GB2014132A - Thio propionamides, processes for their preparation and pharmaceutical compositions containing them - Google Patents

Thio propionamides, processes for their preparation and pharmaceutical compositions containing them

Info

Publication number
GB2014132A
GB2014132A GB7849881A GB7849881A GB2014132A GB 2014132 A GB2014132 A GB 2014132A GB 7849881 A GB7849881 A GB 7849881A GB 7849881 A GB7849881 A GB 7849881A GB 2014132 A GB2014132 A GB 2014132A
Authority
GB
United Kingdom
Prior art keywords
lower alkyl
group
formula
amino
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7849881A
Other versions
GB2014132B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union et Cie filed Critical Science Union et Cie
Publication of GB2014132A publication Critical patent/GB2014132A/en
Application granted granted Critical
Publication of GB2014132B publication Critical patent/GB2014132B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings

Abstract

The invention provides compounds of the formula <IMAGE> in which R is a hydrogen atom, a lower alkyl, lower alkenyl or aryl-lower alkyl group or the acyl radical of a lower alkyl-carboxylic acid or an aryl- carboxylic acid each having up to 10 carbon atoms; R1 is a hydroxy, lower alkoxy, di- (lower alkyl)-amino-lower alkoxy, amino, monosubstituted amino, disubstituted amino or dihydroxy-lower alkyl group; A and B together are a lower alkylene group of the formula (CH2)m-CH2-, a group of the formula <IMAGE> a group of the formula (CH2)ml- CH = CH or a disubstituted lower alkylene group of the formula <IMAGE> Z is sulphur or a sulphinyl or sulphonyl group; R' is a hydrogen atom or a lower alkyl group; R'' is a lower alkyl group; n is zero or 1; m is 1 or 2; m1 is zero, 1 or 2; and m2 is 1 or 2; and their diastereoisomers, optically active isomers and salts with inorganlc and organic bases. The invention also provides a process for preparing such compounds, and pharmaceutical compositions containing them. The compounds may be used in the treatment of hypertension.
GB7849881A 1977-12-22 1978-12-22 Thio propionamides processes for their preparation and pharmaceutical compositions containing them Expired GB2014132B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7738728A FR2412537A1 (en) 1977-12-22 1977-12-22 NEW SUBSTITUTE THIOBUTYRAMIDES, THEIR METHODS OF OBTAINING AND THEIR PHARMACEUTICAL APPLICATION

Publications (2)

Publication Number Publication Date
GB2014132A true GB2014132A (en) 1979-08-22
GB2014132B GB2014132B (en) 1982-08-11

Family

ID=9199179

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7849881A Expired GB2014132B (en) 1977-12-22 1978-12-22 Thio propionamides processes for their preparation and pharmaceutical compositions containing them

Country Status (14)

Country Link
AR (1) AR222815A1 (en)
BE (1) BE872972A (en)
DD (1) DD142545A5 (en)
DE (1) DE2854877A1 (en)
ES (1) ES476314A1 (en)
FR (1) FR2412537A1 (en)
GB (1) GB2014132B (en)
GR (1) GR66839B (en)
IT (1) IT1158184B (en)
OA (1) OA06139A (en)
PT (1) PT68966A (en)
SE (1) SE7813180L (en)
SU (1) SU860696A1 (en)
ZA (1) ZA787196B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284561A (en) 1979-12-03 1981-08-18 E. R. Squibb & Sons, Inc. Hydroxamic acid derivatives of mercaptoacyl amino acids
US4308392A (en) 1979-12-03 1981-12-29 E. R. Squibb & Sons, Inc. Hydroxamic acid derivatives of mercaptoacyl amino acids
US4482725A (en) * 1980-04-03 1984-11-13 E. R. Squibb & Sons, Inc. S-Acylation products of mercaptoacyl amino acids and carboxyl group containing diuretics

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1109475A (en) * 1978-07-27 1981-09-22 Miguel A. Ondetti Thiopropanoylamino acid derivatives
US4483861A (en) * 1978-10-31 1984-11-20 Santen Pharmaceutical Co., Ltd. Antihypertensive sulfur-containing compounds
ZA802420B (en) * 1979-05-18 1981-04-29 Squibb & Sons Inc Aminoacyl derivatives of mercaptoacyl amino acids
ZA802709B (en) * 1979-05-30 1981-05-27 Merrell Toraude & Co N-acyl-amino acid derivatives
JPS5683483A (en) * 1979-12-13 1981-07-08 Santen Pharmaceut Co Ltd Thiazolidine compound
JPS56139455A (en) * 1980-04-02 1981-10-30 Santen Pharmaceut Co Ltd Sulfur-containing acylaminoacid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4052511A (en) * 1976-02-13 1977-10-04 E. R. Squibb & Sons, Inc. Carboxyacylproline derivatives

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284561A (en) 1979-12-03 1981-08-18 E. R. Squibb & Sons, Inc. Hydroxamic acid derivatives of mercaptoacyl amino acids
US4308392A (en) 1979-12-03 1981-12-29 E. R. Squibb & Sons, Inc. Hydroxamic acid derivatives of mercaptoacyl amino acids
US4482725A (en) * 1980-04-03 1984-11-13 E. R. Squibb & Sons, Inc. S-Acylation products of mercaptoacyl amino acids and carboxyl group containing diuretics

Also Published As

Publication number Publication date
AR222815A1 (en) 1981-06-30
IT1158184B (en) 1987-02-18
GR66839B (en) 1981-05-04
PT68966A (en) 1979-01-01
DD142545A5 (en) 1980-07-02
SU860696A1 (en) 1981-08-30
OA06139A (en) 1981-06-30
ZA787196B (en) 1979-11-28
GB2014132B (en) 1982-08-11
FR2412537A1 (en) 1979-07-20
ES476314A1 (en) 1979-04-16
DE2854877A1 (en) 1979-06-28
BE872972A (en) 1979-06-21
IT7852406A0 (en) 1978-12-21
FR2412537B1 (en) 1981-10-16
SE7813180L (en) 1979-06-23

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee