DK0876818T3 - Middel til behnadling af nerodegenerative lidelser - Google Patents
Middel til behnadling af nerodegenerative lidelserInfo
- Publication number
- DK0876818T3 DK0876818T3 DK96935637T DK96935637T DK0876818T3 DK 0876818 T3 DK0876818 T3 DK 0876818T3 DK 96935637 T DK96935637 T DK 96935637T DK 96935637 T DK96935637 T DK 96935637T DK 0876818 T3 DK0876818 T3 DK 0876818T3
- Authority
- DK
- Denmark
- Prior art keywords
- neurodegenerative disorders
- treating neurodegenerative
- remedy
- nmda
- indoles
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU95118252A RU2106864C1 (ru) | 1995-10-23 | 1995-10-23 | Средство для лечения болезни альцгеймера |
PCT/RU1996/000306 WO1997015225A1 (fr) | 1995-10-23 | 1996-10-23 | Agent therapeutique contre les troubles neurodegeneratifs |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0876818T3 true DK0876818T3 (da) | 2003-03-31 |
Family
ID=20173218
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96935637T DK0876818T3 (da) | 1995-10-23 | 1996-10-23 | Middel til behnadling af nerodegenerative lidelser |
Country Status (11)
Country | Link |
---|---|
US (6) | US6187785B1 (de) |
EP (1) | EP0876818B1 (de) |
AT (1) | ATE229806T1 (de) |
AU (1) | AU7347496A (de) |
CA (1) | CA2269698C (de) |
DE (1) | DE69625518T2 (de) |
DK (1) | DK0876818T3 (de) |
ES (1) | ES2188793T3 (de) |
HK (1) | HK1016893A1 (de) |
RU (1) | RU2106864C1 (de) |
WO (1) | WO1997015225A1 (de) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2106864C1 (ru) | 1995-10-23 | 1998-03-20 | Николай Серафимович Зефиров | Средство для лечения болезни альцгеймера |
CA2363244C (en) * | 2000-11-07 | 2006-06-13 | Research In Motion Limited | Multifunctional keyboard for a mobile communication device and method of operating the same |
WO2004035580A1 (en) * | 2002-10-21 | 2004-04-29 | Aprea Ab | Reactivation of wild type p53 in human tumour cells by a low molecular weight compound |
RU2283108C2 (ru) * | 2003-12-08 | 2006-09-10 | Сергей Олегович Бачурин | ГЕРОПРОТЕКТОР НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
US20070179174A1 (en) * | 2003-12-08 | 2007-08-02 | Bachurin Sergei O | Methods and compositions for slowing aging |
FR2885905A1 (fr) * | 2005-05-23 | 2006-11-24 | Trophos Sa | Nouveaux composes chimiques et leurs utilisations comme medicament |
WO2007032699A1 (fr) * | 2005-09-12 | 2007-03-22 | Avdulov, Nikolai Andreevich | Isomeres optiques (+) et (-) de trans-2,3,4,4a,5,9b-hexahydro-2,8-dimethyl-1h-pirido[4,3-b]indole |
US20070117834A1 (en) * | 2005-10-04 | 2007-05-24 | David Hung | Methods and compositions for treating Huntington's disease |
RU2338537C2 (ru) * | 2006-01-25 | 2008-11-20 | Сергей Олегович Бачурин | СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ ШИЗОФРЕНИИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
RU2317989C1 (ru) | 2006-08-24 | 2008-02-27 | Андрей Александрович Иващенко | ЗАМЕЩЕННЫЕ АЗЕПИНО[4,3-b]ИНДОЛЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
