
US7066029B2 (en) 2003-09-25 2006-06-27 Deka Products Limited Partnership System and method for improved volume measurement
EP1692128A1 (de) 2003-11-19 2006-08-23 Signal Pharmaceuticals LLC Indazolverbindungen und verfahren zu deren anwendung als proteinkinaseinhibitoren
EP1729784A1 (de) * 2004-02-23 2006-12-13 Attenuon, LLC Formulierungen von thiomolybdat oder thiowolframat-verbindungen und ihre verwendungen
EP1595531A1 (de) 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stabile Arzneimittellösung für Druckdosierinhalatoren
ATE446581T1 (de) * 2004-03-12 2009-11-15 Trinity College Dublin Magnetoresistives medium
US7448385B2 (en) * 2004-06-07 2008-11-11 Purepharm Inc. Nasal adaptation of an oral inhaler device
US7241807B2 (en) * 2004-07-12 2007-07-10 Xenoport, Inc. Prodrugs of propofol, compositions and uses thereof
ATE410408T1 (de) * 2004-07-12 2008-10-15 Xenoport Inc Von aminosäuren abgeleitete prodrugs von propofolzusammensetzungen und anwendungen davon
US20060128676A1 (en) * 2004-07-13 2006-06-15 Pharmacofore, Inc. Compositions of nicotinic agonists and therapeutic agents and methods for treating or preventing diseases or pain
PL1786784T3 (pl) 2004-08-20 2011-04-29 Mannkind Corp Kataliza syntezy diketopiperazyn
EP2322180B1 (de) 2004-08-23 2015-05-27 MannKind Corporation Diketopiperazinsalze zur Arzneimitteldarreichung
CA2616997C (en) * 2004-09-13 2014-12-23 Oriel Therapeutics, Inc. Dry powder inhalers that inhibit agglomeration, related devices and methods
US20080035142A1 (en) * 2004-10-15 2008-02-14 Amar Lulla Spacer
GT200500373A (es) * 2004-12-17 2006-10-02 Compuestos de piridazinones
DK1824482T3 (en) 2004-12-17 2014-03-24 Anadys Pharmaceuticals Inc AND 3,5-disubstituted 3,5,7-trisubstituted-3H-oxazolo AND 3H-thiazolo [4,5-d] pyrimidin-2-one compounds and prodrugs thereof
US7619110B2 (en) * 2004-12-23 2009-11-17 Xenoport, Inc. Amino acid derived prodrugs of propofol, compositions, uses and crystalline forms thereof
FR2881118B1 (fr) * 2005-01-25 2007-04-20 Valois Sas Dispositif de distribution de produit fluide.
US7785277B2 (en) 2005-06-23 2010-08-31 Celleration, Inc. Removable applicator nozzle for ultrasound wound therapy device
US7713218B2 (en) 2005-06-23 2010-05-11 Celleration, Inc. Removable applicator nozzle for ultrasound wound therapy device
EP1907357A1 (de) 2005-07-22 2008-04-09 Amgen Inc. Anilinsulfonsäureamidderivate und anwendungen davon
US20070135380A1 (en) 2005-08-12 2007-06-14 Radiorx, Inc. O-nitro compounds, pharmaceutical compositions thereof and uses thereof
US7507842B2 (en) * 2005-08-12 2009-03-24 Radiorx, Inc. Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof
US8163701B2 (en) 2005-08-19 2012-04-24 Signature Therapeutics, Inc. Prodrugs of active agents
RU2390325C2 (ru) 2005-09-14 2010-05-27 Маннкайнд Корпорейшн Способ приготовления лекарственного препарата, основанный на увеличении сродства активных агентов к поверхностям кристаллических микрочастиц
DE102005054383B4 (de) * 2005-11-15 2013-10-31 Boehringer Ingelheim Pharma Gmbh & Co. Kg Nadel zum Lochen von Pulverkapseln für die Inhalation
US20070197486A1 (en) * 2005-12-20 2007-08-23 Verus Pharmaceuticals, Inc. Methods and systems for the delivery of corticosteroids
US20070185066A1 (en) * 2005-12-20 2007-08-09 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids
US20070160542A1 (en) * 2005-12-20 2007-07-12 Verus Pharmaceuticals, Inc. Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile
US20070178049A1 (en) * 2005-12-20 2007-08-02 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids having an enhanced pharmacokinetic profile
US20070249572A1 (en) * 2005-12-20 2007-10-25 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids
CN109621078B (zh) 2006-02-09 2022-05-27 德卡产品有限公司 用于控制可配戴医疗器件的系统
WO2007095341A2 (en) * 2006-02-15 2007-08-23 Tika Läkemedel Ab Sterilization of corticosteroids with reduced mass loss
DE102006007495A1 (de) * 2006-02-17 2007-08-23 Siegfried Generics International Ag Dispergiereinheit
AU2013205495B2 (en) * 2006-02-17 2015-11-26 Sanofi Sa Dispersing unit
GB2433207B (en) * 2006-02-21 2009-01-07 Jianhe Li Active suction actuated inhalers with timing devices
RU2403059C2 (ru) 2006-02-22 2010-11-10 Маннкайнд Корпорейшн Способ улучшения фармацевтических свойств микрочастиц, содержащих дикетопиперазин и активный агент
