CA2246779C - Improvements in or relating to contrast agents - Google Patents

Improvements in or relating to contrast agents Download PDF

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Publication number
CA2246779C
CA2246779C CA002246779A CA2246779A CA2246779C CA 2246779 C CA2246779 C CA 2246779C CA 002246779 A CA002246779 A CA 002246779A CA 2246779 A CA2246779 A CA 2246779A CA 2246779 C CA2246779 C CA 2246779C
Authority
CA
Canada
Prior art keywords
phospholipid
gas
microbubble
phosphatidylserine
synthetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002246779A
Other languages
English (en)
French (fr)
Other versions
CA2246779A1 (en
Inventor
Harald Dugstad
Jo Klaveness
Pal Rongved
Roald Skurtveit
Jorun Braenden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
GE Healthcare AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603466.5A external-priority patent/GB9603466D0/en
Priority claimed from GBGB9611894.8A external-priority patent/GB9611894D0/en
Priority claimed from GBGB9625663.1A external-priority patent/GB9625663D0/en
Application filed by GE Healthcare AS filed Critical GE Healthcare AS
Publication of CA2246779A1 publication Critical patent/CA2246779A1/en
Application granted granted Critical
Publication of CA2246779C publication Critical patent/CA2246779C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
CA002246779A 1996-02-19 1997-02-19 Improvements in or relating to contrast agents Expired - Lifetime CA2246779C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB9603466.5A GB9603466D0 (en) 1996-02-19 1996-02-19 Improvements in or relating to contrast agents
GB9603466.5 1996-02-19
GBGB9611894.8A GB9611894D0 (en) 1996-06-07 1996-06-07 Improvements in or relating to contrast agents
GB9611894.8 1996-06-07
GB9625663.1 1996-12-11
GBGB9625663.1A GB9625663D0 (en) 1996-12-11 1996-12-11 Improvements in or relating to contrast agents
PCT/GB1997/000459 WO1997029783A1 (en) 1996-02-19 1997-02-19 Improvements in or relating to contrast agents

Publications (2)

Publication Number Publication Date
CA2246779A1 CA2246779A1 (en) 1997-08-21
CA2246779C true CA2246779C (en) 2008-04-29

Family

ID=27268137

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002246779A Expired - Lifetime CA2246779C (en) 1996-02-19 1997-02-19 Improvements in or relating to contrast agents

Country Status (24)

Country Link
US (4) US6221337B1 (enExample)
EP (2) EP1331013A3 (enExample)
JP (1) JP4418033B2 (enExample)
KR (1) KR100500334B1 (enExample)
CN (1) CN1278740C (enExample)
AP (1) AP890A (enExample)
AT (1) ATE238072T1 (enExample)
AU (1) AU726503B2 (enExample)
BG (1) BG102758A (enExample)
CA (1) CA2246779C (enExample)
CZ (1) CZ293986B6 (enExample)
DE (1) DE69721235T2 (enExample)
EA (1) EA001135B1 (enExample)
EE (1) EE04224B1 (enExample)
ES (1) ES2197986T3 (enExample)
HU (1) HU229090B1 (enExample)
IL (1) IL125748A (enExample)
NZ (1) NZ331509A (enExample)
OA (1) OA10839A (enExample)
PL (1) PL328406A1 (enExample)
PT (1) PT881915E (enExample)
SK (1) SK284200B6 (enExample)
TR (1) TR199801613T2 (enExample)
WO (1) WO1997029783A1 (enExample)

