DK1071665T3 - Substituted indolinones with an inhibitory effect on kinases and cyclin / CDK complexes - Google Patents
Substituted indolinones with an inhibitory effect on kinases and cyclin / CDK complexesInfo
- Publication number
- DK1071665T3 DK1071665T3 DK99920635T DK99920635T DK1071665T3 DK 1071665 T3 DK1071665 T3 DK 1071665T3 DK 99920635 T DK99920635 T DK 99920635T DK 99920635 T DK99920635 T DK 99920635T DK 1071665 T3 DK1071665 T3 DK 1071665T3
- Authority
- DK
- Denmark
- Prior art keywords
- cyclin
- kinases
- inhibitory effect
- cdk complexes
- substituted indolinones
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- AIDS & HIV (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19816624A DE19816624A1 (en) | 1998-04-15 | 1998-04-15 | Novel substituted indolinones, their preparation and their use as pharmaceuticals |
| PCT/EP1999/002436 WO1999052869A1 (en) | 1998-04-15 | 1999-04-10 | Substituted indolinones having an inhibiting effect on kinases and cycline/cdk complexes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1071665T3 true DK1071665T3 (en) | 2004-01-05 |
Family
ID=7864562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99920635T DK1071665T3 (en) | 1998-04-15 | 1999-04-10 | Substituted indolinones with an inhibitory effect on kinases and cyclin / CDK complexes |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP1071665B1 (en) |
| JP (1) | JP4015365B2 (en) |
| KR (1) | KR100588250B1 (en) |
| CN (1) | CN100338036C (en) |
| AR (1) | AR015763A1 (en) |
| AT (1) | ATE251138T1 (en) |
| AU (1) | AU749829B2 (en) |
| BG (1) | BG64443B1 (en) |
| BR (1) | BR9909688A (en) |
| CA (1) | CA2323111C (en) |
| CO (1) | CO5011040A1 (en) |
| DE (2) | DE19816624A1 (en) |
| DK (1) | DK1071665T3 (en) |
| EA (1) | EA003532B1 (en) |
| EE (1) | EE04432B1 (en) |
| ES (1) | ES2207209T3 (en) |
| HU (1) | HUP0101568A3 (en) |
| ID (1) | ID26420A (en) |
| IL (1) | IL138036A0 (en) |
| MY (1) | MY122357A (en) |
| NO (1) | NO317298B1 (en) |
| NZ (1) | NZ507967A (en) |
| PL (1) | PL343314A1 (en) |
| PT (1) | PT1071665E (en) |
| SK (1) | SK283824B6 (en) |
| TR (1) | TR200002980T2 (en) |
| TW (1) | TW510897B (en) |
| UA (1) | UA63009C2 (en) |
| WO (1) | WO1999052869A1 (en) |
| YU (1) | YU59800A (en) |
| ZA (1) | ZA200004623B (en) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6569868B2 (en) | 1998-04-16 | 2003-05-27 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| GB9904995D0 (en) * | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Substituted aza-oxindole derivatives |
| US6624171B1 (en) | 1999-03-04 | 2003-09-23 | Smithkline Beecham Corporation | Substituted aza-oxindole derivatives |
| GB9904932D0 (en) * | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Composition and method for preventing/reducing the severity of side effects of chemotherapy and/or radiation therapy |
| GB9904933D0 (en) * | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
| DE19924401A1 (en) * | 1999-05-27 | 2000-11-30 | Boehringer Ingelheim Pharma | Novel substituted indolinones, their preparation and their use as pharmaceuticals |
| WO2001016130A1 (en) * | 1999-08-27 | 2001-03-08 | Boehringer Ingelheim Pharma Kg | Substituted indolinones as tyrosine kinase inhibitors |
| UA75054C2 (en) * | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Substituted in position 6 indolinones, producing and use thereof as medicament |
| US6762180B1 (en) | 1999-10-13 | 2004-07-13 | Boehringer Ingelheim Pharma Kg | Substituted indolines which inhibit receptor tyrosine kinases |
| US6620818B1 (en) | 2000-03-01 | 2003-09-16 | Smithkline Beecham Corporation | Method for reducing the severity of side effects of chemotherapy and/or radiation therapy |
| MY128449A (en) | 2000-05-24 | 2007-02-28 | Sugen Inc | Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
| EP1294688A2 (en) | 2000-06-02 | 2003-03-26 | Sugen, Inc. | Indolinone derivatives as protein kinase/phosphatase inhibitors |
| AU2002215053A1 (en) * | 2000-11-27 | 2002-06-24 | Pharmacia Italia S.P.A. | Phenylacetamido- pyrazole derivatives and their use as antitumor agents |
