FR2412537A1 - NEW SUBSTITUTE THIOBUTYRAMIDES, THEIR METHODS OF OBTAINING AND THEIR PHARMACEUTICAL APPLICATION - Google Patents

NEW SUBSTITUTE THIOBUTYRAMIDES, THEIR METHODS OF OBTAINING AND THEIR PHARMACEUTICAL APPLICATION

Info

Publication number
FR2412537A1
FR2412537A1 FR7738728A FR7738728A FR2412537A1 FR 2412537 A1 FR2412537 A1 FR 2412537A1 FR 7738728 A FR7738728 A FR 7738728A FR 7738728 A FR7738728 A FR 7738728A FR 2412537 A1 FR2412537 A1 FR 2412537A1
Authority
FR
France
Prior art keywords
radical
thiobutyramides
alcoxy
obtaining
substitute
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7738728A
Other languages
French (fr)
Other versions
FR2412537B1 (en
Inventor
Charles Malen
Pierre Roger
Michel Laubie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union et Cie filed Critical Science Union et Cie
Priority to FR7738728A priority Critical patent/FR2412537A1/en
Priority to DE19782854877 priority patent/DE2854877A1/en
Priority to IL56279A priority patent/IL56279A0/en
Priority to DK573878A priority patent/DK573878A/en
Priority to GR57961A priority patent/GR66839B/el
Priority to AR274935A priority patent/AR222815A1/en
Priority to NZ189280A priority patent/NZ189280A/en
Priority to PT68966A priority patent/PT68966A/en
Priority to ZA00787196A priority patent/ZA787196B/en
Priority to SE7813180A priority patent/SE7813180L/en
Priority to IT52406/78A priority patent/IT1158184B/en
Priority to BE192487A priority patent/BE872972A/en
Priority to SU782704624A priority patent/SU860696A1/en
Priority to ES476314A priority patent/ES476314A1/en
Priority to GB7849881A priority patent/GB2014132B/en
Priority to FI783968A priority patent/FI783968A/en
Priority to NL7812533A priority patent/NL7812533A/en
Priority to OA56695A priority patent/OA06139A/en
Priority to AU42847/78A priority patent/AU4284778A/en
Priority to DD78210134A priority patent/DD142545A5/en
Publication of FR2412537A1 publication Critical patent/FR2412537A1/en
Application granted granted Critical
Publication of FR2412537B1 publication Critical patent/FR2412537B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings

Abstract

LA PRESENTE INVENTION SE RAPPORTE A DES O-THIOBUTYRAMIDES N-SUBSTITUES DE FORMULE GENERALE I: (CF DESSIN DANS BOPI) DANS LAQUELLE R REPRESENTE DE L'HYDROGENE, UN RADICAL ALCOYLE INFERIEUR, ALCENYLE INFERIEUR, ACYLE DERIVE D'UN ACIDE ALCOYL-CARBOXYLIQUE OU ARYLCARBOXYLIQUE AYANT JUSQU'A 10ATOMES DE CARBONE; R EST UN HYDROXYLE, UN RADICAL ALCOXY INFERIEUR, UN RADICAL DIHYDROXY ALCOXY INFERIEUR, UN RADICAL AMINO, UN RADICAL AMINO MONOSUBSTITUE, UN RADICAL AMINO DISUBSTITUE, UN RADICAL DIALCOYLAMINO ALCOXY INFERIEUR. A ET B ENSEMBLE REPRESENTENT UN RADICAL ALCOYLENE DE LA FORME (CH)-CH, UN RADICAL THIALCOYLENE-Z-CH, UN RADICAL ALCENYLENE DE LA FORME (CH)-CHCH- OU UN RADICAL ALCOYLENE SUBSTITUE DE LA FORME -C-(CH)2THE PRESENT INVENTION RELATES TO N-SUBSTITUTE O-THIOBUTYRAMIDES OF GENERAL FORMULA I: (CF DRAWING IN BOPI) IN WHICH R REPRESENTS HYDROGEN, A LOWER ALKYL RADICAL, LOWER ALKENYL, ACYL DERIVED FROM CARBON ACID OR ARYLCARBOXYL HAVING UP TO 10ATOMS OF CARBON; R IS A HYDROXYL, A LOWER RADICAL ALCOXY, A LOWER RADICAL DIHYDROXY ALCOXY, A RADICAL AMINO, A RADICAL AMINO MONOSUBSTITUTE, A RADICAL AMINO DISUBSTITUE, A RADICAL DIALCOYLAMINO ALCOXY LOWER. A AND B TOGETHER REPRESENT A RADICAL ALCOYLENE OF THE FORM (CH) -CH, A RADICAL THIALCOYLENE-Z-CH, A RADICAL ALKENYLENE OF THE FORM (CH) -CHCH- OR A RADICAL ALCOYLENE SUBSTITUTE OF THE FORM -C- (CH ) 2

