EP0876818A2 - Wirkstoff zur behandlung neurodegenerativer störungen - Google Patents
Wirkstoff zur behandlung neurodegenerativer störungen Download PDFInfo
- Publication number
- EP0876818A2 EP0876818A2 EP96935637A EP96935637A EP0876818A2 EP 0876818 A2 EP0876818 A2 EP 0876818A2 EP 96935637 A EP96935637 A EP 96935637A EP 96935637 A EP96935637 A EP 96935637A EP 0876818 A2 EP0876818 A2 EP 0876818A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- weeks
- treatment
- changes
- nos
- prior
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Physics & Mathematics (AREA)
- Neurosurgery (AREA)
- Optics & Photonics (AREA)
- Oncology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI9630572T SI0876818T1 (en) | 1995-10-23 | 1996-10-23 | Agent for treating neuro-degenerative disorders |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU95118252A RU2106864C1 (ru) | 1995-10-23 | 1995-10-23 | Средство для лечения болезни альцгеймера |
RU95118252 | 1995-10-23 | ||
PCT/RU1996/000306 WO1997015225A1 (fr) | 1995-10-23 | 1996-10-23 | Agent therapeutique contre les troubles neurodegeneratifs |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0876818A2 true EP0876818A2 (de) | 1998-11-11 |
EP0876818A4 EP0876818A4 (de) | 1999-01-07 |
EP0876818B1 EP0876818B1 (de) | 2002-12-18 |
Family
ID=20173218
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP96935637A Expired - Lifetime EP0876818B1 (de) | 1995-10-23 | 1996-10-23 | Wirkstoff zur behandlung neurodegenerativer störungen |
Country Status (11)
Country | Link |
---|---|
US (6) | US6187785B1 (de) |
EP (1) | EP0876818B1 (de) |
AT (1) | ATE229806T1 (de) |
AU (1) | AU7347496A (de) |
CA (1) | CA2269698C (de) |
DE (1) | DE69625518T2 (de) |
DK (1) | DK0876818T3 (de) |
ES (1) | ES2188793T3 (de) |
HK (1) | HK1016893A1 (de) |
RU (1) | RU2106864C1 (de) |
WO (1) | WO1997015225A1 (de) |
Cited By (11)
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---|---|---|---|---|
WO2004035580A1 (en) * | 2002-10-21 | 2004-04-29 | Aprea Ab | Reactivation of wild type p53 in human tumour cells by a low molecular weight compound |
FR2885905A1 (fr) * | 2005-05-23 | 2006-11-24 | Trophos Sa | Nouveaux composes chimiques et leurs utilisations comme medicament |
WO2007041697A2 (en) * | 2005-10-04 | 2007-04-12 | Medivation, Inc. | Hydrogenated pyrido-indole compounds for the treatment of huntington ' s disease |
WO2008112238A1 (en) * | 2007-03-12 | 2008-09-18 | Grey Fox Llc | 2, 8-dimethyl-5- [2- (6-methylpyridin-3-yl) -ethyl] -2,3,4, 5-tetrahydro- ih- pyrido [4, 3 -b] indole dihydrochloride (dimebon) for the treatment of chronic pain |
WO2009120720A1 (en) | 2008-03-24 | 2009-10-01 | Medivation Technologies,Inc. | Bridged heterocyclic compounds and methods of use |
EP2184064A2 (de) * | 2006-11-16 | 2010-05-12 | Alla Chem, LLC. | Liganden von 5-ht6-rezeptoren, pharmazeutische zusammensetzung, herstellungsverfahren und verwendung |
WO2010068480A1 (en) * | 2008-11-25 | 2010-06-17 | Concert Pharmaceuticals, Inc. | Deuterated derivatives of dimeboline |
US8815843B2 (en) | 2011-02-18 | 2014-08-26 | Medivation Technologies, Inc. | Compounds and methods of treating diabetes |
US8859561B2 (en) | 2009-09-23 | 2014-10-14 | Medivation Technologies, Inc. | Pyrido[4,3-b]indoles and methods of use |
WO2014207241A1 (en) * | 2013-06-28 | 2014-12-31 | Alzprotect | NEW Na-SUBSTITUTED CARBOLINE COMPOUNDS USABLE FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES |
US9006234B2 (en) | 2009-09-23 | 2015-04-14 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2106864C1 (ru) | 1995-10-23 | 1998-03-20 | Николай Серафимович Зефиров | Средство для лечения болезни альцгеймера |
CA2363244C (en) * | 2000-11-07 | 2006-06-13 | Research In Motion Limited | Multifunctional keyboard for a mobile communication device and method of operating the same |
RU2283108C2 (ru) * | 2003-12-08 | 2006-09-10 | Сергей Олегович Бачурин | ГЕРОПРОТЕКТОР НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
US20070179174A1 (en) * | 2003-12-08 | 2007-08-02 | Bachurin Sergei O | Methods and compositions for slowing aging |
US20080262019A1 (en) * | 2005-09-12 | 2008-10-23 | Ramiz Medzhidovich Salimov | Optical Isomers of (+) and (-)-Trans-2,3,4,4A,5,9B-Hexahydro-2,8-Dimethyl-1H-Pyrido[4,3-B] Indole |
RU2338537C2 (ru) * | 2006-01-25 | 2008-11-20 | Сергей Олегович Бачурин | СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ ШИЗОФРЕНИИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
RU2317989C1 (ru) | 2006-08-24 | 2008-02-27 | Андрей Александрович Иващенко | ЗАМЕЩЕННЫЕ АЗЕПИНО[4,3-b]ИНДОЛЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