AU2007297618A1 (en) * | 2006-09-20 | 2008-03-27 | Medivation Neurology, Inc. | Hydrogenated pyrido [4,3-b] indoles such as dimebon for treating canine Cognitive Dysfunction Syndrome |
US20100099700A1 (en) * | 2006-09-20 | 2010-04-22 | David Hung | Hydrogenated pyrido (4,3-b) indoles for treating amyotrophic lateral sclerosis (als) |
WO2008051599A2 (en) * | 2006-10-27 | 2008-05-02 | Medivation Neurology, Inc. | Combination therapies for treating alzheimer's disease using i. a. dimebon and dolepezil |
RU2329044C1 (ru) * | 2006-11-16 | 2008-07-20 | Андрей Александрович Иващенко | Лиганды 5-ht6 рецепторов, фармацевтическая композиция, способ ее получения и лекарственное средство |
RU2334514C1 (ru) * | 2006-12-01 | 2008-09-27 | Институт физиологически активных веществ Российской Академии наук | СРЕДСТВО ДЛЯ УЛУЧШЕНИЯ КОГНИТИВНЫХ ФУНКЦИЙ И ПАМЯТИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО (4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
RU2340342C2 (ru) * | 2006-12-07 | 2008-12-10 | Сергей Олегович Бачурин | СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ ОСТРЫХ И ХРОНИЧЕСКИХ НАРУШЕНИЙ МОЗГОВОГО КРОВООБРАЩЕНИЯ, В ТОМ ЧИСЛЕ ИНСУЛЬТА, НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО[4,3-b]ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
WO2008112238A1 (en) * | 2007-03-12 | 2008-09-18 | Grey Fox Llc | 2, 8-dimethyl-5- [2- (6-methylpyridin-3-yl) -ethyl] -2,3,4, 5-tetrahydro- ih- pyrido [4, 3 -b] indole dihydrochloride (dimebon) for the treatment of chronic pain |
RU2334747C1 (ru) * | 2007-04-05 | 2008-09-27 | Андрей Александрович Иващенко | ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
RU2327480C1 (ru) | 2007-05-23 | 2008-06-27 | Виктор Иванович Рощин | Активный ингредиент лекарственного средства, лекарственное средство, фармацевтическая композиция и способ лечения больных с дементным синдромом |
RU2338533C1 (ru) * | 2007-06-28 | 2008-11-20 | Сергей Олегович Бачурин | СРЕДСТВО, ОБЛАДАЮЩЕЕ АНКСИОЛИТИЧЕСКИМ ДЕЙСТВИЕМ, НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
EP2194980A4 (de) * | 2007-09-20 | 2012-01-18 | D2E Llc | Fluor-haltige derivate von hydrogenierten pyrido[4,3-b]indolen mit neuroprotektiven und kognitionsverbessernden eigenschaften, herstellungsverfahren und verwendung |
RU2007139634A (ru) * | 2007-10-25 | 2009-04-27 | Сергей Олегович Бачурин (RU) | Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения |
TWI447117B (zh) * | 2007-10-25 | 2014-08-01 | Medivation Technologies Inc | 新穎四環化合物 |
JP2011507835A (ja) * | 2007-12-21 | 2011-03-10 | アンドレイ・アレクサンドロビッチ・イワシェンコ | α−アドレナリン受容体、ドーパミン、ヒスタミン、イミダゾリン及びセロトニン受容体のリガンド並びにその使用 |
RU2544856C2 (ru) | 2008-01-25 | 2015-03-20 | Сергей Олегович Бачурин | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
CN102046625B (zh) | 2008-03-24 | 2015-04-08 | 梅迪维新技术公司 | 桥连杂环化合物及其使用方法 |
BRPI0906244A2 (pt) * | 2008-03-24 | 2015-06-30 | Medivation Technologies Inc | Composto, composição farmacêutica, método para tratar um distúrbio cognitivo, psicótico, mediado por neurotransmissores ou um distúrbio neuronal em um indivíduo, uso de um composto e kit |
