EE04224B1 - Gaasi mikromullide dispersioon ja selle lüofiliseeritud jääk, ultraheli kontrastaine ja selle valmistamismeetod, mikromulle eraldav maatriks ning ultraheli kontrastaine kompositsioon - Google Patents

Gaasi mikromullide dispersioon ja selle lüofiliseeritud jääk, ultraheli kontrastaine ja selle valmistamismeetod, mikromulle eraldav maatriks ning ultraheli kontrastaine kompositsioon

Info

Publication number
EE04224B1
EE04224B1 EE9800249A EE9800249A EE04224B1 EE 04224 B1 EE04224 B1 EE 04224B1 EE 9800249 A EE9800249 A EE 9800249A EE 9800249 A EE9800249 A EE 9800249A EE 04224 B1 EE04224 B1 EE 04224B1
Authority
EE
Estonia
Prior art keywords
contrast medium
ultrasonic contrast
microbubbles
dispersion
matrix
Prior art date
Application number
EE9800249A
Other languages
English (en)
Estonian (et)
Other versions
EE9800249A (et
Inventor
Undheim Br�nden Jorunn
Dugstad Harald
Klaveness Jo
Rongved P�l
Skurtveit Roald
Original Assignee
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603466.5A external-priority patent/GB9603466D0/en
Priority claimed from GBGB9611894.8A external-priority patent/GB9611894D0/en
Priority claimed from GBGB9625663.1A external-priority patent/GB9625663D0/en
Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As
Publication of EE9800249A publication Critical patent/EE9800249A/xx
Publication of EE04224B1 publication Critical patent/EE04224B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
EE9800249A 1996-02-19 1997-02-19 Gaasi mikromullide dispersioon ja selle lüofiliseeritud jääk, ultraheli kontrastaine ja selle valmistamismeetod, mikromulle eraldav maatriks ning ultraheli kontrastaine kompositsioon EE04224B1 (et)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9603466.5A GB9603466D0 (en) 1996-02-19 1996-02-19 Improvements in or relating to contrast agents
GBGB9611894.8A GB9611894D0 (en) 1996-06-07 1996-06-07 Improvements in or relating to contrast agents
GBGB9625663.1A GB9625663D0 (en) 1996-12-11 1996-12-11 Improvements in or relating to contrast agents
PCT/GB1997/000459 WO1997029783A1 (en) 1996-02-19 1997-02-19 Improvements in or relating to contrast agents

Publications (2)

Publication Number Publication Date
EE9800249A EE9800249A (et) 1999-02-15
EE04224B1 true EE04224B1 (et) 2004-02-16

Family

ID=27268137

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9800249A EE04224B1 (et) 1996-02-19 1997-02-19 Gaasi mikromullide dispersioon ja selle lüofiliseeritud jääk, ultraheli kontrastaine ja selle valmistamismeetod, mikromulle eraldav maatriks ning ultraheli kontrastaine kompositsioon

Country Status (24)

