IL124760A - Diesters of 2-amino-9-[4-hydroxy-2-(hydroxymethyl) butyl] purines, their preparation and pharmaceutical compositions containing them - Google Patents

Diesters of 2-amino-9-[4-hydroxy-2-(hydroxymethyl) butyl] purines, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL124760A
IL124760A IL12476097A IL12476097A IL124760A IL 124760 A IL124760 A IL 124760A IL 12476097 A IL12476097 A IL 12476097A IL 12476097 A IL12476097 A IL 12476097A IL 124760 A IL124760 A IL 124760A
Authority
IL
Israel
Prior art keywords
purines
diesters
hydroxymethyl
hydroxy
butyl
Prior art date
Application number
IL12476097A
Other languages
English (en)
Other versions
IL124760A0 (en
Original Assignee
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9600613A external-priority patent/SE9600613D0/xx
Priority claimed from SE9600614A external-priority patent/SE9600614D0/xx
Application filed by Medivir Ab filed Critical Medivir Ab
Priority to IL14446597A priority Critical patent/IL144465A/en
Publication of IL124760A0 publication Critical patent/IL124760A0/xx
Publication of IL124760A publication Critical patent/IL124760A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL12476097A 1996-02-16 1997-02-14 Diesters of 2-amino-9-[4-hydroxy-2-(hydroxymethyl) butyl] purines, their preparation and pharmaceutical compositions containing them IL124760A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL14446597A IL144465A (en) 1996-02-16 1997-02-14 9-[4,4-bis(etherifiedhydroxy)-2-(hydroxymethyl)butyl]guanine derivatives

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9600613A SE9600613D0 (sv) 1996-02-16 1996-02-16 Acyclic nucleoside derivatives
SE9600614A SE9600614D0 (sv) 1996-02-16 1996-02-16 Antiviral compounds
PCT/SE1997/000241 WO1997030051A1 (en) 1996-02-16 1997-02-14 Acyclic nucleoside derivatives

Publications (2)

Publication Number Publication Date
IL124760A0 IL124760A0 (en) 1999-01-26
IL124760A true IL124760A (en) 2003-09-17

Family

ID=26662518

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12476097A IL124760A (en) 1996-02-16 1997-02-14 Diesters of 2-amino-9-[4-hydroxy-2-(hydroxymethyl) butyl] purines, their preparation and pharmaceutical compositions containing them

Country Status (26)

Country Link
US (5) US5869493A (ru)
EP (2) EP0880521B1 (ru)
JP (2) JP2000504721A (ru)
KR (1) KR100464692B1 (ru)
CN (1) CN1067073C (ru)
AR (1) AR005827A1 (ru)
AT (2) ATE231508T1 (ru)
AU (1) AU715062B2 (ru)
BG (1) BG64179B1 (ru)
CA (1) CA2243826C (ru)
CZ (1) CZ292169B6 (ru)
DE (2) DE69718626T2 (ru)
DK (1) DK0888348T3 (ru)
EA (2) EA001404B1 (ru)
ES (2) ES2189941T3 (ru)
HK (1) HK1015773A1 (ru)
HU (1) HU229865B1 (ru)
IL (1) IL124760A (ru)
MY (1) MY123083A (ru)
NO (1) NO322930B1 (ru)
NZ (1) NZ330472A (ru)
PL (1) PL184892B1 (ru)
SK (1) SK284613B6 (ru)
TR (1) TR199801318T2 (ru)
TW (1) TW533213B (ru)
WO (2) WO1997030052A1 (ru)

Families Citing this family (19)

