WO1997012985A3 - Multi-functional hematopoietic receptor agonists - Google Patents

Multi-functional hematopoietic receptor agonists

Info

Publication number
WO1997012985A3
WO1997012985A3 PCT/US1996/015774 US9615774W WO9712985A3 WO 1997012985 A3 WO1997012985 A3 WO 1997012985A3 US 9615774 W US9615774 W US 9615774W WO 9712985 A3 WO9712985 A3 WO 9712985A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor agonists
hematopoietic receptor
functional hematopoietic
proteins
functional
Prior art date
Application number
PCT/US1996/015774
Other languages
French (fr)
Other versions
WO1997012985A2 (en
WO1997012985A9 (en
Inventor
Yiqing Feng
Nicholas R Staten
Charles M Baum
Neena L Summers
Maire H Caparon
S C Bauer
Linda Zurfluh
John P Mckearn
Barbara Kure Klein
Stephen C Lee
Charles A Mcwherter
Judith G Giri
Original Assignee
Searle & Co
Yiqing Feng
Nicholas R Staten
Charles M Baum
Neena L Summers
Maire H Caparon
S C Bauer
Linda Zurfluh
John P Mckearn
Barbara Kure Klein
Stephen C Lee
Charles A Mcwherter
Judith G Giri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to PL96326072A priority Critical patent/PL184424B1/en
Application filed by Searle & Co, Yiqing Feng, Nicholas R Staten, Charles M Baum, Neena L Summers, Maire H Caparon, S C Bauer, Linda Zurfluh, John P Mckearn, Barbara Kure Klein, Stephen C Lee, Charles A Mcwherter, Judith G Giri filed Critical Searle & Co
Priority to BRPI9610977A priority patent/BRPI9610977A2/en
Priority to AU73844/96A priority patent/AU705083B2/en
Priority to EP96936114A priority patent/EP0854928A2/en
Priority to IL12383296A priority patent/IL123832A0/en
Priority to JP9514385A priority patent/JPH11510062A/en
Priority to NZ320978A priority patent/NZ320978A/en
Priority to US08/835,162 priority patent/US6066318A/en
Publication of WO1997012985A2 publication Critical patent/WO1997012985A2/en
Publication of WO1997012985A9 publication Critical patent/WO1997012985A9/en
Publication of WO1997012985A3 publication Critical patent/WO1997012985A3/en
Priority to NO981500A priority patent/NO981500L/en
Priority to US10/695,584 priority patent/US20040171115A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Disclosed are novel multi-functional hematopoietic receptor agonist proteins, DNAs which encode the multi-functional hematopoietic receptor agonists proteins, methods of making the multi-functional hematopoietic receptor agonists proteins and methods of using the multi-functional hematopoietic receptor agonists proteins.
PCT/US1996/015774 1995-10-05 1996-10-04 Multi-functional hematopoietic receptor agonists WO1997012985A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP9514385A JPH11510062A (en) 1995-10-05 1996-10-04 Multifunctional hematopoietic receptor agonist
BRPI9610977A BRPI9610977A2 (en) 1995-10-05 1996-10-04 multifunctional hematopoietic receptor agonists
AU73844/96A AU705083B2 (en) 1995-10-05 1996-10-04 Multi-functional hematopoietic receptor agonists
EP96936114A EP0854928A2 (en) 1995-10-05 1996-10-04 Multi-functional hematopoietic receptor agonists
IL12383296A IL123832A0 (en) 1995-10-05 1996-10-04 Multi-functional hematopoietic receptor antagonists
PL96326072A PL184424B1 (en) 1995-10-05 1996-10-04 Agonists of haemopoietic multifunctional receptors
NZ320978A NZ320978A (en) 1995-10-05 1996-10-04 Hematopoietic proteins and nucleic acid sequences encoding them
US08/835,162 US6066318A (en) 1995-10-05 1997-04-04 Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
NO981500A NO981500L (en) 1995-10-05 1998-04-02 Multi-functional hematopoietic receptor antagonists
US10/695,584 US20040171115A1 (en) 1995-10-05 2003-10-27 Multi-functional hematopoietic fusion proteins between sequence rearranged G-CSF receptor agonists and other hematopoietic factors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US483495P 1995-10-05 1995-10-05
US60/004,834 1995-10-05

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US08/835,162 Continuation-In-Part US6066318A (en) 1995-10-05 1997-04-04 Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors

Publications (3)

Publication Number Publication Date
WO1997012985A2 WO1997012985A2 (en) 1997-04-10
WO1997012985A9 WO1997012985A9 (en) 1997-05-29
WO1997012985A3 true WO1997012985A3 (en) 1997-08-07

