NO20005770D0 - 2-fenyl-1-(4-(2-aminoetoksy)-benzyl)-indol i kombinasjon med östrogener - Google Patents

2-fenyl-1-(4-(2-aminoetoksy)-benzyl)-indol i kombinasjon med östrogener

Info

Publication number
NO20005770D0
NO20005770D0 NO20005770A NO20005770A NO20005770D0 NO 20005770 D0 NO20005770 D0 NO 20005770D0 NO 20005770 A NO20005770 A NO 20005770A NO 20005770 A NO20005770 A NO 20005770A NO 20005770 D0 NO20005770 D0 NO 20005770D0
Authority
NO
Norway
Prior art keywords
aminoethoxy
estrogens
indole
benzyl
phenyl
Prior art date
Application number
NO20005770A
Other languages
English (en)
Other versions
NO328129B1 (no
NO20005770L (no
Inventor
James Harrison Pickar
Barry Samuel Komm
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22151320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20005770(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by American Home Prod filed Critical American Home Prod
Publication of NO20005770D0 publication Critical patent/NO20005770D0/no
Publication of NO20005770L publication Critical patent/NO20005770L/no
Publication of NO328129B1 publication Critical patent/NO328129B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20005770A 1998-05-15 2000-11-14 Farmasoytisk sammensetning samt anvendelse NO328129B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7956198A 1998-05-15 1998-05-15
PCT/US1999/010217 WO1999059581A1 (en) 1998-05-15 1999-05-11 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens

Publications (3)

Publication Number Publication Date
NO20005770D0 true NO20005770D0 (no) 2000-11-14
NO20005770L NO20005770L (no) 2001-01-12
NO328129B1 NO328129B1 (no) 2009-12-14

Family

ID=22151320

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20005770A NO328129B1 (no) 1998-05-15 2000-11-14 Farmasoytisk sammensetning samt anvendelse
NO2015015C NO2015015I1 (no) 1998-05-15 2015-06-02 Bazedoksifen, eventuelt på form av et farmasøytisk akseptabelt salt slik som acetatsaltet, og konjugerte østrogener.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2015015C NO2015015I1 (no) 1998-05-15 2015-06-02 Bazedoksifen, eventuelt på form av et farmasøytisk akseptabelt salt slik som acetatsaltet, og konjugerte østrogener.

Country Status (42)

