EE04224B1 - Gaasi mikromullide dispersioon ja selle lüofiliseeritud jääk, ultraheli kontrastaine ja selle valmistamismeetod, mikromulle eraldav maatriks ning ultraheli kontrastaine kompositsioon - Google Patents

Gaasi mikromullide dispersioon ja selle lüofiliseeritud jääk, ultraheli kontrastaine ja selle valmistamismeetod, mikromulle eraldav maatriks ning ultraheli kontrastaine kompositsioon

Info

Publication number
EE04224B1
EE04224B1 EE9800249A EE9800249A EE04224B1 EE 04224 B1 EE04224 B1 EE 04224B1 EE 9800249 A EE9800249 A EE 9800249A EE 9800249 A EE9800249 A EE 9800249A EE 04224 B1 EE04224 B1 EE 04224B1
Authority
EE
Estonia
Prior art keywords
contrast medium
ultrasonic contrast
microbubbles
dispersion
matrix
Prior art date
Application number
EE9800249A
Other languages
English (en)
Estonian (et)
Other versions
EE9800249A (et
Inventor
Undheim Br�nden Jorunn
Dugstad Harald
Klaveness Jo
Rongved P�l
Skurtveit Roald
Original Assignee
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603466.5A external-priority patent/GB9603466D0/en
Priority claimed from GBGB9611894.8A external-priority patent/GB9611894D0/en
Priority claimed from GBGB9625663.1A external-priority patent/GB9625663D0/en
Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As
Publication of EE9800249A publication Critical patent/EE9800249A/xx
Publication of EE04224B1 publication Critical patent/EE04224B1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
EE9800249A 1996-02-19 1997-02-19 Gaasi mikromullide dispersioon ja selle lüofiliseeritud jääk, ultraheli kontrastaine ja selle valmistamismeetod, mikromulle eraldav maatriks ning ultraheli kontrastaine kompositsioon EE04224B1 (et)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9603466.5A GB9603466D0 (en) 1996-02-19 1996-02-19 Improvements in or relating to contrast agents
GBGB9611894.8A GB9611894D0 (en) 1996-06-07 1996-06-07 Improvements in or relating to contrast agents
GBGB9625663.1A GB9625663D0 (en) 1996-12-11 1996-12-11 Improvements in or relating to contrast agents
PCT/GB1997/000459 WO1997029783A1 (en) 1996-02-19 1997-02-19 Improvements in or relating to contrast agents

Publications (2)

Publication Number Publication Date
EE9800249A EE9800249A (et) 1999-02-15
EE04224B1 true EE04224B1 (et) 2004-02-16

Family

ID=27268137

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9800249A EE04224B1 (et) 1996-02-19 1997-02-19 Gaasi mikromullide dispersioon ja selle lüofiliseeritud jääk, ultraheli kontrastaine ja selle valmistamismeetod, mikromulle eraldav maatriks ning ultraheli kontrastaine kompositsioon

Country Status (25)