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US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
EP0942916A2 (en) * 1996-11-12 1999-09-22 Medivir Aktiebolag Nucleosides
US6184376B1 (en) * 1997-02-10 2001-02-06 Mediver Ab Synthesis of acyclic nucleoside derivatives
CA2277151C (en) * 1997-02-10 2007-04-17 Medivir Ab Synthesis of acyclic nucleoside derivatives
SG96604A1 (en) * 1997-08-15 2003-06-16 Medivir Ab Nucleosides analogues, such as antivirals including inhibitors of retroviral reverse transcriptase and the dna polymerase of hepatitis b virus (hbv)
AU1711599A (en) * 1997-12-19 1999-07-12 Bristol-Myers Squibb Company Prodrugs of lobucavir and methods of use
US20040266795A1 (en) * 2003-04-30 2004-12-30 Genny Shamai Process for the preparation of famciclovir
DE602005013697D1 (de) 2004-12-30 2009-05-14 Medivir Ab Verbindungen zur behandlung von hiv
WO2006082588A2 (en) * 2005-02-07 2006-08-10 Pharmalight Inc. Method and device for ophthalmic administration of active pharmaceutical ingredients
CN101033238B (zh) * 2006-03-06 2011-02-16 中国科学院上海药物研究所 嘌呤类化合物双氨基酸酯的制备方法和用途
ZA200702234B (en) * 2006-03-21 2008-07-30 Cipla Ltd Preparation of ester of purine derivatives
CN101835374B (zh) 2007-07-09 2014-08-27 东弗吉尼亚医学院 具有抗病毒和抗微生物性质的取代的核苷衍生物
US20100240681A1 (en) 2007-09-21 2010-09-23 Epiphany Biosciences, Inc. Valomaciclovir polymorphs
WO2011022712A1 (en) * 2009-08-21 2011-02-24 Epiphany Biosciences, Inc. Method of treating infectious mononucleosis with acylic nucleoside derivatives
DK2691530T3 (en) 2011-06-10 2018-05-22 Univ Oregon Health & Science CMV GLYCOPROTEIN AND RECOMBINANT VECTORS
KR101763127B1 (ko) 2015-06-23 2017-08-01 (주)농협아그로 끈끈이 엠보싱 트랩 테이프
WO2024118480A1 (en) * 2022-11-28 2024-06-06 Epiphany Biosciences Use of antiviral agents, composition of matter, combination preparations/agents to treat chronic diseases associated with epstein-barr virus and other human herpes viruses

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FR2040177A1 (en) 1969-01-31 1971-01-22 Robugen Gmbh 2-deoxyribosyl-uracil derivs
US3817982A (en) 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
US4267171A (en) 1979-07-02 1981-05-12 The Regents Of The University Of California C-5 Substituted cytosine nucleosides
US4247544A (en) 1979-07-02 1981-01-27 The Regents Of The University Of California C-5 Substituted uracil nucleosides
JPS57146798A (en) 1981-03-06 1982-09-10 Yamasa Shoyu Co Ltd Hexosyl nucleoside derivative
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
SE8406538D0 (sv) * 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US4724232A (en) 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
EP0286825A3 (en) 1987-03-18 1989-04-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Use of 3'-fluro-3' deoxythymidine for the manufacture of a medicament for the treatment of virus infections
SE8701605D0 (sv) 1987-04-16 1987-04-16 Astra Ab Novel medicinal compounds
AP55A (en) * 1987-08-15 1989-09-26 The Wellcome Foundation Ltd Therapeutic Acyclic Nucleosides
CA1321994C (en) * 1987-10-28 1993-09-07 Reid Von Borstel Acylated uridine and cytidine and uses thereof
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US5284837A (en) 1988-05-06 1994-02-08 Medivir Ab Derivatives of purine, process for their preparation and a pharmaceutical preparation
SE8801729D0 (sv) 1988-05-06 1988-05-06 Astra Ab Purine derivatives for use in therapy
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GB9307043D0 (en) * 1993-04-05 1993-05-26 Norsk Hydro As Chemical compounds
DE4311801A1 (de) * 1993-04-09 1994-10-13 Hoechst Ag Neue Carbonsäureester von 2-Amino-7-(1,3-dihydroxy-2-propoxymethyl)purin, deren Herstellung sowie deren Verwendung
GB9320316D0 (en) * 1993-10-01 1993-11-17 Smithkline Beecham Plc Pharmaceuticals
TW282470B (ru) * 1993-11-18 1996-08-01 Ajinomoto Kk
US5521161A (en) 1993-12-20 1996-05-28 Compagnie De Developpment Aguettant S.A. Method of treating HIV in humans by administration of ddI and hydroxycarbamide
WO1995022330A1 (en) * 1994-02-17 1995-08-24 Commonwealth Scientific And Industrial Research Organisation Antiviral agents
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
PE32296A1 (es) * 1994-07-28 1996-08-07 Hoffmann La Roche Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables
JP3906488B2 (ja) 1995-02-21 2007-04-18 味の素株式会社 プリン誘導体の製造方法
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
CN1064683C (zh) * 1996-01-26 2001-04-18 弗·哈夫曼-拉罗切有限公司 制备嘌呤衍生物的方法
AU1592897A (en) * 1996-01-26 1997-08-20 F. Hoffmann-La Roche Ag Process for preparing purine derivatives
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6703394B2 (en) * 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
EP0827960A1 (en) 1996-09-10 1998-03-11 Ajinomoto Co., Inc. Process for producing purine derivatives

