EG25226A - Pyridinoylpiperidines as 5-HT1F agon. - Google Patents
Pyridinoylpiperidines as 5-HT1F agon.Info
- Publication number
- EG25226A EG25226A EG2003030289A EG2003030289A EG25226A EG 25226 A EG25226 A EG 25226A EG 2003030289 A EG2003030289 A EG 2003030289A EG 2003030289 A EG2003030289 A EG 2003030289A EG 25226 A EG25226 A EG 25226A
- Authority
- EG
- Egypt
- Prior art keywords
- pyridinoylpiperidines
- ht1f
- agon
- ht1f agon
- Prior art date
Links
- 102100036311 5-hydroxytryptamine receptor 1F Human genes 0.000 title 1
- 101710138086 5-hydroxytryptamine receptor 1F Proteins 0.000 title 1
- RZTAMFZIAATZDJ-UHFFFAOYSA-N felodipine Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC(Cl)=C1Cl RZTAMFZIAATZDJ-UHFFFAOYSA-N 0.000 title 1
- YSWVIKAWHDUJFE-UHFFFAOYSA-N piperidin-1-yl(pyridin-2-yl)methanone Chemical class C=1C=CC=NC=1C(=O)N1CCCCC1 YSWVIKAWHDUJFE-UHFFFAOYSA-N 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36908802P | 2002-03-29 | 2002-03-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EG25226A true EG25226A (en) | 2011-11-17 |
Family
ID=28791923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EG2003030289A EG25226A (en) | 2002-03-29 | 2003-03-26 | Pyridinoylpiperidines as 5-HT1F agon. |
Country Status (31)
| Country | Link |
|---|---|
| US (6) | US7423050B2 (enExample) |
| EP (1) | EP1492786B1 (enExample) |
| JP (2) | JP4493345B2 (enExample) |
| KR (1) | KR100985995B1 (enExample) |
| CN (1) | CN100352817C (enExample) |
| AR (1) | AR039150A1 (enExample) |
| AT (1) | ATE341543T1 (enExample) |
| AU (1) | AU2003224719B2 (enExample) |
| BR (1) | BRPI0308495B8 (enExample) |
| CA (2) | CA2478229C (enExample) |
| CR (1) | CR7496A (enExample) |
| CY (1) | CY1105899T1 (enExample) |
| DE (1) | DE60308850T2 (enExample) |
| DK (1) | DK1492786T3 (enExample) |
| EA (1) | EA007966B1 (enExample) |
| EC (1) | ECSP045317A (enExample) |
| EG (1) | EG25226A (enExample) |
| ES (1) | ES2277074T3 (enExample) |
| HR (1) | HRP20040883B1 (enExample) |
| IL (1) | IL163928A0 (enExample) |
| MX (1) | MXPA04009497A (enExample) |
| MY (1) | MY134666A (enExample) |
| NO (1) | NO330394B1 (enExample) |
| NZ (1) | NZ534952A (enExample) |
| PE (1) | PE20030976A1 (enExample) |
| PL (1) | PL210019B1 (enExample) |
| PT (1) | PT1492786E (enExample) |
| TW (1) | TWI263497B (enExample) |
| UA (1) | UA77504C2 (enExample) |
| WO (1) | WO2003084949A1 (enExample) |
| ZA (1) | ZA200407666B (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI263497B (en) * | 2002-03-29 | 2006-10-11 | Lilly Co Eli | Pyridinoylpiperidines as 5-HT1F agonists |
| WO2004094380A1 (en) | 2003-04-18 | 2004-11-04 | Eli Lilly And Company | (piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-ht1f agonists |
| AU2003903597A0 (en) * | 2003-07-11 | 2003-07-24 | Jakov Vaisman | Treatment of premature ejaculation |
| UA82711C2 (en) | 2003-09-12 | 2008-05-12 | Эли Лилли Энд Компани | Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-ht1f agonists |
| JP2007516266A (ja) * | 2003-12-17 | 2007-06-21 | イーライ リリー アンド カンパニー | ５−ｈｔ１ｆアゴニストとしての置換（４−アミノシクロヘキセン−１−イル）フェニルおよび（４−アミノシクロヘキセン−１−イル）ピリジニル化合物 |
| WO2006022442A1 (ja) * | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
| EP1794130A1 (en) * | 2004-09-20 | 2007-06-13 | Biolipox AB | Pyrazole compounds useful in the treatment of inflammation |