US7524848B2 (en) * 2006-03-23 2009-04-28 Amgen Inc. Diaza heterocyclic amide compounds and their uses
AU2007267510B2 (en) 2006-05-26 2013-01-31 Signature Therapeutics, Inc. Controlled release of phenolic opioids
US8562547B2 (en) 2006-06-07 2013-10-22 Eliaz Babaev Method for debriding wounds
US7431704B2 (en) * 2006-06-07 2008-10-07 Bacoustics, Llc Apparatus and method for the treatment of tissue with ultrasound energy by direct contact
TW200808695A (en) * 2006-06-08 2008-02-16 Amgen Inc Benzamide derivatives and uses related thereto
US7659287B2 (en) * 2006-06-08 2010-02-09 Amgen Inc. Benzamide derivatives and uses related thereto
US20080090814A1 (en) * 2006-06-22 2008-04-17 Anadys Pharmaceuticals, Inc. Pyridazinone compounds
WO2007150001A1 (en) 2006-06-22 2007-12-27 Anadys Pharmaceuticals, Inc. Pyrro[1,2-b]pyridazinone compounds
ATE496924T1 (de) 2006-06-22 2011-02-15 Anadys Pharmaceuticals Inc Prodrugs von 5-amino-3-(3'-deoxy-beta-d- ribofuranosyl)-thiazolä4,5-düpyrimidin-2,7-dion
EP2037999B1 (de) 2006-07-07 2016-12-28 Proteus Digital Health, Inc. Intelligentes parenterales verabreichungssystem
DE602007012881D1 (en) 2006-07-18 2011-04-14 Anadys Pharmaceuticals Inc Carbonat- und carbamat-prodrugs von thiazolo ä4,5-dü-pyrimidinen
US7666888B2 (en) * 2006-07-20 2010-02-23 Amgen Inc. Substituted azole aromatic heterocycles as inhibitors of 11β-HSD-1
CA2698137A1 (en) 2006-08-30 2008-03-06 Kurve Technology, Inc. Aerosol generating and delivery device
BRPI0603695A (pt) * 2006-09-13 2008-04-29 Cesar Eduardo Marques Da Silva aerocámara para aplicação de medicamentos aerossol com válvula geométrica
US20080087279A1 (en) * 2006-10-11 2008-04-17 Tieck Catharine Laureen Johnso Metered dose inhaler
US20080177221A1 (en) * 2006-12-22 2008-07-24 Celleration, Inc. Apparatus to prevent applicator re-use
AU2007343726A1 (en) * 2006-12-26 2008-07-24 Amgen Inc. N-cyclohexyl benzamides and benzeneacetamides as inhibitors of 11-beta-hydroxysteroid dehydrogenases
US20080275032A1 (en) * 2006-12-29 2008-11-06 Yuefen Zhou Pyridazinone compounds
US8491521B2 (en) * 2007-01-04 2013-07-23 Celleration, Inc. Removable multi-channel applicator nozzle
US20080214965A1 (en) * 2007-01-04 2008-09-04 Celleration, Inc. Removable multi-channel applicator nozzle
KR20090129998A (ko) 2007-02-11 2009-12-17 맵 파마슈티컬스, 인코포레이티드 부작용 프로파일을 최소화하면서 편두통의 빠른 완화를 가능하게 하는 dhe의 치료적 투여 방법
CN101652153B (zh) * 2007-02-27 2014-05-14 艾瓦克斯医药爱尔兰公司 定量吸入器
JP4916954B2 (ja) * 2007-05-30 2012-04-18 株式会社吉野工業所 吸引式投薬器
US7928111B2 (en) 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US9603848B2 (en) * 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
US20080306076A1 (en) * 2007-06-08 2008-12-11 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
US8633186B2 (en) 2007-06-08 2014-01-21 Senomyx Inc. Modulation of chemosensory receptors and ligands associated therewith
JP5243548B2 (ja) 2007-10-25 2013-07-24 プロテウス デジタル ヘルス, インコーポレイテッド 情報システムのための流体伝達ポート
GB2454742B (en) * 2007-11-17 2011-02-02 David Ohayon Inhaler adapter
WO2009067463A1 (en) 2007-11-19 2009-05-28 Proteus Biomedical, Inc. Body-associated fluid transport structure evaluation devices
DE102007056263A1 (de) 2007-11-22 2009-05-28 Siegfried Generics International Ag Dosiervorrichtung zur Inhalierung einer pulverförmigen Substanz
ES2394589T3 (es) 2007-12-14 2013-02-04 Aerodesigns, Inc Suministro de productos alimenticios transformables en aerosol
EP2231279A1 (de) * 2007-12-28 2010-09-29 Celleration, Inc. Verfahren zur behandlung von entzündlichen hauterkrankungen
US20090177123A1 (en) * 2007-12-28 2009-07-09 Celleration, Inc. Methods for treating inflammatory disorders
US8636001B2 (en) 2008-06-13 2014-01-28 Mannkind Corporation Dry powder inhaler and system for drug delivery
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
DK2609954T3 (da) 2008-06-20 2022-02-14 Mannkind Corp Interaktivt apparat til realtidsafbildning af inhalationspræstationer
WO2010008523A1 (en) * 2008-07-13 2010-01-21 Map Pharmaceuticals, Inc. Methods and apparatus for delivering aerosolized medication
US20100022919A1 (en) * 2008-07-22 2010-01-28 Celleration, Inc. Methods of Skin Grafting Using Ultrasound
ES2525551T3 (es) 2008-07-31 2014-12-26 Senomyx, Inc. Composiciones que comprenden potenciadores de dulzor y métodos de producirlas