| DE10117204A1 (en) | 2001-04-06 | 2002-10-10 | Boehringer Ingelheim Pharma | Indolinones substituted in the 6-position, their preparation and their use as medicaments |
| AU2002303892A1 (en) | 2001-05-30 | 2002-12-09 | Jingrong Cui | 5-aralkylsulfonyl-3- (pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors |
| CN1633296A (en) | 2002-03-26 | 2005-06-29 | 贝林格尔·英格海姆药物公司 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| US7169936B2 (en) | 2002-07-23 | 2007-01-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments |
| DE10233500A1 (en) * | 2002-07-24 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-Z- [1- (4- (N - ((4-methyl-piperazin-1-yl) -methylcarbonyl) -N-methyl-amino) -anilino) -1-phenyl-methylene] -6-methoxycarbonyl- 2-indolinone monoethanesulfonate and its use as a medicament |
| DE10237423A1 (en) * | 2002-08-16 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Treating immunological (or related) diseases, e.g. inflammatory bowel disease, rheumatoid arthritis or psoriasis, comprises administration of 3-methylene-2-indolinone derivative or quinazoline compound |
| JP4879492B2 (en) * | 2002-11-27 | 2012-02-22 | アラーガン、インコーポレイテッド | Kinase inhibitors for the treatment of diseases |
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| UY28526A1 (en) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | GLUCOCORTICOID MIMETICS, METHODS OF PREPARATION PHARMACEUTICAL COMPOSITIONS AND USES OF THE SAME |
| EP1670789B1 (en) | 2003-10-03 | 2008-11-19 | Boehringer Ingelheim Pharmaceuticals Inc. | Fluorescent probes for use in protein kinase inhibitor binding assay |
| DE102004012070A1 (en) * | 2004-03-12 | 2005-09-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New cycloalkyl-containing 5-acylindolinones, their preparation and their use as medicaments |
| US7795272B2 (en) | 2004-03-13 | 2010-09-14 | Boehringer Ingelheim Pharmaceutical, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
| PE20060777A1 (en) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | INDOLINONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES |
| ES2326907T3 (en) | 2004-12-27 | 2009-10-21 | Boehringer Ingelheim Pharmaceuticals Inc. | GLUCOCORTICOID MIMETICS, METHODS FOR PREPARATION, PHARMACEUTICAL COMPOSITIONS AND USE. |
| ES2348099T3 (en) * | 2005-06-10 | 2010-11-30 | Merck Patent Gmbh | OXINDOLS AS KINASE INHIBITORS. |
| WO2007057399A2 (en) * | 2005-11-15 | 2007-05-24 | Boehringer Ingelheim International Gmbh | Treatment of cancer with indole derivatives |
| WO2008070507A2 (en) | 2006-12-06 | 2008-06-12 | Boehringer Ingelheim International Gmbh | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| MX2010013095A (en) | 2008-06-06 | 2010-12-21 | Boehringer Ingelheim Int | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof. |
| US20170065529A1 (en) | 2015-09-09 | 2017-03-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical dosage form for immediate release of an indolinone derivative |
| WO2011032320A1 (en) * | 2009-09-21 | 2011-03-24 | F. Hoffmann-La Roche Ag | Novel alkene oxindole derivatives |
| JP6072058B2 (en) * | 2011-11-14 | 2017-02-01 | リガンド・ファーマシューティカルズ・インコーポレイテッド | Methods and compositions for binding to granulocyte colony stimulating factor receptor |
| US9962370B2 (en) * | 2013-03-15 | 2018-05-08 | Ligand Pharmaceuticals Incorporated | Methods of treatment associated with the granulocyte colony-stimulating factor receptor |
| CN107033064B (en) * | 2017-04-28 | 2019-07-09 | 西安医学院 | A kind of 3- (morpholine replaces fragrant imido grpup) Benzazole compounds and its preparation method and application |
| CN111285872B (en) * | 2018-12-06 | 2022-05-17 | 北京志健金瑞生物医药科技有限公司 | Indole-2-ketone derivative and preparation method and application thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9501567D0 (en) * | 1995-01-26 | 1995-03-15 | Pharmacia Spa | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| GB9718913D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| DE19824922A1 (en) * | 1998-06-04 | 1999-12-09 | Boehringer Ingelheim Pharma | Novel substituted indolinones, their preparation and their use as pharmaceuticals |
| UA75054C2 (en) * | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Substituted in position 6 indolinones, producing and use thereof as medicament |