| EP1794145A1 (en) * | 2004-09-20 | 2007-06-13 | Biolipox AB | Pyrazole compounds useful in the treatment of inflammation |
| US20060178349A1 (en) * | 2005-01-24 | 2006-08-10 | Pozen Inc. | Compositions and therapeutic methods utilizing a combination of a 5-HT1F inhibitor and an NSAID |
| TW200800911A (en) * | 2005-10-20 | 2008-01-01 | Biolipox Ab | Pyrazoles useful in the treatment of inflammation |
| WO2007051982A1 (en) * | 2005-10-31 | 2007-05-10 | Biolipox Ab | Triazole compounds as lipoxygenase inhibitors |
| TW200732320A (en) * | 2005-10-31 | 2007-09-01 | Biolipox Ab | Pyrazoles useful in the treatment of inflammation |
| EP1943225A1 (en) * | 2005-11-01 | 2008-07-16 | Biolipox AB | Pyrazoles useful in the treatment of inflammation |
| WO2007093540A1 (en) | 2006-02-17 | 2007-08-23 | F. Hoffmann-La Roche Ag | Benzoyl-piperidine derivatives as 5ht2/d3 modulators |
| LT2413933T (lt) | 2009-04-02 | 2018-02-26 | Colucid Pharmaceuticals, Inc. | 2,4,6-trifluor-n-[6-(1-metil-piperidin-4-karbonil)-piridin-2-il]-benzamidas, skirtas migrenos gydymui peroraliniu ar intraveniniu keliu |
| US8429652B2 (en) | 2009-06-22 | 2013-04-23 | Citrix Systems, Inc. | Systems and methods for spillover in a multi-core system |
| CA2795062A1 (en) | 2010-04-02 | 2011-10-06 | Colucid Pharmaceuticals, Inc. | Compositions and methods of synthesis of pyridinoylpiperidine 5-ht1f agonists |
| WO2012068209A2 (en) | 2010-11-18 | 2012-05-24 | Janssen Pharmaceutica Nv | Bisthiazole inhibitors of pro-matrix metalloproteinase activation |
| CN102993086A (zh) * | 2012-10-11 | 2013-03-27 | 南通市华峰化工有限责任公司 | 一种2，6-二溴吡啶的合成方法 |
| CN108137536A (zh) * | 2016-07-15 | 2018-06-08 | 杭州领业医药科技有限公司 | 一种受体激动剂的晶型及其制备方法和药物组合物 |
| CA3036632A1 (en) | 2016-09-23 | 2018-03-29 | Teva Pharmaceuticals International Gmbh | Treating refractory migraine |
| CN108137605B (zh) | 2016-10-05 | 2021-07-13 | 杭州领业医药科技有限公司 | Acp-196的晶型及其制备方法和药物组合物 |
| US11014892B2 (en) | 2016-11-02 | 2021-05-25 | Musc Foundation For Research Development | 5HT1F receptor agonists and mitochondrial biogenesis |
| NZ752906A (en) * | 2016-12-06 | 2021-07-30 | Colucid Pharmaceuticals Inc | Compositions and methods related to pyridinoylpiperidine 5-ht1f agonists |
| CA3049319A1 (en) | 2017-01-13 | 2018-07-19 | Sumitomo Dainippon Pharma Co., Ltd. | Therapeutic agent for non-motor symptoms associated with parkinson's disease |
| US10899770B2 (en) | 2017-02-20 | 2021-01-26 | Hangzhou Solipharma Co., Ltd. | Crystal form of ACP-196 salt and preparation method, pharmaceutical composition, and use thereof |
| MA49014A (fr) * | 2017-03-21 | 2020-02-05 | Arbutus Biopharma Corp | Dihydroindène-4-carboxamides substitués, leurs analogues et procédés d'utilisation correspondant |
| TWI754772B (zh) | 2017-09-06 | 2022-02-11 | 美商美國禮來大藥廠 | 用於治療偏頭痛之拉米迪坦(lasmiditan)與cgrp拮抗劑之組合療法 |
| CN110386918B (zh) * | 2018-04-23 | 2020-06-09 | 新发药业有限公司 | 一种5-ht1f激动剂化合物的制备方法 |
| JP7405834B2 (ja) * | 2018-08-24 | 2023-12-26 | サンシャイン・レイク・ファーマ・カンパニー・リミテッド | ピリジニルメチレンピペリジン誘導体及びその使用 |
| TWI826514B (zh) * | 2018-09-04 | 2023-12-21 | 美商美國禮來大藥廠 | 用於預防偏頭痛之拉米迪坦(lasmiditan)長期夜間投藥 |
| WO2020095171A1 (en) * | 2018-11-05 | 2020-05-14 | Glenmark Life Sciences Limited, Glenmark Pharmaceuticals Limited | Process for preparation of lasmiditan |
| ES2801774B2 (es) | 2019-07-01 | 2022-03-30 | Moehs Iberica Sl | 2,2-dimetil-n-[6-(1-metil-piperidin-4-carbonil)-piridin-2-il]-propionamida, procedimiento para la preparacion de (6-amino-piridin-2-il)-(1-metil-piperidin-4-il)-metanona usando dicho compuesto y uso de dicho compuesto en la preparacion de lasmiditan |
