EA201101244A1 - N-(ГЕТЕРО)АРИЛ-, 2-(ГЕТЕРО)АРИЛЗАМЕЩЕННЫЕ АЦЕТАМИДЫ, ПРЕДНАЗНАЧЕННЫЕ ДЛЯ ПРИМЕНЕНИЯ В КАЧЕСТВЕ МОДУЛЯТОРОВ ПЕРЕДАЧИ СИГНАЛОВ Wnt - Google Patents
N-(ГЕТЕРО)АРИЛ-, 2-(ГЕТЕРО)АРИЛЗАМЕЩЕННЫЕ АЦЕТАМИДЫ, ПРЕДНАЗНАЧЕННЫЕ ДЛЯ ПРИМЕНЕНИЯ В КАЧЕСТВЕ МОДУЛЯТОРОВ ПЕРЕДАЧИ СИГНАЛОВ WntInfo
- Publication number
- EA201101244A1 EA201101244A1 EA201101244A EA201101244A EA201101244A1 EA 201101244 A1 EA201101244 A1 EA 201101244A1 EA 201101244 A EA201101244 A EA 201101244A EA 201101244 A EA201101244 A EA 201101244A EA 201101244 A1 EA201101244 A1 EA 201101244A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- aryl
- getero
- acetamides
- hetero
- intended
- Prior art date
Links
- 150000003869 acetamides Chemical class 0.000 title 1
- 230000008054 signal transmission Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000004156 Wnt signaling pathway Effects 0.000 abstract 1
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- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract
В заявке описаны соединения формул (1) и (2) и способы модуляции сигнального пути Wnt с использованием этих соединений, в которых А, А, В, Y и Z обозначают кольца
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15659909P | 2009-03-02 | 2009-03-02 | |
US24518709P | 2009-09-23 | 2009-09-23 | |
PCT/US2010/025813 WO2010101849A1 (en) | 2009-03-02 | 2010-03-01 | N- (hetero)aryl, 2- (hetero)aryl-substituted acetamides for use as wnt signaling modulators |
Publications (2)
Publication Number | Publication Date |
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EA201101244A1 true EA201101244A1 (ru) | 2012-04-30 |
EA021225B1 EA021225B1 (ru) | 2015-05-29 |
Family
ID=42112245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201101244A EA021225B1 (ru) | 2009-03-02 | 2010-03-01 | N-(ГЕТЕРО)АРИЛ,2-(ГЕТЕРО)АРИЛЗАМЕЩЕННЫЕ АЦЕТАМИДЫ, ПРЕДНАЗНАЧЕННЫЕ ДЛЯ ПРИМЕНЕНИЯ В КАЧЕСТВЕ МОДУЛЯТОРОВ ПЕРЕДАЧИ СИГНАЛОВ Wnt |
Country Status (41)
Cited By (3)
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US9795550B2 (en) | 2014-08-20 | 2017-10-24 | Samumed, Llc | Gamma-diketones for treatment and prevention of aging skin and wrinkles |
US9884053B2 (en) | 2010-08-18 | 2018-02-06 | Samumed, Llc | β- and γ-diketones and γ-hydroxyketones as WNT/β-catenin signaling pathway activators |
US9951053B2 (en) | 2013-02-22 | 2018-04-24 | Samumed, Llc | γ-diketones as Wnt/β-catenin signaling pathway activators |
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UA103918C2 (en) * | 2009-03-02 | 2013-12-10 | Айерем Элелси | N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators |
JP2012521406A (ja) | 2009-03-23 | 2012-09-13 | グレンマーク ファーマシューティカルズ, エセ.アー. | Trpa1調節因子としてのフロピリミジンジオン誘導体 |
AU2011226073B2 (en) | 2010-03-10 | 2015-05-28 | Astrazeneca Ab | 4-Phenyl pyridine analogues as protein kinase inhibitors. |
UY33469A (es) | 2010-06-29 | 2012-01-31 | Irm Llc Y Novartis Ag | Composiciones y metodos para modular la via de señalizacion de wnt |
EP2573085A1 (en) | 2011-09-26 | 2013-03-27 | AiCuris GmbH & Co. KG | N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range |
EP2573086A1 (en) * | 2011-09-26 | 2013-03-27 | AiCuris GmbH & Co. KG | N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate |
CN104302782A (zh) * | 2012-02-28 | 2015-01-21 | 诺华股份有限公司 | 利用rnf43突变状态选择wnt信号转导抑制剂给药的癌症患者 |
US9725427B2 (en) * | 2012-03-16 | 2017-08-08 | Biohaven Pharmaceutical Holding Company Limited | Prodrugs of riluzole and their method of use |
US9234176B2 (en) * | 2012-11-13 | 2016-01-12 | The Board Of Trustees Of The Leland Stanford Junior University | Chemically defined production of cardiomyocytes from pluripotent stem cells |
KR101418168B1 (ko) * | 2012-11-21 | 2014-07-09 | 부경대학교 산학협력단 | 신규 테트라하이드로피리디놀 유도체 화합물 및 이를 유효성분으로 포함하는 암 예방 또는 치료용 약제학적 조성물 |
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TWI582239B (zh) | 2013-03-11 | 2017-05-11 | 諾華公司 | 與wnt抑制劑相關之標記 |
KR20150125665A (ko) | 2013-03-12 | 2015-11-09 | 큐어제닉스 인크. | 암 치료용 화합물 |
GB2513403A (en) * | 2013-04-26 | 2014-10-29 | Agency Science Tech & Res | WNT pathway modulators |
GB201309333D0 (en) | 2013-05-23 | 2013-07-10 | Agency Science Tech & Res | Purine diones as WNT pathway modulators |
TW201506024A (zh) | 2013-07-02 | 2015-02-16 | 必治妥美雅史谷比公司 | 作為有效rock抑制劑的三環甲醯胺衍生物 |
US9663529B2 (en) | 2013-07-02 | 2017-05-30 | Bristol-Myers Squibb Company | Tricyclic pyrido-carboxamide derivatives as rock inhibitors |
CA2922230A1 (en) | 2013-08-30 | 2015-03-05 | Ambit Biosciences Corporation | Biaryl acetamide compounds and methods of use thereof |
EP3757130A1 (en) | 2013-09-26 | 2020-12-30 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
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