DK2323997T3 (en) 2008-07-31 2017-12-11 Senomyx Inc METHODS AND INTERMEDIATES FOR THE MANUFACTURE OF SWEET TASTE AMPLIFIERS
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
TWI480272B (zh) 2008-10-09 2015-04-11 Anadys Pharmaceuticals Inc 藉由5,6-二氫-1h-吡啶-2-酮與一或多種其他抗病毒化合物的組合物抑制c型肝炎病毒的方法
EP2370136A4 (de) * 2008-12-01 2015-12-30 Map Pharmaceuticals Inc Inhalative freisetzungsverfahren und vorrichtungen
US8555875B2 (en) * 2008-12-23 2013-10-15 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2405963B1 (de) 2009-03-11 2013-11-06 MannKind Corporation Gerät, system und verfahren zur messung von widerstand in einem inhaliergerät
CN102647979B (zh) 2009-06-12 2015-03-04 曼金德公司 具有确定比表面积的二酮哌嗪颗粒
US8495998B2 (en) * 2009-06-17 2013-07-30 British American Tobacco (Investments) Limited Inhaler
WO2010151804A1 (en) * 2009-06-26 2010-12-29 Map Pharmaceuticals, Inc. Administration of dihydroergotamine mesylate particles using a metered dose inhaler
EP2496295A1 (de) 2009-11-03 2012-09-12 MannKind Corporation Vorrichtung und verfahren zur simulation von einatmungsanstrengungen
CN102905694B (zh) * 2009-11-17 2015-10-14 西普拉有限公司 吸入溶液
EP2515978B1 (de) 2009-12-23 2018-02-14 Map Pharmaceuticals Inc. Verbessertes ejektordesign
EP2531096A4 (de) 2010-02-01 2013-09-11 Proteus Digital Health Inc Datensammelsystem für zwei handgelenke
CN102946798A (zh) 2010-02-01 2013-02-27 普罗秋斯数字健康公司 数据采集系统
US8471041B2 (en) * 2010-02-09 2013-06-25 Alliant Techsystems Inc. Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same
MX340696B (es) 2010-04-30 2016-07-21 Alexion Pharma Inc Anticuerpos anti-c5a y metodos para usar los anticuerpos.
DE102010024912B4 (de) * 2010-06-15 2013-02-28 Aptar Radolfzell Gmbh Inhalationsvorrichtung
EP2582421A1 (de) 2010-06-21 2013-04-24 MannKind Corporation System und verfahren zur verabreichung von arzneimitteln in trockenpulverform
JP2013533243A (ja) 2010-06-22 2013-08-22 ザ リージェンツ オブ ザ ユニヴァーシティ オブ コロラド,ア ボディ コーポレート 補体成分3のC3d断片に対する抗体
US9000054B2 (en) 2010-08-12 2015-04-07 Senomyx, Inc. Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer
WO2012135765A2 (en) 2011-04-01 2012-10-04 Mannkind Corporation Blister package for pharmaceutical cartridges
WO2012158271A1 (en) 2011-04-06 2012-11-22 Anadys Pharmaceuticals, Inc. Bridged polycyclic compounds as antiviral agents
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
US8664247B2 (en) 2011-08-26 2014-03-04 Radiorx, Inc. Acyclic organonitro compounds for use in treating cancer
WO2013052164A1 (en) 2011-10-07 2013-04-11 Radiorx, Inc. Organonitro thioether compounds and medical uses thereof
WO2013052803A2 (en) 2011-10-07 2013-04-11 Radiorx, Inc. Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products
CN103945859A (zh) 2011-10-24 2014-07-23 曼金德公司 用于治疗疼痛的方法和组合物
EP2809780B1 (de) 2012-02-01 2018-05-02 Protalix Ltd. Inhalierbare flüssige formulierungen der dnase i
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
KR20150041040A (ko) 2012-08-06 2015-04-15 세노믹스, 인코포레이티드 단맛 향미 개질제
US9713687B2 (en) * 2012-08-21 2017-07-25 Philip Morris Usa Inc. Ventilator aerosol delivery system with transition adapter for introducing carrier gas
GB201215282D0 (en) * 2012-08-28 2012-10-10 Kind Consumer Ltd An inhaler
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
JO3155B1 (ar) 2013-02-19 2017-09-20 Senomyx Inc معدِّل نكهة حلوة
SG11201507564PA (en) 2013-03-15 2015-10-29 Mannkind Corp Microcrystalline diketopiperazine compositions and methods
MX2020009878A (es) 2013-07-18 2022-07-27 Mannkind Corp Composiciones farmaceuticas en polvo seco estables al calor y metodos.
EP3030294B1 (de) 2013-08-05 2020-10-07 MannKind Corporation Insufflationsvorrichtung
AU2014355072A1 (en) 2013-11-26 2016-06-02 Alliqua Biomedical, Inc. Systems and methods for producing and delivering ultrasonic therapies for wound treatment and healing
GB2524469A (en) * 2014-02-14 2015-09-30 Kind Consumer Ltd A cannabinoid inhaler and composition therefor
NZ711451A (en) 2014-03-07 2016-05-27 Alexion Pharma Inc Anti-c5 antibodies having improved pharmacokinetics
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
SI3151893T1 (en) * 2014-06-06 2018-06-29 Rijksuniversiteit Groningen Dry powder inhaler triggered by the breath