EP2272955B1 (de) * | 2008-04-09 | 2015-08-26 | Tokyo Metropolitan Institute of Medical Science | Tdp-43-speicherzellmodell |
RU2374245C1 (ru) * | 2008-08-22 | 2009-11-27 | Андрей Александрович Иващенко | Лиганд с широким спектром одновременной рецепторной активности, фармацевтическая композиция, способ ее получения и лекарственное средство |
EP2340254B8 (de) | 2008-09-15 | 2014-05-21 | Biovista, Inc. | Zusammensetzungen und verfahren zur behandlung von epilepsie |
US9625475B2 (en) | 2008-09-29 | 2017-04-18 | Abbvie Inc. | Indole and indoline derivatives and methods of use thereof |
EP2344505A2 (de) | 2008-09-29 | 2011-07-20 | Abbott Laboratories | Indol- und indolinderivate sowie verwendungsverfahren dafür |
BRPI0919948A2 (pt) | 2008-10-31 | 2015-08-25 | Madivation Technologies Inc | Pirido[4,3-b]indois contendo porções rígidas |
US8569287B2 (en) | 2008-10-31 | 2013-10-29 | Medivation Technologies, Inc. | Azepino[4,5-B]indoles and methods of use |
US20100137215A1 (en) * | 2008-11-25 | 2010-06-03 | Concert Pharmaceuticals Inc. | Novel tetrahydro-1h-pyrido[4,3-b]indoles |
CN107595841A (zh) | 2009-01-09 | 2018-01-19 | 得克萨斯州大学系统董事会 | 前神经原性化合物 |
US9162980B2 (en) | 2009-01-09 | 2015-10-20 | Board Of Regents Of The University Of Texas System | Anti-depression compounds |
US9962368B2 (en) | 2009-01-09 | 2018-05-08 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
US8362277B2 (en) | 2009-01-09 | 2013-01-29 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
EP2396327A1 (de) | 2009-02-11 | 2011-12-21 | Sunovion Pharmaceuticals Inc. | Inverse histamin-h3-agonisten und -antagonisten und verfahren zu ihrer verwendung |
EP2236160A3 (de) | 2009-03-31 | 2011-12-14 | Sanovel Ilac Sanayi ve Ticaret A.S. | Dimebolin enthaltende Zusammensetzungen mit modifizierter Freisetzung |
EP2236159A3 (de) | 2009-03-31 | 2011-12-07 | Sanovel Ilac Sanayi ve Ticaret A.S. | Dimebolin enthaltende Zusammensetzungen mit modifizierter Freisetzung |
TR200903014A1 (tr) | 2009-04-17 | 2010-11-22 | Sanovel İlaç San. Ve Ti̇c. A.Ş. | Oral yolla dağılan dimebolin bileşimleri. |
CA2760516A1 (en) | 2009-04-29 | 2011-02-17 | Medivation Technologies, Inc. | Pyrido[4,3-b]indoles and methods of use |
US9255094B2 (en) | 2009-04-29 | 2016-02-09 | Medivation Technologies, Inc. | Pyrido[4,3-B]indoles and methods of use |
EP2480081A4 (de) | 2009-09-23 | 2013-03-06 | Medivation Technologies Inc | Gebrückte heterocyclische verbindungen und verfahren zu ihrer verwendung |
EP2480078A4 (de) | 2009-09-23 | 2013-03-06 | Medivation Technologies Inc | Pyrido-[4,3-b-]indole und verwendungsverfahren dafür |
CN102724875B (zh) | 2009-09-23 | 2015-05-27 | 梅迪维新技术公司 | 吡啶并[3,4-b]吲哚化合物及其使用方法 |
WO2011039675A2 (en) | 2009-09-30 | 2011-04-07 | Pfizer Inc. | Latrepirdine transdermal therapeutic dosage forms |
WO2011039686A1 (en) | 2009-09-30 | 2011-04-07 | Pfizer Inc. | Latrepirdine oral sustained release dosage forms |
WO2011039670A1 (en) | 2009-09-30 | 2011-04-07 | Pfizer Inc. | Novel forms of (2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1h-pyrido[4,3-b] indole) |
