WO1997012985A3 - Multi-functional hematopoietic receptor agonists - Google Patents
Multi-functional hematopoietic receptor agonistsInfo
- Publication number
- WO1997012985A3 WO1997012985A3 PCT/US1996/015774 US9615774W WO9712985A3 WO 1997012985 A3 WO1997012985 A3 WO 1997012985A3 US 9615774 W US9615774 W US 9615774W WO 9712985 A3 WO9712985 A3 WO 9712985A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- receptor agonists
- hematopoietic receptor
- functional hematopoietic
- proteins
- functional
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/524—Thrombopoietin, i.e. C-MPL ligand
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5403—IL-3
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9514385A JPH11510062A (en) | 1995-10-05 | 1996-10-04 | Multifunctional hematopoietic receptor agonist |
BRPI9610977A BRPI9610977A2 (en) | 1995-10-05 | 1996-10-04 | multifunctional hematopoietic receptor agonists |
AU73844/96A AU705083B2 (en) | 1995-10-05 | 1996-10-04 | Multi-functional hematopoietic receptor agonists |
EP96936114A EP0854928A2 (en) | 1995-10-05 | 1996-10-04 | Multi-functional hematopoietic receptor agonists |
IL12383296A IL123832A0 (en) | 1995-10-05 | 1996-10-04 | Multi-functional hematopoietic receptor antagonists |
PL96326072A PL184424B1 (en) | 1995-10-05 | 1996-10-04 | Agonists of haemopoietic multifunctional receptors |
NZ320978A NZ320978A (en) | 1995-10-05 | 1996-10-04 | Hematopoietic proteins and nucleic acid sequences encoding them |
US08/835,162 US6066318A (en) | 1995-10-05 | 1997-04-04 | Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors |
NO981500A NO981500L (en) | 1995-10-05 | 1998-04-02 | Multi-functional hematopoietic receptor antagonists |
US10/695,584 US20040171115A1 (en) | 1995-10-05 | 2003-10-27 | Multi-functional hematopoietic fusion proteins between sequence rearranged G-CSF receptor agonists and other hematopoietic factors |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US483495P | 1995-10-05 | 1995-10-05 | |
US60/004,834 | 1995-10-05 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/835,162 Continuation-In-Part US6066318A (en) | 1995-10-05 | 1997-04-04 | Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors |
Publications (3)
Publication Number | Publication Date |
---|---|
WO1997012985A2 WO1997012985A2 (en) | 1997-04-10 |
WO1997012985A9 WO1997012985A9 (en) | 1997-05-29 |
WO1997012985A3 true WO1997012985A3 (en) | 1997-08-07 |
Family
ID=21712756
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/015774 WO1997012985A2 (en) | 1995-10-05 | 1996-10-04 | Multi-functional hematopoietic receptor agonists |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0854928A2 (en) |
JP (1) | JPH11510062A (en) |
KR (1) | KR100456212B1 (en) |
CN (2) | CN1590407A (en) |
AU (1) | AU705083B2 (en) |
BR (1) | BRPI9610977A2 (en) |
CA (1) | CA2234061A1 (en) |
CZ (1) | CZ295518B6 (en) |
IL (1) | IL123832A0 (en) |
MX (1) | MX9802730A (en) |
NO (1) | NO981500L (en) |
NZ (1) | NZ320978A (en) |
PL (1) | PL184424B1 (en) |
WO (1) | WO1997012985A2 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5581476A (en) | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
US6967092B1 (en) | 1996-10-25 | 2005-11-22 | Mc Kearn John P | Multi-functional chimeric hematopoietic receptor agonists |
US5969105A (en) * | 1996-10-25 | 1999-10-19 | Feng; Yiqing | Stem cell factor receptor agonists |
US6660257B1 (en) * | 1996-10-25 | 2003-12-09 | Pharmacia Corporation | Circular permuteins of flt3 ligand |
US6242570B1 (en) | 1997-07-10 | 2001-06-05 | Beth Israel Deaconess Medical Center | Production and use of recombinant protein multimers with increased biological activity |
US6187564B1 (en) | 1997-07-10 | 2001-02-13 | Beth Israel Deaconess Medical Center | DNA encoding erythropoietin multimers having modified 5′ and 3′ sequences and its use to prepare EPO therapeutics |
US6165476A (en) * | 1997-07-10 | 2000-12-26 | Beth Israel Deaconess Medical Center | Fusion proteins with an immunoglobulin hinge region linker |