Country Link
US (4) US6221337B1 (cs)
EP (2) EP0881915B1 (cs)
JP (1) JP4418033B2 (cs)
KR (1) KR100500334B1 (cs)
CN (1) CN1278740C (cs)
AP (1) AP890A (cs)
AT (1) ATE238072T1 (cs)
AU (1) AU726503B2 (cs)
BG (1) BG102758A (cs)
CA (1) CA2246779C (cs)
CZ (1) CZ293986B6 (cs)
DE (1) DE69721235T2 (cs)
EA (1) EA001135B1 (cs)
EE (1) EE04224B1 (cs)
ES (1) ES2197986T3 (cs)
HK (1) HK1014872A1 (cs)
HU (1) HU229090B1 (cs)
IL (1) IL125748A (cs)
NZ (1) NZ331509A (cs)
OA (1) OA10839A (cs)
PL (1) PL328406A1 (cs)
PT (1) PT881915E (cs)
SK (1) SK284200B6 (cs)
TR (1) TR199801613T2 (cs)
WO (1) WO1997029783A1 (cs)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU784367B2 (en) * 1996-08-02 2006-03-16 Ge Healthcare As Improvements in or relating to contrast agents
CZ28999A3 (cs) 1996-08-02 1999-07-14 Nycomed Imaging As Použití kontrastního prostředku
CA2268324C (en) * 1997-08-12 2007-06-12 Bracco Research S.A. Administrable compositions and methods for magnetic resonance imaging
GB9717476D0 (en) * 1997-08-18 1997-10-22 Nycomed Imaging As Process
GB9717588D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
GB9717589D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
GB9717542D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Process
GB9726773D0 (en) 1997-12-18 1998-02-18 Nycomed Imaging As Improvements in or relating to ultrasonagraphy
EP1073716B1 (en) * 1998-04-28 2004-04-28 Amersham Health AS Improvements in or relating to separation processes
GB9813568D0 (en) 1998-06-23 1998-08-19 Nycomed Imaging As Improvements in or relating to cardiac imaging
US6514209B1 (en) 1999-06-07 2003-02-04 Drexel University Method of enhancing ultrasonic techniques via measurement of ultraharmonic signals
US20030103960A1 (en) * 1999-12-22 2003-06-05 Pierre Philippart Sealant and bone generating product
EP2279757A3 (en) 2000-06-02 2011-08-03 Bracco Suisse SA Compounds for targeting endothelial cells
NO20004795D0 (no) 2000-09-26 2000-09-26 Nycomed Imaging As Peptidbaserte forbindelser
US6984373B2 (en) 2000-12-23 2006-01-10 Dyax Corp. Fibrin binding moieties useful as imaging agents
KR100373712B1 (ko) * 2000-12-23 2003-02-25 사회복지법인삼성생명공익재단(삼성서울병원) 초음파 조영제 및 그의 제조방법
ATE376803T1 (de) 2001-04-06 2007-11-15 Bracco Research Sa Vorrichtung zur messung lokaler physikalischer parameter in einem flüssigkeitsgefüllten hohlraum
AU2003205930B2 (en) * 2002-02-01 2007-08-16 Shimoda Biotech (Pty) Ltd Pharmaceutical composition
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
WO2004065621A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
EP2301587B1 (en) 2002-03-01 2014-06-25 Dyax Corp. KDR and VEGF/KDR binding peptides and their use in diagnosis
NO20024755D0 (no) * 2002-10-03 2002-10-03 Amersham Health As Metode
EP1572001A1 (en) 2002-11-29 2005-09-14 Amersham Health AS Ultrasound triggering method
KR101076053B1 (ko) 2003-02-04 2011-10-21 브라코 인터내셔날 비.브이. 초음파 조영제 및 그것의 제조방법
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
ES2557286T3 (es) 2003-03-03 2016-01-25 Dyax Corp. Usos de péptidos que se unen específicamente al receptor del HGF (cMet)
US20060222694A1 (en) * 2003-06-27 2006-10-05 Oh Choon K Stabilized topotecan liposomal composition and methods
US20050019379A1 (en) 2003-07-22 2005-01-27 Kimberly-Clark Worldwide, Inc. Wipe and methods for improving skin health
NO20035401D0 (no) * 2003-12-04 2003-12-04 Amersham Health As Metode
EP1696965B1 (en) * 2003-12-22 2014-12-10 Bracco Suisse SA Assembly of gas-filled microvesicle with active component for contrast imaging
AU2004308756B2 (en) * 2003-12-22 2010-06-24 Bracco Suisse S.A. Gas-filled microvesicle assembly for contrast imaging
US7025726B2 (en) 2004-01-22 2006-04-11 The Regents Of The University Of Nebraska Detection of endothelial dysfunction by ultrasonic imaging
JP4837663B2 (ja) 2004-08-18 2011-12-14 ブラッコ・シュイス・ソシエテ・アノニム 造影画像化のためのガス充填微小胞組成物
WO2006044996A2 (en) * 2004-10-15 2006-04-27 The Trustees Of Columbia University In The City Of New York System and method for automated boundary detection of body structures
WO2006044997A2 (en) * 2004-10-15 2006-04-27 The Trustees Of Columbia University In The City Of New York System and method for localized measurement and imaging of viscosity of tissues
CN100574809C (zh) * 2005-01-10 2009-12-30 重庆海扶(Hifu)技术有限公司 一种高强度聚焦超声治疗用氟碳乳剂类助剂及其应用
CN100427142C (zh) * 2005-01-10 2008-10-22 重庆海扶(Hifu)技术有限公司 一种高强度聚焦超声治疗用助剂及其筛选方法
US10687785B2 (en) 2005-05-12 2020-06-23 The Trustees Of Columbia Univeristy In The City Of New York System and method for electromechanical activation of arrhythmias
EP1937151A4 (en) * 2005-09-19 2011-07-06 Univ Columbia SYSTEMS AND METHOD FOR OPENING THE BLOOD-BRAIN BARRIER OF A PERSON WITH ULTRASOUND