| AR119319A1 (es) * | 2019-07-09 | 2021-12-09 | Lilly Co Eli | Procesos e intermediario para la preparación a gran escala de hemisuccinato de 2,4,6-trifluoro-n-[6-(1-metil-piperidina-4-carbonil)-piridin-2-il]-benzamida y preparación de acetato de 2,4,6-trifluoro-n-[6-(1-metil-piperidina-4-carbonil)-piridin-2-il]-benzamida |
| CN110981854B (zh) * | 2019-09-10 | 2023-03-28 | 南京三元阳普医药科技有限公司 | 2-氨基-6-(1-烷基哌啶-4-羰基)吡啶类化合物的合成方法 |
| CN111187251B (zh) * | 2019-11-22 | 2023-06-09 | 广东东阳光药业有限公司 | 吡啶酰基哌啶衍生物及其用途 |
| CN110845402B (zh) * | 2019-11-22 | 2023-05-09 | 广东东阳光药业有限公司 | 吡啶亚甲基哌嗪衍生物及其用途 |
| CN114728929A (zh) * | 2019-11-22 | 2022-07-08 | 广东东阳光药业有限公司 | 吡啶亚甲基哌啶衍生物及其用途 |
| CN111187252B (zh) * | 2019-11-22 | 2023-06-09 | 广东东阳光药业有限公司 | 吡啶酰基氮杂螺庚烷衍生物及其用途 |
| IT201900023937A1 (it) | 2019-12-13 | 2021-06-13 | Olon Spa | Procedimento per la preparazione di Lasmiditan e di un intermedio di sintesi |
| CN113045540B (zh) * | 2019-12-27 | 2024-02-13 | 上海天慈国际药业有限公司 | 一种拉司米地坦的制备方法 |
| WO2021152462A1 (en) | 2020-01-31 | 2021-08-05 | Glenmark Life Sciences Limited | Process for preparation of lasmiditan |
| CN113637003B (zh) * | 2020-05-11 | 2024-03-19 | 鲁南制药集团股份有限公司 | 一种制备2-氨基-6-（哌啶-4-酰基）吡啶衍生物的方法 |
| CN111943930B (zh) * | 2020-08-25 | 2022-11-01 | 南京三元阳普医药科技有限公司 | Lasmiditan的合成工艺 |
| WO2022079591A1 (en) * | 2020-10-14 | 2022-04-21 | Alembic Pharmaceuticals Limited | Pharmaceutical composition of lasmiditan and process of preparation thereof |
| CN114573555A (zh) * | 2020-11-30 | 2022-06-03 | 上海天慈国际药业有限公司 | 一种用于治疗偏头痛的化合物的制备方法 |
| CN114685439B (zh) * | 2020-12-30 | 2025-07-22 | 鲁南制药集团股份有限公司 | 一种拉司米地坦的制备方法 |
| BR112023022680A2 (pt) | 2021-05-07 | 2024-01-23 | Lilly Co Eli | Composições com sabor mascarado de hemissuccinato de 2,4,6-trifluoro-n-[6-(1-metil-piperidin-4-carbonil)-piridin-2-il]-benzamida, comprimido desintegrante oralmente compreendendo o mesmo, seus usos, e processo para fabricação de comprimido |
| CN115594665A (zh) * | 2021-07-08 | 2023-01-13 | 北京万全德众医药生物技术有限公司（Cn） | 拉司米地坦的新制备方法 |
| IT202100023861A1 (it) | 2021-09-16 | 2023-03-16 | Procos Spa | Processo per la preparazione di (6-alopiridin-2-il)(1-metilpiperidin-4-il)metanone |
| CN113866318B (zh) * | 2021-10-21 | 2023-07-04 | 佛山奕安赛医药科技有限公司 | 一种(6-氨基吡啶-2-基)(1-甲基哌啶-4-基)甲酮双盐酸盐的检测方法 |
| CN116239569B (zh) * | 2021-12-07 | 2025-11-21 | 山东新时代药业有限公司 | 一种半琥珀酸拉司米地坦晶型及其制备方法 |
| CN116239570B (zh) * | 2021-12-08 | 2025-11-25 | 山东新时代药业有限公司 | 一种半琥珀酸拉司米地坦新晶型 |
| WO2023152081A1 (en) | 2022-02-09 | 2023-08-17 | Inke, S.A. | Process for preparing pyridinoylpiperidines 5-ht1f agonists and salts thereof |
| WO2025240390A1 (en) * | 2024-05-13 | 2025-11-20 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Mary1 and derivatives thereof for the treatment of mitochondrial dysfunction, vascular injury, kidney diseases, and organ aging |
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| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| JPH03255426A (ja) | 1990-03-06 | 1991-11-14 | Toshiba Corp | 有機非線形光学材料 |
| US5385912A (en) * | 1991-03-08 | 1995-01-31 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Multicyclic tertiary amine polyaromatic squalene synthase inhibitors |
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