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US20170304459A1 (en) 2014-10-10 2017-10-26 Alnylam Pharmaceuticals, Inc. Methods and compositions for inhalation delivery of conjugated oligonucleotide
KR102641177B1 (ko) 2015-07-20 2024-02-26 펄 테라퓨틱스 인코포레이티드 에어로졸 전달 시스템 및 관련 방법
CN105092786A (zh) * 2015-07-23 2015-11-25 上海化工研究院 一种对冲式定量雾化给药装置
EP3355885A4 (de) 2015-10-01 2019-04-24 Elysium Therapeutics, Inc. Mehrfachuntereinheit-opioid-prodrugs mit resistenz gegen überdosierung und missbrauch
US10335406B2 (en) 2015-10-01 2019-07-02 Elysium Therapeutics, Inc. Opioid compositions resistant to overdose and abuse
US10342778B1 (en) 2015-10-20 2019-07-09 Epicentrx, Inc. Treatment of brain metastases using organonitro compound combination therapy
US9987270B1 (en) 2015-10-29 2018-06-05 Epicentrix, Inc. Treatment of gliomas using organonitro compound combination therapy
US11083855B2 (en) 2015-12-21 2021-08-10 Kindeva Drug Delivery L.P. Auto-reset dose release firing systems, medicinal inhalers comprising same, and methods of using same
US11071837B2 (en) 2015-12-21 2021-07-27 Kindeva Drug Delivery L.P. Dose release firing systems and medicinal inhalers comprising same
EP3402480B1 (de) 2016-01-11 2021-03-24 EpicentRx, Inc. Zusammensetzungen und verfahren zur intravenösen verabreichung von 2-bromo-1-( 3,3-dinitroazetidin-1-yl)ethanon
FR3050115B1 (fr) * 2016-04-15 2023-05-12 Aptar France Sas Dispositif de distribution de produit fluide synchronise avec l'inhalation.
FR3050116B1 (fr) * 2016-04-15 2020-05-15 Aptar France Sas Dispositif de distribution de produit fluide synchronise avec l'inhalation
WO2018064825A1 (zh) * 2016-10-09 2018-04-12 益得生物科技股份有限公司 药物传递装置及其系统
SG11201903312VA (en) 2016-10-14 2019-05-30 Epicentrix Inc Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine
WO2018170465A1 (en) 2017-03-17 2018-09-20 Elysium Therapeutics, Inc. Polysubunit opioid prodrugs resistant to overdose and abuse
US11744859B2 (en) 2017-07-07 2023-09-05 Epicentrx, Inc. Compositions and methods for parenteral administration of therapeutic agents
EP3658184B1 (de) 2017-07-27 2023-09-06 Alexion Pharmaceuticals, Inc. Hochkonzentrierte anti-c5-antikörperformulierungen
CN109481802A (zh) * 2017-09-12 2019-03-19 张海飞 全自动定量气雾吸入装置
IL255520A0 (en) * 2017-11-08 2017-12-31 Omrix Biopharmaceuticals Ltd Powder release device
US11510901B2 (en) 2018-01-08 2022-11-29 Epicentrx, Inc. Methods and compositions utilizing RRx-001 combination therapy for radioprotection
US11524129B2 (en) * 2018-01-23 2022-12-13 Shl Medical Ag Aerosol generator with obstructed air jets
JP2021521280A (ja) 2018-04-12 2021-08-26 マトルクス セラピューティクス コーポレーション 弾性線維分解を治療するための組成物及び方法
WO2019234584A1 (en) * 2018-06-04 2019-12-12 Trudell Medical International Positive air pressure therapy device, kit and methods for the use and assembly thereof
CN109078234A (zh) * 2018-07-03 2018-12-25 李骏达 用于慢性伤口清创的局部组织闭合涡流冲洗器
MX2021001193A (es) 2018-08-07 2021-04-28 Firmenich Incorporated 2,2-dioxidos de 4-amino-1h-benzo[c][1,2,6]tiadiazina 5-sustituidos y formulaciones y usos de los mismos.
JP7250317B2 (ja) * 2019-03-18 2023-04-03 学校法人日本大学 薬剤吸入器
NL2023033B1 (en) * 2019-04-30 2020-11-23 Medspray B V Spray inhaler device
US20200368456A1 (en) * 2019-05-24 2020-11-26 Blue Ocean Group, LLC Compact Spacer for Metered Dose Inhaler
KR102200764B1 (ko) * 2020-02-18 2021-01-08 가톨릭대학교 산학협력단 마취용 기화기의 마취액용기 가압유지장치
CN111359060A (zh) * 2020-02-20 2020-07-03 深圳麦克韦尔科技有限公司 雾化吸嘴及雾化装置
CN111214737B (zh) * 2020-03-06 2020-10-20 张洁 一种儿童用雾化器
CN111544715B (zh) * 2020-04-02 2022-08-19 佛山市澳斯卡医疗器械有限公司 一种瓶装雾化器
CN111536555A (zh) * 2020-05-08 2020-08-14 中国航发湖南动力机械研究所 发动机及其发动机燃烧室
US11925749B2 (en) * 2021-03-18 2024-03-12 Funai Electric Co., Ltd. Venting of pharmaceutical drug delivery device for air flow and humidity control
CN115120819B (zh) * 2021-03-24 2024-02-09 心诚镁行动医电股份有限公司 雾化装置以及喷嘴模块
WO2023178283A1 (en) 2022-03-18 2023-09-21 Epicentrx, Inc. Co-crystals of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone and methods
WO2023215229A1 (en) 2022-05-02 2023-11-09 Epicentrx, Inc. Compositions and methods for treatment of pulmonary hypertension
WO2023215227A1 (en) 2022-05-02 2023-11-09 Epicentrx, Inc. Systems and methods to improve exercise tolerance
WO2023244973A1 (en) 2022-06-13 2023-12-21 Epicentrx, Inc. Compositions and methods for reducing adverse side effects in cancer treatment