CN103204911B (zh) 2005-12-09 2015-04-01 布拉科瑞士有限公司 靶向载体-磷脂缀合物
EP1797919A1 (en) 2005-12-16 2007-06-20 Bracco Research S.A. Liquid transfer device for medical dispensing containers
EP1991577A2 (en) 2006-01-31 2008-11-19 Parkinson, John F. Modulation of mdl-1 activity for treatment of inflammatory disease
US7967753B2 (en) 2006-08-01 2011-06-28 Stichting Voor de Technische Wetenschappen of Van Vollenhovenlaan Pulse inversion sequences for nonlinear imaging
WO2008027520A2 (en) * 2006-08-30 2008-03-06 The Trustees Of Columbia University In The City Of New York Systems and methods for composite elastography and wave imaging
EP2061517B1 (en) 2006-09-05 2010-06-02 Bracco Research S.A. Gas-filled microvesicles with polymer-modified lipids
EP2005970A1 (de) 2007-06-22 2008-12-24 Berlin Science Partners GmbH i.V. Bildgebende Diagnostik durch Kombination von Kontrastmitteln
WO2011035312A1 (en) 2009-09-21 2011-03-24 The Trustees Of Culumbia University In The City Of New York Systems and methods for opening of a tissue barrier
JP2010005512A (ja) * 2008-06-25 2010-01-14 Kao Corp 微細気泡前駆体組成物
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
WO2010014977A1 (en) * 2008-08-01 2010-02-04 The Trustees Of Columbia University In The City Of New York Systems and methods for matching and imaging tissue characteristics
WO2010030819A1 (en) 2008-09-10 2010-03-18 The Trustees Of Columbia University In The City Of New York Systems and methods for opening a tissue
EP2334239A4 (en) * 2008-09-10 2011-10-19 Univ Columbia ISOLATION OF SIZED RANGE MICROBULLES SELECTED FROM POLYDISPERSED MICROBULLES
EP2470287A4 (en) 2009-08-28 2015-01-21 Univ Columbia SYSTEMS, METHODS AND DEVICES FOR PRODUCING GAS-FILLED MICROBUBBLES
WO2011034892A2 (en) * 2009-09-15 2011-03-24 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for microbubbles
US9700640B2 (en) * 2009-09-21 2017-07-11 Drexel University Stabilized ultrasound contrast agent
US8834846B2 (en) 2010-05-06 2014-09-16 Bruker Biospin Corporation Fluorescent NIRF activatable probes for disease detection
EP2600771A1 (en) * 2010-08-06 2013-06-12 The Trustees of Columbia University in the City of New York Medical imaging contrast devices, methods, and systems
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
WO2012162664A1 (en) 2011-05-26 2012-11-29 The Trustees Of Columbia University In The City Of New York Systems and methods for opening of a tissue barrier in primates
IN2014DN09192A (cs) 2012-04-30 2015-07-10 Ge Healthcare As
IN2014DN10714A (cs) 2012-06-26 2015-09-04 Ge Healthcare As
WO2014059170A1 (en) 2012-10-10 2014-04-17 The Trustees Of Columbia University In The City Of New York Systems and methods for mechanical mapping of cardiac rhythm
WO2014096165A2 (en) 2012-12-21 2014-06-26 Bracco Suisse Sa Gas-filled microvesicles
WO2014142926A1 (en) 2013-03-14 2014-09-18 Empire Technology Development Llc Identification of surgical smoke
US10017551B2 (en) 2013-03-15 2018-07-10 The Regents Of The University Of California Peptides having reduced toxicity that stimulate cholesterol efflux
US9247921B2 (en) 2013-06-07 2016-02-02 The Trustees Of Columbia University In The City Of New York Systems and methods of high frame rate streaming for treatment monitoring
US10322178B2 (en) 2013-08-09 2019-06-18 The Trustees Of Columbia University In The City Of New York Systems and methods for targeted drug delivery
US10028723B2 (en) 2013-09-03 2018-07-24 The Trustees Of Columbia University In The City Of New York Systems and methods for real-time, transcranial monitoring of blood-brain barrier opening
GB201405735D0 (en) * 2014-03-31 2014-05-14 Ge Healthcare As Ultrasound precursor preparation method
JP6803839B2 (ja) 2014-12-18 2020-12-23 ブラッコ・スイス・ソシエテ・アノニムBracco Suisse SA 標的化されたガス入りの微小胞の製剤
EP3308779B1 (en) * 2015-06-10 2019-08-07 Teikyo University Theranostic bubble preparation (tb), and method for using same
CN107233583B (zh) * 2016-03-29 2020-04-24 北京飞锐达医疗科技有限公司 一种具有超长持续时间的超声造影剂及其制备方法
GB201821049D0 (en) * 2018-12-21 2019-02-06 Ge Healthcare As Ultrasound contrast agent and methods for use therof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
IN172208B (cs) * 1990-04-02 1993-05-01 Sint Sa
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
DE4100470A1 (de) * 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echokontrastmittel
GB9106673D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
DE4328642A1 (de) * 1993-08-26 1995-03-02 Byk Gulden Lomberg Chem Fab Ultraschallkontrastmittel
GB9511488D0 (en) * 1995-06-07 1995-08-02 Nycomed Imaging As Improvements in or relating to contrast agents
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator

