ECSP024371A - Soluciones de meloxicam estables muy concentradas - Google Patents

Soluciones de meloxicam estables muy concentradas

Info

Publication number
ECSP024371A
ECSP024371A EC2002004371A ECSP024371A ECSP024371A EC SP024371 A ECSP024371 A EC SP024371A EC 2002004371 A EC2002004371 A EC 2002004371A EC SP024371 A ECSP024371 A EC SP024371A EC SP024371 A ECSP024371 A EC SP024371A
Authority
EC
Ecuador
Prior art keywords
concentrated stable
meloxicam solutions
stable meloxicam
solutions
salt
Prior art date
Application number
EC2002004371A
Other languages
English (en)
Inventor
Stephan Henke
Klaus Daneck
Martin Andreas Folger
Bernhard Hassel
Hans-Juergen Kroff
Bernd Kruss
Axel Prox
Original Assignee
Boehringer Ingelheim Vetmedica Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7646375&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP024371(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Vetmedica Gmbh filed Critical Boehringer Ingelheim Vetmedica Gmbh
Publication of ECSP024371A publication Critical patent/ECSP024371A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a una solución acuosa de meloxicam, administrable por vía oral o parental y exenta de ciclodextrina, que contiene una sal de mexolicam farmacológicamente compatible de una base orgánica o inorgánica y uno o más coadyuvantes adecuados, encontrándose el contenido en sal de melixicam disuelta por encima de 10 mg/ml. La formulación de acuerdo con la invención presenta una estabilidad de hasta 24 meses o mayor.
EC2002004371A 2000-06-20 2002-12-05 Soluciones de meloxicam estables muy concentradas ECSP024371A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10030345A DE10030345A1 (de) 2000-06-20 2000-06-20 Hochkonzentrierte stabile Meloxicamlösungen

Publications (1)

Publication Number Publication Date
ECSP024371A true ECSP024371A (es) 2003-02-06

Family

ID=7646375

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2002004371A ECSP024371A (es) 2000-06-20 2002-12-05 Soluciones de meloxicam estables muy concentradas

Country Status (31)

Country Link
EP (1) EP1299107B1 (es)
JP (2) JP2003535902A (es)
KR (1) KR100805651B1 (es)
CN (1) CN1236774C (es)
AR (2) AR028967A1 (es)
AT (1) ATE297736T1 (es)
AU (2) AU8185201A (es)
BG (1) BG65798B1 (es)
CA (1) CA2414063C (es)
CZ (1) CZ302717B6 (es)
DE (2) DE10030345A1 (es)
EA (1) EA005765B1 (es)
EC (1) ECSP024371A (es)
EE (1) EE04930B1 (es)
ES (1) ES2244643T3 (es)
HR (1) HRP20021011B1 (es)
HU (1) HU229184B1 (es)
IL (2) IL153114A0 (es)
ME (1) ME00253B (es)
MX (1) MXPA02012732A (es)
MY (1) MY137729A (es)
NO (1) NO330199B1 (es)
NZ (1) NZ523583A (es)
PT (1) PT1299107E (es)
RS (1) RS50142B (es)
SK (1) SK286938B6 (es)
TW (1) TWI250018B (es)
UA (1) UA73584C2 (es)
UY (1) UY26781A1 (es)
WO (1) WO2001097813A2 (es)
ZA (1) ZA200209989B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020035107A1 (en) 2000-06-20 2002-03-21 Stefan Henke Highly concentrated stable meloxicam solutions
DE10030345A1 (de) * 2000-06-20 2002-01-10 Boehringer Ingelheim Vetmed Hochkonzentrierte stabile Meloxicamlösungen
DE10161077A1 (de) 2001-12-12 2003-06-18 Boehringer Ingelheim Vetmed Hochkonzentrierte stabile Meloxicamlösungen zur nadellosen Injektion
EP1348436A1 (en) * 2002-03-30 2003-10-01 Boehringer Ingelheim International GmbH Meloxicam suppositories
JP4707316B2 (ja) * 2002-10-11 2011-06-22 ロート製薬株式会社 水性液状組成物
DE10250081A1 (de) * 2002-10-25 2004-05-13 Boehringer Ingelheim Vetmedica Gmbh Wasserlösliche Meloxicam Granulate
US8992980B2 (en) 2002-10-25 2015-03-31 Boehringer Ingelheim Vetmedica Gmbh Water-soluble meloxicam granules
EP1568369A1 (en) * 2004-02-23 2005-08-31 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam for the treatment of respiratory diseases in pigs
DE102004025324A1 (de) * 2004-05-19 2005-12-08 Boehringer Ingelheim Vetmedica Gmbh Flüssige Zubereitung für die Veterinärmedizin, Verfahren zu deren Herstellung und deren Verwendung
DE102004030409A1 (de) * 2004-06-23 2006-01-26 Boehringer Ingelheim Vetmedica Gmbh Neue Verwendung von Meloxicam in der Veterinärmedizin
DE602005009016D1 (de) 2004-12-06 2008-09-25 Janssen Pharmaceutica Nv Orale suspension mit meloxicam
EP1848270B1 (en) * 2005-02-17 2014-05-21 Abbott Laboratories Transmucosal administration of drug compositions for treating and preventing disorders in animals
RU2383344C2 (ru) * 2008-01-22 2010-03-10 Закрытое Акционерное Общество "Канонфарма Продакшн" Фармацевтический раствор мелоксикама и глицина, способ его получения и способ лечения
CN101584696A (zh) * 2008-05-21 2009-11-25 上海艾力斯医药科技有限公司 包含喹唑啉衍生物的组合物及制备方法、用途
TR200809200A1 (tr) 2008-12-01 2009-12-21 Sanovel �La� Sanay� Ve T�Caret Anon�M ��Rket� Meloksikam içeren farmasötik formülasyonlar
EP2488145B1 (en) 2009-10-12 2024-04-24 Boehringer Ingelheim Vetmedica GmbH Containers for compositions comprising meloxicam
US9149480B2 (en) 2010-03-03 2015-10-06 Boehringer Ingeleheim Vetmedica GmbH Use of meloxicam for the long-term treatment of musculoskeletal disorders in cats
US9795568B2 (en) 2010-05-05 2017-10-24 Boehringer Ingelheim Vetmedica Gmbh Low concentration meloxicam tablets
KR101045052B1 (ko) * 2011-01-18 2011-06-28 지수광 자세교정용 발받침대
CN102908310A (zh) * 2012-11-02 2013-02-06 青岛康地恩药业股份有限公司 一种犬、猫用治疗类风湿性关节炎的美洛昔康注射液
CN104983686A (zh) * 2015-07-13 2015-10-21 胡涵 畜禽用美洛昔康可溶性粉剂及其制备方法
CN105213402B (zh) * 2015-09-30 2018-12-18 洛阳市兽药厂 一种畜禽复方恩诺沙星美洛昔康可溶性粉
WO2018209150A1 (en) * 2017-05-10 2018-11-15 Axsome Therapeutics, Inc. Pharmaceutical compositions comprising meloxicam
TW201912148A (zh) * 2017-08-24 2019-04-01 大陸商江蘇恆瑞醫藥股份有限公司 一種包含美洛昔康的可注射的醫藥組成物及其製備方法
KR20190107481A (ko) * 2018-03-12 2019-09-20 충북대학교 산학협력단 멜록시캄을 포함하는 구강붕해필름 제조방법 및 이에 의해 제조된 멜록시캄을 포함하는 구강붕해필름
US12059423B2 (en) 2018-05-11 2024-08-13 Nanjing Delova Biotech Co., Ltd. Meloxicam composition, pharmaceutical preparation and preparation method and use thereof
CN112823786A (zh) * 2019-11-21 2021-05-21 北京泰德制药股份有限公司 一种含有美洛昔康的药物组合物及应用
WO2021224815A1 (en) * 2020-05-06 2021-11-11 Cadila Healthcare Limited Stable aqueous parenteral solutions of nonsteroidal anti-inflammatory drug (nsaid)
CN115068419A (zh) * 2022-07-22 2022-09-20 潍坊恒邦兽药有限公司 兽用高浓度美洛昔康注射剂及其加工设备

