DK2403832T3 - N-(hetero)aryl,2-(hetero)aryl substitueret acetamider til anvendelse som Wnt signalerende modulatorer. - Google Patents

N-(hetero)aryl,2-(hetero)aryl substitueret acetamider til anvendelse som Wnt signalerende modulatorer.

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Publication number
DK2403832T3
DK2403832T3 DK10708670.4T DK10708670T DK2403832T3 DK 2403832 T3 DK2403832 T3 DK 2403832T3 DK 10708670 T DK10708670 T DK 10708670T DK 2403832 T3 DK2403832 T3 DK 2403832T3
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DK
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Prior art keywords
hetero
aryl
wnt signaling
signaling modulators
substituted acetamides
Prior art date
Application number
DK10708670.4T
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English (en)
Inventor
Dai Cheng
Guobao Zhang
Wenqi Gao
Dong Han
Shifeng Pan
Original Assignee
Irm Llc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42112245&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2403832(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Irm Llc filed Critical Irm Llc
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Publication of DK2403832T3 publication Critical patent/DK2403832T3/da

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK10708670.4T 2009-03-02 2010-03-01 N-(hetero)aryl,2-(hetero)aryl substitueret acetamider til anvendelse som Wnt signalerende modulatorer. DK2403832T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15659909P 2009-03-02 2009-03-02
US24518709P 2009-09-23 2009-09-23
PCT/US2010/025813 WO2010101849A1 (en) 2009-03-02 2010-03-01 N- (hetero)aryl, 2- (hetero)aryl-substituted acetamides for use as wnt signaling modulators

Publications (1)

Publication Number Publication Date
DK2403832T3 true DK2403832T3 (da) 2014-01-06

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ID=42112245

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Application Number Title Priority Date Filing Date
DK10708670.4T DK2403832T3 (da) 2009-03-02 2010-03-01 N-(hetero)aryl,2-(hetero)aryl substitueret acetamider til anvendelse som Wnt signalerende modulatorer.

Country Status (41)

Country Link
US (4) US8546396B2 (da)
EP (2) EP2403832B1 (da)
JP (2) JP5490153B2 (da)
KR (1) KR101359873B1 (da)
CN (2) CN102369187B (da)
AR (1) AR076067A1 (da)
AU (1) AU2010221493C1 (da)
BR (1) BRPI1009235B8 (da)
CA (1) CA2753552C (da)
CL (1) CL2011002116A1 (da)
CO (1) CO6450669A2 (da)
CR (2) CR20190039A (da)
CU (1) CU24050B1 (da)
DK (1) DK2403832T3 (da)
DO (1) DOP2011000273A (da)
EA (1) EA021225B1 (da)
EC (1) ECSP11011359A (da)
ES (2) ES2543320T3 (da)
GE (2) GEP20146082B (da)
HK (1) HK1160464A1 (da)
HN (1) HN2011002346A (da)
HR (1) HRP20140156T1 (da)
IL (1) IL214516A (da)
JO (1) JO2933B1 (da)
MA (1) MA33157B1 (da)
MX (1) MX2011009246A (da)
MY (1) MY150583A (da)
NI (1) NI201100165A (da)
NZ (2) NZ603137A (da)
PE (1) PE20120650A1 (da)
PL (1) PL2403832T3 (da)
PT (1) PT2403832E (da)
SG (1) SG173467A1 (da)
SI (1) SI2403832T1 (da)
SM (1) SMT201400032B (da)
TN (1) TN2011000378A1 (da)
TW (2) TWI429644B (da)
UA (1) UA103918C2 (da)
UY (2) UY32469A (da)
WO (1) WO2010101849A1 (da)
ZA (1) ZA201106750B (da)

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UA103918C2 (en) * 2009-03-02 2013-12-10 Айерем Элелси N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
PT2411395E (pt) 2009-03-23 2013-06-06 Glenmark Pharmaceuticals Sa Derivados de furopirimidinadiona como moduladores de trpa1
US8518948B2 (en) * 2010-03-10 2013-08-27 Ingenium Pharmaceuticals Gmbh Inhibitors of protein kinases
UY33469A (es) * 2010-06-29 2012-01-31 Irm Llc Y Novartis Ag Composiciones y metodos para modular la via de señalizacion de wnt
US8609717B2 (en) 2010-08-18 2013-12-17 Samumed, Llc β- and γ-diketones and γ-hydroxyketones as WNT/β-catenin signaling pathway activators
EP2573086A1 (en) * 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate
EP2573085A1 (en) 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range
KR20140132712A (ko) * 2012-02-28 2014-11-18 노파르티스 아게 RNF43 돌연변이 상태를 사용한 Wnt 신호전달 억제제의 투여를 위한 암 환자 선택
WO2013138753A1 (en) 2012-03-16 2013-09-19 Fox Chase Chemical Diversity Center, Inc. Prodrugs of riluzole and their method of use
WO2014078414A1 (en) * 2012-11-13 2014-05-22 Joseph Wu Chemically defined production of cardiomyocytes from pluripotent stem cells
KR101418168B1 (ko) * 2012-11-21 2014-07-09 부경대학교 산학협력단 신규 테트라하이드로피리디놀 유도체 화합물 및 이를 유효성분으로 포함하는 암 예방 또는 치료용 약제학적 조성물
ES2709824T3 (es) 2013-02-22 2019-04-17 Samumed Llc Gamma-dicetonas como activadores de la ruta de señalización Wnt/beta-catenina
CN103113353B (zh) * 2013-03-13 2014-09-10 中国科学院昆明植物研究所 三氮唑类化合物，其药物组合物和其制备方法与应用
TWI582239B (zh) * 2013-03-11 2017-05-11 諾華公司 與ｗｎｔ抑制劑相關之標記
EP2968348A4 (en) 2013-03-12 2016-11-09 Curegenix Inc COMPOUNDS FOR THE TREATMENT OF CANCER
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