RU2428185C1 (ru) * | 2009-12-29 | 2011-09-10 | Учреждение Российской Академии Наук Институт Физиологически Активных Веществ Ран (Ифав Ран) | ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ ДЛЯ ЛЕЧЕНИЯ НЕЙРОДЕГЕНЕРАТИВНЫХ ЗАБОЛЕВАНИЙ НА ОСНОВЕ ГИДРИРОВАННОГО ПИРИДО(4,3-b)ИНДОЛА, СПОСОБ ЕЕ ПОЛУЧЕНИЯ И ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕЕ ОСНОВЕ |
TR201001117A1 (tr) | 2010-02-15 | 2011-09-21 | Sanovel İlaç San.Ve Ti̇c.A.Ş. | Dimebolin ve memantin kombinasyonları |
US9193728B2 (en) | 2010-02-18 | 2015-11-24 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
US9034865B2 (en) | 2010-02-18 | 2015-05-19 | Medivation Technologies, Inc. | Pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
WO2011103485A1 (en) | 2010-02-18 | 2011-08-25 | Medivation Technologies, Inc. | Fused tetracyclic pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
WO2011103430A1 (en) | 2010-02-19 | 2011-08-25 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
WO2012006419A2 (en) | 2010-07-07 | 2012-01-12 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
WO2012016708A1 (en) | 2010-08-06 | 2012-02-09 | Ratiopharm Gmbh | Oral dosage form comprising dimebolin and donepezil |
WO2012016707A2 (en) | 2010-08-06 | 2012-02-09 | Ratiopharm Gmbh | Oral dosage form for the modified release of dimebolin |
RU2451686C1 (ru) * | 2010-12-27 | 2012-05-27 | Александр Васильевич Иващенко | ЗАМЕЩЕННЫЕ ГИДРИРОВАННЫЕ ТИЕНО-ПИРРОЛО [3,2-c] ПИРИДИНЫ, ЛИГАНДЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ИХ ПРИМЕНЕНИЯ |
US20140155384A1 (en) | 2011-02-18 | 2014-06-05 | Medivation Technologies, Inc. | Compounds and methods of treating diabetes |
US9035056B2 (en) | 2011-02-18 | 2015-05-19 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
AU2012254158B2 (en) | 2011-02-18 | 2016-02-04 | Medivation Technologies, Inc. | Compounds and methods of treating diabetes |
US9434747B2 (en) | 2011-02-18 | 2016-09-06 | Medivation Technologies, Inc. | Methods of treating diabetes |
DE102012003065A1 (de) * | 2012-02-13 | 2013-08-14 | Friedrich-Schiller-Universität Jena | Neue bivalente Gammacarbolinderivate sowie deren Herstellung und Verwendung als Antidementiva |
WO2013130422A1 (en) | 2012-02-27 | 2013-09-06 | Biovista, Inc. | Compositions and methods for treating mitochondrial diseases |
EP2887805A4 (de) * | 2012-08-22 | 2016-08-17 | Medivation Technologies Inc | Verbindungen und verfahren zur behandlung von bluthochdruck |
EP2887803A4 (de) | 2012-08-24 | 2016-08-03 | Univ Texas | Pro-neurogene verbindungen |
WO2014207241A1 (en) * | 2013-06-28 | 2014-12-31 | Alzprotect | NEW Na-SUBSTITUTED CARBOLINE COMPOUNDS USABLE FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES |
EP3068388A4 (de) | 2013-11-11 | 2017-04-12 | Board of Regents of the University of Texas System | Nervenschützende verbindungen und verwendung davon |
WO2015070237A1 (en) | 2013-11-11 | 2015-05-14 | Board Of Regents Of The University Of Texas System | Neuroprotective chemicals and methods for identifying and using same |
