ATE245026T1 - 2-phenyl-1-(-(2-aminoethoxy)-benzyl -indol und estrogen als kombinationpräparate - Google Patents

2-phenyl-1-(-(2-aminoethoxy)-benzyl -indol und estrogen als kombinationpräparate

Info

Publication number
ATE245026T1
ATE245026T1 AT99921834T AT99921834T ATE245026T1 AT E245026 T1 ATE245026 T1 AT E245026T1 AT 99921834 T AT99921834 T AT 99921834T AT 99921834 T AT99921834 T AT 99921834T AT E245026 T1 ATE245026 T1 AT E245026T1
Authority
AT
Austria
Prior art keywords
aminoethoxy
estrogen
indole
benzyl
phenyl
Prior art date
Application number
AT99921834T
Other languages
English (en)
Inventor
James Harrison Pickar
Barry Samuel Komm
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22151320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE245026(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of ATE245026T1 publication Critical patent/ATE245026T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT99921834T 1998-05-15 1999-05-11 2-phenyl-1-(-(2-aminoethoxy)-benzyl -indol und estrogen als kombinationpräparate ATE245026T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7956198A 1998-05-15 1998-05-15
PCT/US1999/010217 WO1999059581A1 (en) 1998-05-15 1999-05-11 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens

Publications (1)

Publication Number Publication Date
ATE245026T1 true ATE245026T1 (de) 2003-08-15

Family

ID=22151320

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99921834T ATE245026T1 (de) 1998-05-15 1999-05-11 2-phenyl-1-(-(2-aminoethoxy)-benzyl -indol und estrogen als kombinationpräparate

Country Status (42)

Country Link
EP (1) EP1076558B1 (de)
JP (3) JP2002515431A (de)
KR (1) KR100620772B1 (de)
CN (1) CN1230163C (de)
AP (1) AP1424A (de)
AR (1) AR020074A1 (de)
AT (1) ATE245026T1 (de)
AU (1) AU760378B2 (de)
BE (1) BE2015C026I2 (de)
BG (1) BG64783B1 (de)
BR (1) BR9911040A (de)
CA (1) CA2329530A1 (de)
CU (1) CU23241B7 (de)
CY (1) CY2015020I1 (de)
CZ (1) CZ299334B6 (de)
DE (1) DE69909616T2 (de)
DK (1) DK1076558T3 (de)
EA (1) EA005932B1 (de)
EE (1) EE04262B1 (de)
ES (1) ES2203131T3 (de)
FR (1) FR15C0035I2 (de)
GE (1) GEP20033079B (de)
HK (1) HK1031691A1 (de)
HR (1) HRP20000778B1 (de)
HU (2) HU226587B1 (de)
ID (1) ID26890A (de)
IL (1) IL139130A (de)
IN (1) IN192220B (de)
LT (1) LTC1076558I2 (de)
LU (1) LU92699I2 (de)
NO (2) NO328129B1 (de)
NZ (1) NZ508200A (de)
OA (1) OA11552A (de)
PL (1) PL194750B1 (de)
PT (1) PT1076558E (de)
SI (1) SI1076558T1 (de)
SK (1) SK284666B6 (de)
TR (1) TR200003377T2 (de)
TW (1) TW565554B (de)
UA (1) UA66861C2 (de)
WO (1) WO1999059581A1 (de)
ZA (1) ZA200006959B (de)

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JP2002515431A (ja) * 1998-05-15 2002-05-28 アメリカン・ホーム・プロダクツ・コーポレイション エストロゲンと組み合わせる２−フェニル−１−［４−（２−アミノエトキシ）ベンジルオキシ］インドール
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
DK1196163T3 (da) 1999-07-06 2010-03-29 Endorech Inc Farmaceutiske sammensætninger til behandling af insulinresistens
US20020013327A1 (en) * 2000-04-18 2002-01-31 Lee Andrew G. Compositions and methods for treating female sexual dysfunction
JP2004502731A (ja) * 2000-07-06 2004-01-29 ワイス スタチン、エストロゲン剤および所望によるエストロゲンの組み合わせ
WO2002003989A2 (en) * 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for treating sphincter incontinence
WO2002003992A2 (en) * 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for treating prosthesis-related bone degeneration
US6376486B1 (en) 2000-07-06 2002-04-23 American Home Products Corporation Methods of inhibiting sphincter incontinence
US6455568B2 (en) 2000-07-06 2002-09-24 Wyeth Combination therapy for inhibiting sphincter incontinence
MXPA02012897A (es) * 2000-07-06 2003-10-24 Wyeth Corp Combinaciones de bisfosfonatos, agentes estrigenicos y opcionalmente estrogenos.
DE10117441A1 (de) * 2001-04-03 2002-10-10 Schering Ag 1-Indolylderivate, deren Verwendung zur Herstellung von Arzneimitteln, ein Verfahren zur Herstellung der 1-Indolylderivate sowie 1-Indolylderivate enthaltende pharmzeutische Präparate
SK622004A3 (en) 2001-07-31 2004-08-03 Pfizer Prod Inc Pharmaceutical compositions, kits and methods comprising combinations of estrogen agonists/antagonists, estrogens and progestins
KR100470274B1 (ko) 2002-11-08 2005-02-05 진 장 덮개층을 이용한 비정질 물질의 상 변화 방법
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
FR2880625B1 (fr) * 2005-01-07 2007-03-09 Sanofi Aventis Sa Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
AU2009237657B2 (en) 2008-04-16 2013-04-04 Oasmia Pharmaceutical Ab Novel estrogen receptor ligands
AR072297A1 (es) * 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
CN102690225B (zh) * 2012-04-11 2014-12-24 南京友杰医药科技有限公司 巴多昔芬的合成方法
CN103709090A (zh) * 2014-01-16 2014-04-09 江苏万特制药有限公司 醋酸巴多昔芬的制备方法及其关键中间体
CN103739540B (zh) * 2014-01-20 2016-05-04 华润赛科药业有限责任公司 一种醋酸巴多昔芬中间体的制备方法
CN105669518B (zh) * 2014-12-04 2019-06-04 上海医药集团股份有限公司 醋酸巴多昔芬及其a晶型的制备方法
BR112020011668A2 (pt) * 2017-12-15 2020-11-17 Bristol-Myers Squibb Company compostos de éter de indol substituído
IT201800006562A1 (it) * 2018-06-21 2019-12-21 Procedimento e intermedi utili per la preparazione di indoli
US20230158152A1 (en) * 2020-03-17 2023-05-25 Medshine Discovery Inc. Proteolysis regulator and method for using same

