EA200000787A1 - Промежуточные соединения для получения ациклических нуклеозидов - Google Patents

Промежуточные соединения для получения ациклических нуклеозидов

Info

Publication number
EA200000787A1
EA200000787A1 EA200000787A EA200000787A EA200000787A1 EA 200000787 A1 EA200000787 A1 EA 200000787A1 EA 200000787 A EA200000787 A EA 200000787A EA 200000787 A EA200000787 A EA 200000787A EA 200000787 A1 EA200000787 A1 EA 200000787A1
Authority
EA
Eurasian Patent Office
Prior art keywords
obtaining
radicals
intermediate connections
acyclic nucleoside
monounsaturated
Prior art date
Application number
EA200000787A
Other languages
English (en)
Other versions
EA002809B1 (ru
Inventor
Роберт Линна
Майкл Расмуссен
Original Assignee
Медивир Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9600613A external-priority patent/SE9600613D0/xx
Priority claimed from SE9600614A external-priority patent/SE9600614D0/xx
Application filed by Медивир Аб filed Critical Медивир Аб
Publication of EA200000787A1 publication Critical patent/EA200000787A1/ru
Publication of EA002809B1 publication Critical patent/EA002809B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к новым промежуточным соединениям для получения биологически активных соединений общей формулы I, в которой один из радикалов Rи Rпредставляет собой -C(O)CH(CH(CH))NHили -C(O)CH(CH(CH)CHCH)NH; другой из радикалов Rи Rпредставляет собой -C(=O)C-C, насыщенный или мононенасыщенный, необязательно замещенный алкил; а Rпредставляет собой OH или H; и фармацевтически приемлемые соли такого соединения находят применение в качестве антивирусных агентов с усиленной биоприменимостью против герпеса и ретровирусных инфекций.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000787A 1996-02-16 1997-02-14 Промежуточные соединения для получения ациклических нуклеозидов EA002809B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9600613A SE9600613D0 (sv) 1996-02-16 1996-02-16 Acyclic nucleoside derivatives
SE9600614A SE9600614D0 (sv) 1996-02-16 1996-02-16 Antiviral compounds
PCT/SE1997/000241 WO1997030051A1 (en) 1996-02-16 1997-02-14 Acyclic nucleoside derivatives

Publications (2)

Publication Number Publication Date
EA200000787A1 true EA200000787A1 (ru) 2001-04-23
EA002809B1 EA002809B1 (ru) 2002-10-31

Family

ID=26662518

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200000787A EA002809B1 (ru) 1996-02-16 1997-02-14 Промежуточные соединения для получения ациклических нуклеозидов
EA199800729A EA001404B1 (ru) 1996-02-16 1997-02-14 Производные ациклических нуклеозидов

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA199800729A EA001404B1 (ru) 1996-02-16 1997-02-14 Производные ациклических нуклеозидов

Country Status (26)

Country Link
US (5) US5869493A (ru)
EP (2) EP0880521B1 (ru)
JP (2) JP4171069B2 (ru)
KR (1) KR100464692B1 (ru)
CN (1) CN1067073C (ru)
AR (1) AR005827A1 (ru)
AT (2) ATE231508T1 (ru)
AU (1) AU715062B2 (ru)
BG (1) BG64179B1 (ru)
CA (1) CA2243826C (ru)
CZ (1) CZ292169B6 (ru)
DE (2) DE69718619T2 (ru)
DK (1) DK0888348T3 (ru)
EA (2) EA002809B1 (ru)
ES (2) ES2189941T3 (ru)
HK (1) HK1015773A1 (ru)
HU (1) HU229865B1 (ru)
IL (1) IL124760A (ru)
MY (1) MY123083A (ru)
NO (1) NO322930B1 (ru)
NZ (1) NZ330472A (ru)
PL (1) PL184892B1 (ru)
SK (1) SK284613B6 (ru)
TR (1) TR199801318T2 (ru)
TW (1) TW533213B (ru)
WO (2) WO1997030052A1 (ru)

