HUS1500023I1 - 2-Fenil-1-[4-(2-amino-etoxi)-benzil]-indol-származékok és ösztrogének kombinációját tartalmazó gyógyszerkészítmények - Google Patents

2-Fenil-1-[4-(2-amino-etoxi)-benzil]-indol-származékok és ösztrogének kombinációját tartalmazó gyógyszerkészítmények

Info

Publication number
HUS1500023I1
HUS1500023I1 HUS1500023C HUS1500023C HUS1500023I1 HU S1500023 I1 HUS1500023 I1 HU S1500023I1 HU S1500023 C HUS1500023 C HU S1500023C HU S1500023 C HUS1500023 C HU S1500023C HU S1500023 I1 HUS1500023 I1 HU S1500023I1
Authority
HU
Hungary
Prior art keywords
aminoethoxy
estrogens
indole
benzyl
phenyl
Prior art date
Application number
HUS1500023C
Other languages
English (en)
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22151320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUS1500023(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of HUS1500023I1 publication Critical patent/HUS1500023I1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
HUS1500023C 1998-05-15 2015-04-17 2-Fenil-1-[4-(2-amino-etoxi)-benzil]-indol-származékok és ösztrogének kombinációját tartalmazó gyógyszerkészítmények HUS1500023I1 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7956198A 1998-05-15 1998-05-15

Publications (1)

Publication Number Publication Date
HUS1500023I1 true HUS1500023I1 (hu) 2017-03-28

Family

ID=22151320

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0103096A HU226587B1 (en) 1998-05-15 1999-05-11 Pharmaceutical composition containing 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens
HUS1500023C HUS1500023I1 (hu) 1998-05-15 2015-04-17 2-Fenil-1-[4-(2-amino-etoxi)-benzil]-indol-származékok és ösztrogének kombinációját tartalmazó gyógyszerkészítmények

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU0103096A HU226587B1 (en) 1998-05-15 1999-05-11 Pharmaceutical composition containing 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens

Country Status (42)

