TR200003377T2 - Estrojenler ile bütünleşik 2-fenil-1-[4-(2-aminoetoksi)benzil]-indol - Google Patents
Estrojenler ile bütünleşik 2-fenil-1-[4-(2-aminoetoksi)benzil]-indolInfo
- Publication number
- TR200003377T2 TR200003377T2 TR2000/03377T TR200003377T TR200003377T2 TR 200003377 T2 TR200003377 T2 TR 200003377T2 TR 2000/03377 T TR2000/03377 T TR 2000/03377T TR 200003377 T TR200003377 T TR 200003377T TR 200003377 T2 TR200003377 T2 TR 200003377T2
- Authority
- TR
- Turkey
- Prior art keywords
- aminoethoxy
- estrogens
- benzyl
- phenyl
- indole
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
Bu bulus, bir veya daha fazla estrojen ve 2-fenil-1-[4-(2-aminoetoksi)benzil]-indol bilesiklerini içeren, estrojenik ajanlar olarak yararli yeni formülasyonlar ve farmakolojik kompozisyonlar ile bilesikleri kullanan tedavi yöntemlerine iliskin olup burada (I) ve (II) genel yapilari söz konusudur.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7956198A | 1998-05-15 | 1998-05-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200003377T2 true TR200003377T2 (tr) | 2001-03-21 |
Family
ID=22151320
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/03377T TR200003377T2 (tr) | 1998-05-15 | 1999-05-11 | Estrojenler ile bütünleşik 2-fenil-1-[4-(2-aminoetoksi)benzil]-indol |
Country Status (42)
Country | Link |
---|---|
EP (1) | EP1076558B1 (tr) |
JP (3) | JP2002515431A (tr) |
KR (1) | KR100620772B1 (tr) |
CN (1) | CN1230163C (tr) |
AP (1) | AP1424A (tr) |
AR (1) | AR020074A1 (tr) |
AT (1) | ATE245026T1 (tr) |
AU (1) | AU760378B2 (tr) |
BE (1) | BE2015C026I2 (tr) |
BG (1) | BG64783B1 (tr) |
BR (1) | BR9911040A (tr) |
CA (1) | CA2329530A1 (tr) |
CU (1) | CU23241B7 (tr) |
CY (1) | CY2015020I1 (tr) |
CZ (1) | CZ299334B6 (tr) |
DE (1) | DE69909616T2 (tr) |
DK (1) | DK1076558T3 (tr) |
EA (1) | EA005932B1 (tr) |
EE (1) | EE04262B1 (tr) |
ES (1) | ES2203131T3 (tr) |
FR (1) | FR15C0035I2 (tr) |
GE (1) | GEP20033079B (tr) |
HK (1) | HK1031691A1 (tr) |
HR (1) | HRP20000778B1 (tr) |
HU (2) | HU226587B1 (tr) |
ID (1) | ID26890A (tr) |
IL (1) | IL139130A (tr) |
IN (1) | IN192220B (tr) |
LT (1) | LTC1076558I2 (tr) |
LU (1) | LU92699I2 (tr) |
NO (2) | NO328129B1 (tr) |
NZ (1) | NZ508200A (tr) |
OA (1) | OA11552A (tr) |
PL (1) | PL194750B1 (tr) |
PT (1) | PT1076558E (tr) |
SI (1) | SI1076558T1 (tr) |
SK (1) | SK284666B6 (tr) |
TR (1) | TR200003377T2 (tr) |
TW (1) | TW565554B (tr) |
UA (1) | UA66861C2 (tr) |
WO (1) | WO1999059581A1 (tr) |
ZA (1) | ZA200006959B (tr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AP1424A (en) * | 1998-05-15 | 2005-06-06 | Wyeth Corp | 2-Phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens. |
US7005428B1 (en) | 1998-06-11 | 2006-02-28 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
US6465445B1 (en) | 1998-06-11 | 2002-10-15 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
WO2001001969A2 (en) | 1999-07-06 | 2001-01-11 | Endorecherche, Inc. | Methods of treating and/or suppressing weight gain |
US20020013327A1 (en) * | 2000-04-18 | 2002-01-31 | Lee Andrew G. | Compositions and methods for treating female sexual dysfunction |
US6376486B1 (en) | 2000-07-06 | 2002-04-23 | American Home Products Corporation | Methods of inhibiting sphincter incontinence |
AU2001271784A1 (en) * | 2000-07-06 | 2002-01-21 | Wyeth | Therapy for prosthesis-related bone degeneration |
US6455568B2 (en) | 2000-07-06 | 2002-09-24 | Wyeth | Combination therapy for inhibiting sphincter incontinence |
