AU8004291A - Use of alkyl phospholipids as antiviral drugs, as well as new compounds - Google Patents

Use of alkyl phospholipids as antiviral drugs, as well as new compounds

Info

Publication number
AU8004291A
AU8004291A AU80042/91A AU8004291A AU8004291A AU 8004291 A AU8004291 A AU 8004291A AU 80042/91 A AU80042/91 A AU 80042/91A AU 8004291 A AU8004291 A AU 8004291A AU 8004291 A AU8004291 A AU 8004291A
Authority
AU
Australia
Prior art keywords
alkyl
alkane
alkoxy
chain
antiviral drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU80042/91A
Inventor
Elmar Bosies
Dieter Herrmann
Edith Koch
Harald Zilch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of AU8004291A publication Critical patent/AU8004291A/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/683Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/091Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/10Phosphatides, e.g. lecithin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/16Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165Esters of thiophosphoric acids
    • C07F9/1651Esters of thiophosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to the use of compounds of formula (I), where R<1> is a straight-chain or branched, saturated or unsaturated aliphatic residue, in particular an alkyl residue, with 9 to 30 carbon atoms, which can also be part of a C5-C7 cycloalkane ring and may be substituted with one or more hydroxy, halogen, nitrile, a C5-C7 cycloalkyl, phenyl, C1-C20 alkoxy carbonyl, C1-C20 alkyl carbonyl, C1-C20 alkyl carbamoyl, C1-C20 alkyl mercapto, C1-C20 alkane sulphinyl, C1-C20 alkane sulphonyl, C1-C20 acyl amino groups or by C1-C20 alkoxy which in turn can be substituted by phenyl, C1-C20 alkyl mercapto, C1-C20 alkane sulphinyl, C1-C20 alkane sulphonyl, C1-C20 acyl amino, C1-C20 alkoxy carbonyl, nitrile, hydroxy, C1-C20 alkoxy or C1-C20 alkyl carbamoyl, R<2> is a straight-chain or branched alkylene chain with 2 to 6, preferably 2 to 4, carbon atoms, R<3> is hydrogen or a C1-C6 alkyl group, and Y is an oxygen or a sulphur atom. The invention also relates to their pharmacologically acceptable salts and optical isomers for manufacturing antiviral drugs. Also described are selected new phospholipids and their use to manufacture drugs, in particular for treating viral or retroviral infections.
AU80042/91A 1989-12-23 1990-12-05 Use of alkyl phospholipids as antiviral drugs, as well as new compounds Abandoned AU8004291A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3942933 1989-12-23
DE3942933A DE3942933A1 (en) 1989-12-23 1989-12-23 USE OF ALKYLPHOSPHOLIPIDES AS ANTIVIRAL MEDICINAL PRODUCTS AND NEW PHOSPHOLIPID DERIVATIVES

Publications (1)

Publication Number Publication Date
AU8004291A true AU8004291A (en) 1991-07-24

Family

ID=6396421

Family Applications (1)

Application Number Title Priority Date Filing Date
AU80042/91A Abandoned AU8004291A (en) 1989-12-23 1990-12-05 Use of alkyl phospholipids as antiviral drugs, as well as new compounds

Country Status (5)

Country Link
EP (1) EP0506704B1 (en)
AT (1) ATE103177T1 (en)
AU (1) AU8004291A (en)
DE (2) DE3942933A1 (en)
WO (1) WO1991009602A2 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6252060B1 (en) 1988-07-07 2001-06-26 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US5817638A (en) * 1988-07-07 1998-10-06 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US6599887B2 (en) 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
CA2001401A1 (en) * 1988-10-25 1990-04-25 Claude Piantadosi Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions
US6172050B1 (en) 1992-07-11 2001-01-09 Asta Medica Aktiengesellschaft Phospholipid derivatives
DE4222910A1 (en) * 1992-07-11 1994-01-13 Asta Medica Ag New phospholipid derivatives
US5958906A (en) * 1992-10-01 1999-09-28 Asta-Medica Aktiengesellschaft Phospholipid derivatives containing higher elements of the fifth main group
DE4233044A1 (en) * 1992-10-01 1994-04-07 Asta Medica Ag Phospholipid derivatives that contain higher elements of the 5th main group
EP0702556B1 (en) * 1993-06-10 2002-10-23 Wake Forest University (phospho)lipids for combatting hepatitis b virus infection
DE4404085B4 (en) * 1994-02-09 2006-09-21 Rhône-Poulenc Rorer GmbH Pharmaceutical and / or cosmetic composition
DE4416166C2 (en) * 1994-05-06 1997-11-20 Immuno Ag Stable preparation for the treatment of blood clotting disorders
US6017891A (en) * 1994-05-06 2000-01-25 Baxter Aktiengesellschaft Stable preparation for the treatment of blood coagulation disorders
US7135584B2 (en) 1995-08-07 2006-11-14 Wake Forest University Lipid analogs for treating viral infections
WO1996006620A2 (en) 1994-08-29 1996-03-07 Wake Forest University Lipid analogs for treating viral infections
US7026469B2 (en) 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
US7309696B2 (en) 2000-10-19 2007-12-18 Wake Forest University Compositions and methods for targeting cancer cells
US7551837B2 (en) 2001-08-31 2009-06-23 Thomson Licensing Sequence counter for an audio visual stream
WO2006110656A2 (en) 2005-04-08 2006-10-19 Chimerix, Inc. Compounds, compositions and methods for the treatment of viral infections and other medical disorders
AR058397A1 (en) * 2005-12-19 2008-01-30 Zentaris Gmbh DERIVATIVES OF ALQUILFOSFOLIPIDOS WITH REDUCED CYTOTOXICITY AND USES OF THE SAME
EP1800684A1 (en) * 2005-12-20 2007-06-27 Zentaris GmbH Novel alkyl phospholipid derivatives and uses thereof
EP2254582B1 (en) 2008-01-25 2016-01-20 Chimerix, Inc. Methods of treating viral infections
WO2011100698A2 (en) 2010-02-12 2011-08-18 Chimerix, Inc. Methods of treating viral infection
EP2563367A4 (en) 2010-04-26 2013-12-04 Chimerix Inc Methods of treating retroviral infections and related dosage regimes
CN115461380A (en) 2020-04-30 2022-12-09 陶氏环球技术有限责任公司 Ziegler-natta (pro-) catalyst systems prepared with nitrogen heterocycles

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5984824A (en) * 1982-11-08 1984-05-16 Takeda Chem Ind Ltd Antitumor agent
US4857514A (en) * 1985-09-17 1989-08-15 Yeda Research And Development Company, Ltd. Virus inactivation
JPS62126108A (en) * 1985-11-28 1987-06-08 Pola Chem Ind Inc External drug for skin

Also Published As

Publication number Publication date
WO1991009602A2 (en) 1991-07-11
EP0506704A1 (en) 1992-10-07
EP0506704B1 (en) 1994-03-23
WO1991009602A3 (en) 1992-12-10
DE3942933A1 (en) 1991-06-27
ATE103177T1 (en) 1994-04-15
DE59005139D1 (en) 1994-04-28

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