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US6184376B1 (en) 1997-02-10 2001-02-06 Mediver Ab Synthesis of acyclic nucleoside derivatives
ATE227289T1 (de) * 1997-02-10 2002-11-15 Medivir Ab Verfahren zur herstellung von azyklischen nukleosiden
DK0988304T3 (da) * 1997-08-15 2001-08-20 Medivir Ab Nukleosidanaloger såsom antivirale midler omfattende inhibitorer af retroviral revers transkriptase og DNA-polymerasen fra hepatitis B-virus (HBV)
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US20100240681A1 (en) * 2007-09-21 2010-09-23 Epiphany Biosciences, Inc. Valomaciclovir polymorphs
WO2011022712A1 (en) * 2009-08-21 2011-02-24 Epiphany Biosciences, Inc. Method of treating infectious mononucleosis with acylic nucleoside derivatives
LT2691530T (lt) 2011-06-10 2018-08-10 Oregon Health & Science University Cmv glikoproteinai ir rekombinantiniai vektoriai
KR101763127B1 (ko) 2015-06-23 2017-08-01 (주)농협아그로 끈끈이 엠보싱 트랩 테이프
WO2024118480A1 (en) * 2022-11-28 2024-06-06 Epiphany Biosciences Use of antiviral agents, composition of matter, combination preparations/agents to treat chronic diseases associated with epstein-barr virus and other human herpes viruses

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Also Published As

Publication number Publication date
NO322930B1 (no) 2006-12-18
AU1818297A (en) 1997-09-02
SK98598A3 (en) 1998-12-02
WO1997030052A1 (en) 1997-08-21
US5869493A (en) 1999-02-09
EP0880521B1 (en) 2003-01-22
CA2243826C (en) 2005-12-27
AR005827A1 (es) 1999-07-14
EA001404B1 (ru) 2001-02-26
HUP9900680A2 (hu) 1999-06-28
MY123083A (en) 2006-05-31
ES2189941T3 (es) 2003-07-16
CZ292169B6 (cs) 2003-08-13
JP4171069B2 (ja) 2008-10-22
NO983216D0 (no) 1998-07-13
US6255312B1 (en) 2001-07-03
AU713916B2 (en) 1999-12-16
WO1997030051A1 (en) 1997-08-21
SK284613B6 (sk) 2005-07-01
US6576763B1 (en) 2003-06-10
NZ330472A (en) 2000-02-28
IL124760A0 (en) 1999-01-26
ATE231507T1 (de) 2003-02-15
HUP9900680A3 (en) 2001-02-28
ATE231508T1 (de) 2003-02-15
EP0888348B1 (en) 2003-01-22
ES2189942T3 (es) 2003-07-16
CZ232298A3 (cs) 1998-10-14
PL328335A1 (en) 1999-01-18
US8124609B2 (en) 2012-02-28
AU715062B2 (en) 2000-01-13
IL124760A (en) 2003-09-17
TW533213B (en) 2003-05-21
CN1067073C (zh) 2001-06-13
US20090076041A1 (en) 2009-03-19
AU1818397A (en) 1997-09-02
CA2243826A1 (en) 1997-08-21
DK0888348T3 (da) 2003-04-14
HK1015773A1 (en) 1999-10-22
BG64179B1 (bg) 2004-03-31
TR199801318T2 (xx) 1998-10-21
EP0888348A1 (en) 1999-01-07
DE69718619T2 (de) 2003-08-21
US20120123119A1 (en) 2012-05-17
HU229865B1 (en) 2014-10-28
JP2000504720A (ja) 2000-04-18
DE69718626D1 (de) 2003-02-27
DE69718619D1 (de) 2003-02-27
NO983216L (no) 1998-10-13
CN1210537A (zh) 1999-03-10
KR19990082571A (ko) 1999-11-25
PL184892B1 (pl) 2003-01-31
BG102647A (en) 1999-04-30
JP2000504721A (ja) 2000-04-18
DE69718626T2 (de) 2003-09-11
EA199800729A1 (ru) 1999-02-25
EA002809B1 (ru) 2002-10-31
KR100464692B1 (ko) 2005-06-21
EP0880521A1 (en) 1998-12-02

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