AU2003224719B2 - Pyridinoylpiperidines as 5-HT1F agonists - Google Patents

Pyridinoylpiperidines as 5-HT1F agonists Download PDF

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Publication number
AU2003224719B2
AU2003224719B2 AU2003224719A AU2003224719A AU2003224719B2 AU 2003224719 B2 AU2003224719 B2 AU 2003224719B2 AU 2003224719 A AU2003224719 A AU 2003224719A AU 2003224719 A AU2003224719 A AU 2003224719A AU 2003224719 B2 AU2003224719 B2 AU 2003224719B2
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compound
methyl
substituted
halo
carbonyl
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AU2003224719A1 (en
Inventor
Michael Philip Cohen
Daniel Timothy Kohlman
Sidney Xi Liang
Vincent Mancuso
Frantz Victor
Yao-Chang Xu
Bai-Ping Ying
Deanna Piatt Zacherl
Deyi Zhang
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Eli Lilly and Co
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Eli Lilly and Co
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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    • A—HUMAN NECESSITIES
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
AU2003224719A 2002-03-29 2003-03-27 Pyridinoylpiperidines as 5-HT1F agonists Expired AU2003224719B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36908802P 2002-03-29 2002-03-29
US60/369,088 2002-03-29
PCT/US2003/008455 WO2003084949A1 (en) 2002-03-29 2003-03-27 Pyridinoylpiperidines as 5-ht1f agonists

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AU2003224719A1 AU2003224719A1 (en) 2003-10-20
AU2003224719B2 true AU2003224719B2 (en) 2008-08-14

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EP (1) EP1492786B1 (enExample)
JP (2) JP4493345B2 (enExample)
KR (1) KR100985995B1 (enExample)
CN (1) CN100352817C (enExample)
AR (1) AR039150A1 (enExample)
AT (1) ATE341543T1 (enExample)
AU (1) AU2003224719B2 (enExample)
BR (1) BRPI0308495B8 (enExample)
CA (2) CA2478229C (enExample)
CR (1) CR7496A (enExample)
CY (1) CY1105899T1 (enExample)
DE (1) DE60308850T2 (enExample)
DK (1) DK1492786T3 (enExample)
EA (1) EA007966B1 (enExample)
EC (1) ECSP045317A (enExample)
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IL (1) IL163928A0 (enExample)
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NO (1) NO330394B1 (enExample)
NZ (1) NZ534952A (enExample)
PE (1) PE20030976A1 (enExample)
PL (1) PL210019B1 (enExample)
PT (1) PT1492786E (enExample)
TW (1) TWI263497B (enExample)
UA (1) UA77504C2 (enExample)
WO (1) WO2003084949A1 (enExample)
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CN113637003B (zh) * 2020-05-11 2024-03-19 鲁南制药集团股份有限公司 一种制备2-氨基-6-（哌啶-4-酰基）吡啶衍生物的方法
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CN114685439B (zh) * 2020-12-30 2025-07-22 鲁南制药集团股份有限公司 一种拉司米地坦的制备方法
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CN115594665A (zh) * 2021-07-08 2023-01-13 北京万全德众医药生物技术有限公司（Cn） 拉司米地坦的新制备方法
IT202100023861A1 (it) 2021-09-16 2023-03-16 Procos Spa Processo per la preparazione di (6-alopiridin-2-il)(1-metilpiperidin-4-il)metanone
CN113866318B (zh) * 2021-10-21 2023-07-04 佛山奕安赛医药科技有限公司 一种(6-氨基吡啶-2-基)(1-甲基哌啶-4-基)甲酮双盐酸盐的检测方法
CN116239569B (zh) * 2021-12-07 2025-11-21 山东新时代药业有限公司 一种半琥珀酸拉司米地坦晶型及其制备方法
CN116239570B (zh) * 2021-12-08 2025-11-25 山东新时代药业有限公司 一种半琥珀酸拉司米地坦新晶型
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