OA11552A - 2-Phenyl-1-Ä4-(2-Aminoethoxy)-BenzylÜ-Indole in Combination with Estrogens. - Google Patents

2-Phenyl-1-Ä4-(2-Aminoethoxy)-BenzylÜ-Indole in Combination with Estrogens. Download PDF

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Publication number
OA11552A
OA11552A OA1200000311A OA1200000311A OA11552A OA 11552 A OA11552 A OA 11552A OA 1200000311 A OA1200000311 A OA 1200000311A OA 1200000311 A OA1200000311 A OA 1200000311A OA 11552 A OA11552 A OA 11552A
Authority
OA
OAPI
Prior art keywords
alkyl
dmso
nmr
indol
indole
Prior art date
Application number
OA1200000311A
Other languages
English (en)
Inventor
Barry Samuel Komm
James Harrison Pickar
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22151320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=OA11552(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by American Home Prod filed Critical American Home Prod
Publication of OA11552A publication Critical patent/OA11552A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
OA1200000311A 1998-05-15 1999-05-11 2-Phenyl-1-Ä4-(2-Aminoethoxy)-BenzylÜ-Indole in Combination with Estrogens. OA11552A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7956198A 1998-05-15 1998-05-15

Publications (1)

Publication Number Publication Date
OA11552A true OA11552A (en) 2004-06-07

Family

ID=22151320

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200000311A OA11552A (en) 1998-05-15 1999-05-11 2-Phenyl-1-Ä4-(2-Aminoethoxy)-BenzylÜ-Indole in Combination with Estrogens.

Country Status (42)

Country Link
EP (1) EP1076558B1 (hu)
JP (3) JP2002515431A (hu)
KR (1) KR100620772B1 (hu)
CN (1) CN1230163C (hu)
AP (1) AP1424A (hu)
AR (1) AR020074A1 (hu)
AT (1) ATE245026T1 (hu)
AU (1) AU760378B2 (hu)
BE (1) BE2015C026I2 (hu)
BG (1) BG64783B1 (hu)
BR (1) BR9911040A (hu)
CA (1) CA2329530A1 (hu)
CU (1) CU23241B7 (hu)
CY (1) CY2015020I1 (hu)
CZ (1) CZ299334B6 (hu)
DE (1) DE69909616T2 (hu)
DK (1) DK1076558T3 (hu)
EA (1) EA005932B1 (hu)
EE (1) EE04262B1 (hu)
ES (1) ES2203131T3 (hu)
FR (1) FR15C0035I2 (hu)
GE (1) GEP20033079B (hu)
HK (1) HK1031691A1 (hu)
HR (1) HRP20000778B1 (hu)
HU (2) HU226587B1 (hu)
ID (1) ID26890A (hu)
IL (1) IL139130A (hu)
IN (1) IN192220B (hu)
LT (1) LTC1076558I2 (hu)
LU (1) LU92699I2 (hu)
NO (2) NO328129B1 (hu)
NZ (1) NZ508200A (hu)
OA (1) OA11552A (hu)
PL (1) PL194750B1 (hu)
PT (1) PT1076558E (hu)
SI (1) SI1076558T1 (hu)
SK (1) SK284666B6 (hu)
TR (1) TR200003377T2 (hu)
TW (1) TW565554B (hu)
UA (1) UA66861C2 (hu)
WO (1) WO1999059581A1 (hu)
ZA (1) ZA200006959B (hu)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002515431A (ja) * 1998-05-15 2002-05-28 アメリカン・ホーム・プロダクツ・コーポレイション エストロゲンと組み合わせる２−フェニル−１−［４−（２−アミノエトキシ）ベンジルオキシ］インドール
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
ATE447947T1 (de) 1999-07-06 2009-11-15 Endorech Inc Pharmazeutische zubereitungen zur behandlung von insulinresitenz
US20020013327A1 (en) * 2000-04-18 2002-01-31 Lee Andrew G. Compositions and methods for treating female sexual dysfunction
BR0112364A (pt) * 2000-07-06 2003-07-29 Wyeth Corp Combinações de bisfosfonatos, agentes estrogênicos e opcionalmente estrogênios
WO2002003992A2 (en) * 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for treating prosthesis-related bone degeneration
US6455568B2 (en) 2000-07-06 2002-09-24 Wyeth Combination therapy for inhibiting sphincter incontinence
MXPA02012896A (es) * 2000-07-06 2003-10-24 Wyeth Corp Combinaciones de estatinas, agentes estrogenicos y opcionalmente estrogenos.
AU2001271781A1 (en) * 2000-07-06 2002-01-21 Wyeth Use of substituted indole compounds for treating sphincter incontinence
US6376486B1 (en) 2000-07-06 2002-04-23 American Home Products Corporation Methods of inhibiting sphincter incontinence
DE10117441A1 (de) * 2001-04-03 2002-10-10 Schering Ag 1-Indolylderivate, deren Verwendung zur Herstellung von Arzneimitteln, ein Verfahren zur Herstellung der 1-Indolylderivate sowie 1-Indolylderivate enthaltende pharmzeutische Präparate
JP2005504032A (ja) 2001-07-31 2005-02-10 ファイザー・プロダクツ・インク エストロゲン・アゴニスト／アンタゴニスト、エストロゲン及びプロゲスチンの組み合わせを含む医薬組成物、キット及び方法
KR100470274B1 (ko) 2002-11-08 2005-02-05 진 장 덮개층을 이용한 비정질 물질의 상 변화 방법
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
FR2880625B1 (fr) * 2005-01-07 2007-03-09 Sanofi Aventis Sa Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
HUE025471T2 (hu) 2008-04-16 2016-03-29 Karobio Ab Új ösztrogén receptor ligandumok
AR072297A1 (es) * 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
CN102690225B (zh) * 2012-04-11 2014-12-24 南京友杰医药科技有限公司 巴多昔芬的合成方法
CN103709090A (zh) * 2014-01-16 2014-04-09 江苏万特制药有限公司 醋酸巴多昔芬的制备方法及其关键中间体
CN103739540B (zh) * 2014-01-20 2016-05-04 华润赛科药业有限责任公司 一种醋酸巴多昔芬中间体的制备方法
CN105669518B (zh) * 2014-12-04 2019-06-04 上海医药集团股份有限公司 醋酸巴多昔芬及其a晶型的制备方法
CA3085333A1 (en) * 2017-12-15 2019-06-20 Bristol-Myers Squibb Company Substituted indole ether compounds
IT201800006562A1 (it) * 2018-06-21 2019-12-21 Procedimento e intermedi utili per la preparazione di indoli
US20230158152A1 (en) * 2020-03-17 2023-05-25 Medshine Discovery Inc. Proteolysis regulator and method for using same

