IL138036A0 - Substituted indolines having an inhibiting effect in kinases and cycline/cdk complexes - Google Patents
Substituted indolines having an inhibiting effect in kinases and cycline/cdk complexesInfo
- Publication number
- IL138036A0 IL138036A0 IL13803699A IL13803699A IL138036A0 IL 138036 A0 IL138036 A0 IL 138036A0 IL 13803699 A IL13803699 A IL 13803699A IL 13803699 A IL13803699 A IL 13803699A IL 138036 A0 IL138036 A0 IL 138036A0
- Authority
- IL
- Israel
- Prior art keywords
- cycline
- kinases
- inhibiting effect
- cdk complexes
- substituted indolines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- AIDS & HIV (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19816624A DE19816624A1 (en) | 1998-04-15 | 1998-04-15 | Novel substituted indolinones, their preparation and their use as pharmaceuticals |
PCT/EP1999/002436 WO1999052869A1 (en) | 1998-04-15 | 1999-04-10 | Substituted indolinones having an inhibiting effect on kinases and cycline/cdk complexes |
Publications (1)
Publication Number | Publication Date |
---|---|
IL138036A0 true IL138036A0 (en) | 2001-10-31 |
Family
ID=7864562
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13803699A IL138036A0 (en) | 1998-04-15 | 1999-04-10 | Substituted indolines having an inhibiting effect in kinases and cycline/cdk complexes |
Country Status (31)
Country | Link |
---|---|
EP (1) | EP1071665B1 (en) |
JP (1) | JP4015365B2 (en) |
KR (1) | KR100588250B1 (en) |
CN (1) | CN100338036C (en) |
AR (1) | AR015763A1 (en) |
AT (1) | ATE251138T1 (en) |
AU (1) | AU749829B2 (en) |
BG (1) | BG64443B1 (en) |
BR (1) | BR9909688A (en) |
CA (1) | CA2323111C (en) |
CO (1) | CO5011040A1 (en) |
DE (2) | DE19816624A1 (en) |
DK (1) | DK1071665T3 (en) |
EA (1) | EA003532B1 (en) |
EE (1) | EE04432B1 (en) |
ES (1) | ES2207209T3 (en) |
HU (1) | HUP0101568A3 (en) |
ID (1) | ID26420A (en) |
IL (1) | IL138036A0 (en) |
MY (1) | MY122357A (en) |
NO (1) | NO317298B1 (en) |
NZ (1) | NZ507967A (en) |
PL (1) | PL343314A1 (en) |
PT (1) | PT1071665E (en) |
SK (1) | SK283824B6 (en) |
TR (1) | TR200002980T2 (en) |
TW (1) | TW510897B (en) |
UA (1) | UA63009C2 (en) |
WO (1) | WO1999052869A1 (en) |
YU (1) | YU59800A (en) |
ZA (1) | ZA200004623B (en) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6569868B2 (en) | 1998-04-16 | 2003-05-27 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
GB9904995D0 (en) * | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Substituted aza-oxindole derivatives |
GB9904932D0 (en) * | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Composition and method for preventing/reducing the severity of side effects of chemotherapy and/or radiation therapy |
US6624171B1 (en) | 1999-03-04 | 2003-09-23 | Smithkline Beecham Corporation | Substituted aza-oxindole derivatives |
DE19924401A1 (en) * | 1999-05-27 | 2000-11-30 | Boehringer Ingelheim Pharma | Novel substituted indolinones, their preparation and their use as pharmaceuticals |
JP3952369B2 (en) | 1999-08-27 | 2007-08-01 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | Novel substituted indolinones, their production and their use as pharmaceuticals |
US6762180B1 (en) | 1999-10-13 | 2004-07-13 | Boehringer Ingelheim Pharma Kg | Substituted indolines which inhibit receptor tyrosine kinases |
UA75054C2 (en) * | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Substituted in position 6 indolinones, producing and use thereof as medicament |
US6620818B1 (en) | 2000-03-01 | 2003-09-16 | Smithkline Beecham Corporation | Method for reducing the severity of side effects of chemotherapy and/or radiation therapy |
TWI270545B (en) | 2000-05-24 | 2007-01-11 | Sugen Inc | Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
US6706709B2 (en) | 2000-06-02 | 2004-03-16 | Sugen, Inc. | Indolinone derivatives as protein kinase/phosphatase inhibitors |
US20040019046A1 (en) * | 2000-11-27 | 2004-01-29 | Paolo Pevarello | Phenylacetamido-pyrazole derivatives and their use as antitumor agents |
DE10117204A1 (en) | 2001-04-06 | 2002-10-10 | Boehringer Ingelheim Pharma | Indolinones substituted in the 6-position, their preparation and their use as medicaments |