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5040527A (en) * 1990-12-18 1991-08-20 Healthscan Products Inc. Metered dose inhalation unit with slide means
US5060643A (en) * 1990-08-07 1991-10-29 Tenax Corporation Breath-activated inhalation device
US5178138A (en) * 1990-09-11 1993-01-12 Walstrom Dennis R Drug delivery device
US5301666A (en) * 1991-12-14 1994-04-12 Asta Medica Aktiengesellschaft Powder inhaler
US5309900A (en) * 1991-03-21 1994-05-10 Paul Ritzau Pari-Werk Gmbh Atomizer particularly for use in devices for inhalation therapy
GB2279879A (en) * 1993-07-14 1995-01-18 Bespak Plc Medicament inhalers
US5435297A (en) * 1991-08-29 1995-07-25 Christoph Klein Medical device for inhaling metered aerosols
US5590645A (en) * 1990-03-02 1997-01-07 Glaxo Group Limited Inhalation device
EP0839544A2 (de) * 1996-10-30 1998-05-06 Bespak plc Inhalatoren

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2305210A (en) * 1940-10-28 1942-12-15 Spraying Systems Co Spray shaper
US2751252A (en) * 1953-12-14 1956-06-19 Spraying Systems Co Whirl spray nozzle
US2984420A (en) * 1959-11-20 1961-05-16 Jr John W Hession Aerosol devices
US3072346A (en) * 1961-09-29 1963-01-08 Spraying Systems Co Spray nozzle
FR1322998A (fr) * 1962-02-23 1963-04-05 Perfectionnements aux dispositifs de production d'aérosols
US3240431A (en) * 1964-05-27 1966-03-15 Clayton Corp Of Delaware Combination valve spout and spray head assembly
US3385295A (en) * 1966-02-07 1968-05-28 Puritan Compressed Gas Corp Apparatus for use in administering intermittent positive pressure breathing therapy
US3406913A (en) * 1966-09-01 1968-10-22 Revlon Mechanical break-up actuator for fluid dispensers
US3456644A (en) * 1967-01-19 1969-07-22 Dart Ind Inc Inhalation-actuated aerosol dispensing device
GB1253221A (de) * 1968-04-23 1971-11-10
US3522806A (en) * 1968-08-07 1970-08-04 G S Intern Lab Corp Aerosol apparatus for inhalation therapy
DE1813993C3 (de) * 1968-12-11 1974-01-24 Paul Ritzau Pari-Werk Kg, 8135 Soecking Vorrichtung zum Zerstäuben und Vernebeln von flüssigen oder pulverförmigen Stoffen
US3565070A (en) * 1969-02-28 1971-02-23 Riker Laboratories Inc Inhalation actuable aerosol dispenser
US3636949A (en) * 1969-08-08 1972-01-25 Armstrong Kropp Dev Corp Inhalation-initiated aerosol dispenser
US3838686A (en) * 1971-10-14 1974-10-01 G Szekely Aerosol apparatus for inhalation therapy
US4049200A (en) * 1976-04-05 1977-09-20 Sobol Jacob M Nebulizer
EP0045419B1 (de) * 1980-08-04 1984-10-17 FISONS plc Inhalationsvorrichtung zum Verabreichen von Medikamenten
DE3043377A1 (de) * 1980-11-17 1982-07-01 Brugger, Inge, 8130 Starnberg Zerstaeuber
FI69962C (fi) * 1983-12-28 1986-09-12 Huhtamaeki Oy Inhalationsanordning
US4534343A (en) * 1984-01-27 1985-08-13 Trutek Research, Inc. Metered dose inhaler
DE8621135U1 (de) * 1985-09-02 1987-01-29 Callahan, George Edgar, Prof.
SE453566B (sv) * 1986-03-07 1988-02-15 Draco Ab Anordning vid pulverinhalatorer
US4739754A (en) * 1986-05-06 1988-04-26 Shaner William T Suction resistant inhalator
GB8614805D0 (en) * 1986-06-18 1986-07-23 British American Tobacco Co Aerosol device
EP0261649B2 (de) * 1986-09-22 1995-04-26 Omron Tateisi Electronics Co. Vernebler
JP2587817B2 (ja) * 1986-09-22 1997-03-05 オムロン株式会社 霧化器