Country Link
US (4) US6221337B1 (enExample)
EP (2) EP1331013A3 (enExample)
JP (1) JP4418033B2 (enExample)
KR (1) KR100500334B1 (enExample)
CN (1) CN1278740C (enExample)
AP (1) AP890A (enExample)
AT (1) ATE238072T1 (enExample)
AU (1) AU726503B2 (enExample)
BG (1) BG102758A (enExample)
CA (1) CA2246779C (enExample)
CZ (1) CZ293986B6 (enExample)
DE (1) DE69721235T2 (enExample)
EA (1) EA001135B1 (enExample)
EE (1) EE04224B1 (enExample)
ES (1) ES2197986T3 (enExample)
HU (1) HU229090B1 (enExample)
IL (1) IL125748A (enExample)
NZ (1) NZ331509A (enExample)
OA (1) OA10839A (enExample)
PL (1) PL328406A1 (enExample)
PT (1) PT881915E (enExample)
SK (1) SK284200B6 (enExample)
TR (1) TR199801613T2 (enExample)
WO (1) WO1997029783A1 (enExample)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE411055T1 (de) * 1996-08-02 2008-10-15 Ge Healthcare As Verbesserungen für oder in bezug auf kontrastmittel
AU784367B2 (en) * 1996-08-02 2006-03-16 Ge Healthcare As Improvements in or relating to contrast agents
CN1103605C (zh) * 1997-08-12 2003-03-26 勃勒柯研究有限公司 磁共振成象用可投药组合物及方法
GB9717476D0 (en) * 1997-08-18 1997-10-22 Nycomed Imaging As Process
GB9717589D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
GB9717588D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
GB9717542D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Process
GB9726773D0 (en) 1997-12-18 1998-02-18 Nycomed Imaging As Improvements in or relating to ultrasonagraphy
EP1073716B1 (en) * 1998-04-28 2004-04-28 Amersham Health AS Improvements in or relating to separation processes
GB9813568D0 (en) 1998-06-23 1998-08-19 Nycomed Imaging As Improvements in or relating to cardiac imaging
US6514209B1 (en) 1999-06-07 2003-02-04 Drexel University Method of enhancing ultrasonic techniques via measurement of ultraharmonic signals
US20030103960A1 (en) * 1999-12-22 2003-06-05 Pierre Philippart Sealant and bone generating product
CA2410887C (en) 2000-06-02 2012-07-24 Bracco Research Usa Compounds for targeting endothelial cells, compositions containing the same and methods for their use
NO20004795D0 (no) 2000-09-26 2000-09-26 Nycomed Imaging As Peptidbaserte forbindelser
KR100373712B1 (ko) * 2000-12-23 2003-02-25 사회복지법인삼성생명공익재단(삼성서울병원) 초음파 조영제 및 그의 제조방법
US6984373B2 (en) 2000-12-23 2006-01-10 Dyax Corp. Fibrin binding moieties useful as imaging agents
JP3819845B2 (ja) 2001-04-06 2006-09-13 ブラッコ・リサーチ・ソシエテ・アノニム 流体で充填された空洞内の局所物理パラメータの改善された測定方法
MXPA04007328A (es) * 2002-02-01 2005-07-05 Shimoda Biotech Pty Ltd Composicion farmaceutica.
AU2003278807A1 (en) 2002-03-01 2004-08-13 Bracco International B.V. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
EP2014310B8 (en) 2002-03-01 2012-12-26 Dyax Corp. KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
NO20024755D0 (no) * 2002-10-03 2002-10-03 Amersham Health As Metode
CA2504668A1 (en) 2002-11-29 2004-06-17 Amersham Health As Ultrasound triggering method
MXPA05007730A (es) * 2003-02-04 2006-01-31 Bracco Int Bv Agentes de contraste para ultrasonido y proceso para la preparacion de los mismos.
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
EP1603935A4 (en) 2003-03-03 2007-03-21 Dyax Corp SPECIFIC TO HGF RECEPTOR (cMET) BINDING PEPTIDES AND THEIR USE
WO2005002546A1 (en) * 2003-06-27 2005-01-13 Smithkline Beecham Corporation Stabilized topotecan liposomal composition and methods
US20050019379A1 (en) 2003-07-22 2005-01-27 Kimberly-Clark Worldwide, Inc. Wipe and methods for improving skin health
NO20035401D0 (no) * 2003-12-04 2003-12-04 Amersham Health As Metode
US9750821B2 (en) 2003-12-22 2017-09-05 Bracco Suisse S.A. Gas-filled microvesicle assembly for contrast imaging
US20070081946A1 (en) * 2003-12-22 2007-04-12 Bracco Research S.A. Assembly of gas-filled microvesicle with active component for contrast imaging
US7025726B2 (en) 2004-01-22 2006-04-11 The Regents Of The University Of Nebraska Detection of endothelial dysfunction by ultrasonic imaging
CN103120799A (zh) 2004-08-18 2013-05-29 博莱科瑞士股份有限公司 用于反差成像的充气微泡组合物
WO2006044997A2 (en) * 2004-10-15 2006-04-27 The Trustees Of Columbia University In The City Of New York System and method for localized measurement and imaging of viscosity of tissues
WO2006044996A2 (en) * 2004-10-15 2006-04-27 The Trustees Of Columbia University In The City Of New York System and method for automated boundary detection of body structures
CN100574809C (zh) * 2005-01-10 2009-12-30 重庆海扶(Hifu)技术有限公司 一种高强度聚焦超声治疗用氟碳乳剂类助剂及其应用
CN100427142C (zh) * 2005-01-10 2008-10-22 重庆海扶(Hifu)技术有限公司 一种高强度聚焦超声治疗用助剂及其筛选方法
CN100574811C (zh) * 2005-01-10 2009-12-30 重庆海扶(Hifu)技术有限公司 一种高强度聚焦超声治疗用微粒类助剂及其应用
US10687785B2 (en) 2005-05-12 2020-06-23 The Trustees Of Columbia Univeristy In The City Of New York System and method for electromechanical activation of arrhythmias
EP1937151A4 (en) * 2005-09-19 2011-07-06 Univ Columbia Systems and methods for opening of the blood-brain barrier of a subject using ultrasound