AU2001273125A1 (en) * | 2000-07-06 | 2002-01-21 | American Home Products Corporation | Combinations of bisphosphonates, estrogenic agents and optionally estrogens |
CA2414060A1 (en) * | 2000-07-06 | 2002-01-17 | Wyeth | Combinations of statins, estrogenic agents and optionally estrogens |
WO2002003989A2 (en) * | 2000-07-06 | 2002-01-17 | Wyeth | Use of substituted indole compounds for treating sphincter incontinence |
DE10117441A1 (de) * | 2001-04-03 | 2002-10-10 | Schering Ag | 1-Indolylderivate, deren Verwendung zur Herstellung von Arzneimitteln, ein Verfahren zur Herstellung der 1-Indolylderivate sowie 1-Indolylderivate enthaltende pharmzeutische Präparate |
CZ2004118A3 (cs) | 2001-07-31 | 2004-09-15 | Pfizer Products Inc. | Farmaceutický prostředek, kit a způsoby zahrnující kombinaci činidla estrogenový agonist/antagonist, estrogenu a progestinu |
KR100470274B1 (ko) | 2002-11-08 | 2005-02-05 | 진 장 | 덮개층을 이용한 비정질 물질의 상 변화 방법 |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
FR2880625B1 (fr) * | 2005-01-07 | 2007-03-09 | Sanofi Aventis Sa | Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
DK2276732T3 (en) | 2008-04-16 | 2015-08-17 | Karobio Ab | Novel østrogenreceptorligander |
AR072297A1 (es) * | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
GB201113538D0 (en) | 2011-08-04 | 2011-09-21 | Karobio Ab | Novel estrogen receptor ligands |
CN102690225B (zh) * | 2012-04-11 | 2014-12-24 | 南京友杰医药科技有限公司 | 巴多昔芬的合成方法 |
CN103709090A (zh) * | 2014-01-16 | 2014-04-09 | 江苏万特制药有限公司 | 醋酸巴多昔芬的制备方法及其关键中间体 |
CN103739540B (zh) * | 2014-01-20 | 2016-05-04 | 华润赛科药业有限责任公司 | 一种醋酸巴多昔芬中间体的制备方法 |
CN105669518B (zh) * | 2014-12-04 | 2019-06-04 | 上海医药集团股份有限公司 | 醋酸巴多昔芬及其a晶型的制备方法 |
AU2018386201A1 (en) * | 2017-12-15 | 2020-07-30 | Bristol-Myers Squibb Company | Substituted indole ether compounds |
IT201800006562A1 (it) | 2018-06-21 | 2019-12-21 | Procedimento e intermedi utili per la preparazione di indoli | |
JP2023517393A (ja) * | 2020-03-17 | 2023-04-25 | メッドシャイン ディスカバリー インコーポレイテッド | タンパク質分解調整剤およびその使用方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4729999A (en) * | 1984-10-12 | 1988-03-08 | Bcm Technologies | Antiestrogen therapy for symptoms of estrogen deficiency |
EP0639567A1 (en) * | 1992-05-08 | 1995-02-22 | Otsuka Pharmaceutical Factory, Inc. | Indole derivative |
TW366342B (en) * | 1992-07-28 | 1999-08-11 | Lilly Co Eli | The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss |
GB9326332D0 (en) * | 1993-12-23 | 1994-02-23 | Karo Bio | Indole derivatives |
DE4426625A1 (de) * | 1994-07-27 | 1996-03-14 | Schering Ag | 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln |
TW397821B (en) * | 1996-04-19 | 2000-07-11 | American Home Produits Corp | 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof |
ES2162198T3 (es) * | 1996-04-19 | 2001-12-16 | American Home Prod | Agentes estrogenos. |
CA2259598A1 (en) * | 1996-07-09 | 1998-01-15 | Smithkline Beecham S.P.A. | Indole derivatives for the treatment of osteoporosis |
US5672609A (en) * | 1996-07-18 | 1997-09-30 | Eli Lilly And Company | Pyridine compounds, intermediates compositions and methods of use |
KR100669836B1 (ko) * | 1997-10-15 | 2007-01-18 | 와이어쓰 | 신규한 아릴옥시-알킬-디알킬아민 및 이의 제조 방법 |
WO1999021557A1 (en) * | 1997-10-28 | 1999-05-06 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
ID24568A (id) * | 1997-11-06 | 2000-07-27 | American Home Prod | Kontrasepsi oral yang mengandung anti-estrogen plus progestin |
AP1424A (en) * | 1998-05-15 | 2005-06-06 | Wyeth Corp | 2-Phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens. |
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1999