EP2918792A1 (de) * | 2014-03-13 | 2015-09-16 | Siemens Aktiengesellschaft | Dampfkraftanlage mit Spindelleckdampfleitung |
CN109535157B (zh) * | 2018-12-03 | 2021-10-15 | 江苏科技大学 | 一种半蜡梅碱类似物、其合成方法及其用途 |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU1138164A1 (ru) * | 1963-04-25 | 1985-02-07 | Shadurskij Konstantin S | Антигистаминное средство "димебон |
DE1813229A1 (de) | 1967-12-08 | 1970-08-20 | Sumitomo Chemical Co | gamma-Carboline und ihre Salze und Verfahren zu ihrer Herstellung |
US3743740A (en) * | 1968-10-31 | 1973-07-03 | I Zhukova | 3,6-dimethyl - 1,2,3,4,4a,9a - hexahydro-ypsilon-carboline dihydrochloride for treating mental diseases |
GB1276113A (en) | 1969-10-17 | 1972-06-01 | Nii Farmakologii I Khim | 3,6-DIMETHYL 1,2,3,4a,9a-HEXAHYDRO-gamma-CARBOLINE DIHYDROCHLORIDE |
DE1952800C3 (de) | 1969-10-20 | 1974-04-18 | Nautschno-Issledowatelskij Institut Farmakologii I Chimioterapii, Moskau | 3,6-Dimethyl-l,2,3,4,4a,9a-hexahydro-gamma-carbolin-dihydrochlorid |
US3718657A (en) * | 1970-12-03 | 1973-02-27 | Abbott Lab | Certain-2-substituted-1,2,3,4-tetrahydro-beta or gamma carbolines |
SE7414572L (de) * | 1973-12-06 | 1975-06-09 | Endo Lab | |
AR205452A1 (es) * | 1973-12-06 | 1976-05-07 | Endo Lab | Metodo para preparar nuevos trans-2, 3, 4, 4a, 5, 9b-hexahidro-5-fenil-1h-pirido(4,3-b) indoles |
US4174453A (en) * | 1973-12-06 | 1979-11-13 | Endo Laboratories, Inc. | Trans-hexahydro-pyrido-indoles |
SE441448B (sv) * | 1977-05-23 | 1985-10-07 | Pfizer | Sett att framstella hexahydro-gamma-karbolinforeningar |
US4636563A (en) * | 1985-09-16 | 1987-01-13 | American Home Products Corporation | Antipsychotic γ-carbolines |
GB8600783D0 (en) | 1986-01-14 | 1986-02-19 | Merck Sharp & Dohme | N-methyl-d-aspartate receptor antagonists |
US4801612A (en) * | 1986-07-03 | 1989-01-31 | Regents Of The University Of California | Method of inhibiting inflammatory response |
US4985256A (en) * | 1988-04-27 | 1991-01-15 | Bionix Corporation | Methods for diagnosing, monitoring and controlling the onset and progression of certain dementias and impeding memory loss or improving impairment of memory |
US6017957A (en) * | 1989-08-08 | 2000-01-25 | The United States Of America As Represented By The Department Of Health And Human Services | Partial agonists of the strychnine insensitive glycine modulatory site of the N-methyl-D-aspartate receptor complex as neuropsychopharmacological agents |
EP0424179A3 (en) | 1989-10-20 | 1991-12-27 | John William Olney | Use of combined excitatory amino acid and cholinergic antagonists to prevent neurological deterioration |
US5455279A (en) * | 1991-04-19 | 1995-10-03 | The Children's Medical Center Corporation | Regimen method of mediating neuronal damage using nitroglycerine |
US5319096A (en) * | 1992-04-03 | 1994-06-07 | Hoechst-Roussel Pharmaceuticals Inc. | (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use |
DE4212529A1 (de) * | 1992-04-10 | 1993-10-14 | Schering Ag | Verwendung von µ-Carbolinen als nicht-kompetitive Glutamat-Antagonisten |
US5248690A (en) | 1992-07-07 | 1993-09-28 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