-
1998
- 1998-04-15 DE DE19816624A patent/DE19816624A1/en not_active Withdrawn
-
1999
- 1999-04-10 YU YU59800A patent/YU59800A/en unknown
- 1999-04-10 DK DK99920635T patent/DK1071665T3/en active
- 1999-04-10 EP EP99920635A patent/EP1071665B1/en not_active Expired - Lifetime
- 1999-04-10 PT PT99920635T patent/PT1071665E/en unknown
- 1999-04-10 CN CNB998050296A patent/CN100338036C/en not_active Expired - Fee Related
- 1999-04-10 TR TR2000/02980T patent/TR200002980T2/en unknown
- 1999-04-10 DE DE59907199T patent/DE59907199D1/en not_active Expired - Lifetime
- 1999-04-10 PL PL99343314A patent/PL343314A1/en not_active Application Discontinuation
- 1999-04-10 ID IDW20002062A patent/ID26420A/en unknown
- 1999-04-10 KR KR1020007011454A patent/KR100588250B1/en not_active IP Right Cessation
- 1999-04-10 BR BR9909688-9A patent/BR9909688A/en not_active Application Discontinuation
- 1999-04-10 EE EEP200000598A patent/EE04432B1/en not_active IP Right Cessation
- 1999-04-10 NZ NZ507967A patent/NZ507967A/en unknown
- 1999-04-10 HU HU0101568A patent/HUP0101568A3/en unknown
- 1999-04-10 EA EA200001021A patent/EA003532B1/en not_active IP Right Cessation
- 1999-04-10 JP JP2000543432A patent/JP4015365B2/en not_active Expired - Lifetime
- 1999-04-10 SK SK1513-2000A patent/SK283824B6/en unknown
- 1999-04-10 IL IL13803699A patent/IL138036A0/en not_active IP Right Cessation
- 1999-04-10 AT AT99920635T patent/ATE251138T1/en active
- 1999-04-10 WO PCT/EP1999/002436 patent/WO1999052869A1/en active IP Right Grant
- 1999-04-10 ES ES99920635T patent/ES2207209T3/en not_active Expired - Lifetime
- 1999-04-10 CA CA002323111A patent/CA2323111C/en not_active Expired - Fee Related
- 1999-04-10 AU AU38149/99A patent/AU749829B2/en not_active Ceased
- 1999-04-13 MY MYPI99001427A patent/MY122357A/en unknown
- 1999-04-14 AR ARP990101700A patent/AR015763A1/en active Pending
- 1999-04-14 CO CO99022218A patent/CO5011040A1/en unknown
- 1999-04-14 TW TW088105963A patent/TW510897B/en active
- 1999-10-04 UA UA2000116456A patent/UA63009C2/en unknown
-
2000
- 2000-09-04 ZA ZA200004623A patent/ZA200004623B/en unknown
- 2000-09-29 BG BG104813A patent/BG64443B1/en active Active
- 2000-10-13 NO NO20005151A patent/NO317298B1/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1071665T3 (en) | Substituted indolinones with an inhibitory effect on kinases and cyclin / CDK complexes | |
| HUP0104973A3 (en) | Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes, process for their use and medicaments containing them | |
| DK1454907T3 (en) | Quninazoline and pyridopyrmidine derivatives | |
| DE69909584D1 (en) | Screw with recess and screwdriver bit for this purpose | |
| ATE277941T1 (en) | ADENOSINE DERIVATIVES | |
| PT1157019E (en) | 4-Alkenyl (and alkynyl) oxindoles as inhibitors of cyclin-dependent kinase in particular CDK2 | |
| FI980640A0 (en) | Exemption from the aid scheme and the aid scheme | |
| NO990053D0 (en) | Milling control with orientation and depth determination | |
| ATE231508T1 (en) | AZYCLIC NUCLEOSIDE DERIVATIVES | |
| NO986174D0 (en) | Triazine derivatives and their use | |
| ZA200102260B (en) | Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes. | |
| NO984836L (en) | Substituted benzylamines and their use in the treatment of depression | |
| NO20013085D0 (en) | Phosphorus-organic compounds and their use | |
| DE69939932D1 (en) | IMPROVING SECURITY AT DATA CONFERENCES | |
| DE59900242D1 (en) | DRILLING AND MILLING HEAD | |
| DK1226137T3 (en) | Phenyl and pyridyl tetrahydropyridines with an inhibitory effect on TNF | |
| NO20012606L (en) | Compound having inhibitory effect on cholesterol-transferring protein and preparation thereof | |
| FI965024A0 (en) | Electronic communication procedures are used in the case of security clearances | |
| SI1071665T1 (en) | Substituted indolinones having an inhibiting effect on kinases and cycline/cdk complexes | |
| ES1035703Y (en) | PERFECTED PLUG. | |
| ES1039353Y (en) | PERFECTED PLUG. | |
| ES1039500Y (en) | PERFECTED PLUG. | |
| ES1033292Y (en) | PERFECTED PLUG. | |
| ES1039069Y (en) | PERFECTED PLUG. | |
| ES1040083Y (en) | NUT AND SCREW SET. |