US6599902B2 (en) | 2001-05-30 | 2003-07-29 | Sugen, Inc. | 5-aralkysufonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors |
UA80120C2 (en) | 2002-03-26 | 2007-08-27 | Boehringer Ingelheim Pharma | Glucocorticoid mimetics, pharmaceutical composition based thereon |
US7169936B2 (en) | 2002-07-23 | 2007-01-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments |
DE10233500A1 (en) * | 2002-07-24 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-Z- [1- (4- (N - ((4-methyl-piperazin-1-yl) -methylcarbonyl) -N-methyl-amino) -anilino) -1-phenyl-methylene] -6-methoxycarbonyl- 2-indolinone monoethanesulfonate and its use as a medicament |
DE10237423A1 (en) | 2002-08-16 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Treating immunological (or related) diseases, e.g. inflammatory bowel disease, rheumatoid arthritis or psoriasis, comprises administration of 3-methylene-2-indolinone derivative or quinazoline compound |
JP4879492B2 (en) * | 2002-11-27 | 2012-02-22 | アラーガン、インコーポレイテッド | Kinase inhibitors for the treatment of diseases |
US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
UY28526A1 (en) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | GLUCOCORTICOID MIMETICS, METHODS OF PREPARATION PHARMACEUTICAL COMPOSITIONS AND USES OF THE SAME |
EP1670789B1 (en) * | 2003-10-03 | 2008-11-19 | Boehringer Ingelheim Pharmaceuticals Inc. | Fluorescent probes for use in protein kinase inhibitor binding assay |
DE102004012070A1 (en) * | 2004-03-12 | 2005-09-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New cycloalkyl-containing 5-acylindolinones, their preparation and their use as medicaments |
US7795272B2 (en) | 2004-03-13 | 2010-09-14 | Boehringer Ingelheim Pharmaceutical, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
PE20060777A1 (en) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | INDOLINONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES |
ATE433958T1 (en) | 2004-12-27 | 2009-07-15 | Boehringer Ingelheim Pharma | GLUCOCORTICOID MIMETICS, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF |
CA2611401C (en) * | 2005-06-10 | 2014-02-11 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Oxindoles as kinase inhibitors |
WO2007057399A2 (en) * | 2005-11-15 | 2007-05-24 | Boehringer Ingelheim International Gmbh | Treatment of cancer with indole derivatives |
BRPI0720131A2 (en) | 2006-12-06 | 2014-02-04 | Boehringer Ingelheim Int | MIMETIC GLYCORTICOIDS, METHODS FOR MAKING THEM, PHARMACEUTICAL COMPOSITIONS AND USES OF THE SAME. |
DK2300472T3 (en) | 2008-06-06 | 2012-04-10 | Boehringer Ingelheim Int | Glucocorticoid mimetics, methods of their preparation, pharmaceutical compositions and uses thereof |
US20170065529A1 (en) | 2015-09-09 | 2017-03-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical dosage form for immediate release of an indolinone derivative |
WO2011032320A1 (en) * | 2009-09-21 | 2011-03-24 | F. Hoffmann-La Roche Ag | Novel alkene oxindole derivatives |
US9492430B2 (en) | 2011-11-14 | 2016-11-15 | Ligand Pharmaceuticals, Incorporated | Methods and compositions associated with the granulocyte colony-stimulating factor receptor |
WO2014150252A1 (en) * | 2013-03-15 | 2014-09-25 | Ligand Pharmaceuticals Incorporated | Methods of treatment associated with the granulocyte colony-stimulating factor receptor |
CN107033064B (en) * | 2017-04-28 | 2019-07-09 | 西安医学院 | A kind of 3- (morpholine replaces fragrant imido grpup) Benzazole compounds and its preparation method and application |
CN111285872B (en) * | 2018-12-06 | 2022-05-17 | 北京志健金瑞生物医药科技有限公司 | Indole-2-ketone derivative and preparation method and application thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9501567D0 (en) * | 1995-01-26 | 1995-03-15 | Pharmacia Spa | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
GB9718913D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
DE19824922A1 (en) * | 1998-06-04 | 1999-12-09 | Boehringer Ingelheim Pharma | Novel substituted indolinones, their preparation and their use as pharmaceuticals |
UA75054C2 (en) * | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Substituted in position 6 indolinones, producing and use thereof as medicament |
-
1998
