EE05428B1 - Protsess ülipuhta perindopriili ja sünteesi kasulike vaheühendite valmistamiseks - Google Patents
Protsess ülipuhta perindopriili ja sünteesi kasulike vaheühendite valmistamiseksInfo
- Publication number
- EE05428B1 EE05428B1 EEP200400107A EEP200400107A EE05428B1 EE 05428 B1 EE05428 B1 EE 05428B1 EE P200400107 A EEP200400107 A EE P200400107A EE P200400107 A EEP200400107 A EE P200400107A EE 05428 B1 EE05428 B1 EE 05428B1
- Authority
- EE
- Estonia
- Prior art keywords
- synthesis
- preparation
- highly pure
- useful intermediates
- pure perindopril
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title 1
- 229960002582 perindopril Drugs 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02290206A EP1333026B1 (en) | 2002-01-30 | 2002-01-30 | Process for the preparation of high purity perindopril and intermediates useful in the synthesis |
| PCT/IB2003/000691 WO2003064388A2 (en) | 2002-01-30 | 2003-01-29 | Process for the preparation of high purity perindopril and intermediates useful in the synthesis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE200400107A EE200400107A (et) | 2004-10-15 |
| EE05428B1 true EE05428B1 (et) | 2011-06-15 |
Family
ID=8185713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200400107A EE05428B1 (et) | 2002-01-30 | 2003-01-29 | Protsess ülipuhta perindopriili ja sünteesi kasulike vaheühendite valmistamiseks |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US7326794B2 (cs) |
| EP (1) | EP1333026B1 (cs) |
| JP (1) | JP4171423B2 (cs) |
| KR (1) | KR100673701B1 (cs) |
| CN (1) | CN1300111C (cs) |
| AP (1) | AP1741A (cs) |
| AR (1) | AR038340A1 (cs) |
| AT (1) | ATE365714T1 (cs) |
| AU (1) | AU2003206055B2 (cs) |
| BG (1) | BG66126B1 (cs) |
| BR (2) | BR0307293A (cs) |
| CA (1) | CA2474003C (cs) |
| CY (1) | CY1106721T1 (cs) |
| CZ (1) | CZ305892B6 (cs) |
| DE (1) | DE60220877T2 (cs) |
| DK (1) | DK1333026T3 (cs) |
| EA (1) | EA009277B1 (cs) |
| EE (1) | EE05428B1 (cs) |
| ES (1) | ES2289060T3 (cs) |
| GE (1) | GEP20063899B (cs) |
| HR (1) | HRP20040781A8 (cs) |
| HU (1) | HU227591B1 (cs) |
| ME (1) | ME00444B (cs) |
| MX (1) | MXPA04007444A (cs) |
| NO (1) | NO330223B1 (cs) |
| NZ (1) | NZ534168A (cs) |
| OA (1) | OA12759A (cs) |
| PL (1) | PL212354B1 (cs) |
| PT (1) | PT1333026E (cs) |
| RS (1) | RS52465B (cs) |
| SI (1) | SI1333026T1 (cs) |
| SK (1) | SK287866B6 (cs) |
| UA (1) | UA77756C2 (cs) |
| WO (1) | WO2003064388A2 (cs) |
| ZA (1) | ZA200405548B (cs) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60330603D1 (de) * | 2003-10-21 | 2010-01-28 | Servier Lab | Verfahren zur herstellung kristallinem perindopril erbumin |
| SI21704A (en) * | 2004-01-14 | 2005-08-31 | Lek Farmacevtska Druzba Dd | New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia |
| ES2603856T3 (es) * | 2004-03-29 | 2017-03-01 | Les Laboratoires Servier | Procedimiento para preparar una composición farmacéutica sólida |
| SI21800A (sl) | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
| SI21881A (sl) | 2004-10-15 | 2006-04-30 | Diagen, Smartno Pri Ljubljani, D.O.O. | Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine |
| ES2255872B1 (es) * | 2004-12-31 | 2007-08-16 | Quimica Sintetica, S.A. | Procedimiento para la preparacion de perindopril erbumina. |
| DE602005009918D1 (de) | 2005-01-06 | 2008-11-06 | Ipca Lab Ltd | Verfahren zur Synthese von (2S,3aS,7aS)-1-(S)-Alanyl-octahydro-1H-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril |
| US7710739B2 (en) | 2005-04-28 | 2010-05-04 | Semiconductor Energy Laboratory Co., Ltd. | Semiconductor device and display device |
| WO2006137082A1 (en) * | 2005-06-23 | 2006-12-28 | Ramesh Babu Potluri | Process for industrially viable preparation of perindopril erbumine |
| US20070032661A1 (en) * | 2005-08-03 | 2007-02-08 | Glenmark Pharmaceuticals Limited | Process for the preparation of intermediates of perindopril |
| CA2618561C (en) * | 2005-08-12 | 2014-04-29 | Lek Pharmaceuticals D.D. | A process for the preparation of perindopril erbumine |
| EP1792896A1 (en) * | 2005-12-01 | 2007-06-06 | KRKA, tovarna zdravil, d.d., Novo mesto | Process for the preparation of perindopril and salts thereof |
