EE04262B1 - Östrogeeni ja 2-fenüül-1-[4-(2-aminoetoksü)bensüül]indooli ühendit sisaldav farmatseutiline kompositsioon ja produkt - Google Patents

Östrogeeni ja 2-fenüül-1-[4-(2-aminoetoksü)bensüül]indooli ühendit sisaldav farmatseutiline kompositsioon ja produkt

Info

Publication number
EE04262B1
EE04262B1 EEP200000652A EEP200000652A EE04262B1 EE 04262 B1 EE04262 B1 EE 04262B1 EE P200000652 A EEP200000652 A EE P200000652A EE P200000652 A EEP200000652 A EE P200000652A EE 04262 B1 EE04262 B1 EE 04262B1
Authority
EE
Estonia
Prior art keywords
aminoethoxy
estrogen
benzyl
phenyl
product
Prior art date
Application number
EEP200000652A
Other languages
English (en)
Estonian (et)
Inventor
Harrison Pickar James
Samuel Komm Barry
Original Assignee
American Home Products Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22151320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE04262(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by American Home Products Corporation filed Critical American Home Products Corporation
Publication of EE200000652A publication Critical patent/EE200000652A/xx
Publication of EE04262B1 publication Critical patent/EE04262B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EEP200000652A 1998-05-15 1999-05-11 Östrogeeni ja 2-fenüül-1-[4-(2-aminoetoksü)bensüül]indooli ühendit sisaldav farmatseutiline kompositsioon ja produkt EE04262B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7956198A 1998-05-15 1998-05-15
PCT/US1999/010217 WO1999059581A1 (en) 1998-05-15 1999-05-11 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens

Publications (2)

Publication Number Publication Date
EE200000652A EE200000652A (et) 2002-04-15
EE04262B1 true EE04262B1 (et) 2004-04-15

Family

ID=22151320

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000652A EE04262B1 (et) 1998-05-15 1999-05-11 Östrogeeni ja 2-fenüül-1-[4-(2-aminoetoksü)bensüül]indooli ühendit sisaldav farmatseutiline kompositsioon ja produkt

Country Status (41)