US6362160B1 (en) * | 1993-06-30 | 2002-03-26 | The Johns Hopkins University School Of Medicine | Immunophilin-binding agents prevent glutamate neurotoxicity associated with vascular stroke and neurodegenerative diseases |
US5587384A (en) * | 1994-02-04 | 1996-12-24 | The Johns Hopkins University | Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity |
US5849761A (en) * | 1995-09-12 | 1998-12-15 | Regents Of The University Of California | Peripherally active anti-hyperalgesic opiates |
RU2140417C1 (ru) | 1995-10-17 | 1999-10-27 | Институт физиологически активных веществ РАН | Производные гидрированных пиридо(4,3-b)индолов, способы их получения, фармацевтическая композиция и способ лечения |
RU2106864C1 (ru) * | 1995-10-23 | 1998-03-20 | Николай Серафимович Зефиров | Средство для лечения болезни альцгеймера |
US6391871B1 (en) * | 1996-09-20 | 2002-05-21 | John W. Olney | Preventing neuronal degeneration in Alzheimer's disease |
US5958919A (en) * | 1996-09-20 | 1999-09-28 | Washington University | Treatment of presymptomatic alzheimer's disease to prevent neuronal degeneration |
US6306909B1 (en) * | 1997-03-12 | 2001-10-23 | Queen's University At Kingston | Anti-epileptogenic agents |
US6379882B1 (en) * | 1998-09-14 | 2002-04-30 | Elan Pharmaceuticals, Inc. | Method for selecting compounds for treating ischemia-related cellular damage |
JP2003517023A (ja) * | 1999-12-16 | 2003-05-20 | バイオジェン インコーポレイテッド | 中枢神経系の虚血性損傷または出血性損傷を、抗α4インテグリンアンタゴニストを用いて処置する方法 |
RU2283108C2 (ru) | 2003-12-08 | 2006-09-10 | Сергей Олегович Бачурин | ГЕРОПРОТЕКТОР НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
-
1995
- 1995-10-23 RU RU95118252A patent/RU2106864C1/ru active
-
1996
- 1996-10-23 US US09/269,602 patent/US6187785B1/en not_active Expired - Lifetime
- 1996-10-23 AU AU73474/96A patent/AU7347496A/en not_active Abandoned
- 1996-10-23 WO PCT/RU1996/000306 patent/WO1997015225A1/ru active IP Right Grant
- 1996-10-23 AT AT96935637T patent/ATE229806T1/de active
- 1996-10-23 ES ES96935637T patent/ES2188793T3/es not_active Expired - Lifetime
- 1996-10-23 DK DK96935637T patent/DK0876818T3/da active
- 1996-10-23 EP EP96935637A patent/EP0876818B1/de not_active Expired - Lifetime
- 1996-10-23 CA CA002269698A patent/CA2269698C/en not_active Expired - Fee Related
- 1996-10-23 DE DE69625518T patent/DE69625518T2/de not_active Expired - Lifetime
-
1999
- 1999-05-11 HK HK99102096A patent/HK1016893A1/xx not_active IP Right Cessation
-
2001
- 2001-02-06 US US09/778,662 patent/US20010020028A1/en not_active Abandoned
-
2002
- 2002-01-23 US US10/057,688 patent/US20020115682A1/en not_active Abandoned
-
2003
- 2003-08-28 US US10/652,435 patent/US20040044022A1/en not_active Abandoned
-
2004
- 2004-12-02 US US11/004,001 patent/US7071206B2/en not_active Expired - Fee Related
-
2006
- 2006-02-24 US US11/361,628 patent/US20060140866A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
HK1016893A1 (en) | 1999-11-12 |
US20020115682A1 (en) | 2002-08-22 |
US7071206B2 (en) | 2006-07-04 |