| EP2044010B1 (en) * | 2006-05-12 | 2014-01-08 | EGIS Gyógyszergyár Nyilvánosan Müködõ Részvénytársaság | New pharmaceutical intermediates in the synthesis of ace-inihibitors and the use thereof |
| WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
| PH12018502155B1 (en) | 2016-04-20 | 2024-03-27 | Servier Lab | Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK144769C (da) | 1979-12-06 | 1982-12-13 | Voelund Vaskerimaskiner | Tromlevaskemaskine med varmeveksler |
| US4565819A (en) * | 1979-12-07 | 1986-01-21 | Adir | Substituted imino diacids, their preparation and pharmaceutical compositions which contain them |
| FR2503155A2 (fr) * | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| IN156096B (cs) | 1981-03-19 | 1985-05-11 | Usv Pharma Corp | |
| FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
| SI9600169A (en) | 1996-05-22 | 1997-12-31 | Krka Tovarna Zdravil | Process for preparation of compounds with ace inhibitory effect |
| FR2807431B1 (fr) | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
| FR2827860B1 (fr) | 2001-07-24 | 2004-12-10 | Servier Lab | Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril |
| AR036187A1 (es) | 2001-07-24 | 2004-08-18 | Adir | Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario |
-
2002
- 2002-01-30 PT PT02290206T patent/PT1333026E/pt unknown
- 2002-01-30 DK DK02290206T patent/DK1333026T3/da active
- 2002-01-30 SI SI200230586T patent/SI1333026T1/sl unknown
- 2002-01-30 AT AT02290206T patent/ATE365714T1/de active
- 2002-01-30 DE DE60220877T patent/DE60220877T2/de not_active Expired - Lifetime
- 2002-01-30 ES ES02290206T patent/ES2289060T3/es not_active Expired - Lifetime
- 2002-01-30 EP EP02290206A patent/EP1333026B1/en not_active Expired - Lifetime
-
2003
- 2003-01-29 BR BR0307293-2A patent/BR0307293A/pt not_active IP Right Cessation
- 2003-01-29 HU HU0300231A patent/HU227591B1/hu not_active IP Right Cessation
- 2003-01-29 KR KR1020047011731A patent/KR100673701B1/ko not_active Expired - Fee Related
- 2003-01-29 JP JP2003564011A patent/JP4171423B2/ja not_active Expired - Fee Related
- 2003-01-29 GE GE5686A patent/GEP20063899B/en unknown
- 2003-01-29 OA OA1200400196A patent/OA12759A/en unknown
- 2003-01-29 SK SK329-2004A patent/SK287866B6/sk not_active IP Right Cessation
- 2003-01-29 ME MEP-2008-674A patent/ME00444B/me unknown
- 2003-01-29 ZA ZA200405548A patent/ZA200405548B/xx unknown
- 2003-01-29 PL PL358514A patent/PL212354B1/pl unknown
- 2003-01-29 UA UA20040807143A patent/UA77756C2/uk unknown
- 2003-01-29 EA EA200400929A patent/EA009277B1/ru not_active IP Right Cessation
- 2003-01-29 MX MXPA04007444A patent/MXPA04007444A/es active IP Right Grant
- 2003-01-29 AU AU2003206055A patent/AU2003206055B2/en not_active Ceased
- 2003-01-29 BR BRPI0307293-2A patent/BRPI0307293B1/pt unknown
- 2003-01-29 HR HR20040781A patent/HRP20040781A8/xx not_active IP Right Cessation
- 2003-01-29 CZ CZ2004-906A patent/CZ305892B6/cs not_active IP Right Cessation
- 2003-01-29 CN CNB038027143A patent/CN1300111C/zh not_active Expired - Fee Related
- 2003-01-29 US US10/503,272 patent/US7326794B2/en not_active Expired - Fee Related
- 2003-01-29 NZ NZ534168A patent/NZ534168A/en not_active IP Right Cessation
- 2003-01-29 AP APAP/P/2004/003091A patent/AP1741A/en active
- 2003-01-29 CA CA002474003A patent/CA2474003C/en not_active Expired - Fee Related
- 2003-01-29 EE EEP200400107A patent/EE05428B1/xx not_active IP Right Cessation
- 2003-01-29 WO PCT/IB2003/000691 patent/WO2003064388A2/en active Application Filing
- 2003-01-29 RS YU66704A patent/RS52465B/en unknown
- 2003-01-30 AR ARP030100263A patent/AR038340A1/es not_active Application Discontinuation
-
2004
- 2004-08-20 NO NO20043472A patent/NO330223B1/no not_active IP Right Cessation
- 2004-08-27 BG BG108858A patent/BG66126B1/bg unknown
-
2007
- 2007-04-20 US US11/788,454 patent/US7279595B2/en not_active Expired - Fee Related
- 2007-07-12 CY CY20071100925T patent/CY1106721T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapsed by not paying the annual fees |
Effective date: 20200129 |