Country Link
EP (1) EP1076558B1 (de)
JP (3) JP2002515431A (de)
KR (1) KR100620772B1 (de)
CN (1) CN1230163C (de)
AP (1) AP1424A (de)
AR (1) AR020074A1 (de)
AT (1) ATE245026T1 (de)
AU (1) AU760378B2 (de)
BE (1) BE2015C026I2 (de)
BG (1) BG64783B1 (de)
BR (1) BR9911040A (de)
CA (1) CA2329530A1 (de)
CU (1) CU23241B7 (de)
CY (1) CY2015020I1 (de)
CZ (1) CZ299334B6 (de)
DE (1) DE69909616T2 (de)
DK (1) DK1076558T3 (de)
EA (1) EA005932B1 (de)
EE (1) EE04262B1 (de)
ES (1) ES2203131T3 (de)
FR (1) FR15C0035I2 (de)
GE (1) GEP20033079B (de)
HR (1) HRP20000778B1 (de)
HU (2) HU226587B1 (de)
ID (1) ID26890A (de)
IL (1) IL139130A (de)
IN (1) IN192220B (de)
LT (1) LTC1076558I2 (de)
LU (1) LU92699I2 (de)
NO (2) NO328129B1 (de)
NZ (1) NZ508200A (de)
OA (1) OA11552A (de)
PL (1) PL194750B1 (de)
PT (1) PT1076558E (de)
SI (1) SI1076558T1 (de)
SK (1) SK284666B6 (de)
TR (1) TR200003377T2 (de)
TW (1) TW565554B (de)
UA (1) UA66861C2 (de)
WO (1) WO1999059581A1 (de)
ZA (1) ZA200006959B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20033079B (en) * 1998-05-15 2003-10-27 Wyeth Corp Pharmaceutical Compositions for Treatment of Diseases Caused by Estrogens Deficiency
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
WO2001001969A2 (en) 1999-07-06 2001-01-11 Endorecherche, Inc. Methods of treating and/or suppressing weight gain
US20020013327A1 (en) * 2000-04-18 2002-01-31 Lee Andrew G. Compositions and methods for treating female sexual dysfunction
WO2002003989A2 (en) * 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for treating sphincter incontinence
AU2001271784A1 (en) * 2000-07-06 2002-01-21 Wyeth Therapy for prosthesis-related bone degeneration
US6376486B1 (en) 2000-07-06 2002-04-23 American Home Products Corporation Methods of inhibiting sphincter incontinence
EP1299093A2 (de) * 2000-07-06 2003-04-09 Wyeth Kombinationen aus bisphosphonaten, östrogenmitteln und gegebenenfalls östrogenen
CN1468110A (zh) * 2000-07-06 2004-01-14 惠氏公司 他汀类、雌激素药物以及任选雌激素的联合应用
US6455568B2 (en) 2000-07-06 2002-09-24 Wyeth Combination therapy for inhibiting sphincter incontinence
DE10117441A1 (de) * 2001-04-03 2002-10-10 Schering Ag 1-Indolylderivate, deren Verwendung zur Herstellung von Arzneimitteln, ein Verfahren zur Herstellung der 1-Indolylderivate sowie 1-Indolylderivate enthaltende pharmzeutische Präparate
CZ2004118A3 (cs) 2001-07-31 2004-09-15 Pfizer Products Inc. Farmaceutický prostředek, kit a způsoby zahrnující kombinaci činidla estrogenový agonist/antagonist, estrogenu a progestinu
KR100470274B1 (ko) 2002-11-08 2005-02-05 진 장 덮개층을 이용한 비정질 물질의 상 변화 방법
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
FR2880625B1 (fr) * 2005-01-07 2007-03-09 Sanofi Aventis Sa Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
MX2010011408A (es) 2008-04-16 2010-12-20 Karobio Ab Ligandos de receptor de estrogeno novedosos.
AR072297A1 (es) * 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
CN102690225B (zh) * 2012-04-11 2014-12-24 南京友杰医药科技有限公司 巴多昔芬的合成方法
CN103709090A (zh) * 2014-01-16 2014-04-09 江苏万特制药有限公司 醋酸巴多昔芬的制备方法及其关键中间体
CN103739540B (zh) * 2014-01-20 2016-05-04 华润赛科药业有限责任公司 一种醋酸巴多昔芬中间体的制备方法
CN105669518B (zh) * 2014-12-04 2019-06-04 上海医药集团股份有限公司 醋酸巴多昔芬及其a晶型的制备方法
CN111527080B (zh) * 2017-12-15 2023-09-22 百时美施贵宝公司 取代的吲哚醚化合物
IT201800006562A1 (it) * 2018-06-21 2019-12-21 Procedimento e intermedi utili per la preparazione di indoli
CN115380026B (zh) * 2020-03-17 2023-11-07 南京明德新药研发有限公司 蛋白降解调节剂与其使用方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4729999A (en) * 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency
KR950701317A (ko) * 1992-05-08 1995-03-23 오오쓰까 아끼히꼬 인돌 유도체(Indole Derivative)
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
GB9326332D0 (en) * 1993-12-23 1994-02-23 Karo Bio Indole derivatives
DE4426625A1 (de) * 1994-07-27 1996-03-14 Schering Ag 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
TW397821B (en) * 1996-04-19 2000-07-11 American Home Produits Corp 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof
ATE206701T1 (de) * 1996-04-19 2001-10-15 American Home Prod Östrogene verbindungen
PL330994A1 (en) * 1996-07-09 1999-06-21 Smithkline Beecham Spa Indolic derivatives for use in treating osteoporosis
US5672609A (en) * 1996-07-18 1997-09-30 Eli Lilly And Company Pyridine compounds, intermediates compositions and methods of use
TR200001012T2 (tr) * 1997-10-15 2000-09-21 American Home Products Corporation Yeni ariloksi-alkil-dialkilaminler.
WO1999021557A1 (en) * 1997-10-28 1999-05-06 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
ID24568A (id) * 1997-11-06 2000-07-27 American Home Prod Kontrasepsi oral yang mengandung anti-estrogen plus progestin
GEP20033079B (en) * 1998-05-15 2003-10-27 Wyeth Corp Pharmaceutical Compositions for Treatment of Diseases Caused by Estrogens Deficiency