Also Published As

Publication number Publication date
US5869493A (en) 1999-02-09
EP0880521B1 (en) 2003-01-22
SK98598A3 (en) 1998-12-02
CN1067073C (zh) 2001-06-13
US6255312B1 (en) 2001-07-03
TR199801318T2 (xx) 1998-10-21
US20090076041A1 (en) 2009-03-19
ATE231507T1 (de) 2003-02-15
AU713916B2 (en) 1999-12-16
DE69718626T2 (de) 2003-09-11
WO1997030051A1 (en) 1997-08-21
MY123083A (en) 2006-05-31
IL124760A0 (en) 1999-01-26
DK0888348T3 (da) 2003-04-14
AR005827A1 (es) 1999-07-14
CN1210537A (zh) 1999-03-10
TW533213B (en) 2003-05-21
ES2189941T3 (es) 2003-07-16
AU1818397A (en) 1997-09-02
ES2189942T3 (es) 2003-07-16
EA200000787A1 (ru) 2001-04-23
ATE231508T1 (de) 2003-02-15
WO1997030052A1 (en) 1997-08-21
EP0888348B1 (en) 2003-01-22
JP2000504721A (ja) 2000-04-18
SK284613B6 (sk) 2005-07-01
PL328335A1 (en) 1999-01-18
JP4171069B2 (ja) 2008-10-22
NO983216D0 (no) 1998-07-13
EP0888348A1 (en) 1999-01-07
NO983216L (no) 1998-10-13
NO322930B1 (no) 2006-12-18
BG102647A (en) 1999-04-30
JP2000504720A (ja) 2000-04-18
BG64179B1 (bg) 2004-03-31
EA001404B1 (ru) 2001-02-26
DE69718619D1 (de) 2003-02-27
NZ330472A (en) 2000-02-28
EP0880521A1 (en) 1998-12-02
EA002809B1 (ru) 2002-10-31
US8124609B2 (en) 2012-02-28
HU229865B1 (en) 2014-10-28
AU715062B2 (en) 2000-01-13
US6576763B1 (en) 2003-06-10
EA199800729A1 (ru) 1999-02-25
CZ232298A3 (cs) 1998-10-14
CA2243826A1 (en) 1997-08-21
KR19990082571A (ko) 1999-11-25
PL184892B1 (pl) 2003-01-31
AU1818297A (en) 1997-09-02
US20120123119A1 (en) 2012-05-17
HUP9900680A2 (hu) 1999-06-28
CA2243826C (en) 2005-12-27
HK1015773A1 (en) 1999-10-22
HUP9900680A3 (en) 2001-02-28
DE69718626D1 (de) 2003-02-27
DE69718619T2 (de) 2003-08-21
KR100464692B1 (ko) 2005-06-21
CZ292169B6 (cs) 2003-08-13

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Legal Events

Date Code Title Description
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MM9K Patent not in force due to non-payment of renewal fees