- 1998-04-15 DE DE19816624A patent/DE19816624A1/en not_active Withdrawn
-
1999
- 1999-04-10 JP JP2000543432A patent/JP4015365B2/en not_active Expired - Lifetime
- 1999-04-10 NZ NZ507967A patent/NZ507967A/en unknown
- 1999-04-10 EP EP99920635A patent/EP1071665B1/en not_active Expired - Lifetime
- 1999-04-10 ES ES99920635T patent/ES2207209T3/en not_active Expired - Lifetime
- 1999-04-10 EA EA200001021A patent/EA003532B1/en not_active IP Right Cessation
- 1999-04-10 CA CA002323111A patent/CA2323111C/en not_active Expired - Fee Related
- 1999-04-10 PL PL99343314A patent/PL343314A1/en not_active Application Discontinuation
- 1999-04-10 HU HU0101568A patent/HUP0101568A3/en unknown
- 1999-04-10 BR BR9909688-9A patent/BR9909688A/en not_active Application Discontinuation
- 1999-04-10 AU AU38149/99A patent/AU749829B2/en not_active Ceased
- 1999-04-10 CN CNB998050296A patent/CN100338036C/en not_active Expired - Fee Related
- 1999-04-10 AT AT99920635T patent/ATE251138T1/en active
- 1999-04-10 EE EEP200000598A patent/EE04432B1/en not_active IP Right Cessation
- 1999-04-10 IL IL13803699A patent/IL138036A0/en not_active IP Right Cessation
- 1999-04-10 YU YU59800A patent/YU59800A/en unknown
- 1999-04-10 ID IDW20002062A patent/ID26420A/en unknown
- 1999-04-10 KR KR1020007011454A patent/KR100588250B1/en not_active IP Right Cessation
- 1999-04-10 WO PCT/EP1999/002436 patent/WO1999052869A1/en active IP Right Grant
- 1999-04-10 DK DK99920635T patent/DK1071665T3/en active
- 1999-04-10 DE DE59907199T patent/DE59907199D1/en not_active Expired - Lifetime
- 1999-04-10 TR TR2000/02980T patent/TR200002980T2/en unknown
- 1999-04-10 PT PT99920635T patent/PT1071665E/en unknown
- 1999-04-10 SK SK1513-2000A patent/SK283824B6/en unknown
- 1999-04-13 MY MYPI99001427A patent/MY122357A/en unknown
- 1999-04-14 TW TW088105963A patent/TW510897B/en active
- 1999-04-14 AR ARP990101700A patent/AR015763A1/en active Pending
- 1999-04-14 CO CO99022218A patent/CO5011040A1/en unknown
- 1999-10-04 UA UA2000116456A patent/UA63009C2/en unknown
-
2000
- 2000-09-04 ZA ZA200004623A patent/ZA200004623B/en unknown
- 2000-09-29 BG BG104813A patent/BG64443B1/en active Active
- 2000-10-13 NO NO20005151A patent/NO317298B1/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL138036A0 (en) | Substituted indolines having an inhibiting effect in kinases and cycline/cdk complexes | |
GB9819795D0 (en) | Plug and plug set for use in wellbore | |
IL146094A0 (en) | Diaminothiazoles and their use for inhibiting protein kinases | |
IL144214A0 (en) | Benzoheterocycles and their use as mek inhibitors | |
ZA200104118B (en) | Substituted benzimidazoles and their use as PARP inhibitors. | |
PL356066A1 (en) | Caspase inhibitors and uses thereof | |
PL343680A1 (en) | Quinolones used as mrs inhibitors and bactericides | |
IL116485A0 (en) | Monocyclic beta-lactams for use in inhibiting lrho pla2 | |
EP1056456A4 (en) | R-lansoprazole compositions and methods | |
GB2336924B (en) | Semiconductor device with common pin for address and data | |
EP1073333A4 (en) | S-rabeprazole compositions and methods | |
ZA200102260B (en) | Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes. | |
IL127518A0 (en) | Substituted heterocyclic benzocycloalkenes and the use thereof as substances having an analgesic effect | |
GB0026072D0 (en) | Improvements in plugs | |
AU4686299A (en) | Nek-related and bub1-related protein kinases | |
GB9813781D0 (en) | Improvements in security documents and substrates therefor | |
SI1071665T1 (en) | Substituted indolinones having an inhibiting effect on kinases and cycline/cdk complexes | |
GB2334885B (en) | Lockable sink plug | |
AU7675798A (en) | Nitrogen-containing heterocyclic compounds having antiplatelet aggregation effect and medicinal use thereof | |
IL139961A0 (en) | Composition based on pentoxifylline and anticytokin | |
GB9813747D0 (en) | Security arrangement and device | |
GB9607823D0 (en) | Improvements in bath and sink plugs | |
TW363785U (en) | Assemblied plug and socket set | |
SI1214312T1 (en) | 5-aminoalkyl and 5-aminocarbonyl substituted indoles | |
TW354046U (en) | Vehicular UPS socket and plug |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |