EE04854B1 - Oksabispidiinühendid, nende valmistamise meetod ning ravimvorm kasutamiseks südame arütmia raviks ja profülaktikaks - Google Patents

Oksabispidiinühendid, nende valmistamise meetod ning ravimvorm kasutamiseks südame arütmia raviks ja profülaktikaks

Info

Publication number
EE04854B1
EE04854B1 EEP200200203A EEP200200203A EE04854B1 EE 04854 B1 EE04854 B1 EE 04854B1 EE P200200203 A EEP200200203 A EE P200200203A EE P200200203 A EEP200200203 A EE P200200203A EE 04854 B1 EE04854 B1 EE 04854B1
Authority
EE
Estonia
Prior art keywords
prophylaxis
formulations
treatment
methods
cardiac arrhythmias
Prior art date
Application number
EEP200200203A
Other languages
English (en)
Estonian (et)
Inventor
Bj�re Annika
Bj�rsne Magnus
Cladingboel David
Hoffmann Kurt-J�rgen
Pavey John
Pont�n Fritiof
Strandlund Gert
Svensson Peder
Thomson Colin
Wilstermann Michael
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of EE200200203A publication Critical patent/EE200200203A/xx
Publication of EE04854B1 publication Critical patent/EE04854B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
EEP200200203A 1999-10-18 2000-10-13 Oksabispidiinühendid, nende valmistamise meetod ning ravimvorm kasutamiseks südame arütmia raviks ja profülaktikaks EE04854B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9903759A SE9903759D0 (sv) 1999-10-18 1999-10-18 Pharmaceutically active compounds
PCT/SE2000/001994 WO2001028992A2 (en) 1999-10-18 2000-10-13 New oxabispidine compounds useful in the treatment of cardiac arrhythmias

Publications (2)

Publication Number Publication Date
EE200200203A EE200200203A (et) 2003-06-16
EE04854B1 true EE04854B1 (et) 2007-06-15

Family

ID=20417401

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200203A EE04854B1 (et) 1999-10-18 2000-10-13 Oksabispidiinühendid, nende valmistamise meetod ning ravimvorm kasutamiseks südame arütmia raviks ja profülaktikaks

Country Status (41)

Country Link
US (6) US6559143B1 (uk)
EP (2) EP1235831B1 (uk)
JP (3) JP3973906B2 (uk)
KR (1) KR100796142B1 (uk)
CN (2) CN101265262A (uk)
AP (1) AP1536A (uk)
AR (2) AR026064A1 (uk)
AT (1) ATE292134T1 (uk)
AU (1) AU769513B2 (uk)
BG (1) BG65785B1 (uk)
BR (1) BR0014804A (uk)
CA (1) CA2386910A1 (uk)
CO (1) CO5271655A1 (uk)
CU (1) CU23210A3 (uk)
CZ (1) CZ20021328A3 (uk)
DE (1) DE60019158T2 (uk)
DK (1) DK1235831T3 (uk)
EA (1) EA005319B1 (uk)
EE (1) EE04854B1 (uk)
ES (1) ES2239047T3 (uk)
HK (1) HK1049003B (uk)
HR (1) HRP20020336B1 (uk)
HU (1) HUP0204085A3 (uk)
IL (5) IL149108A0 (uk)
IS (2) IS2224B (uk)
MX (1) MXPA02003848A (uk)
MY (1) MY130661A (uk)
NO (1) NO327977B1 (uk)
NZ (2) NZ531260A (uk)
OA (1) OA12067A (uk)
PL (1) PL354970A1 (uk)
PT (1) PT1235831E (uk)
RS (1) RS50760B (uk)
SE (1) SE9903759D0 (uk)
SI (1) SI1235831T1 (uk)
SK (1) SK286723B6 (uk)
TR (1) TR200201059T2 (uk)
TW (1) TWI283680B (uk)
UA (1) UA75052C2 (uk)
WO (1) WO2001028992A2 (uk)
ZA (1) ZA200202575B (uk)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas
SE0101329D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab Pharmaceutical formulation
TWI259836B (en) * 2001-04-12 2006-08-11 Astrazeneca Ab Modified release formulation suitable for antiarrhythmic compounds
SE0101324D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab New process
SE0101327D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
SE0101323D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
BR0214225A (pt) * 2001-11-22 2004-09-21 Astrazeneca Ab Processos para a preparação e para a formação de um composto, e, composto
SE0201373D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Combination therapy
SE0201374D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Pharmaceutical combination
SE0201662D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Pharmaceutical combination
GB0223712D0 (en) * 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate
SE0401540D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SE0401539D0 (sv) 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
AR057064A1 (es) * 2005-06-13 2007-11-14 Astrazeneca Ab Compuestos para el tratamiento de arritmias cardiacas, formulacion farmaceutica y preparacion del compuesto
AR053901A1 (es) * 2005-06-20 2007-05-23 Astrazeneca Ab Formas fisicas de oxabispidinas n,n'- disustituidas
WO2006137769A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab Process for the preparation of 3,7-dihydroxy-1,5-diazacyclooctanes
BRPI0611841A2 (pt) * 2005-06-20 2016-08-30 Astrazeneca Ab processos para isolar um sal, para preparar um sal, e para a preparação de um composto
EP1915380A4 (en) * 2005-06-20 2010-03-17 Astrazeneca Ab PROCESS FOR THE SYNTHESIS OF N, N'-DISUBSTITUTED OXABISPIDINES
CN1330636C (zh) * 2005-09-26 2007-08-08 鲁南制药集团股份有限公司 盐酸替罗非班中间体的合成方法
TW200734342A (en) * 2005-12-15 2007-09-16 Astrazeneca Ab New compounds for the treatment of cardiac arrhythmias
TW201004963A (en) * 2008-07-03 2010-02-01 Targacept Inc Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands
GB2495308B (en) * 2011-10-05 2014-09-10 John Royce Method and apparatus for cleaning a filter
PE20161035A1 (es) 2013-03-15 2016-11-13 Global Blood Therapeutics Inc Compuestos y usos de estos para la modulacion de la hemoglobina
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
US10231970B2 (en) 2014-09-30 2019-03-19 NV Heterocycles Methods of producing heteropolycycles via bis-epoxidation

