ES2188563T3 - Solucion estable de xilometazolina y oximetazolina. - Google Patents

Solucion estable de xilometazolina y oximetazolina.

Info

Publication number
ES2188563T3
ES2188563T3 ES00947853T ES00947853T ES2188563T3 ES 2188563 T3 ES2188563 T3 ES 2188563T3 ES 00947853 T ES00947853 T ES 00947853T ES 00947853 T ES00947853 T ES 00947853T ES 2188563 T3 ES2188563 T3 ES 2188563T3
Authority
ES
Spain
Prior art keywords
eventually
xylometazoline
formulation
active metal
oximetazoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00947853T
Other languages
English (en)
Inventor
Frieder Ulrich Maerz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23322017&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2188563(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Application granted granted Critical
Publication of ES2188563T3 publication Critical patent/ES2188563T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/38—Silver; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Formulación en solución isotónica estable con un valor del pH de 4, 5-7, 5, que consta de - hidrocloruro de xilometazolina y/o hidrocloruro de oximetazolina como sustancia activa, - un disolvente farmacológicamente compatible para la aplicación nasal, - un adyuvante seleccionado entre el conjunto formado por sorbitol y/o glicerol - un tampón seleccionado entre el conjunto de los tampones del pH inorgánicos y del tampón orgánico trometamol, y - eventualmente ácido clorhídrico y/o hidróxido de sodio, - eventualmente sustancias necesarias para el ajuste de la isotonía - eventualmente un metal activo oligodinámicamente o iones de metales activos oligodinámicamente en una cantidad farmacéuticamente aceptable, no conteniendo la formulación ninguna otra sustancia aditiva orgánica.
ES00947853T 1999-06-22 2000-06-17 Solucion estable de xilometazolina y oximetazolina. Expired - Lifetime ES2188563T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33778999A 1999-06-22 1999-06-22

Publications (1)

Publication Number Publication Date
ES2188563T3 true ES2188563T3 (es) 2003-07-01

Family

ID=23322017

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00947853T Expired - Lifetime ES2188563T3 (es) 1999-06-22 2000-06-17 Solucion estable de xilometazolina y oximetazolina.

Country Status (22)

Country Link
US (2) US20040191177A1 (es)
EP (1) EP1194145B1 (es)
JP (1) JP2003502361A (es)
KR (1) KR20020012001A (es)
CN (1) CN1164271C (es)
AT (1) ATE232099T1 (es)
AU (1) AU765736B2 (es)
BR (1) BR0011950A (es)
CA (1) CA2376121C (es)
CZ (1) CZ295595B6 (es)
DE (1) DE50001217D1 (es)
EA (1) EA003329B1 (es)
ES (1) ES2188563T3 (es)
HK (1) HK1045945B (es)
HU (1) HUP0201700A3 (es)
IL (1) IL147023A0 (es)
MX (1) MXPA01012912A (es)
PL (1) PL197542B1 (es)
PT (1) PT1194145E (es)
TR (1) TR200103694T2 (es)
WO (1) WO2000078297A2 (es)
ZA (1) ZA200110386B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ531792A (en) 2001-09-18 2006-02-24 Nycomed Danmark Aps Compositions for treatment of common cold
CA2489528A1 (en) * 2002-06-20 2003-12-31 Novartis Consumer Health S.A. Nasal compositions comprising a mucopolysaccharide and propylene glycol
AU2003272517A1 (en) * 2002-09-13 2004-04-30 Zicam, Llc. Compositions to reduce congestion and methods for application thereof to the nasal membrane
DE10337186A1 (de) * 2003-08-13 2005-03-17 Merck Patent Gmbh Wässrige Wirkstoff-Lösung
US20090136598A1 (en) * 2006-04-26 2009-05-28 Aciex, Inc. Compositions for the Treatment and Prevention of Eyelid Swelling
AU2007243334A1 (en) * 2006-04-26 2007-11-08 Aciex Therapeutics, Inc. Compositions for the treatment and prevention of eyelid swelling
CN101912363A (zh) * 2010-07-29 2010-12-15 蔡海德 溶解超滤-喷雾干燥-分子分散包衣-水化制粒-冷冻干燥生产脂质体组合药物
WO2016102984A1 (en) 2014-12-24 2016-06-30 Jadran - Galenski Laboratorij D.D. A nasal composition containing sea water as stability-improving excipient
WO2023046590A1 (en) 2021-09-22 2023-03-30 Jadran - Galenski Laboratorij D.D. An improved pharmaceutical composition for nasal use, preparation, and use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4603131A (en) * 1982-04-26 1986-07-29 Bernstein Joel E Method and composition for treating and preventing irritation of the mucous membranes of the nose
US4970240A (en) * 1989-10-18 1990-11-13 Schering Corporation Fruity flavored nasal decongestant composition
US5114979A (en) * 1989-10-18 1992-05-19 Schering Corporation Fruity flavored nasal decongestant composition
US5540930A (en) * 1993-10-25 1996-07-30 Pharmos Corporation Suspension of loteprednol etabonate for ear, eye, or nose treatment
DE19549421C2 (de) * 1995-11-10 1999-11-18 Klosterfrau Mcm Vetrieb Gmbh Pharmazeutische Zubereitung zur Behandlung akuter Rhinitiden
DE19542959C1 (de) * 1995-11-17 1996-10-24 Ursatec Verpackung Gmbh Vor Kontamination schützende Abgabevorrichtung für Fluide
EP0861128B1 (de) * 1995-11-17 2003-02-19 Ursatec Verpackung Gmbh Vor kontamination schützende abgabevorrichtung für fluide
DE69901936T2 (de) * 1998-01-30 2002-11-28 Novartis Consumer Health Sa Nasale lösungen

Also Published As

Publication number Publication date
DE50001217D1 (de) 2003-03-13
EA003329B1 (ru) 2003-04-24
PL197542B1 (pl) 2008-04-30
EP1194145B1 (de) 2003-02-05
ATE232099T1 (de) 2003-02-15
EP1194145A2 (de) 2002-04-10
AU6150600A (en) 2001-01-09
HK1045945A1 (en) 2002-12-20
KR20020012001A (ko) 2002-02-09
CA2376121C (en) 2008-06-10
HUP0201700A3 (en) 2003-02-28
CA2376121A1 (en) 2000-12-28
PL352354A1 (en) 2003-08-11
BR0011950A (pt) 2002-03-12
US20040191177A1 (en) 2004-09-30
PT1194145E (pt) 2003-06-30
CZ20014568A3 (cs) 2002-03-13
HK1045945B (zh) 2005-01-28
AU765736B2 (en) 2003-09-25
JP2003502361A (ja) 2003-01-21
EA200200042A1 (ru) 2002-06-27
CZ295595B6 (cs) 2005-08-17
WO2000078297A3 (de) 2001-03-01
IL147023A0 (en) 2002-08-14
ZA200110386B (en) 2003-04-22
CN1164271C (zh) 2004-09-01
HUP0201700A2 (hu) 2002-12-28
US20080011293A1 (en) 2008-01-17
TR200103694T2 (tr) 2002-04-22
CN1361689A (zh) 2002-07-31
MXPA01012912A (es) 2002-09-18
WO2000078297A2 (de) 2000-12-28

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