- 1999-05-11 AP APAP/P/2000/001970A patent/AP1424A/en active
- 1999-05-11 GE GEAP19995675A patent/GEP20033079B/en unknown
- 1999-05-11 CZ CZ20004254A patent/CZ299334B6/cs not_active IP Right Cessation
- 1999-05-11 JP JP2000549246A patent/JP2002515431A/ja not_active Withdrawn
- 1999-05-11 SK SK1720-2000A patent/SK284666B6/sk not_active IP Right Cessation
- 1999-05-11 ES ES99921834T patent/ES2203131T3/es not_active Expired - Lifetime
- 1999-05-11 AU AU38944/99A patent/AU760378B2/en active Active
- 1999-05-11 UA UA2000127184A patent/UA66861C2/uk unknown
- 1999-05-11 TR TR2000/03377T patent/TR200003377T2/tr unknown
- 1999-05-11 WO PCT/US1999/010217 patent/WO1999059581A1/en active IP Right Grant
- 1999-05-11 SI SI9930339T patent/SI1076558T1/xx unknown
- 1999-05-11 AT AT99921834T patent/ATE245026T1/de active
- 1999-05-11 KR KR1020007012821A patent/KR100620772B1/ko not_active IP Right Cessation
- 1999-05-11 OA OA1200000311A patent/OA11552A/en unknown
- 1999-05-11 PL PL99345268A patent/PL194750B1/pl unknown
- 1999-05-11 EP EP99921834A patent/EP1076558B1/en not_active Expired - Lifetime
- 1999-05-11 CA CA002329530A patent/CA2329530A1/en not_active Abandoned
- 1999-05-11 EA EA200001193A patent/EA005932B1/ru not_active IP Right Cessation
- 1999-05-11 CN CNB99808655XA patent/CN1230163C/zh not_active Expired - Lifetime
- 1999-05-11 NZ NZ508200A patent/NZ508200A/en not_active IP Right Cessation
- 1999-05-11 IL IL13913099A patent/IL139130A/xx not_active IP Right Cessation
- 1999-05-11 EE EEP200000652A patent/EE04262B1/xx active Protection Beyond IP Right Term
- 1999-05-11 PT PT99921834T patent/PT1076558E/pt unknown
- 1999-05-11 DE DE69909616T patent/DE69909616T2/de not_active Expired - Lifetime
- 1999-05-11 HU HU0103096A patent/HU226587B1/hu active Protection Beyond IP Right Term
- 1999-05-11 DK DK99921834T patent/DK1076558T3/da active
- 1999-05-11 BR BR9911040-7A patent/BR9911040A/pt not_active Application Discontinuation
- 1999-05-11 ID IDW20002312A patent/ID26890A/id unknown
- 1999-05-13 TW TW088107747A patent/TW565554B/zh not_active IP Right Cessation
- 1999-05-14 AR ARP990102310A patent/AR020074A1/es not_active Application Discontinuation
-
2000
- 2000-11-08 BG BG104930A patent/BG64783B1/bg unknown
- 2000-11-14 NO NO20005770A patent/NO328129B1/no not_active IP Right Cessation
- 2000-11-15 CU CU20000255A patent/CU23241B7/es not_active IP Right Cessation
- 2000-11-15 HR HR20000778A patent/HRP20000778B1/xx not_active IP Right Cessation
- 2000-11-27 ZA ZA200006959A patent/ZA200006959B/en unknown
-
2001
- 2001-03-26 HK HK01102189A patent/HK1031691A1/xx not_active IP Right Cessation
- 2001-07-31 IN IN419CA2001 patent/IN192220B/en unknown
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2008
- 2008-07-29 JP JP2008195115A patent/JP5607871B2/ja not_active Expired - Lifetime
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2014
- 2014-05-12 JP JP2014098831A patent/JP5872624B2/ja not_active Expired - Lifetime
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2015
- 2015-04-15 LT LTPA2015018C patent/LTC1076558I2/lt unknown
- 2015-04-17 HU HUS1500023C patent/HUS1500023I1/hu unknown
- 2015-04-24 LU LU92699C patent/LU92699I2/xx unknown
- 2015-04-28 BE BE2015C026C patent/BE2015C026I2/fr unknown
- 2015-05-06 FR FR15C0035C patent/FR15C0035I2/fr active Active
- 2015-05-29 CY CY2015020C patent/CY2015020I1/el unknown
- 2015-06-02 NO NO2015015C patent/NO2015015I1/no not_active IP Right Cessation
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