Country Link
EP (1) EP1076558B1 (no)
JP (3) JP2002515431A (no)
KR (1) KR100620772B1 (no)
CN (1) CN1230163C (no)
AP (1) AP1424A (no)
AR (1) AR020074A1 (no)
AT (1) ATE245026T1 (no)
AU (1) AU760378B2 (no)
BE (1) BE2015C026I2 (no)
BG (1) BG64783B1 (no)
BR (1) BR9911040A (no)
CA (1) CA2329530A1 (no)
CU (1) CU23241B7 (no)
CY (1) CY2015020I1 (no)
CZ (1) CZ299334B6 (no)
DE (1) DE69909616T2 (no)
DK (1) DK1076558T3 (no)
EA (1) EA005932B1 (no)
EE (1) EE04262B1 (no)
ES (1) ES2203131T3 (no)
FR (1) FR15C0035I2 (no)
GE (1) GEP20033079B (no)
HK (1) HK1031691A1 (no)
HR (1) HRP20000778B1 (no)
HU (2) HU226587B1 (no)
ID (1) ID26890A (no)
IL (1) IL139130A (no)
IN (1) IN192220B (no)
LT (1) LTC1076558I2 (no)
LU (1) LU92699I2 (no)
NO (2) NO328129B1 (no)
NZ (1) NZ508200A (no)
OA (1) OA11552A (no)
PL (1) PL194750B1 (no)
PT (1) PT1076558E (no)
SI (1) SI1076558T1 (no)
SK (1) SK284666B6 (no)
TR (1) TR200003377T2 (no)
TW (1) TW565554B (no)
UA (1) UA66861C2 (no)
WO (1) WO1999059581A1 (no)
ZA (1) ZA200006959B (no)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1076558E (pt) * 1998-05-15 2003-11-28 Wyeth Corp 2-fenil-1-¬4-(2-aminoetoxi)-benzil|-indole em combinacao com estrogenios
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
HU230543B1 (hu) 1999-07-06 2016-11-28 Endorecherche, Inc. Inzulinrezisztencia kezelésére és/vagy megakadályozására szolgáló gyógyszerkészítmények
US20020013327A1 (en) * 2000-04-18 2002-01-31 Lee Andrew G. Compositions and methods for treating female sexual dysfunction
WO2002003989A2 (en) * 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for treating sphincter incontinence
BR0112364A (pt) * 2000-07-06 2003-07-29 Wyeth Corp Combinações de bisfosfonatos, agentes estrogênicos e opcionalmente estrogênios
MXPA02012896A (es) * 2000-07-06 2003-10-24 Wyeth Corp Combinaciones de estatinas, agentes estrogenicos y opcionalmente estrogenos.
WO2002003992A2 (en) * 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for treating prosthesis-related bone degeneration
US6376486B1 (en) 2000-07-06 2002-04-23 American Home Products Corporation Methods of inhibiting sphincter incontinence
US6455568B2 (en) 2000-07-06 2002-09-24 Wyeth Combination therapy for inhibiting sphincter incontinence
DE10117441A1 (de) * 2001-04-03 2002-10-10 Schering Ag 1-Indolylderivate, deren Verwendung zur Herstellung von Arzneimitteln, ein Verfahren zur Herstellung der 1-Indolylderivate sowie 1-Indolylderivate enthaltende pharmzeutische Präparate
CN1599606A (zh) 2001-07-31 2005-03-23 辉瑞产品公司 包含雌激素激动剂/拮抗剂、雌激素与孕激素组合的药物组合物、试剂盒和方法
KR100470274B1 (ko) 2002-11-08 2005-02-05 진 장 덮개층을 이용한 비정질 물질의 상 변화 방법
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
FR2880625B1 (fr) * 2005-01-07 2007-03-09 Sanofi Aventis Sa Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
US8367665B2 (en) 2008-04-16 2013-02-05 Karo Bio Ab Estrogen receptor ligands
AR072297A1 (es) * 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
CN102690225B (zh) * 2012-04-11 2014-12-24 南京友杰医药科技有限公司 巴多昔芬的合成方法
CN103709090A (zh) * 2014-01-16 2014-04-09 江苏万特制药有限公司 醋酸巴多昔芬的制备方法及其关键中间体
CN103739540B (zh) * 2014-01-20 2016-05-04 华润赛科药业有限责任公司 一种醋酸巴多昔芬中间体的制备方法
CN105669518B (zh) * 2014-12-04 2019-06-04 上海医药集团股份有限公司 醋酸巴多昔芬及其a晶型的制备方法
SG11202005513TA (en) * 2017-12-15 2020-07-29 Bristol Myers Squibb Co Substituted indole ether compounds
IT201800006562A1 (it) * 2018-06-21 2019-12-21 Procedimento e intermedi utili per la preparazione di indoli
US20230158152A1 (en) * 2020-03-17 2023-05-25 Medshine Discovery Inc. Proteolysis regulator and method for using same

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4729999A (en) * 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency
US5496844A (en) * 1992-05-08 1996-03-05 Otsuka Pharmaceutical Factory, Inc. Indole derivatives
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
GB9326332D0 (en) * 1993-12-23 1994-02-23 Karo Bio Indole derivatives
DE4426625A1 (de) * 1994-07-27 1996-03-14 Schering Ag 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
NZ314601A (en) * 1996-04-19 1999-09-29 American Home Prod 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole derivatives as estrogenic agents and pharmaceutical compositions
TW397821B (en) * 1996-04-19 2000-07-11 American Home Produits Corp 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof
TR199900138T2 (xx) * 1996-07-09 1999-04-21 Smithkline Beecham S.P.A. Osteoporozun tedavisi i�in indolin t�revleri.
US5672609A (en) * 1996-07-18 1997-09-30 Eli Lilly And Company Pyridine compounds, intermediates compositions and methods of use
EP1777214A3 (en) * 1997-10-15 2007-05-09 Wyeth Novel aryloxy-alkyl-dialkylamines
WO1999021557A1 (en) * 1997-10-28 1999-05-06 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
ID24568A (id) * 1997-11-06 2000-07-27 American Home Prod Kontrasepsi oral yang mengandung anti-estrogen plus progestin
PT1076558E (pt) * 1998-05-15 2003-11-28 Wyeth Corp 2-fenil-1-¬4-(2-aminoetoxi)-benzil|-indole em combinacao com estrogenios