JP2010504337A (ja) * | 2006-09-20 | 2010-02-12 | メディベイション ニューロロジー, インコーポレイテッド | イヌの認知機能障害症候群の治療のためのディメボン(dimebon)などの水素化ピリド[4,3−b]インドール |
AU2007297539A1 (en) * | 2006-09-20 | 2008-03-27 | Medivation Neurology, Inc. | Methods and compositions for treating amyotrophic lateral sclerosis (ALS) |
BRPI0718437A2 (pt) | 2006-10-27 | 2013-11-19 | Medivation Neurology Inc | Métodos e terapias de combinação para tratar a doença de alzheimer usando, entre outros, dimebon e dolepezil |
RU2334514C1 (ru) * | 2006-12-01 | 2008-09-27 | Институт физиологически активных веществ Российской Академии наук | СРЕДСТВО ДЛЯ УЛУЧШЕНИЯ КОГНИТИВНЫХ ФУНКЦИЙ И ПАМЯТИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО (4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
RU2340342C2 (ru) * | 2006-12-07 | 2008-12-10 | Сергей Олегович Бачурин | СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ ОСТРЫХ И ХРОНИЧЕСКИХ НАРУШЕНИЙ МОЗГОВОГО КРОВООБРАЩЕНИЯ, В ТОМ ЧИСЛЕ ИНСУЛЬТА, НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО[4,3-b]ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
RU2334747C1 (ru) * | 2007-04-05 | 2008-09-27 | Андрей Александрович Иващенко | ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
RU2327480C1 (ru) | 2007-05-23 | 2008-06-27 | Виктор Иванович Рощин | Активный ингредиент лекарственного средства, лекарственное средство, фармацевтическая композиция и способ лечения больных с дементным синдромом |
RU2338533C1 (ru) * | 2007-06-28 | 2008-11-20 | Сергей Олегович Бачурин | СРЕДСТВО, ОБЛАДАЮЩЕЕ АНКСИОЛИТИЧЕСКИМ ДЕЙСТВИЕМ, НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
CA2700160A1 (en) * | 2007-09-20 | 2009-03-26 | D2E, Llc | Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use |
RU2007139634A (ru) | 2007-10-25 | 2009-04-27 | Сергей Олегович Бачурин (RU) | Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения |
TWI447117B (zh) * | 2007-10-25 | 2014-08-01 | Medivation Technologies Inc | 新穎四環化合物 |
WO2009082268A2 (ru) * | 2007-12-21 | 2009-07-02 | Alla Chem, Llc | ЛИГАНДЫ α-АДРЕНОЦЕПТОРОВ, ДОПАМИНОВЫХ, ГИСТАМИНОВЫХ, ИМИДАЗОЛИНОВЫХ И СЕРОТОНИНОВЫХ РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ |
RU2544856C2 (ru) | 2008-01-25 | 2015-03-20 | Сергей Олегович Бачурин | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
TWI443098B (zh) | 2008-03-24 | 2014-07-01 | Medivation Technologies Inc | 吡啶并〔3,4-b〕吲哚及使用方法 |
WO2009125646A1 (ja) * | 2008-04-09 | 2009-10-15 | 財団法人東京都医学研究機構 | Tdp-43蓄積細胞モデル |
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JP2012502915A (ja) | 2008-09-15 | 2012-02-02 | バイオビスタ インコーポレイテッド | てんかんを治療する組成物及び方法 |
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US9625475B2 (en) | 2008-09-29 | 2017-04-18 | Abbvie Inc. | Indole and indoline derivatives and methods of use thereof |
JP5588991B2 (ja) | 2008-10-31 | 2014-09-10 | メディベイション テクノロジーズ, インコーポレイテッド | 剛性の部分を有するピリド[4,3−b]インドール |
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EP2236160A3 (de) | 2009-03-31 | 2011-12-14 | Sanovel Ilac Sanayi ve Ticaret A.S. | Dimebolin enthaltende Zusammensetzungen mit modifizierter Freisetzung |
EP2236159A3 (de) | 2009-03-31 | 2011-12-07 | Sanovel Ilac Sanayi ve Ticaret A.S. | Dimebolin enthaltende Zusammensetzungen mit modifizierter Freisetzung |
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FR2885905A1 (fr) * | 2005-05-23 | 2006-11-24 | Trophos Sa | Nouveaux composes chimiques et leurs utilisations comme medicament |
WO2006125887A1 (fr) * | 2005-05-23 | 2006-11-30 | Trophos | Composes derives de 5h-pyrido[4,3-b]indole et leurs utilisations comme medicament pour traiter les maladies neurodegeneratives a polyglutamines |
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Also Published As
Publication number | Publication date |
---|---|
RU2106864C1 (ru) | 1998-03-20 |
ES2188793T3 (es) | 2003-07-01 |
WO1997015225A1 (fr) | 1997-05-01 |
US20020115682A1 (en) | 2002-08-22 |
US7071206B2 (en) | 2006-07-04 |
US20060140866A1 (en) | 2006-06-29 |
DK0876818T3 (da) | 2003-03-31 |
CA2269698A1 (en) | 1997-05-01 |
EP0876818B1 (de) | 2002-12-18 |
AU7347496A (en) | 1997-05-15 |
ATE229806T1 (de) | 2003-01-15 |
DE69625518T2 (de) | 2003-09-04 |
US20050096342A1 (en) | 2005-05-05 |
HK1016893A1 (en) | 1999-11-12 |
US20010020028A1 (en) | 2001-09-06 |
CA2269698C (en) | 2007-09-18 |
US20040044022A1 (en) | 2004-03-04 |
DE69625518D1 (de) | 2003-01-30 |
US6187785B1 (en) | 2001-02-13 |
EP0876818A4 (de) | 1999-01-07 |
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