Also Published As

Publication number Publication date
CN1230163C (zh) 2005-12-07
KR100620772B1 (ko) 2006-09-13
PL194750B1 (pl) 2007-06-29
BE2015C026I2 (en) 2018-08-24
CU23241B7 (es) 2007-10-17
DE69909616D1 (de) 2003-08-21
NZ508200A (en) 2003-09-26
CY2015020I1 (el) 2020-05-29
ATE245026T1 (de) 2003-08-15
AP1424A (en) 2005-06-06
UA66861C2 (uk) 2004-06-15
ZA200006959B (en) 2001-11-27
FR15C0035I2 (fr) 2015-08-28
EA005932B1 (ru) 2005-08-25
HUS1500023I1 (hu) 2017-03-28
JP2014159472A (ja) 2014-09-04
SK284666B6 (sk) 2005-08-04
HRP20000778B1 (en) 2004-10-31
IN192220B (de) 2004-03-20
GEP20033079B (en) 2003-10-27
TR200003377T2 (tr) 2001-03-21
EP1076558A1 (de) 2001-02-21
DE69909616T2 (de) 2004-06-17
SI1076558T1 (en) 2003-10-31
JP2009019042A (ja) 2009-01-29
NO2015015I1 (no) 2015-06-02
KR20010043641A (ko) 2001-05-25
JP5872624B2 (ja) 2016-03-01
CZ299334B6 (cs) 2008-06-25
EE200000652A (et) 2002-04-15
HUP0103096A2 (hu) 2002-05-29
SK17202000A3 (sk) 2001-07-10
EP1076558B1 (de) 2003-07-16
JP5607871B2 (ja) 2014-10-15
EA200001193A1 (ru) 2001-12-24
BG104930A (en) 2001-07-31
AP2000001970A0 (en) 2000-12-31
PT1076558E (pt) 2003-11-28
CA2329530A1 (en) 1999-11-25
AR020074A1 (es) 2002-04-10
PL345268A1 (en) 2001-12-03
NO20005770D0 (no) 2000-11-14
AU760378B2 (en) 2003-05-15
FR15C0035I1 (de) 2015-06-26
JP2002515431A (ja) 2002-05-28
TW565554B (en) 2003-12-11
DK1076558T3 (da) 2003-11-03
IL139130A0 (en) 2001-11-25
LU92699I2 (fr) 2015-06-24
BR9911040A (pt) 2001-02-13
LTC1076558I2 (lt) 2016-11-10
ID26890A (id) 2001-02-15
NO20005770L (no) 2001-01-12
NO328129B1 (no) 2009-12-14
HK1031691A1 (en) 2001-06-22
HUP0103096A3 (en) 2002-11-28
HRP20000778A2 (en) 2001-06-30
IL139130A (en) 2005-11-20
HU226587B1 (en) 2009-04-28
CN1326347A (zh) 2001-12-12
NO2015015I2 (no) 2015-06-02
WO1999059581A1 (en) 1999-11-25
BG64783B1 (bg) 2006-04-28
ES2203131T3 (es) 2004-04-01
CZ20004254A3 (cs) 2001-12-12
OA11552A (en) 2004-06-07
AU3894499A (en) 1999-12-06

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