Also Published As

Publication number Publication date
CZ262598A3 (cs) 1999-05-12
JP4418033B2 (ja) 2010-02-17
US20050201942A1 (en) 2005-09-15
JP2000511510A (ja) 2000-09-05
AU1884797A (en) 1997-09-02
AP9801319A0 (en) 1998-09-30
HUP9900813A2 (hu) 1999-07-28
DE69721235T2 (de) 2004-02-05
TR199801613T2 (xx) 1998-11-23
EP1331013A3 (en) 2004-03-24
EP0881915B1 (en) 2003-04-23
OA10839A (en) 2001-08-13
US6221337B1 (en) 2001-04-24
IL125748A0 (en) 1999-04-11
WO1997029783A1 (en) 1997-08-21
EA199800745A1 (ru) 1999-02-25
CN1213972A (zh) 1999-04-14
SK284200B6 (sk) 2004-10-05
US20010010811A1 (en) 2001-08-02
EA001135B1 (ru) 2000-10-30
DE69721235D1 (de) 2003-05-28
EE9800249A (et) 1999-02-15
HK1014872A1 (en) 1999-10-08
AP890A (en) 2000-11-13
SK112698A3 (en) 1999-04-13
CZ293986B6 (cs) 2004-09-15
KR19990082669A (ko) 1999-11-25
NZ331509A (en) 2000-04-28
IL125748A (en) 2002-05-23
CA2246779C (en) 2008-04-29
AU726503B2 (en) 2000-11-09
PL328406A1 (en) 1999-01-18
HU229090B1 (en) 2013-07-29
EP1331013A2 (en) 2003-07-30
CN1278740C (zh) 2006-10-11
CA2246779A1 (en) 1997-08-21
PT881915E (pt) 2003-09-30
HUP9900813A3 (en) 1999-11-29
KR100500334B1 (ko) 2005-09-09
EP0881915A1 (en) 1998-12-09
ES2197986T3 (es) 2004-01-16
ATE238072T1 (de) 2003-05-15
US20030202942A1 (en) 2003-10-30
BG102758A (en) 1999-09-30

Similar Documents

Publication Publication Date Title
EE04224B1 (et) Gaasi mikromullide dispersioon ja selle lüofiliseeritud jääk, ultraheli kontrastaine ja selle valmistamismeetod, mikromulle eraldav maatriks ning ultraheli kontrastaine kompositsioon
AU6544598A (en) Compositions and methods for analysis of nucleic acids
AU7980298A (en) Methods and compositions for multiplex amplification of nucleic acids
WO2002090539A3 (en) Compositions, methods, and kits for isolating nucleic acids using surfactants and proteases
CA2207608A1 (en) Isolation of nucleic acid
IL132704A0 (en) Methods and compositions for the selective modification of nucleic acids
AU2500197A (en) Method, apparatus and kits for sequencing of nucleic acids using multiple dyes
ID16801A (id) Metode untuk dispersi semen dan komposisi semen
WO2001071732A3 (en) Porous ferro- or ferrimagnetic glass particles for isolating molecules
AU4226900A (en) Apparatus for fast preparation and analysis of nucleic acids
WO1998055495A3 (en) Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
ATE264911T1 (de) Eine universelle immunmodulatorische cytokin- expressierende zelllinie in wartestelling. entsprechende zusammensetzungen und methoden ihrer herstellung und verwendungen
AU2816797A (en) Method for determination of nucleic acid sequences and diagnostic applications thereof
AU2001269031A1 (en) Novel compositions for isolating and/or stabilising nucleic acids in biological material
AU2002359522A1 (en) Compositions and methods of selective nucleic acid isolation
EE9800053A (et) Kõrge efektiivsusega segusti ja selle valmistamise meetod
DE69706587D1 (de) Keramikmatrix-Verbundwerkstoff und Verfahren zur Herstellung desselben
EP0685199A3 (en) Method for analyzing an enzyme and device for its implementation.
AU4145699A (en) Modified gellan gum composition process for preparation of same and use thereof
CA2263713A1 (en) Lyophilization of cultured human cells to preserve rna and dna
DE69931735D1 (de) Homokinetisches Kreuzgelenk und Verfahren zur seiner Herstellung
AU1686395A (en) (deltex) proteins, nucleic acids, and antibodies, and related methods and compositions
WO1998001557A3 (en) Mammalian chemokine reagents
ID28612A (id) Metode pembuatan asam tereftalat dan asam isoftalat murni dari campuran xilena
WO1999025861A3 (fr) Vecteurs adenoviraux et methode de reduction des evenements de recombinaison homologue

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20041231

MM4A Lapsed by not paying the annual fees

Effective date: 20050219