Country Link
EP (1) EP1076558B1 (hu)
JP (3) JP2002515431A (hu)
KR (1) KR100620772B1 (hu)
CN (1) CN1230163C (hu)
AP (1) AP1424A (hu)
AR (1) AR020074A1 (hu)
AT (1) ATE245026T1 (hu)
AU (1) AU760378B2 (hu)
BE (1) BE2015C026I2 (hu)
BG (1) BG64783B1 (hu)
BR (1) BR9911040A (hu)
CA (1) CA2329530A1 (hu)
CU (1) CU23241B7 (hu)
CY (1) CY2015020I1 (hu)
CZ (1) CZ299334B6 (hu)
DE (1) DE69909616T2 (hu)
DK (1) DK1076558T3 (hu)
EA (1) EA005932B1 (hu)
EE (1) EE04262B1 (hu)
ES (1) ES2203131T3 (hu)
FR (1) FR15C0035I2 (hu)
GE (1) GEP20033079B (hu)
HK (1) HK1031691A1 (hu)
HR (1) HRP20000778B1 (hu)
HU (2) HU226587B1 (hu)
ID (1) ID26890A (hu)
IL (1) IL139130A (hu)
IN (1) IN192220B (hu)
LT (1) LTC1076558I2 (hu)
LU (1) LU92699I2 (hu)
NO (2) NO328129B1 (hu)
NZ (1) NZ508200A (hu)
OA (1) OA11552A (hu)
PL (1) PL194750B1 (hu)
PT (1) PT1076558E (hu)
SI (1) SI1076558T1 (hu)
SK (1) SK284666B6 (hu)
TR (1) TR200003377T2 (hu)
TW (1) TW565554B (hu)
UA (1) UA66861C2 (hu)
WO (1) WO1999059581A1 (hu)
ZA (1) ZA200006959B (hu)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1076558T3 (da) * 1998-05-15 2003-11-03 Wyeth Corp 2-Phenyl-1-[4-(2-aminoethoxy)benzyl]indol i kombination med østrogener
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
TR200403328T2 (tr) 1999-07-06 2005-03-21 Endorecherche, Inc. Kilo alımını tedavi ve/veya önleme metotları.
US20020013327A1 (en) * 2000-04-18 2002-01-31 Lee Andrew G. Compositions and methods for treating female sexual dysfunction
CA2414060A1 (en) * 2000-07-06 2002-01-17 Wyeth Combinations of statins, estrogenic agents and optionally estrogens
MXPA02012897A (es) * 2000-07-06 2003-10-24 Wyeth Corp Combinaciones de bisfosfonatos, agentes estrigenicos y opcionalmente estrogenos.
US6376486B1 (en) 2000-07-06 2002-04-23 American Home Products Corporation Methods of inhibiting sphincter incontinence
US6455568B2 (en) 2000-07-06 2002-09-24 Wyeth Combination therapy for inhibiting sphincter incontinence
WO2002003989A2 (en) * 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for treating sphincter incontinence
AU2001271784A1 (en) * 2000-07-06 2002-01-21 Wyeth Therapy for prosthesis-related bone degeneration
DE10117441A1 (de) * 2001-04-03 2002-10-10 Schering Ag 1-Indolylderivate, deren Verwendung zur Herstellung von Arzneimitteln, ein Verfahren zur Herstellung der 1-Indolylderivate sowie 1-Indolylderivate enthaltende pharmzeutische Präparate
CA2448235A1 (en) 2001-07-31 2003-02-13 Pfizer Products Inc. Pharmaceutical compositions, kits and methods comprising combinations of estrogen agonists/antagonists, estrogens and progestins
KR100470274B1 (ko) 2002-11-08 2005-02-05 진 장 덮개층을 이용한 비정질 물질의 상 변화 방법
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
FR2880625B1 (fr) * 2005-01-07 2007-03-09 Sanofi Aventis Sa Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
ES2543599T3 (es) 2008-04-16 2015-08-20 Karo Bio Ab Nuevos ligandos de receptor de estrógeno
AR072297A1 (es) * 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
CN102690225B (zh) * 2012-04-11 2014-12-24 南京友杰医药科技有限公司 巴多昔芬的合成方法
CN103709090A (zh) * 2014-01-16 2014-04-09 江苏万特制药有限公司 醋酸巴多昔芬的制备方法及其关键中间体
CN103739540B (zh) * 2014-01-20 2016-05-04 华润赛科药业有限责任公司 一种醋酸巴多昔芬中间体的制备方法
CN105669518B (zh) * 2014-12-04 2019-06-04 上海医药集团股份有限公司 醋酸巴多昔芬及其a晶型的制备方法
CA3085333A1 (en) * 2017-12-15 2019-06-20 Bristol-Myers Squibb Company Substituted indole ether compounds
IT201800006562A1 (it) 2018-06-21 2019-12-21 Procedimento e intermedi utili per la preparazione di indoli
WO2021185291A1 (zh) * 2020-03-17 2021-09-23 南京明德新药研发有限公司 蛋白降解调节剂与其使用方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4729999A (en) * 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency
EP0639567A1 (en) * 1992-05-08 1995-02-22 Otsuka Pharmaceutical Factory, Inc. Indole derivative
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
GB9326332D0 (en) * 1993-12-23 1994-02-23 Karo Bio Indole derivatives
DE4426625A1 (de) * 1994-07-27 1996-03-14 Schering Ag 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
TW397821B (en) * 1996-04-19 2000-07-11 American Home Produits Corp 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof
DE122009000061I1 (de) * 1996-04-19 2009-12-31 Wyeth N D Ges D Staates Delawa Östrogene Verbindungen
IL127668A0 (en) * 1996-07-09 1999-10-28 Smithkline Beecham Spa Indole derivatives for the treatment of osteoporosis
US5672609A (en) * 1996-07-18 1997-09-30 Eli Lilly And Company Pyridine compounds, intermediates compositions and methods of use
KR100669836B1 (ko) * 1997-10-15 2007-01-18 와이어쓰 신규한 아릴옥시-알킬-디알킬아민 및 이의 제조 방법
CA2308069A1 (en) * 1997-10-28 1999-05-06 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
ID24568A (id) * 1997-11-06 2000-07-27 American Home Prod Kontrasepsi oral yang mengandung anti-estrogen plus progestin
DK1076558T3 (da) * 1998-05-15 2003-11-03 Wyeth Corp 2-Phenyl-1-[4-(2-aminoethoxy)benzyl]indol i kombination med østrogener