AU7825500A (en) * | 1999-10-07 | 2001-04-23 | Pharmacia Corporation | Inhibition enzyme linked immunosorbent assay (iELISA) for the detection and quantification of antibodies in biological samples |
EP1425304B9 (en) | 2001-07-11 | 2010-09-08 | Maxygen, Inc. | G-csf conjugates |
MX2007015156A (en) | 2005-06-01 | 2008-02-15 | Maxygen Holdings Ltd | Pegylated g-csf polypeptides and methods of producing same. |
WO2007075899A2 (en) * | 2005-12-21 | 2007-07-05 | Maxygen, Inc. | Dual agonist compounds and uses thereof |
CN102675472B (en) * | 2012-05-07 | 2014-07-30 | 北京诺派生物科技有限公司 | Kit for detecting pig suffering from porcine reproductive and respiratory syndrome |
JP6584956B2 (en) | 2012-12-21 | 2019-10-02 | アステラス インスティテュート フォー リジェネレイティブ メディシン | Method and composition for producing platelets from pluripotent stem cells |
LT6161B (en) | 2013-09-27 | 2015-06-25 | Uab Profarma | Fused proteins of granulocyte colony-stimulating factor with other partners of growh factor, preferably with stem cell factor, and method of preparation thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990012877A1 (en) * | 1989-04-19 | 1990-11-01 | Cetus Corporation | Multifunctional m-csf proteins and genes encoding therefor |
WO1995021197A1 (en) * | 1994-02-04 | 1995-08-10 | G.D. Searle & Co. | Il-3 variant hematopoiesis fusion protein |
WO1995021254A1 (en) * | 1994-02-04 | 1995-08-10 | G. D. Searle & Co. | Multivariant il-3 hematopoiesis fusion protein |
WO1995027732A2 (en) * | 1994-04-08 | 1995-10-19 | The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services | Circularly permuted ligands and circularly permuted chimeric molecules |
-
1996
- 1996-10-04 KR KR10-1998-0702547A patent/KR100456212B1/en not_active IP Right Cessation
- 1996-10-04 CZ CZ1998965A patent/CZ295518B6/en not_active IP Right Cessation
- 1996-10-04 WO PCT/US1996/015774 patent/WO1997012985A2/en not_active Application Discontinuation
- 1996-10-04 IL IL12383296A patent/IL123832A0/en unknown
- 1996-10-04 CN CNA031551432A patent/CN1590407A/en active Pending
- 1996-10-04 AU AU73844/96A patent/AU705083B2/en not_active Ceased
- 1996-10-04 PL PL96326072A patent/PL184424B1/en not_active IP Right Cessation
- 1996-10-04 EP EP96936114A patent/EP0854928A2/en not_active Withdrawn
- 1996-10-04 NZ NZ320978A patent/NZ320978A/en unknown
- 1996-10-04 JP JP9514385A patent/JPH11510062A/en not_active Abandoned
- 1996-10-04 CA CA002234061A patent/CA2234061A1/en not_active Abandoned
- 1996-10-04 BR BRPI9610977A patent/BRPI9610977A2/en not_active IP Right Cessation
- 1996-10-04 CN CN96198815A patent/CN1124348C/en not_active Expired - Fee Related
-
1998
- 1998-04-02 NO NO981500A patent/NO981500L/en not_active Application Discontinuation
- 1998-04-06 MX MX9802730A patent/MX9802730A/en not_active IP Right Cessation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990012877A1 (en) * | 1989-04-19 | 1990-11-01 | Cetus Corporation | Multifunctional m-csf proteins and genes encoding therefor |
WO1995021197A1 (en) * | 1994-02-04 | 1995-08-10 | G.D. Searle & Co. | Il-3 variant hematopoiesis fusion protein |
WO1995021254A1 (en) * | 1994-02-04 | 1995-08-10 | G. D. Searle & Co. | Multivariant il-3 hematopoiesis fusion protein |
WO1995027732A2 (en) * | 1994-04-08 | 1995-10-19 | The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services | Circularly permuted ligands and circularly permuted chimeric molecules |
Also Published As
Publication number | Publication date |
---|---|
CA2234061A1 (en) | 1997-04-10 |
CZ295518B6 (en) | 2005-08-17 |
KR19990064068A (en) | 1999-07-26 |
PL326072A1 (en) | 1998-08-17 |
JPH11510062A (en) | 1999-09-07 |
MX9802730A (en) | 1998-09-30 |
CN1124348C (en) | 2003-10-15 |
KR100456212B1 (en) | 2005-01-15 |
NO981500D0 (en) | 1998-04-02 |
CZ96598A3 (en) | 1998-09-16 |
EP0854928A2 (en) | 1998-07-29 |
WO1997012985A2 (en) | 1997-04-10 |
CN1204369A (en) | 1999-01-06 |
BRPI9610977A2 (en) | 2019-09-17 |
NZ320978A (en) | 2001-03-30 |
AU7384496A (en) | 1997-04-28 |
CN1590407A (en) | 2005-03-09 |
PL184424B1 (en) | 2002-10-31 |
AU705083B2 (en) | 1999-05-13 |
NO981500L (en) | 1998-05-20 |
IL123832A0 (en) | 1998-10-30 |
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