Also Published As

Publication number Publication date
JP2002515431A (ja) 2002-05-28
EA005932B1 (ru) 2005-08-25
HUS1500023I1 (hu) 2017-03-28
TW565554B (en) 2003-12-11
CZ20004254A3 (cs) 2001-12-12
LU92699I2 (fr) 2015-06-24
KR100620772B1 (ko) 2006-09-13
FR15C0035I1 (no) 2015-06-26
FR15C0035I2 (fr) 2015-08-28
AP2000001970A0 (en) 2000-12-31
PL194750B1 (pl) 2007-06-29
HUP0103096A3 (en) 2002-11-28
EE04262B1 (et) 2004-04-15
BG104930A (en) 2001-07-31
NO2015015I2 (no) 2015-06-02
CY2015020I1 (el) 2020-05-29
IL139130A (en) 2005-11-20
EP1076558A1 (en) 2001-02-21
CA2329530A1 (en) 1999-11-25
CZ299334B6 (cs) 2008-06-25
DE69909616D1 (de) 2003-08-21
HUP0103096A2 (hu) 2002-05-29
EP1076558B1 (en) 2003-07-16
AU760378B2 (en) 2003-05-15
ES2203131T3 (es) 2004-04-01
ATE245026T1 (de) 2003-08-15
BE2015C026I2 (en) 2018-08-24
CU23241B7 (es) 2007-10-17
HK1031691A1 (en) 2001-06-22
SK284666B6 (sk) 2005-08-04
DK1076558T3 (da) 2003-11-03
EE200000652A (et) 2002-04-15
PL345268A1 (en) 2001-12-03
AU3894499A (en) 1999-12-06
EA200001193A1 (ru) 2001-12-24
WO1999059581A1 (en) 1999-11-25
JP2009019042A (ja) 2009-01-29
SI1076558T1 (en) 2003-10-31
OA11552A (en) 2004-06-07
CN1326347A (zh) 2001-12-12
AR020074A1 (es) 2002-04-10
PT1076558E (pt) 2003-11-28
ZA200006959B (en) 2001-11-27
IN192220B (no) 2004-03-20
JP5607871B2 (ja) 2014-10-15
DE69909616T2 (de) 2004-06-17
KR20010043641A (ko) 2001-05-25
BR9911040A (pt) 2001-02-13
LTC1076558I2 (lt) 2016-11-10
BG64783B1 (bg) 2006-04-28
JP5872624B2 (ja) 2016-03-01
NO328129B1 (no) 2009-12-14
AP1424A (en) 2005-06-06
IL139130A0 (en) 2001-11-25
TR200003377T2 (tr) 2001-03-21
NO20005770L (no) 2001-01-12
ID26890A (id) 2001-02-15
GEP20033079B (en) 2003-10-27
HU226587B1 (en) 2009-04-28
HRP20000778A2 (en) 2001-06-30
NZ508200A (en) 2003-09-26
SK17202000A3 (sk) 2001-07-10
NO2015015I1 (no) 2015-06-02
JP2014159472A (ja) 2014-09-04
UA66861C2 (uk) 2004-06-15
HRP20000778B1 (en) 2004-10-31
CN1230163C (zh) 2005-12-07

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SPCF Filing of supplementary protection certificate

Free format text: PRODUCT NAME: DUAVIVE, KONJUGERTE OESTROGENER/BAZEDOKSIFEN; REG. NO/DATE: EU/1/14/960 20150112

Spc suppl protection certif: 2015015

Filing date: 20150602

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Owner name: WYETH LLC, US

SPCG Granted supplementary protection certificate

Free format text: PRODUCT NAME: BAZEDOKSIFEN, EVENTUELT PA FORM AV ET FARMASOEYTISK AKSEPTABELT SALT SLIK SOM ACETATSALTET, OG KONJUGERTE OESTROGENER.; REG. NO/DATE: EU/1/14/960 20150112

Spc suppl protection certif: 2015015

Filing date: 20150602

Extension date: 20240511

MK1K Patent expired