Also Published As

Publication number Publication date
BG64783B1 (bg) 2006-04-28
HUP0103096A3 (en) 2002-11-28
JP2002515431A (ja) 2002-05-28
CZ20004254A3 (cs) 2001-12-12
UA66861C2 (uk) 2004-06-15
OA11552A (en) 2004-06-07
HU226587B1 (en) 2009-04-28
LU92699I2 (fr) 2015-06-24
CN1230163C (zh) 2005-12-07
GEP20033079B (en) 2003-10-27
ES2203131T3 (es) 2004-04-01
EA005932B1 (ru) 2005-08-25
SI1076558T1 (en) 2003-10-31
ZA200006959B (en) 2001-11-27
HK1031691A1 (en) 2001-06-22
BR9911040A (pt) 2001-02-13
ID26890A (id) 2001-02-15
PL345268A1 (en) 2001-12-03
AP2000001970A0 (en) 2000-12-31
AR020074A1 (es) 2002-04-10
NO2015015I1 (no) 2015-06-02
TW565554B (en) 2003-12-11
EE200000652A (et) 2002-04-15
KR20010043641A (ko) 2001-05-25
SK284666B6 (sk) 2005-08-04
DE69909616D1 (de) 2003-08-21
NO20005770L (no) 2001-01-12
ATE245026T1 (de) 2003-08-15
AU3894499A (en) 1999-12-06
HRP20000778A2 (en) 2001-06-30
EP1076558A1 (en) 2001-02-21
KR100620772B1 (ko) 2006-09-13
HRP20000778B1 (en) 2004-10-31
DK1076558T3 (da) 2003-11-03
NO328129B1 (no) 2009-12-14
SK17202000A3 (sk) 2001-07-10
EE04262B1 (et) 2004-04-15
IN192220B (hu) 2004-03-20
AU760378B2 (en) 2003-05-15
EA200001193A1 (ru) 2001-12-24
FR15C0035I2 (fr) 2015-08-28
NO2015015I2 (no) 2015-06-02
JP5607871B2 (ja) 2014-10-15
NO20005770D0 (no) 2000-11-14
NZ508200A (en) 2003-09-26
JP2014159472A (ja) 2014-09-04
LTC1076558I2 (lt) 2016-11-10
IL139130A0 (en) 2001-11-25
BG104930A (en) 2001-07-31
CN1326347A (zh) 2001-12-12
IL139130A (en) 2005-11-20
DE69909616T2 (de) 2004-06-17
TR200003377T2 (tr) 2001-03-21
FR15C0035I1 (hu) 2015-06-26
HUP0103096A2 (hu) 2002-05-29
BE2015C026I2 (en) 2018-08-24
CU23241B7 (es) 2007-10-17
WO1999059581A1 (en) 1999-11-25
CA2329530A1 (en) 1999-11-25
CZ299334B6 (cs) 2008-06-25
JP2009019042A (ja) 2009-01-29
AP1424A (en) 2005-06-06
PL194750B1 (pl) 2007-06-29
PT1076558E (pt) 2003-11-28
JP5872624B2 (ja) 2016-03-01
CY2015020I1 (el) 2020-05-29
EP1076558B1 (en) 2003-07-16

Similar Documents

Publication Publication Date Title
HUS1500023I1 (hu) 2-Fenil-1-[4-(2-amino-etoxi)-benzil]-indol-származékok és ösztrogének kombinációját tartalmazó gyógyszerkészítmények
HUP9700777A3 (en) Estrogenical 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole derivatives, preparation and use thereof and pharmaceutical compositions containing these compounds
IL139934A0 (en) Pyrrole substituted 2-indolinone derivatives and pharmaceutical compositions containing the same
IL139479A0 (en) Heterocyclic compounds and pharmaceutical compositions containing the same
HUP0103256A3 (en) Thiobenzimidazole derivatives and pharmaceutical compositions containing the compounds
IL138899A0 (en) Amidene derivatives and pharmaceutical compositions containing the same
HUP9903544A3 (en) Pharmaceutical composition with anaesthetic effect for local use
IL148517A0 (en) Heterocyclic compounds and pharmaceutical compositions containing the same
IL150077A0 (en) Heterocyclic compounds and pharmaceutical compositions containing the same
AU141787S (en) Container primarily for moistened wipes
IL143920A0 (en) 3-heteroarylidenyl-2-indolinone derivatives and pharmaceutical compositions containing the same
IL144592A0 (en) Heterocyclic aromatic compounds and pharmaceutical compositions containing the same
HK1027585A1 (en) Improved antiog composition for polyolefin packaging films and use thereof.
HUP0101381A3 (en) Benzofurylpyrone derivatives and pharmaceutical compositions containing them
IL133097A0 (en) Aroyl-piperazine derivatives pharmaceutical compositions containing the same and the use thereof
ZA200106451B (en) Stabilized oral pharmaceutical composition containing iodide and iodate and method.
HUP0003425A3 (en) 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives and pharmaceutical compositions containing the compounds
IL147214A0 (en) 1-methylcarbapenem derivatives and pharmaceutical compositions containing the same
IL149883A0 (en) Heterocyclic compounds and pharmaceutical compositions containing the same
IL143802A0 (en) Imidazole derivatives and pharmaceutical compositions containing the same
HUP0100680A3 (en) Indole derivatives and medicinal compositions containing the same
PL343769A1 (en) Pharmaceutical composition
HUP0000137A3 (en) Controller-release pharmaceutical composition containing anangetics
HUP0203121A3 (en) Pharmaceutical composition containing substituted benzimidazoles and its use
IL134538A (en) Lactacystin derivatives and pharmaceutical compositions containing the same