EE04432B1 - Kinaase ja tsükliin/CDK komplekse inhibeerivad asendatud indolinoonid - Google Patents

Kinaase ja tsükliin/CDK komplekse inhibeerivad asendatud indolinoonid

Info

Publication number
EE04432B1
EE04432B1 EEP200000598A EEP200000598A EE04432B1 EE 04432 B1 EE04432 B1 EE 04432B1 EE P200000598 A EEP200000598 A EE P200000598A EE P200000598 A EEP200000598 A EE P200000598A EE 04432 B1 EE04432 B1 EE 04432B1
Authority
EE
Estonia
Prior art keywords
cyclin
cdk complexes
inhibit kinases
substituted indolinones
indolinones
Prior art date
Application number
EEP200000598A
Other languages
English (en)
Estonian (et)
Inventor
Heckel Armin
Walter Rainer
Grell Wolfgang
C. A. Van Meel Jacobus
Redemann Norbert
Original Assignee
Boehringer Ingelheim Pharma Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Kg filed Critical Boehringer Ingelheim Pharma Kg
Publication of EE200000598A publication Critical patent/EE200000598A/xx
Publication of EE04432B1 publication Critical patent/EE04432B1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/34Oxygen atoms in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
EEP200000598A 1998-04-15 1999-04-10 Kinaase ja tsükliin/CDK komplekse inhibeerivad asendatud indolinoonid EE04432B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19816624A DE19816624A1 (de) 1998-04-15 1998-04-15 Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
PCT/EP1999/002436 WO1999052869A1 (de) 1998-04-15 1999-04-10 Substituierte indolinone mit inhibierender wirkung auf kinasen und cyclin/cdk-komplexe

Publications (2)

Publication Number Publication Date
EE200000598A EE200000598A (et) 2002-04-15
EE04432B1 true EE04432B1 (et) 2005-02-15

Family

ID=7864562

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000598A EE04432B1 (et) 1998-04-15 1999-04-10 Kinaase ja tsükliin/CDK komplekse inhibeerivad asendatud indolinoonid

Country Status (31)

Country Link
EP (1) EP1071665B1 (ru)
JP (1) JP4015365B2 (ru)
KR (1) KR100588250B1 (ru)
CN (1) CN100338036C (ru)
AR (1) AR015763A1 (ru)
AT (1) ATE251138T1 (ru)
AU (1) AU749829B2 (ru)
BG (1) BG64443B1 (ru)
BR (1) BR9909688A (ru)
CA (1) CA2323111C (ru)
CO (1) CO5011040A1 (ru)
DE (2) DE19816624A1 (ru)
DK (1) DK1071665T3 (ru)
EA (1) EA003532B1 (ru)
EE (1) EE04432B1 (ru)
ES (1) ES2207209T3 (ru)
HU (1) HUP0101568A3 (ru)
ID (1) ID26420A (ru)
IL (1) IL138036A0 (ru)
MY (1) MY122357A (ru)
NO (1) NO317298B1 (ru)
NZ (1) NZ507967A (ru)
PL (1) PL343314A1 (ru)
PT (1) PT1071665E (ru)
SK (1) SK283824B6 (ru)
TR (1) TR200002980T2 (ru)
TW (1) TW510897B (ru)
UA (1) UA63009C2 (ru)
WO (1) WO1999052869A1 (ru)
YU (1) YU59800A (ru)
ZA (1) ZA200004623B (ru)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569868B2 (en) 1998-04-16 2003-05-27 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
GB9904932D0 (en) * 1999-03-04 1999-04-28 Glaxo Group Ltd Composition and method for preventing/reducing the severity of side effects of chemotherapy and/or radiation therapy
GB9904995D0 (en) * 1999-03-04 1999-04-28 Glaxo Group Ltd Substituted aza-oxindole derivatives
DE19924401A1 (de) * 1999-05-27 2000-11-30 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
MXPA02002097A (es) * 1999-08-27 2002-11-07 Boehringer Ingelheim Pharma Indolinas sustituidas como inhibidoras de la tirosina cinasa.
US6762180B1 (en) 1999-10-13 2004-07-13 Boehringer Ingelheim Pharma Kg Substituted indolines which inhibit receptor tyrosine kinases
UA75054C2 (ru) * 1999-10-13 2006-03-15 Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг Замещенные в положении 6 индолиноны, их получение и их применение как лекарственного средства
US6620818B1 (en) 2000-03-01 2003-09-16 Smithkline Beecham Corporation Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
MY128450A (en) 2000-05-24 2007-02-28 Upjohn Co 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
CA2410509A1 (en) 2000-06-02 2001-12-13 Sugen, Inc. Indolinone derivatives as protein kinase/phosphatase inhibitors
JP2004517840A (ja) * 2000-11-27 2004-06-17 フアルマシア・イタリア・エツセ・ピー・アー フェニルアセトアミド−ピラゾール誘導体およびそれの抗腫瘍薬としての使用
DE10117204A1 (de) 2001-04-06 2002-10-10 Boehringer Ingelheim Pharma In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
US6599902B2 (en) 2001-05-30 2003-07-29 Sugen, Inc. 5-aralkysufonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
PT1490062E (pt) 2002-03-26 2008-01-30 Boehringer Ingelheim Pharma Miméticos de glucocorticóides, métodos para a sua preparação, composições farmacêuticas e suas utilizações
US7169936B2 (en) 2002-07-23 2007-01-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
DE10233500A1 (de) * 2002-07-24 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel
DE10237423A1 (de) * 2002-08-16 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen
JP4879492B2 (ja) * 2002-11-27 2012-02-22 アラーガン、インコーポレイテッド 疾患の治療のためのキナーゼ阻害剤
US20050043233A1 (en) 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
UY28526A1 (es) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
ATE414701T1 (de) * 2003-10-03 2008-12-15 Boehringer Ingelheim Pharma Fluoreszenzsonden zur verwendung bei einem bindungsassay auf proteinkinaseinhibitoren
DE102004012070A1 (de) * 2004-03-12 2005-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue cycloalkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
EP1836166B1 (en) 2004-12-27 2009-06-17 Boehringer Ingelheim Pharmaceuticals Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7781475B2 (en) 2005-06-10 2010-08-24 Merck Patent Gmbh Oxindoles as kinase inhibitors
WO2007057399A2 (en) * 2005-11-15 2007-05-24 Boehringer Ingelheim International Gmbh Treatment of cancer with indole derivatives
BRPI0720131A2 (pt) 2006-12-06 2014-02-04 Boehringer Ingelheim Int Glicocorticoides miméticos, métodos para fazê-los, composições farmacêuticas e usos dos mesmos.
US20170065529A1 (en) 2015-09-09 2017-03-09 Boehringer Ingelheim International Gmbh Pharmaceutical dosage form for immediate release of an indolinone derivative
WO2009149139A1 (en) 2008-06-06 2009-12-10 Boehringer Ingelheim International Gmbh Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
WO2011032320A1 (en) * 2009-09-21 2011-03-24 F. Hoffmann-La Roche Ag Novel alkene oxindole derivatives
CN109293551A (zh) * 2011-11-14 2019-02-01 利亘制药公司 与粒细胞集落刺激因子受体相关的方法和组合物
WO2014150252A1 (en) * 2013-03-15 2014-09-25 Ligand Pharmaceuticals Incorporated Methods of treatment associated with the granulocyte colony-stimulating factor receptor
CN107033064B (zh) * 2017-04-28 2019-07-09 西安医学院 一种3-(吗啉取代芳亚胺基)吲哚类化合物及其制备方法和应用
CN111285872B (zh) * 2018-12-06 2022-05-17 北京志健金瑞生物医药科技有限公司 吲哚-2-酮衍生物及其制备方法与用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501567D0 (en) * 1995-01-26 1995-03-15 Pharmacia Spa Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
DE19824922A1 (de) * 1998-06-04 1999-12-09 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
UA75054C2 (ru) * 1999-10-13 2006-03-15 Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг Замещенные в положении 6 индолиноны, их получение и их применение как лекарственного средства