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Publication number Priority date Publication date Assignee Title
US4729999A (en) * 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency
CA2135160A1 (en) * 1992-05-08 1993-11-25 Masatoshi Inai Indole derivative
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
GB9326332D0 (en) * 1993-12-23 1994-02-23 Karo Bio Indole derivatives
DE4426625A1 (de) * 1994-07-27 1996-03-14 Schering Ag 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
TW397821B (en) * 1996-04-19 2000-07-11 American Home Produits Corp 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof
ES2162198T3 (es) * 1996-04-19 2001-12-16 American Home Prod Agentes estrogenos.
TR199900138T2 (xx) * 1996-07-09 1999-04-21 Smithkline Beecham S.P.A. Osteoporozun tedavisi i�in indolin t�revleri.
US5672609A (en) * 1996-07-18 1997-09-30 Eli Lilly And Company Pyridine compounds, intermediates compositions and methods of use
EP1025077B1 (de) * 1997-10-15 2007-02-28 Wyeth Neue aryloxy-alkyl-dialkylamine
CA2308069A1 (en) * 1997-10-28 1999-05-06 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
ID24568A (id) * 1997-11-06 2000-07-27 American Home Prod Kontrasepsi oral yang mengandung anti-estrogen plus progestin
JP2002515431A (ja) * 1998-05-15 2002-05-28 アメリカン・ホーム・プロダクツ・コーポレイション エストロゲンと組み合わせる２−フェニル−１−［４−（２−アミノエトキシ）ベンジルオキシ］インドール

Also Published As

Publication number Publication date
ZA200006959B (en) 2001-11-27
IN192220B (de) 2004-03-20
NO20005770L (no) 2001-01-12
HU226587B1 (en) 2009-04-28
LTC1076558I2 (lt) 2016-11-10
EA200001193A1 (ru) 2001-12-24
KR100620772B1 (ko) 2006-09-13
AP1424A (en) 2005-06-06
DK1076558T3 (da) 2003-11-03
JP2002515431A (ja) 2002-05-28
PT1076558E (pt) 2003-11-28
NO328129B1 (no) 2009-12-14
CA2329530A1 (en) 1999-11-25
BG64783B1 (bg) 2006-04-28
BG104930A (en) 2001-07-31
CN1230163C (zh) 2005-12-07
EA005932B1 (ru) 2005-08-25
HUS1500023I1 (hu) 2017-03-28
JP2014159472A (ja) 2014-09-04
HK1031691A1 (en) 2001-06-22
HUP0103096A2 (hu) 2002-05-29
JP2009019042A (ja) 2009-01-29
CY2015020I1 (el) 2020-05-29
AU760378B2 (en) 2003-05-15
DE69909616T2 (de) 2004-06-17
ES2203131T3 (es) 2004-04-01
AP2000001970A0 (en) 2000-12-31
GEP20033079B (en) 2003-10-27
NO2015015I2 (no) 2015-06-02
UA66861C2 (uk) 2004-06-15
CZ20004254A3 (cs) 2001-12-12
BR9911040A (pt) 2001-02-13
EP1076558A1 (de) 2001-02-21
HRP20000778B1 (en) 2004-10-31
WO1999059581A1 (en) 1999-11-25
IL139130A0 (en) 2001-11-25
NO2015015I1 (no) 2015-06-02
PL194750B1 (pl) 2007-06-29
TW565554B (en) 2003-12-11
FR15C0035I1 (de) 2015-06-26
TR200003377T2 (tr) 2001-03-21
NZ508200A (en) 2003-09-26
AR020074A1 (es) 2002-04-10
PL345268A1 (en) 2001-12-03
NO20005770D0 (no) 2000-11-14
SI1076558T1 (en) 2003-10-31
EE04262B1 (et) 2004-04-15
KR20010043641A (ko) 2001-05-25
FR15C0035I2 (fr) 2015-08-28
ID26890A (id) 2001-02-15
IL139130A (en) 2005-11-20
JP5607871B2 (ja) 2014-10-15
SK17202000A3 (sk) 2001-07-10
DE69909616D1 (de) 2003-08-21
EP1076558B1 (de) 2003-07-16
CZ299334B6 (cs) 2008-06-25
CN1326347A (zh) 2001-12-12
HUP0103096A3 (en) 2002-11-28
CU23241B7 (es) 2007-10-17
AU3894499A (en) 1999-12-06
EE200000652A (et) 2002-04-15
JP5872624B2 (ja) 2016-03-01
SK284666B6 (sk) 2005-08-04
OA11552A (en) 2004-06-07
HRP20000778A2 (en) 2001-06-30
LU92699I2 (fr) 2015-06-24
BE2015C026I2 (en) 2018-08-24

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