US4768717A (en) * 1987-02-12 1988-09-06 Specialty Packaging Licensing Company Nozzle
JPH0199570A (ja) * 1987-09-30 1989-04-18 Bootran Medical Technol Inc 吸入装置と吸入方法
EP0604741B1 (de) * 1987-12-11 1998-05-13 Deutsches Zentrum für Luft- und Raumfahrt e.V. Dralldüse zum Zerstäuben einer Flüssigkeit
DE68914932T2 (de) * 1988-10-04 1994-08-11 Univ Johns Hopkins Inhalationsgerät für Aerosolen.
SE466684B (sv) * 1989-03-07 1992-03-23 Draco Ab Anordning vid en inhalator samt foerfarande foer att med anordningen registrera medicinering med inhalator
GB8919131D0 (en) * 1989-08-23 1989-10-04 Riker Laboratories Inc Inhaler
DE8912098U1 (de) * 1989-10-11 1990-11-08 Nolinski, Dieter, Dr., 6908 Wiesloch, De
FR2658081B1 (fr) * 1990-02-09 1995-06-30 Pesenti Yvan Dispositif d'automatisation et synchronisation des appareils aerosols a pompe doseuse.
US5615670A (en) * 1990-03-07 1997-04-01 Fisons Plc Powder inhaler with centrifugal force used to meter powder
GB9015077D0 (en) * 1990-07-09 1990-08-29 Riker Laboratories Inc Inhaler
DE4027391A1 (de) * 1990-08-30 1992-03-12 Boehringer Ingelheim Kg Treibgasfreies inhalationsgeraet
GB9020555D0 (en) * 1990-09-20 1990-10-31 Bespak Plc Dispensing apparatus
US5027808A (en) * 1990-10-31 1991-07-02 Tenax Corporation Breath-activated inhalation device
US5217004A (en) * 1990-12-13 1993-06-08 Tenax Corporation Inhalation actuated dispensing apparatus
EP0683890B1 (de) * 1991-03-05 2002-04-03 Aradigm Corporation Verfahren und vorrichtung zur korrektur eines nullsignals eines drucksensors fur einen durchflussmesser
EP0940154B1 (de) * 1991-07-02 2007-04-18 Nektar Therapeutics Abgabevorrichtung für nebelförmige Medikamente
US5228624A (en) * 1992-03-02 1993-07-20 Mensink Daniel L Swirling structure for mixing two concentric fluid flows at nozzle outlet
DE4208880A1 (de) * 1992-03-19 1993-09-23 Boehringer Ingelheim Kg Separator fuer pulverinhalatoren
SE9201411D0 (sv) * 1992-05-05 1992-05-05 Astra Ab Dosage inhalator with indicating/interupting means
CZ282964B6 (cs) * 1992-10-19 1997-11-12 Dura Pharmaceuticals, Inc. Inhalátor pro inhalování suchého prášku
US5415162A (en) * 1994-01-18 1995-05-16 Glaxo Inc. Multi-dose dry powder inhalation device
GB2299512A (en) * 1995-04-06 1996-10-09 Ian James Sharp Inhaler
US5474059A (en) * 1995-04-08 1995-12-12 Cooper; Guy F. Aerosol dispensing apparatus for dispensing a medicated vapor into the lungs of a patient
US5598836A (en) * 1995-05-26 1997-02-04 Healthscan Products, Inc. Metered dose inhalation unit with slide means
US5724986A (en) * 1995-11-06 1998-03-10 Jones Medical Instrument Co. Casing and spirometer for metered dose inhaler
US6065472A (en) * 1996-01-03 2000-05-23 Glaxo Wellcome Inc. Multidose powder inhalation device
US5875774A (en) * 1996-01-05 1999-03-02 Sunrise Medical Hhg Inc. Nebulizer
GB2312379B (en) * 1996-04-25 1999-11-17 Bespak Plc Improved inhalers
GB2312848B (en) * 1996-04-26 1999-11-17 Bespak Plc Controlled flow inhalers
GB9626263D0 (en) * 1996-12-18 1997-02-05 Innovata Biomed Ltd Powder inhaler
US5894995A (en) * 1997-07-08 1999-04-20 Mazzei; Angelo L. Infusion nozzle imparting axial and rotational flow elements
GB2334686B (en) * 1998-02-26 2002-06-19 Medic Aid Ltd Nebuliser