AU2006321613B2 (en) 2005-12-09 2012-01-12 Bracco Suisse S.A. Targeting vector-phospholipid conjugates
EP1797919A1 (en) 2005-12-16 2007-06-20 Bracco Research S.A. Liquid transfer device for medical dispensing containers
WO2007088051A2 (en) 2006-01-31 2007-08-09 Bayer Schering Pharma Aktiengesellschaft Modulation of mdl-1 activity for treatment of inflammatory disease
US7967753B2 (en) 2006-08-01 2011-06-28 Stichting Voor de Technische Wetenschappen of Van Vollenhovenlaan Pulse inversion sequences for nonlinear imaging
US8150128B2 (en) * 2006-08-30 2012-04-03 The Trustees Of Columbia University In The City Of New York Systems and method for composite elastography and wave imaging
ATE469660T1 (de) 2006-09-05 2010-06-15 Bracco Research Sa Gasgefüllte mikrovesikel mit polymer- modifizierten lipiden
EP2005970A1 (de) 2007-06-22 2008-12-24 Berlin Science Partners GmbH i.V. Bildgebende Diagnostik durch Kombination von Kontrastmitteln
JP2010005512A (ja) * 2008-06-25 2010-01-14 Kao Corp 微細気泡前駆体組成物
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
WO2010014977A1 (en) * 2008-08-01 2010-02-04 The Trustees Of Columbia University In The City Of New York Systems and methods for matching and imaging tissue characteristics
WO2010030819A1 (en) 2008-09-10 2010-03-18 The Trustees Of Columbia University In The City Of New York Systems and methods for opening a tissue
EP2334239A4 (en) * 2008-09-10 2011-10-19 Univ Columbia INSULATION OF MICROBUMS OF A SPECIFIC SIZE OF POLYDISPERSE MICROBUBBLES
WO2011025893A1 (en) 2009-08-28 2011-03-03 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for production of gas-filled microbubbles
US9107950B2 (en) * 2009-09-15 2015-08-18 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for microbubbles
EP2480144B1 (en) 2009-09-21 2024-03-06 The Trustees of Columbia University in the City of New York Systems for opening of a tissue barrier
WO2011035254A1 (en) * 2009-09-21 2011-03-24 Drexel University Stabilized ultrasound contrast agent
US8834846B2 (en) 2010-05-06 2014-09-16 Bruker Biospin Corporation Fluorescent NIRF activatable probes for disease detection
US9265483B2 (en) 2010-08-06 2016-02-23 The Trustees Of Columbia University In The City Of New York Medical imaging contrast devices, methods, and systems
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
WO2012162664A1 (en) 2011-05-26 2012-11-29 The Trustees Of Columbia University In The City Of New York Systems and methods for opening of a tissue barrier in primates
WO2013164269A1 (en) 2012-04-30 2013-11-07 Ge Healthcare As Method for filling a container with a foamable composition
WO2014001297A2 (en) 2012-06-26 2014-01-03 Ge Healthcare As Preparation of composition comprising gas microbubbles
WO2014059170A1 (en) 2012-10-10 2014-04-17 The Trustees Of Columbia University In The City Of New York Systems and methods for mechanical mapping of cardiac rhythm
JP6313329B2 (ja) 2012-12-21 2018-04-18 ブラッコ・スイス・ソシエテ・アノニムＢｒａｃｃｏ Ｓｕｉｓｓｅ ＳＡ ガス封入マイクロベシクル
US9255907B2 (en) 2013-03-14 2016-02-09 Empire Technology Development Llc Identification of surgical smoke
EP2983687B1 (en) 2013-03-15 2019-09-04 The Regents of The University of California Peptides having reduced toxicity that stimulate cholesterol efflux
US9247921B2 (en) 2013-06-07 2016-02-02 The Trustees Of Columbia University In The City Of New York Systems and methods of high frame rate streaming for treatment monitoring
US10322178B2 (en) 2013-08-09 2019-06-18 The Trustees Of Columbia University In The City Of New York Systems and methods for targeted drug delivery
US10028723B2 (en) 2013-09-03 2018-07-24 The Trustees Of Columbia University In The City Of New York Systems and methods for real-time, transcranial monitoring of blood-brain barrier opening
GB201405735D0 (en) * 2014-03-31 2014-05-14 Ge Healthcare As Ultrasound precursor preparation method
HUE043680T2 (hu) 2014-12-18 2019-09-30 Bracco Suisse Sa Célbajuttató gázzal töltött mikrorészecske készítmény
JP6804095B2 (ja) * 2015-06-10 2020-12-23 学校法人帝京大学 セラノスティクス用のバブル製剤（ｔｂ）及びその使用方法
CN107233583B (zh) * 2016-03-29 2020-04-24 北京飞锐达医疗科技有限公司 一种具有超长持续时间的超声造影剂及其制备方法
GB201821049D0 (en) * 2018-12-21 2019-02-06 Ge Healthcare As Ultrasound contrast agent and methods for use therof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
IN172208B (enExample) * 1990-04-02 1993-05-01 Sint Sa
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
DE4100470A1 (de) * 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echokontrastmittel
GB9106673D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
DE4328642A1 (de) * 1993-08-26 1995-03-02 Byk Gulden Lomberg Chem Fab Ultraschallkontrastmittel
GB9511488D0 (en) * 1995-06-07 1995-08-02 Nycomed Imaging As Improvements in or relating to contrast agents
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator

Also Published As

Publication number Publication date
OA10839A (en) 2001-08-13
JP2000511510A (ja) 2000-09-05
ES2197986T3 (es) 2004-01-16
CA2246779C (en) 2008-04-29
CZ293986B6 (cs) 2004-09-15
CN1278740C (zh) 2006-10-11
CN1213972A (zh) 1999-04-14
US20030202942A1 (en) 2003-10-30
AU1884797A (en) 1997-09-02
EP0881915A1 (en) 1998-12-09
PT881915E (pt) 2003-09-30
TR199801613T2 (xx) 1998-11-23
EA001135B1 (ru) 2000-10-30
NZ331509A (en) 2000-04-28
SK284200B6 (sk) 2004-10-05
KR100500334B1 (ko) 2005-09-09
BG102758A (en) 1999-09-30
HUP9900813A2 (hu) 1999-07-28
AU726503B2 (en) 2000-11-09
HUP9900813A3 (en) 1999-11-29
EP0881915B1 (en) 2003-04-23
US6221337B1 (en) 2001-04-24
ATE238072T1 (de) 2003-05-15
HU229090B1 (en) 2013-07-29
IL125748A0 (en) 1999-04-11
JP4418033B2 (ja) 2010-02-17
US20050201942A1 (en) 2005-09-15
IL125748A (en) 2002-05-23
EP1331013A3 (en) 2004-03-24
CA2246779A1 (en) 1997-08-21
WO1997029783A1 (en) 1997-08-21
CZ262598A3 (cs) 1999-05-12
DE69721235D1 (de) 2003-05-28
HK1014872A1 (en) 1999-10-08
AP9801319A0 (en) 1998-09-30
AP890A (en) 2000-11-13
DE69721235T2 (de) 2004-02-05
SK112698A3 (en) 1999-04-13
PL328406A1 (en) 1999-01-18
EA199800745A1 (ru) 1999-02-25
US20010010811A1 (en) 2001-08-02
KR19990082669A (ko) 1999-11-25
EP1331013A2 (en) 2003-07-30
EE9800249A (et) 1999-02-15

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