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US7025726B2 (en) 2004-01-22 2006-04-11 The Regents Of The University Of Nebraska Detection of endothelial dysfunction by ultrasonic imaging
CN103120799A (zh) 2004-08-18 2013-05-29 博莱科瑞士股份有限公司 用于反差成像的充气微泡组合物
WO2006044997A2 (en) * 2004-10-15 2006-04-27 The Trustees Of Columbia University In The City Of New York System and method for localized measurement and imaging of viscosity of tissues
WO2006044996A2 (en) * 2004-10-15 2006-04-27 The Trustees Of Columbia University In The City Of New York System and method for automated boundary detection of body structures
CN100574809C (zh) * 2005-01-10 2009-12-30 重庆海扶(Hifu)技术有限公司 一种高强度聚焦超声治疗用氟碳乳剂类助剂及其应用
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CN100574811C (zh) * 2005-01-10 2009-12-30 重庆海扶(Hifu)技术有限公司 一种高强度聚焦超声治疗用微粒类助剂及其应用
US10687785B2 (en) 2005-05-12 2020-06-23 The Trustees Of Columbia Univeristy In The City Of New York System and method for electromechanical activation of arrhythmias
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WO2010014977A1 (en) * 2008-08-01 2010-02-04 The Trustees Of Columbia University In The City Of New York Systems and methods for matching and imaging tissue characteristics
WO2010030819A1 (en) 2008-09-10 2010-03-18 The Trustees Of Columbia University In The City Of New York Systems and methods for opening a tissue
EP2334239A4 (en) * 2008-09-10 2011-10-19 Univ Columbia INSULATION OF MICROBUMS OF A SPECIFIC SIZE OF POLYDISPERSE MICROBUBBLES
WO2011025893A1 (en) 2009-08-28 2011-03-03 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for production of gas-filled microbubbles
US9107950B2 (en) * 2009-09-15 2015-08-18 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for microbubbles
EP2480144B1 (en) 2009-09-21 2024-03-06 The Trustees of Columbia University in the City of New York Systems for opening of a tissue barrier
WO2011035254A1 (en) * 2009-09-21 2011-03-24 Drexel University Stabilized ultrasound contrast agent
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WO2014001297A2 (en) 2012-06-26 2014-01-03 Ge Healthcare As Preparation of composition comprising gas microbubbles
WO2014059170A1 (en) 2012-10-10 2014-04-17 The Trustees Of Columbia University In The City Of New York Systems and methods for mechanical mapping of cardiac rhythm
JP6313329B2 (ja) 2012-12-21 2018-04-18 ブラッコ・スイス・ソシエテ・アノニムＢｒａｃｃｏ Ｓｕｉｓｓｅ ＳＡ ガス封入マイクロベシクル
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US10322178B2 (en) 2013-08-09 2019-06-18 The Trustees Of Columbia University In The City Of New York Systems and methods for targeted drug delivery
US10028723B2 (en) 2013-09-03 2018-07-24 The Trustees Of Columbia University In The City Of New York Systems and methods for real-time, transcranial monitoring of blood-brain barrier opening
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Also Published As

Publication number Publication date
OA10839A (en) 2001-08-13
JP2000511510A (ja) 2000-09-05
ES2197986T3 (es) 2004-01-16
CZ293986B6 (cs) 2004-09-15
CN1278740C (zh) 2006-10-11
CN1213972A (zh) 1999-04-14
US20030202942A1 (en) 2003-10-30
AU1884797A (en) 1997-09-02
EP0881915A1 (en) 1998-12-09
PT881915E (pt) 2003-09-30
TR199801613T2 (xx) 1998-11-23
EA001135B1 (ru) 2000-10-30
NZ331509A (en) 2000-04-28
SK284200B6 (sk) 2004-10-05
KR100500334B1 (ko) 2005-09-09
BG102758A (en) 1999-09-30
HUP9900813A2 (hu) 1999-07-28
AU726503B2 (en) 2000-11-09
HUP9900813A3 (en) 1999-11-29
EE04224B1 (et) 2004-02-16
EP0881915B1 (en) 2003-04-23
US6221337B1 (en) 2001-04-24
ATE238072T1 (de) 2003-05-15
HU229090B1 (en) 2013-07-29
IL125748A0 (en) 1999-04-11
JP4418033B2 (ja) 2010-02-17
US20050201942A1 (en) 2005-09-15
IL125748A (en) 2002-05-23
EP1331013A3 (en) 2004-03-24
CA2246779A1 (en) 1997-08-21
WO1997029783A1 (en) 1997-08-21
CZ262598A3 (cs) 1999-05-12
DE69721235D1 (de) 2003-05-28
HK1014872A1 (en) 1999-10-08
AP9801319A0 (en) 1998-09-30
AP890A (en) 2000-11-13
DE69721235T2 (de) 2004-02-05
SK112698A3 (en) 1999-04-13
PL328406A1 (en) 1999-01-18
EA199800745A1 (ru) 1999-02-25
US20010010811A1 (en) 2001-08-02
KR19990082669A (ko) 1999-11-25
EP1331013A2 (en) 2003-07-30
EE9800249A (et) 1999-02-15

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