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4729999A (en) * 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency
WO1993023374A1 (en) * 1992-05-08 1993-11-25 Otsuka Pharmaceutical Factory, Inc. Indole derivative
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
GB9326332D0 (en) * 1993-12-23 1994-02-23 Karo Bio Indole derivatives
DE4426625A1 (de) * 1994-07-27 1996-03-14 Schering Ag 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
TW397821B (en) * 1996-04-19 2000-07-11 American Home Produits Corp 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof
PT802183E (pt) * 1996-04-19 2002-03-28 American Home Prod Agentes estrogenicos
WO1998001443A1 (en) * 1996-07-09 1998-01-15 Smithkline Beecham S.P.A. Indole derivatives for the treatment of osteoporosis
US5672609A (en) * 1996-07-18 1997-09-30 Eli Lilly And Company Pyridine compounds, intermediates compositions and methods of use
ES2281937T3 (es) * 1997-10-15 2007-10-01 Wyeth Nuevas ariloxi-alquil-dialquilaminas.
AU1197299A (en) * 1997-10-28 1999-05-17 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
ID24568A (id) * 1997-11-06 2000-07-27 American Home Prod Kontrasepsi oral yang mengandung anti-estrogen plus progestin
JP2002515431A (ja) * 1998-05-15 2002-05-28 アメリカン・ホーム・プロダクツ・コーポレイション エストロゲンと組み合わせる２−フェニル−１−［４−（２−アミノエトキシ）ベンジルオキシ］インドール

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Publication number Publication date
CN1326347A (zh) 2001-12-12
JP2014159472A (ja) 2014-09-04
EA200001193A1 (ru) 2001-12-24
AP2000001970A0 (en) 2000-12-31
KR100620772B1 (ko) 2006-09-13
UA66861C2 (uk) 2004-06-15
DK1076558T3 (da) 2003-11-03
PL194750B1 (pl) 2007-06-29
BR9911040A (pt) 2001-02-13
BG104930A (en) 2001-07-31
HUP0103096A2 (hu) 2002-05-29
DE69909616T2 (de) 2004-06-17
SK284666B6 (sk) 2005-08-04
FR15C0035I2 (fr) 2015-08-28
JP2009019042A (ja) 2009-01-29
LU92699I2 (fr) 2015-06-24
ES2203131T3 (es) 2004-04-01
TR200003377T2 (tr) 2001-03-21
HK1031691A1 (en) 2001-06-22
JP5872624B2 (ja) 2016-03-01
BG64783B1 (bg) 2006-04-28
JP2002515431A (ja) 2002-05-28
IL139130A (en) 2005-11-20
GEP20033079B (en) 2003-10-27
AP1424A (en) 2005-06-06
LTC1076558I2 (lt) 2016-11-10
ID26890A (id) 2001-02-15
PL345268A1 (en) 2001-12-03
ATE245026T1 (de) 2003-08-15
CZ299334B6 (cs) 2008-06-25
CA2329530A1 (en) 1999-11-25
KR20010043641A (ko) 2001-05-25
SK17202000A3 (sk) 2001-07-10
NO20005770L (no) 2001-01-12
DE69909616D1 (de) 2003-08-21
NO2015015I1 (no) 2015-06-02
CN1230163C (zh) 2005-12-07
CY2015020I1 (el) 2020-05-29
NO2015015I2 (no) 2015-06-02
CZ20004254A3 (cs) 2001-12-12
ZA200006959B (en) 2001-11-27
EP1076558B1 (en) 2003-07-16
AU760378B2 (en) 2003-05-15
HRP20000778A2 (en) 2001-06-30
IL139130A0 (en) 2001-11-25
AR020074A1 (es) 2002-04-10
AU3894499A (en) 1999-12-06
EE04262B1 (et) 2004-04-15
SI1076558T1 (en) 2003-10-31
IN192220B (hu) 2004-03-20
HRP20000778B1 (en) 2004-10-31
NO328129B1 (no) 2009-12-14
NZ508200A (en) 2003-09-26
EE200000652A (et) 2002-04-15
TW565554B (en) 2003-12-11
JP5607871B2 (ja) 2014-10-15
HU226587B1 (en) 2009-04-28
HUP0103096A3 (en) 2002-11-28
NO20005770D0 (no) 2000-11-14
WO1999059581A1 (en) 1999-11-25
EA005932B1 (ru) 2005-08-25
HUS1500023I1 (hu) 2017-03-28
EP1076558A1 (en) 2001-02-21
BE2015C026I2 (en) 2018-08-24
CU23241B7 (es) 2007-10-17
PT1076558E (pt) 2003-11-28
FR15C0035I1 (hu) 2015-06-26

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