FR7738728A 1977-12-22 1977-12-22 NEW SUBSTITUTE THIOBUTYRAMIDES, THEIR METHODS OF OBTAINING AND THEIR PHARMACEUTICAL APPLICATION Granted FR2412537A1 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
FR7738728A FR2412537A1 (en) 1977-12-22 1977-12-22 NEW SUBSTITUTE THIOBUTYRAMIDES, THEIR METHODS OF OBTAINING AND THEIR PHARMACEUTICAL APPLICATION
DE19782854877 DE2854877A1 (en) 1977-12-22 1978-12-19 N-SUBSTITUTED OMEGA THIOBUTYRAMID, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE SAME
BE192487A BE872972A (en) 1977-12-22 1978-12-21 NEW SUBSTITUTE THIOBUTYRAMIDES AND THEIR PROCESSING PROCEDURES
GR57961A GR66839B (en) 1977-12-22 1978-12-21
AR274935A AR222815A1 (en) 1977-12-22 1978-12-21 PROCEDURE FOR THE PREPARATION OF ACIDS (ALPHA-TRIFLUOROMETIL-MERCAPTO-PROPIONIL) -PIRROLIDINIL-O TIAZOLIDINIL-CARBOXILICOS
NZ189280A NZ189280A (en) 1977-12-22 1978-12-21 N-substituted-w-thiobutyramides and pharmaceutical compositions
PT68966A PT68966A (en) 1977-12-22 1978-12-21 PROCESS FOR THE PREPARATION OF NOVEL THIOBUTYRAMIDES
ZA00787196A ZA787196B (en) 1977-12-22 1978-12-21 Novel thiobutyramides and processes for their production
SE7813180A SE7813180L (en) 1977-12-22 1978-12-21 NEW SUBSTITUTED TIOBUTYRAMIDS AND WAYS TO PRODUCE THE SAME
IT52406/78A IT1158184B (en) 1977-12-22 1978-12-21 PROCEDURE FOR OBTAINING THIOBUTYRAMMIDES
IL56279A IL56279A0 (en) 1977-12-22 1978-12-21 Novel thiobutyramides, their production and pharmaceuticalcompositions containing them
DK573878A DK573878A (en) 1977-12-22 1978-12-21 PROCEDURE FOR THE PREPARATION OF THIOBUTYRAMIDES
SU782704624A SU860696A1 (en) 1977-12-22 1978-12-22 Method of preparing n-substituted thiobutyramides or their salts
ES476314A ES476314A1 (en) 1977-12-22 1978-12-22 Thio propionamides, processes for their preparation and pharmaceutical compositions containing them
GB7849881A GB2014132B (en) 1977-12-22 1978-12-22 Thio propionamides processes for their preparation and pharmaceutical compositions containing them
FI783968A FI783968A (en) 1977-12-22 1978-12-22 FOERFARANDE FOER FRAMSTAELLNING AV NYA TIOBUTYRAMIDER
NL7812533A NL7812533A (en) 1977-12-22 1978-12-22 (N)-3-Mercapto-2-methyl-propionyl thiazolidinyl-4-carboxylic acids - useful as carboxy-peptidase inhibitors used to treat hypertension
OA56695A OA06139A (en) 1977-12-22 1978-12-22 New substituted thiobutyramides and their production processes.
AU42847/78A AU4284778A (en) 1977-12-22 1978-12-22 Novel thiobutyramides
DD78210134A DD142545A5 (en) 1977-12-22 1978-12-22 PROCESS FOR THE PREPARATION OF NEW OMEGA THIOBUTYRAMIDES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7738728A FR2412537A1 (en) 1977-12-22 1977-12-22 NEW SUBSTITUTE THIOBUTYRAMIDES, THEIR METHODS OF OBTAINING AND THEIR PHARMACEUTICAL APPLICATION

Publications (2)

Publication Number Publication Date
FR2412537A1 true FR2412537A1 (en) 1979-07-20
FR2412537B1 FR2412537B1 (en) 1981-10-16

Family

ID=9199179

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7738728A Granted FR2412537A1 (en) 1977-12-22 1977-12-22 NEW SUBSTITUTE THIOBUTYRAMIDES, THEIR METHODS OF OBTAINING AND THEIR PHARMACEUTICAL APPLICATION

Country Status (14)