Also Published As

Publication number Publication date
AU3814999A (en) 1999-11-01
DE59907199D1 (de) 2003-11-06
CO5011040A1 (es) 2001-02-28
BR9909688A (pt) 2000-12-19
HUP0101568A2 (hu) 2001-09-28
IL138036A0 (en) 2001-10-31
SK15132000A3 (sk) 2001-03-12
YU59800A (sh) 2003-04-30
CN1297438A (zh) 2001-05-30
SK283824B6 (sk) 2004-02-03
DK1071665T3 (da) 2004-01-05
TR200002980T2 (tr) 2001-02-21
JP4015365B2 (ja) 2007-11-28
CN100338036C (zh) 2007-09-19
EE200000598A (et) 2002-04-15
ATE251138T1 (de) 2003-10-15
EP1071665A1 (de) 2001-01-31
CA2323111A1 (en) 1999-10-21
NO20005151D0 (no) 2000-10-13
HUP0101568A3 (en) 2002-12-28
BG64443B1 (en) 2005-02-28
DE19816624A1 (de) 1999-10-21
TW510897B (en) 2002-11-21
MY122357A (en) 2006-04-29
UA63009C2 (en) 2004-01-15
NZ507967A (en) 2003-04-29
KR20010042731A (ko) 2001-05-25
PL343314A1 (en) 2001-08-13
AU749829B2 (en) 2002-07-04
WO1999052869A1 (de) 1999-10-21
ES2207209T3 (es) 2004-05-16
ID26420A (id) 2000-12-21
EA003532B1 (ru) 2003-06-26
ZA200004623B (en) 2001-05-30
NO20005151L (no) 2000-10-13
NO317298B1 (no) 2004-10-04
EA200001021A1 (ru) 2001-06-25
KR100588250B1 (ko) 2006-06-13
AR015763A1 (es) 2001-05-16
PT1071665E (pt) 2004-02-27
JP2002511449A (ja) 2002-04-16
BG104813A (en) 2001-08-31
EP1071665B1 (de) 2003-10-01
CA2323111C (en) 2009-09-15

Similar Documents

Publication Publication Date Title
EE200000598A (et) Kinaase ja tsükliin/CDK komplekse inhibeerivad asendatud indolinoonid
EE200000622A (et) Saatja-vastuvõtja GMSK ja offset-QAM jaoks
HUP0104973A3 (en) Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes, process for their use and medicaments containing them
DK0877845T3 (da) Vendbar indstukken lås
EE200100659A (et) Diaminotiasoolid ja nende kasutamine proteiinikinaaside pärssimiseks
PT904774E (pt) Derivados do resorcinol
DE69916691D1 (de) Herzschrittmacher
ID26130A (id) Penyempurnaan-penyempurnaan dalam alat pengantar obat
FI982525A0 (fi) Suojausjärjestely
NO20003154D0 (no) Stikkplugg
DE69906152D1 (de) 4-alkenyl (und alkinyl)oxoindole als inhibitoren cyclinabhängiger kinasen, insbesondere cdk2
DE59810269D1 (de) Selbstkalibrierender ratenadaptiver Herzschrittmacher
EE200100347A (et) 3,3-biarüülpiperidiini ja 2,2-biarüülmorfoliini derivaadid
NO20010200D0 (no) Organiske fosforforbindelser og deres anvendelse
MA26613A1 (fr) Pyrroles substitues
DE69926591D1 (de) Fehlersicherer Defribrillator
FR2776660B1 (fr) Diazepino-indoles de phosphodiesterases iv
FR2774599B1 (fr) Cataplasme
ZA200102260B (en) Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes.
ATA15398A (de) Verschlussdeckel
DE69920224D1 (de) Harnstoffderivate zur Schmerzbekämpfung
DE59911871D1 (de) Zweikammer-Herzschrittmacher
DE69803818D1 (de) Verbinderverriegelung
DE59813079D1 (de) Fräszahn zur Erdbearbeitung
FI980566A (fi) Uusi täyteaine ja pigmentti

Legal Events

Date Code Title Description
HC1A Change of owner name
KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

MM4A Lapsed by not paying the annual fees

Effective date: 20070410