EA201200260A1 - Гетероциклические гидразоны и их применение для лечения рака и воспаления - Google Patents

Гетероциклические гидразоны и их применение для лечения рака и воспаления

Info

Publication number
EA201200260A1
EA201200260A1 EA201200260A EA201200260A EA201200260A1 EA 201200260 A1 EA201200260 A1 EA 201200260A1 EA 201200260 A EA201200260 A EA 201200260A EA 201200260 A EA201200260 A EA 201200260A EA 201200260 A1 EA201200260 A1 EA 201200260A1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
treatment
compound
inflammation
cancer
Prior art date
Application number
EA201200260A
Other languages
English (en)
Russian (ru)
Inventor
Сяннянь Фу
Фэн Хэ
Юй Ли
Лэй Лю
Юань Ми
Яочан Сюй
Гуолян Хунь
Чжэнтянь Ю
Цзию Чжан (Джефф)
Мяо Дай
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201200260A1 publication Critical patent/EA201200260A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EA201200260A 2009-08-12 2010-08-10 Гетероциклические гидразоны и их применение для лечения рака и воспаления EA201200260A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US23332809P 2009-08-12 2009-08-12
CN2010071981 2010-04-21
CN2010074078 2010-06-18
PCT/EP2010/061609 WO2011018454A1 (en) 2009-08-12 2010-08-10 Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation

Publications (1)

Publication Number Publication Date
EA201200260A1 true EA201200260A1 (ru) 2012-09-28

Family

ID=43385579

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201200260A EA201200260A1 (ru) 2009-08-12 2010-08-10 Гетероциклические гидразоны и их применение для лечения рака и воспаления

Country Status (10)

Country Link
US (1) US8497368B2 (enExample)
EP (1) EP2464649A1 (enExample)
JP (1) JP5781510B2 (enExample)
KR (1) KR20120089643A (enExample)
AU (1) AU2010283806A1 (enExample)
BR (1) BR112012003262A8 (enExample)
CA (1) CA2770873A1 (enExample)
EA (1) EA201200260A1 (enExample)
MX (1) MX2012001838A (enExample)
WO (1) WO2011018454A1 (enExample)

Cited By (2)

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Publication number Priority date Publication date Assignee Title
RU2677698C1 (ru) * 2013-12-09 2019-01-21 Юсб Байофарма Спрл Производные триазолопиридазина в качестве модуляторов активности tnf
RU2677699C1 (ru) * 2013-12-09 2019-01-21 Юсб Байофарма Спрл Производные имидазотриазина в качестве модуляторов активности tnf

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PE20130375A1 (es) * 2009-12-31 2013-04-10 Hutchison Medipharma Ltd Compuestos de triazolopiridinas y triazolopirazinas inhibidores de c-met y composiciones de los mismos
KR101871436B1 (ko) * 2010-05-17 2018-06-27 인코젠 쎄라퓨틱스 프라이빗 리미티드 단백질 키나제의 조절제로서의 신규한 3,5-디치환-3ｈ-이미다조[4,5-ｂ]피리딘 및 3,5- 디치환 -3ｈ-[1,2,3]트리아졸로[4,5-ｂ] 피리딘 화합물
CN103459396B (zh) * 2011-02-10 2015-08-19 诺瓦提斯公司 作为c-Met酪氨酸激酶抑制剂的[1,2,4]三唑并[4,3-b]哒嗪化合物
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EP2755976B1 (en) 2011-09-15 2018-07-18 Novartis AG 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyridines as c-met tyrosine kinase inhibitors
JP2015512425A (ja) 2012-04-03 2015-04-27 ノバルティス アーゲー チロシンキナーゼ阻害剤との組合せ製品及びそれらの使用
US20150051210A1 (en) 2012-04-03 2015-02-19 Novartis Ag Tyrosine Kinase Inhibitor Combinations and their Use
CN102977014B (zh) * 2012-11-05 2015-01-07 沈阳药科大学 新的喹啉类化合物及其用途
CN104854101B (zh) 2012-11-06 2018-05-01 上海复尚慧创医药研究有限公司 Alk激酶抑制剂
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RU2715236C2 (ru) 2014-03-26 2020-02-26 Астекс Терапьютикс Лтд Комбинации
JP6732761B2 (ja) * 2015-01-23 2020-07-29 シンジェンタ パーティシペーションズ アーゲー 殺有害生物的に活性なセミカルバゾンおよびチオセミカルバゾン誘導体
WO2017100644A1 (en) * 2015-12-09 2017-06-15 Case Western Reserve University Method of modulating ribonucleotide reductase
CN106632069A (zh) * 2016-11-18 2017-05-10 山东友帮生化科技有限公司 3‑氯‑6‑肼基哒嗪的合成方法
TWI774755B (zh) * 2017-04-28 2022-08-21 日商佐藤製藥股份有限公司 二氟甲烯化合物之製造法
JP2022515198A (ja) 2018-12-19 2022-02-17 アレイ バイオファーマ インコーポレイテッド ＦＧＦＲチロシンキナーゼの阻害剤としての置換ピラゾロ［１，５－ａ］ピリジン化合物
CN110483526B (zh) * 2019-09-09 2021-10-01 辽宁大学 含芳基腙结构的吡唑并[1,5-a]嘧啶类衍生物及其应用

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EP2464649A1 (en) 2012-06-20
MX2012001838A (es) 2012-02-29
KR20120089643A (ko) 2012-08-13
BR112012003262A2 (pt) 2016-03-01
US20120142681A1 (en) 2012-06-07
US8497368B2 (en) 2013-07-30
AU2010283806A1 (en) 2012-03-01
BR112012003262A8 (pt) 2016-05-17

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