Family

ID=21712756

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/015774 WO1997012985A2 (en) 1995-10-05 1996-10-04 Multi-functional hematopoietic receptor agonists

Country Status (14)

Country Link
EP (1) EP0854928A2 (en)
JP (1) JPH11510062A (en)
KR (1) KR100456212B1 (en)
CN (2) CN1590407A (en)
AU (1) AU705083B2 (en)
BR (1) BRPI9610977A2 (en)
CA (1) CA2234061A1 (en)
CZ (1) CZ295518B6 (en)
IL (1) IL123832A0 (en)
MX (1) MX9802730A (en)
NO (1) NO981500L (en)
NZ (1) NZ320978A (en)
PL (1) PL184424B1 (en)
WO (1) WO1997012985A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5581476A (en) 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
US6967092B1 (en) 1996-10-25 2005-11-22 Mc Kearn John P Multi-functional chimeric hematopoietic receptor agonists
US5969105A (en) * 1996-10-25 1999-10-19 Feng; Yiqing Stem cell factor receptor agonists
US6660257B1 (en) * 1996-10-25 2003-12-09 Pharmacia Corporation Circular permuteins of flt3 ligand
US6242570B1 (en) 1997-07-10 2001-06-05 Beth Israel Deaconess Medical Center Production and use of recombinant protein multimers with increased biological activity
US6187564B1 (en) 1997-07-10 2001-02-13 Beth Israel Deaconess Medical Center DNA encoding erythropoietin multimers having modified 5′ and 3′ sequences and its use to prepare EPO therapeutics
US6165476A (en) * 1997-07-10 2000-12-26 Beth Israel Deaconess Medical Center Fusion proteins with an immunoglobulin hinge region linker
AU7825500A (en) * 1999-10-07 2001-04-23 Pharmacia Corporation Inhibition enzyme linked immunosorbent assay (iELISA) for the detection and quantification of antibodies in biological samples
EP1425304B9 (en) 2001-07-11 2010-09-08 Maxygen, Inc. G-csf conjugates
MX2007015156A (en) 2005-06-01 2008-02-15 Maxygen Holdings Ltd Pegylated g-csf polypeptides and methods of producing same.
WO2007075899A2 (en) * 2005-12-21 2007-07-05 Maxygen, Inc. Dual agonist compounds and uses thereof
CN102675472B (en) * 2012-05-07 2014-07-30 北京诺派生物科技有限公司 Kit for detecting pig suffering from porcine reproductive and respiratory syndrome
JP6584956B2 (en) 2012-12-21 2019-10-02 アステラス インスティテュート フォー リジェネレイティブ メディシン Method and composition for producing platelets from pluripotent stem cells
LT6161B (en) 2013-09-27 2015-06-25 Uab Profarma Fused proteins of granulocyte colony-stimulating factor with other partners of growh factor, preferably with stem cell factor, and method of preparation thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
WO1995021197A1 (en) * 1994-02-04 1995-08-10 G.D. Searle & Co. Il-3 variant hematopoiesis fusion protein
WO1995021254A1 (en) * 1994-02-04 1995-08-10 G. D. Searle & Co. Multivariant il-3 hematopoiesis fusion protein
WO1995027732A2 (en) * 1994-04-08 1995-10-19 The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services Circularly permuted ligands and circularly permuted chimeric molecules

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
WO1995021197A1 (en) * 1994-02-04 1995-08-10 G.D. Searle & Co. Il-3 variant hematopoiesis fusion protein
WO1995021254A1 (en) * 1994-02-04 1995-08-10 G. D. Searle & Co. Multivariant il-3 hematopoiesis fusion protein
WO1995027732A2 (en) * 1994-04-08 1995-10-19 The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services Circularly permuted ligands and circularly permuted chimeric molecules

Also Published As

Publication number Publication date
CA2234061A1 (en) 1997-04-10
CZ295518B6 (en) 2005-08-17
KR19990064068A (en) 1999-07-26
PL326072A1 (en) 1998-08-17
JPH11510062A (en) 1999-09-07
MX9802730A (en) 1998-09-30
CN1124348C (en) 2003-10-15
KR100456212B1 (en) 2005-01-15
NO981500D0 (en) 1998-04-02
CZ96598A3 (en) 1998-09-16
EP0854928A2 (en) 1998-07-29
WO1997012985A2 (en) 1997-04-10
CN1204369A (en) 1999-01-06
BRPI9610977A2 (en) 2019-09-17
NZ320978A (en) 2001-03-30
AU7384496A (en) 1997-04-28
CN1590407A (en) 2005-03-09
PL184424B1 (en) 2002-10-31
AU705083B2 (en) 1999-05-13
NO981500L (en) 1998-05-20
IL123832A0 (en) 1998-10-30

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