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3196154A (en) * 1962-05-17 1965-07-20 Sterling Drug Inc 3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes
US3503939A (en) 1967-03-29 1970-03-31 Du Pont Polyamides from heterocyclic diamines
CH488048A (de) 1969-06-12 1970-03-31 Inventa Ag Verfahren zur Herstellung von Polyesterfasern mit verbesserter Gummihaftung
JPS5772977A (en) * 1980-10-23 1982-05-07 Dainippon Ink & Chem Inc Fluorine-containing diepoxy compound and its preparation
DE3112055A1 (de) * 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
US4533713A (en) * 1983-05-06 1985-08-06 Minnesota Mining And Manufacturing Company Fluoroaliphaticsulfonamides containing oxirane groups and/or N-β-hydroxyalkylene groups
FI67320C (fi) * 1983-05-09 1985-03-11 Partek Ab Foerfarande och glidgjutanordning foer gjutning av betongstycken
JPS6284071A (ja) * 1985-10-07 1987-04-17 Kanegafuchi Chem Ind Co Ltd 新規グリシジル化合物及びその製造方法
JPS6284070A (ja) * 1985-10-07 1987-04-17 Kanegafuchi Chem Ind Co Ltd 新規なグリシジル化合物及びその製造法
DE3732094A1 (de) 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
US5140033A (en) 1989-04-03 1992-08-18 Bayer Aktiengesellschaft Antibacterial 5-alkylquinolonecarboxylic acids
US5110933A (en) 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
FR2664270B1 (fr) * 1990-07-09 1994-04-08 Norsolor Sa Nouveaux composes (meth)acryliques porteurs de fonction thiocyanate, leur procede de preparation et leur application a l'obtention de nouveaux polymeres.
JP2602745B2 (ja) * 1991-06-26 1997-04-23 花王株式会社 フレキシブルディスク用センターハブのピッキング装置
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
US5831099A (en) * 1995-03-10 1998-11-03 The United States Of America As Represented By The Secretary Of The Army Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same
SE9704709D0 (sv) * 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds
SE9803517D0 (sv) * 1998-10-15 1998-10-15 Astra Ab Pharmaceutical preparation
NZ514477A (en) 1999-04-09 2003-04-29 Astrazeneca Ab Adamantane derivatives
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
SE9904765D0 (sv) * 1999-12-23 1999-12-23 Astra Ab Pharmaceutically-useful compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas

Also Published As

Publication number Publication date
EP1235831B1 (en) 2005-03-30
IL149108A0 (en) 2002-11-10
ATE292134T1 (de) 2005-04-15
HK1049003A1 (en) 2003-04-25
IS2224B (is) 2007-04-15
YU29402A (sh) 2004-12-31
IL183854A0 (en) 2009-02-11
KR100796142B1 (ko) 2008-01-21
AR026064A1 (es) 2002-12-26
HUP0204085A2 (hu) 2003-04-28
HRP20020336A2 (en) 2004-02-29
EA005319B1 (ru) 2005-02-24
TR200201059T2 (tr) 2002-09-23
IS8586A (is) 2006-12-27
EP1559717A3 (en) 2009-04-29
AU769513B2 (en) 2004-01-29
IS6346A (is) 2002-04-17
JP3973906B2 (ja) 2007-09-12
US20030153564A1 (en) 2003-08-14
HK1049003B (zh) 2005-09-09
WO2001028992A2 (en) 2001-04-26
CZ20021328A3 (cs) 2002-09-11
US20090326221A1 (en) 2009-12-31
UA75052C2 (en) 2006-03-15
NZ531260A (en) 2005-08-26
NO20021811D0 (no) 2002-04-17
US20070117799A1 (en) 2007-05-24
BG106588A (en) 2003-01-31
SK286723B6 (sk) 2009-04-06
HRP20020336B1 (en) 2006-02-28
AR039226A2 (es) 2005-02-09
AP2002002471A0 (en) 2002-06-30
AU1069101A (en) 2001-04-30
CO5271655A1 (es) 2003-04-30
CN101265262A (zh) 2008-09-17
HUP0204085A3 (en) 2006-01-30
EP1235831A2 (en) 2002-09-04
BR0014804A (pt) 2002-06-11
NO327977B1 (no) 2009-11-02
DK1235831T3 (da) 2005-06-27
ZA200202575B (en) 2003-09-23
US6559143B1 (en) 2003-05-06
DE60019158T2 (de) 2006-02-02
TWI283680B (en) 2007-07-11
MY130661A (en) 2007-07-31
PT1235831E (pt) 2005-06-30
US7351821B2 (en) 2008-04-01
JP2006342182A (ja) 2006-12-21
IL183852A0 (en) 2009-02-11
ES2239047T3 (es) 2005-09-16
KR20020038956A (ko) 2002-05-24
DE60019158D1 (de) 2005-05-04
US7164017B2 (en) 2007-01-16
EA200200390A1 (ru) 2002-10-31
NO20021811L (no) 2002-06-06
WO2001028992A3 (en) 2001-09-13
SI1235831T1 (uk) 2005-08-31
US7772229B2 (en) 2010-08-10
CN1399639A (zh) 2003-02-26
CA2386910A1 (en) 2001-04-26
RS50760B (sr) 2010-08-31
IL149108A (en) 2009-12-24
PL354970A1 (en) 2004-03-22
EP1559717A2 (en) 2005-08-03
MXPA02003848A (es) 2002-10-23
US20060166979A1 (en) 2006-07-27
NZ518156A (en) 2004-05-28
OA12067A (en) 2006-05-04
SE9903759D0 (sv) 1999-10-18
CU23210A3 (es) 2007-06-20
SK5062002A3 (en) 2002-11-06
EE200200203A (et) 2003-06-16
IL183853A0 (en) 2009-02-11
AP1536A (en) 2006-01-09
JP2007204486A (ja) 2007-08-16
BG65785B1 (bg) 2009-11-30
CN100379743C (zh) 2008-04-09
US20060166980A1 (en) 2006-07-27
JP2003512352A (ja) 2003-04-02

Similar Documents

Publication Publication Date Title
EE04854B1 (et) Oksabispidiinühendid, nende valmistamise meetod ning ravimvorm kasutamiseks südame arütmia raviks ja profülaktikaks
EE200300504A (et) 3,7-diasabitsüklo[3.3.1]preparaadid, nende valmistamise meetod ja nimetatud preparaatide kasutaminesüdame arütmiate profülaktikas või ravis
EE200200305A (et) Südame arütmiate ravis kasutatavad uued asabitsüklooktaani derivaadid
EE200300364A (et) 3,7-diasabitsüklo[3,3,0]oktaanid ja nende kasutamine südame arütmiate ravis
HUP0302288A3 (en) New oxabispidine compound useful in the treatment of cardiac arrhythmias
EE200300495A (et) 3,7-diasabitsüklo[3.3.1]preparaadid, nende valmistamise meetod ja nimetatud preparaatide kasutaminesüdame arütmiate profülaktikas või ravis
EE200300506A (et) 3,7-diasabitsüklo[3.3.1]preparaadid, nende valmistamise meetod ja nimetatud preparaatide kasutaminesüdame arütmiate profülaktikas või ravis
EE200300013A (et) Bispidiini uued ühendid ning nende kasutamine südame arütmia ravis
IL146754A0 (en) New bispidine compounds useful in the treatment of cardiac arrhythmias
IL146752A0 (en) New bispidine compounds useful in the treatment of cardiac arrhythmias
FI990736A (fi) Suoja- tai säilöntäainekoostumus, sen valmistusmenetelmä sekä sen käyttö
IL146753A0 (en) New bispidine compounds useful in the treatment of cardiac arrhythmias
PT1192156E (pt) Novos compostos de bispidina uteis no tratamento de arritmias cardiacas
SI1192154T1 (en) Bispidine compounds useful in the treatment of cardiac arrhythmias
NO20031015L (no) Behandlingsmetoder for hjerte arytmi

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20101013