Country Link
AR (1) AR222815A1 (en)
BE (1) BE872972A (en)
DD (1) DD142545A5 (en)
DE (1) DE2854877A1 (en)
ES (1) ES476314A1 (en)
FR (1) FR2412537A1 (en)
GB (1) GB2014132B (en)
GR (1) GR66839B (en)
IT (1) IT1158184B (en)
OA (1) OA06139A (en)
PT (1) PT68966A (en)
SE (1) SE7813180L (en)
SU (1) SU860696A1 (en)
ZA (1) ZA787196B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2432019A1 (en) * 1978-07-27 1980-02-22 Squibb & Sons Inc THIOPROPANOYLAMINO-ACIDS AND THEIR THERAPEUTIC USE
FR2440365A1 (en) * 1978-10-31 1980-05-30 Santen Pharmaceutical Co Ltd NOVEL MERCAPTO-AZOLIDINE-CARBOXYLIC ACID DERIVATIVES USEFUL AS HYPERTENSORS
EP0021883A2 (en) * 1979-05-30 1981-01-07 Merrell Toraude Et Compagnie N-acyl-amino acid derivatives and pharmaceutical compositions containing them, intermediates and starting compounds
FR2467198A1 (en) * 1979-05-18 1981-04-17 Squibb & Sons Inc MERCAPTOACYL AMINO ACID DERIVATIVES SUBSTITUTED ON SULFUR ATOM BY A-AMINO OR A-IMINO GROUP WITH PROTECTED NITROGEN ATOM
EP0031104A1 (en) * 1979-12-13 1981-07-01 Santen Pharmaceutical Co., Ltd. Thiazolidine compounds, processes for their preparation and pharmaceutical compositions containing them

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284561A (en) 1979-12-03 1981-08-18 E. R. Squibb & Sons, Inc. Hydroxamic acid derivatives of mercaptoacyl amino acids
US4308392A (en) 1979-12-03 1981-12-29 E. R. Squibb & Sons, Inc. Hydroxamic acid derivatives of mercaptoacyl amino acids
JPS56139455A (en) * 1980-04-02 1981-10-30 Santen Pharmaceut Co Ltd Sulfur-containing acylaminoacid
US4482725A (en) * 1980-04-03 1984-11-13 E. R. Squibb & Sons, Inc. S-Acylation products of mercaptoacyl amino acids and carboxyl group containing diuretics

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2340933A1 (en) * 1976-02-13 1977-09-09 Squibb & Sons Inc CARBOXYALKYLACYLAMINO ACIDS DERIVED FROM PROLINE, PIPECOLIC ACID AND AZETIDINE-2-CARBOXYLIC ACID
FR2340932A1 (en) * 1976-02-13 1977-09-09 Squibb & Sons Inc PROLINE DERIVATIVES AND RELATED COMPOUNDS USEFUL FOR REDUCING BLOOD TENSION

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2340933A1 (en) * 1976-02-13 1977-09-09 Squibb & Sons Inc CARBOXYALKYLACYLAMINO ACIDS DERIVED FROM PROLINE, PIPECOLIC ACID AND AZETIDINE-2-CARBOXYLIC ACID
FR2340932A1 (en) * 1976-02-13 1977-09-09 Squibb & Sons Inc PROLINE DERIVATIVES AND RELATED COMPOUNDS USEFUL FOR REDUCING BLOOD TENSION

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2432019A1 (en) * 1978-07-27 1980-02-22 Squibb & Sons Inc THIOPROPANOYLAMINO-ACIDS AND THEIR THERAPEUTIC USE
FR2440365A1 (en) * 1978-10-31 1980-05-30 Santen Pharmaceutical Co Ltd NOVEL MERCAPTO-AZOLIDINE-CARBOXYLIC ACID DERIVATIVES USEFUL AS HYPERTENSORS
FR2467198A1 (en) * 1979-05-18 1981-04-17 Squibb & Sons Inc MERCAPTOACYL AMINO ACID DERIVATIVES SUBSTITUTED ON SULFUR ATOM BY A-AMINO OR A-IMINO GROUP WITH PROTECTED NITROGEN ATOM
FR2468589A1 (en) * 1979-05-18 1981-05-08 Squibb & Sons Inc AMINOACYLATED MERCAPTOACYL AMINO ACID DERIVATIVES WITH ANTIHYPERTENSIVE ACTION
EP0021883A2 (en) * 1979-05-30 1981-01-07 Merrell Toraude Et Compagnie N-acyl-amino acid derivatives and pharmaceutical compositions containing them, intermediates and starting compounds
EP0021883A3 (en) * 1979-05-30 1981-03-25 Merrell Toraude Et Compagnie N-acyl-amino acid derivatives and pharmaceutical compositions containing them, intermediates and starting compounds
EP0031104A1 (en) * 1979-12-13 1981-07-01 Santen Pharmaceutical Co., Ltd. Thiazolidine compounds, processes for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FR2412537B1 (en) 1981-10-16
DD142545A5 (en) 1980-07-02
OA06139A (en) 1981-06-30
AR222815A1 (en) 1981-06-30
PT68966A (en) 1979-01-01
BE872972A (en) 1979-06-21
GB2014132A (en) 1979-08-22
GR66839B (en) 1981-05-04
DE2854877A1 (en) 1979-06-28
GB2014132B (en) 1982-08-11
SU860696A1 (en) 1981-08-30
ZA787196B (en) 1979-11-28
IT1158184B (en) 1987-02-18
SE7813180L (en) 1979-06-23
IT7852406A0 (en) 1978-12-21
ES476314A1 (en) 1979-04-16

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Legal Events

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