EA201100506A1 - Комбинация ингибитора протеазы ns3 hcv с интерфероном и рибавирином - Google Patents

Комбинация ингибитора протеазы ns3 hcv с интерфероном и рибавирином

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Publication number
EA201100506A1
EA201100506A1 EA201100506A EA201100506A EA201100506A1 EA 201100506 A1 EA201100506 A1 EA 201100506A1 EA 201100506 A EA201100506 A EA 201100506A EA 201100506 A EA201100506 A EA 201100506A EA 201100506 A1 EA201100506 A1 EA 201100506A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ribavirin
interferon
combination
protease inhibitor
hcv protease
Prior art date
Application number
EA201100506A
Other languages
English (en)
Other versions
EA019965B1 (ru
Inventor
Дейвид Хуан
Герхард Густав Штайнманн
Джерри О. Стерн
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41571875&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201100506(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201100506A1 publication Critical patent/EA201100506A1/ru
Publication of EA019965B1 publication Critical patent/EA019965B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

В заявке описаны терапевтические комбинации, содержащие (а) соединение (1) или его фармацевтически приемлемую соль, представленное/представленную в настоящем описании, (б) интерферон альфа и (в) рибавирин. Соединение (1) представляет собой селективный и эффективный ингибитор сериновой протеазы NS3 HCV. В заявке описаны также способы применения указанных терапевтических комбинаций для лечения инфекции, вызываемой HCV, или облегчения одного или нескольких ее симптомов у пациента.
EA201100506A 2008-09-17 2009-09-14 Комбинация ингибитора протеазы ns3 hcv с интерфероном и рибавирином EA019965B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9775308P 2008-09-17 2008-09-17
US10903308P 2008-10-28 2008-10-28
US17193509P 2009-04-23 2009-04-23
PCT/US2009/056771 WO2010033443A1 (en) 2008-09-17 2009-09-14 Combination of hcv ns3 protease inhibitor with interferon and ribavirin

Publications (2)

Publication Number Publication Date
EA201100506A1 true EA201100506A1 (ru) 2011-10-31
EA019965B1 EA019965B1 (ru) 2014-07-30

Family

ID=41571875

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201100506A EA019965B1 (ru) 2008-09-17 2009-09-14 Комбинация ингибитора протеазы ns3 hcv с интерфероном и рибавирином

Country Status (25)

Country Link
US (1) US8399484B2 (ru)
EP (1) EP2337583A1 (ru)
JP (1) JP5539363B2 (ru)
KR (1) KR20110054003A (ru)
CN (1) CN102159245B (ru)
AR (1) AR073516A1 (ru)
AU (1) AU2009293493B2 (ru)
BR (1) BRPI0918653A2 (ru)
CA (1) CA2737376A1 (ru)
CL (1) CL2011000571A1 (ru)
CO (1) CO6351753A2 (ru)
EA (1) EA019965B1 (ru)
EC (1) ECSP11010877A (ru)
HK (1) HK1156865A1 (ru)
IL (1) IL210152A0 (ru)
MA (1) MA32634B1 (ru)
MX (1) MX2011002602A (ru)
MY (1) MY152824A (ru)
NZ (1) NZ591030A (ru)
PE (1) PE20110343A1 (ru)
TW (1) TWI454263B (ru)
UA (1) UA103496C2 (ru)
UY (1) UY32124A (ru)
WO (1) WO2010033443A1 (ru)
ZA (1) ZA201009151B (ru)

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Also Published As

Publication number Publication date
UA103496C2 (ru) 2013-10-25
TWI454263B (zh) 2014-10-01
NZ591030A (en) 2012-10-26
JP5539363B2 (ja) 2014-07-02
AR073516A1 (es) 2010-11-10
US20100068182A1 (en) 2010-03-18
EP2337583A1 (en) 2011-06-29
TW201016218A (en) 2010-05-01
CN102159245A (zh) 2011-08-17
MX2011002602A (es) 2011-04-07
WO2010033443A1 (en) 2010-03-25
ZA201009151B (en) 2011-09-28
HK1156865A1 (en) 2012-06-22
CO6351753A2 (es) 2011-12-20
AU2009293493B2 (en) 2014-09-18
MY152824A (en) 2014-11-28
JP2012502999A (ja) 2012-02-02
KR20110054003A (ko) 2011-05-24
CN102159245B (zh) 2013-07-24
AU2009293493A1 (en) 2010-03-25
BRPI0918653A2 (pt) 2015-12-01
MA32634B1 (fr) 2011-09-01
CL2011000571A1 (es) 2011-07-29
PE20110343A1 (es) 2011-06-25
US8399484B2 (en) 2013-03-19
ECSP11010877A (es) 2011-04-29
EA019965B1 (ru) 2014-07-30
UY32124A (es) 2010-04-30
IL210152A0 (en) 2011-03-31
CA2737376A1 (en) 2010-03-25

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