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DE10030345A1 (de) * 2000-06-20 2002-01-10 Boehringer Ingelheim Vetmed Hochkonzentrierte stabile Meloxicamlösungen

Also Published As

Publication number Publication date
CN1437472A (zh) 2003-08-20
NO330199B1 (no) 2011-03-07
JP2003535902A (ja) 2003-12-02
HRP20021011B1 (en) 2006-02-28
ATE297736T1 (de) 2005-07-15
JP2010280726A (ja) 2010-12-16
WO2001097813A2 (en) 2001-12-27
ME00253B (me) 2011-05-10
UA73584C2 (en) 2005-08-15
UY26781A1 (es) 2002-01-31
DE60111529T2 (de) 2005-12-15
AU2001281852B2 (en) 2006-04-13
CZ302717B6 (cs) 2011-09-21
KR20030013447A (ko) 2003-02-14
NZ523583A (en) 2004-09-24
SK286938B6 (sk) 2009-07-06
IL153114A0 (en) 2003-06-24
IL153114A (en) 2011-07-31
EE200200701A (et) 2004-08-16
DE10030345A1 (de) 2002-01-10
WO2001097813A3 (en) 2002-05-10
TWI250018B (en) 2006-03-01
KR100805651B1 (ko) 2008-02-26
DE60111529D1 (de) 2005-07-21
MXPA02012732A (es) 2004-09-10
MEP39808A (en) 2011-02-10
RS50142B (sr) 2009-03-25
HRP20021011A2 (en) 2005-02-28
BG65798B1 (bg) 2009-12-31
JP5330347B2 (ja) 2013-10-30
PL359553A1 (en) 2004-08-23
HUP0300854A2 (hu) 2003-08-28
EE04930B1 (et) 2007-12-17
AR028967A1 (es) 2003-05-28
EA200201254A1 (ru) 2003-06-26
EA005765B1 (ru) 2005-06-30
ZA200209989B (en) 2003-10-08
CA2414063A1 (en) 2001-12-27
SK17992002A3 (sk) 2003-04-01
AU8185201A (en) 2002-01-02
ES2244643T3 (es) 2005-12-16
AR100293A2 (es) 2016-09-28
BG107347A (bg) 2003-09-30
YU96402A (sh) 2006-01-16
EP1299107B1 (en) 2005-06-15
CN1236774C (zh) 2006-01-18
PT1299107E (pt) 2005-08-31
NO20026132D0 (no) 2002-12-19
HU229184B1 (en) 2013-09-30
NO20026132L (no) 2003-02-11
HK1057859A1 (en) 2004-04-23
CZ20024191A3 (cs) 2003-04-16
CA2414063C (en) 2008-06-17
EP1299107A2 (en) 2003-04-09
MY137729A (en) 2009-03-31

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