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5590645A (en) * 1990-03-02 1997-01-07 Glaxo Group Limited Inhalation device
US5060643A (en) * 1990-08-07 1991-10-29 Tenax Corporation Breath-activated inhalation device
US5178138A (en) * 1990-09-11 1993-01-12 Walstrom Dennis R Drug delivery device
US5040527A (en) * 1990-12-18 1991-08-20 Healthscan Products Inc. Metered dose inhalation unit with slide means
US5309900A (en) * 1991-03-21 1994-05-10 Paul Ritzau Pari-Werk Gmbh Atomizer particularly for use in devices for inhalation therapy
US5435297A (en) * 1991-08-29 1995-07-25 Christoph Klein Medical device for inhaling metered aerosols
US5301666A (en) * 1991-12-14 1994-04-12 Asta Medica Aktiengesellschaft Powder inhaler
GB2279879A (en) * 1993-07-14 1995-01-18 Bespak Plc Medicament inhalers
EP0839544A2 (de) * 1996-10-30 1998-05-06 Bespak plc Inhalatoren

Also Published As

Publication number Publication date
JP2011098224A (ja) 2011-05-19
EP0911048B1 (de) 2005-12-07
CA2565964A1 (en) 1999-04-17
CN1285759A (zh) 2001-02-28
AU750459B2 (en) 2002-07-18
DK1591137T3 (da) 2010-07-05
EP0911048A2 (de) 1999-04-28
JP2001520088A (ja) 2001-10-30
JP5395100B2 (ja) 2014-01-22
DE69832679T2 (de) 2006-08-24
NO983631D0 (no) 1998-08-07
EP1627655A2 (de) 2006-02-22
DK0911048T3 (da) 2006-04-18
DE69841603D1 (de) 2010-05-20
CA2565964C (en) 2008-06-10
CA2243175C (en) 2008-11-18
ATE311913T1 (de) 2005-12-15
CA2243175A1 (en) 1999-04-17
ES2348495T3 (es) 2010-12-07
AU1084799A (en) 1999-05-10
US5954047A (en) 1999-09-21
JP5352630B2 (ja) 2013-11-27
CA2565088A1 (en) 1999-04-17
JP2011189194A (ja) 2011-09-29
EP1627655A3 (de) 2010-01-13
ES2255134T3 (es) 2006-06-16
NZ504021A (en) 2003-04-29
DE69832679D1 (de) 2006-01-12
EP1591137A2 (de) 2005-11-02
ATE463271T1 (de) 2010-04-15
TR200001033T2 (tr) 2000-11-21
US6095141A (en) 2000-08-01
EP1591137B1 (de) 2010-04-07
JP5114515B2 (ja) 2013-01-09
WO1999020331A1 (en) 1999-04-29
NO983631L (no) 1999-04-19
KR20010031187A (ko) 2001-04-16
US6026808A (en) 2000-02-22
EP1591137A3 (de) 2005-11-23
MXPA00003766A (es) 2002-04-09
JP2009183734A (ja) 2009-08-20
EP1627655B1 (de) 2016-11-23
JP2010115543A (ja) 2010-05-27
CA2565088C (en) 2008-11-18

Similar Documents

Publication Publication Date Title
EP0911048A3 (de) Verfahren und Vorrrichtung zur Verabreichung von einem Arzneimittel in Aerosolform
JP6157542B2 (ja) 強化排出装置設計
JP4688391B2 (ja) 吸入装置のための内部渦機構
USRE42911E1 (en) Atomizer
US6129080A (en) Atomizer
EP0839544A2 (de) Inhalatoren
JP2009183734A5 (de)
EP2189176A3 (de) Deagglomerator für einen atmungsbetätigten Trockenpulverinhalator

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

17P Request for examination filed

Effective date: 19991202

AKX Designation fees paid

Free format text: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

17Q First examination report despatched

Effective date: 20021106

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

RTI1 Title (correction)

Free format text: APPARATUS FOR DELIVERING AEROSOLIZED MEDICATION

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20051207

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REF Corresponds to:

Ref document number: 69832679

Country of ref document: DE

Date of ref document: 20060112

Kind code of ref document: P

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

REG Reference to a national code

Ref country code: GR

Ref legal event code: EP

Ref document number: 20060400853

Country of ref document: GR

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2255134

Country of ref document: ES

Kind code of ref document: T3

ET Fr: translation filed
PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20060731

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20060908

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: TROESCH SCHEIDEGGER WERNER AG

Ref country code: CH

Ref legal event code: AEN

Free format text: DAS PATENT IST AUFGRUND DES WEITERBEHANDLUNGSANTRAGS VOM 05.09.2006 REAKTIVIERT WORDEN.

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20060308

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: LU

Payment date: 20110718

Year of fee payment: 14

REG Reference to a national code

Ref country code: CH

Ref legal event code: PFA

Owner name: SYSTEMIC PULMONARY DELIVERY, LTD.

Free format text: SYSTEMIC PULMONARY DEVELOPMENT, LTD.#4255 WOODSMILL ROAD#ST. LOUIS, MISSOURI (US) -TRANSFER TO- SYSTEMIC PULMONARY DELIVERY, LTD.#4255 WOODSMILL ROAD#ST. LOUIS, MISSOURI (US)

REG Reference to a national code

Ref country code: DE

Ref legal event code: R082

Ref document number: 69832679

Country of ref document: DE

Representative=s name: VOSSIUS & PARTNER, DE

REG Reference to a national code

Ref country code: GB

Ref legal event code: S117

Free format text: REQUEST FILED; REQUEST FOR CORRECTION UNDER SECTION 117 FILED ON 5 JANUARY 2012

REG Reference to a national code

Ref country code: FR

Ref legal event code: RM

Effective date: 20120315

REG Reference to a national code

Ref country code: DE

Ref legal event code: R082

Ref document number: 69832679

Country of ref document: DE

Representative=s name: VOSSIUS & PARTNER PATENTANWAELTE RECHTSANWAELT, DE

Effective date: 20120309

Ref country code: DE

Ref legal event code: R081

Ref document number: 69832679

Country of ref document: DE

Owner name: MAP PHARMACEUTICALS, INC. (N. D. GES. D. STAAT, US

Free format text: FORMER OWNER: SYSTEMIC PULMONARY DEVELOPMENT, LTD., ST. LOUIS, MO., US

Effective date: 20120309

Ref country code: DE

Ref legal event code: R081

Ref document number: 69832679

Country of ref document: DE

Owner name: SYSTEMIC PULMONARY DELIVERY, LTD., ST. LOUIS, US

Free format text: FORMER OWNER: SYSTEMIC PULMONARY DEVELOPMENT, LTD., ST. LOUIS, MO., US

Effective date: 20120309

REG Reference to a national code

Ref country code: AT

Ref legal event code: HC

Ref document number: 311913

Country of ref document: AT

Kind code of ref document: T

Owner name: SYSTEMIC PULMONARY DELIVERY, LTD., US

Effective date: 20120427

REG Reference to a national code

Ref country code: GB

Ref legal event code: S117

Free format text: CORRECTIONS ALLOWED; REQUEST FOR CORRECTION UNDER SECTION 117 FILED ON 5 JANUARY 2012 ALLOWED ON 20 AUGUST 2012

REG Reference to a national code

Ref country code: NL

Ref legal event code: SD

Effective date: 20131127

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120731

REG Reference to a national code

Ref country code: ES

Ref legal event code: PC2A

Owner name: SYSTEMIC PULMONARY DELIVERY, LTD.

Effective date: 20140613

REG Reference to a national code

Ref country code: DE

Ref legal event code: R082

Ref document number: 69832679

Country of ref document: DE

Representative=s name: VOSSIUS & PARTNER PATENTANWAELTE RECHTSANWAELT, DE

REG Reference to a national code

Ref country code: GB

Ref legal event code: 732E

Free format text: REGISTERED BETWEEN 20141113 AND 20141119

REG Reference to a national code

Ref country code: ES

Ref legal event code: PC2A

Owner name: MAP PHARMACEUTICALS, INC.

Effective date: 20141217

REG Reference to a national code

Ref country code: DE

Ref legal event code: R082

Ref document number: 69832679

Country of ref document: DE

Representative=s name: VOSSIUS & PARTNER PATENTANWAELTE RECHTSANWAELT, DE

Effective date: 20141119

Ref country code: DE

Ref legal event code: R081

Ref document number: 69832679

Country of ref document: DE

Owner name: MAP PHARMACEUTICALS, INC. (N. D. GES. D. STAAT, US

Free format text: FORMER OWNER: SYSTEMIC PULMONARY DELIVERY, LTD., ST. LOUIS, MO., US

Effective date: 20141119

REG Reference to a national code

Ref country code: NL

Ref legal event code: SD

Effective date: 20150220

REG Reference to a national code

Ref country code: CH

Ref legal event code: PUE

Owner name: MAP PHARMACEUTICALS, INC., US

Free format text: FORMER OWNER: SYSTEMIC PULMONARY DELIVERY, LTD., US

Ref country code: CH

Ref legal event code: NV

Representative=s name: R.A. EGLI AND CO, PATENTANWAELTE, CH

REG Reference to a national code

Ref country code: PT

Ref legal event code: PC4A

Owner name: MAP PHARMACEUTICALS, INC., UMA SOCIEDADE ORGAN, US

Effective date: 20150305

REG Reference to a national code

Ref country code: FR

Ref legal event code: TP

Owner name: MAP PHARMACEUTICALS, INC., US

Effective date: 20150317

REG Reference to a national code

Ref country code: AT

Ref legal event code: PC

Ref document number: 311913

Country of ref document: AT

Kind code of ref document: T

Owner name: MAP PHARMACEUTICALS, INC., US

Effective date: 20150805

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 19

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20170726

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20170801

Year of fee payment: 20

Ref country code: IT

Payment date: 20170725

Year of fee payment: 20

Ref country code: GB

Payment date: 20170727

Year of fee payment: 20

Ref country code: DE

Payment date: 20170727

Year of fee payment: 20

Ref country code: FI

Payment date: 20170727

Year of fee payment: 20

Ref country code: FR

Payment date: 20170726

Year of fee payment: 20

Ref country code: CH

Payment date: 20170727

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DK

Payment date: 20170725

Year of fee payment: 20

Ref country code: SE

Payment date: 20170727

Year of fee payment: 20

Ref country code: PT

Payment date: 20170703

Year of fee payment: 20

Ref country code: IE

Payment date: 20170728

Year of fee payment: 20

Ref country code: AT

Payment date: 20170705

Year of fee payment: 20

Ref country code: BE

Payment date: 20170727

Year of fee payment: 20

REG Reference to a national code

Ref country code: DE

Ref legal event code: R071

Ref document number: 69832679

Country of ref document: DE

REG Reference to a national code

Ref country code: NL

Ref legal event code: MK

Effective date: 20180730

REG Reference to a national code

Ref country code: DK

Ref legal event code: EUP

Effective date: 20180731

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: GB

Ref legal event code: PE20

Expiry date: 20180730

Ref country code: IE

Ref legal event code: MK9A

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK07

Ref document number: 311913

Country of ref document: AT

Kind code of ref document: T

Effective date: 20180731

REG Reference to a national code

Ref country code: SE

Ref legal event code: EUG

REG Reference to a national code

Ref country code: BE

Ref legal event code: PD

Owner name: MAP PHARMACEUTICALS, INC.; US

Free format text: DETAILS ASSIGNMENT: CHANGE OF OWNER(S), AFFECTATION / CESSION; FORMER OWNER NAME: SYSTEMIC PULMONARY DELIVERY, LTD.

Effective date: 20141218

Ref country code: BE

Ref legal event code: MK

Effective date: 20180731

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20180808

Ref country code: IE

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20180731

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20180730

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20220105

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20180801