DE69625518D1 (de) | 2003-01-30 |
US20040044022A1 (en) | 2004-03-04 |
US20060140866A1 (en) | 2006-06-29 |
CA2269698A1 (en) | 1997-05-01 |
WO1997015225A1 (fr) | 1997-05-01 |
RU2106864C1 (ru) | 1998-03-20 |
US6187785B1 (en) | 2001-02-13 |
US20050096342A1 (en) | 2005-05-05 |
AU7347496A (en) | 1997-05-15 |
DE69625518T2 (de) | 2003-09-04 |
EP0876818B1 (de) | 2002-12-18 |
EP0876818A2 (de) | 1998-11-11 |
CA2269698C (en) | 2007-09-18 |
US20010020028A1 (en) | 2001-09-06 |
EP0876818A4 (de) | 1999-01-07 |
ES2188793T3 (es) | 2003-07-01 |
ATE229806T1 (de) | 2003-01-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0876818T3 (da) | Middel til behnadling af nerodegenerative lidelser | |
ES2194960T3 (es) | N-(2-sustituido-3-(2-aminoetil)-1h-indol-5-il)-amidas como nuevos agonistas de 5-ht1f. | |
TR200002773T2 (tr) | Alzheimer tedavisi için smilagenin ve anzurogenin-D ve bunların kullanımı. | |
DK1112106T3 (da) | Serotonerge 5HT2-agonister til behandling af glaukom | |
PE14199A1 (es) | Agonistas de 5-ht1f | |
ES2123521T3 (es) | Derivados de indol. | |
DK0556332T3 (da) | Substituerede tetrahydropyridiner og hydroxypiperidiner som midler til behandling af centralnervesystemet | |
IL169889A0 (en) | Methods for diagnosis and monitoring of neurological disease by detection of an encephalotoxin | |
TR199902257T2 (xx) | Tetrahidropirido bile�ikleri | |
TR200001102T2 (tr) | İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları. | |
FI964045A0 (fi) | CCK:ta tai gastriinia säätelevä 5-heterosykli-1,5-bentsodiatsepiinejä | |
DE69735417D1 (de) | 2,5-dihydroxybenzylsulfonderivate zur behandlung von sexuellen störungen | |
DK0633879T3 (da) | Enantiomert 1-phenyl-2(2-pyridinyl) ethylamin til behandling af neurodegenerative sygdomme | |
FI905957A (fi) | Foerfarande foer framstaellning av substituerade cyklohexener, som verkar pao det centrala nervsystemet. | |
DK0935598T3 (da) | 5-heteroatom-alkylsubstituerede 3-oxopyrido(1,2-a)benzimidazol-4-carboxamidderivater egnede til behandling af sygdomme i centralnervesystemet | |
BR0012921A (pt) | Compostos calcilìticos | |
NO20011892L (no) | 3-tetrahydropyridin-4-yl-indoler for behandling av psykotiske forstyrrelser | |
TWI245756B (en) | Improved process for the preparation of 1,3-substituted indenes | |
RU97115054A (ru) | Средство для лечения онкологических больных | |
PH24501A (en) | Substituted 3-phenyl-7h-thiazolo(3,2-b)(1,2,4)triazin-7-ones | |
BR9909878A (pt) | 10-canfosulfonato de paroxetina para tratamento de distúrbios do sistema nervoso central | |
NO20012538D0 (no) | Anvendelse av N-substituerte azabicycloalkanderivater for behandling av forstyrrelser i sentralnervesystemet | |
ATE321044T1 (de) | C-6 ringsubstituierte pyrido(1,2- a)benzimidazolderivate zur behandlung von störungen des zentralen nervensystems | |
ITPD960038V0 (it) | Associazione di porfirina cationica e sorgente luminosa coerente o noncoerente per il trattamento di infezioni microbiche dell'endodonto e del periimpianto | |
DK0833638T3 (da) | Anvendelse af imidazo[1,5-a]quinoloner som neuroprotektive midler |