BE905110A - POLY-4-AMINOPYRROLE-2-CARBOXAMIDES AND DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC USES. - Google Patents

POLY-4-AMINOPYRROLE-2-CARBOXAMIDES AND DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC USES.

Info

Publication number
BE905110A
BE905110A BE0/216924A BE216924A BE905110A BE 905110 A BE905110 A BE 905110A BE 0/216924 A BE0/216924 A BE 0/216924A BE 216924 A BE216924 A BE 216924A BE 905110 A BE905110 A BE 905110A
Authority
BE
Belgium
Prior art keywords
group
aminopyrrole
carboxamides
poly
derivatives
Prior art date
Application number
BE0/216924A
Other languages
French (fr)
Inventor
Arcamone Federico
Mongelli Nicola
Penco Sergio
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858517922A external-priority patent/GB8517922D0/en
Priority claimed from GB868613594A external-priority patent/GB8613594D0/en
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of BE905110A publication Critical patent/BE905110A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Abstract

Des composés répondant à la formule générale dans laquelle n est égal à 0 ou à un nombre de 1 à 4 ; R représente un groupe amino libre, ou portant un ou deux substituants définis, ou un groupe -N02 ou -NH-CH0, chacun des symboles R1 représente un atome d'hydrogène ou un groupe alkyle en C1-C4 et R2 représente un groupe alkyle en C1-C6 terminé par un motif basique ou acide ou par un groupe hydroxy libre ou glucosylé, sous réserve de certaines restrictions, ont des propriétés antivirales et antitumeurs exploitables en thérapeutique. Certains de ces composés sont nouveaux; on les prépare par des procédés variés décrits en détail.Compounds corresponding to the general formula in which n is equal to 0 or a number from 1 to 4; R represents a free amino group, or bearing one or two defined substituents, or a group -N02 or -NH-CH0, each of the symbols R1 represents a hydrogen atom or a C1-C4 alkyl group and R2 represents an alkyl group in C1-C6 terminated by a basic or acid motif or by a free or glucosylated hydroxy group, subject to certain restrictions, have antiviral and antitumor properties which can be used in therapy. Some of these compounds are new; they are prepared by various methods described in detail.

BE0/216924A 1985-07-16 1986-07-15 POLY-4-AMINOPYRROLE-2-CARBOXAMIDES AND DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC USES. BE905110A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858517922A GB8517922D0 (en) 1985-07-16 1985-07-16 Carboxamido derivatives
GB868613594A GB8613594D0 (en) 1986-06-04 1986-06-04 Poly-4-aminopyrrole-2-carboxamido derivatives

Publications (1)

Publication Number Publication Date
BE905110A true BE905110A (en) 1987-01-15

Family

ID=26289538

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/216924A BE905110A (en) 1985-07-16 1986-07-15 POLY-4-AMINOPYRROLE-2-CARBOXAMIDES AND DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC USES.

Country Status (26)

Country Link
JP (1) JPH0780843B2 (en)
KR (1) KR930010496B1 (en)
CN (1) CN1018825B (en)
AT (1) AT387013B (en)
AU (1) AU587841B2 (en)
BE (1) BE905110A (en)
CA (1) CA1285934C (en)
CH (1) CH674206A5 (en)
CS (1) CS276981B6 (en)
DE (1) DE3623880A1 (en)
DK (1) DK335986A (en)
ES (1) ES2000502A6 (en)
FI (1) FI83640C (en)
FR (1) FR2585018B1 (en)
GB (1) GB2178036B (en)
GR (1) GR861841B (en)
HU (1) HU205949B (en)
IE (1) IE59073B1 (en)
IL (1) IL79402A (en)
IT (1) IT1196488B (en)
NL (1) NL8601837A (en)
NO (1) NO168826C (en)
NZ (1) NZ216829A (en)
PH (1) PH24714A (en)
PT (1) PT82984B (en)
SE (1) SE468642B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN85103908A (en) * 1985-07-16 1986-11-05 法米塔利·卡洛·埃尔巴有限公司 Preparation 4 '-novel method of the red rhzomorph of Biao Duokesuo
GB8906709D0 (en) * 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
IT1243389B (en) * 1990-11-22 1994-06-10 Menarini Farma Ind POLYAMINE-PYRROLCARBOXIDE DERIVATIVES, PREPARATION PROCESSES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
AU1224392A (en) * 1991-02-06 1992-09-07 Synphar Laboratories, Inc. Oligopeptide antiretroviral agents
IT1247878B (en) * 1991-02-15 1995-01-05 Menarini Farma Ind POLY-4-AMINOPYRROL-2-CARBOXYXID DERIVATIVES, PREPARATION PROCESSES AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
GB2260134A (en) * 1991-10-04 1993-04-07 Erba Carlo Spa Derivatives of poly-5-amino-3-carboxy-1-methyl compounds
IT1262921B (en) * 1992-01-10 1996-07-22 Federico Arcamone ANALOGUE AGENTS ANALOGUES OF PYROL-AMIDINE OLIGOPEPTIDES BACK TO PREPARATION PROCESSES AND PHARMACEUTICAL PRODUCTS CONTAINING THEM
GB9416005D0 (en) * 1994-08-08 1994-09-28 Erba Carlo Spa Peptidic compounds analogous to distamycin a and process for their preparation
WO1997010208A1 (en) * 1995-09-12 1997-03-20 Kyowa Hakko Kogyo Co., Ltd. Compounds uch 15
AU1596097A (en) * 1996-02-02 1997-08-22 Pharmacia & Upjohn S.P.A. Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9615692D0 (en) * 1996-07-25 1996-09-04 Pharmacia Spa Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB0011059D0 (en) 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015447D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0015446D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0016447D0 (en) 2000-07-04 2000-08-23 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
US6969592B2 (en) 2001-09-26 2005-11-29 Pharmacia Italia S.P.A. Method for predicting the sensitivity to chemotherapy

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR86210E (en) * 1963-04-04 1966-03-23
DE1795539A1 (en) * 1963-07-26 1972-01-13 Farmaceutici Italia Process for the production of new pyrrole derivatives and their salts
US3420844A (en) * 1963-07-26 1969-01-07 Farmaceutici Italia Pyrrole-2-carboxamido-propionamidines
BE666612A (en) * 1963-07-26 1965-11-03
NL130086C (en) * 1964-07-14 1970-06-15
CN85103908A (en) * 1985-07-16 1986-11-05 法米塔利·卡洛·埃尔巴有限公司 Preparation 4 '-novel method of the red rhzomorph of Biao Duokesuo

Also Published As

Publication number Publication date
IT1196488B (en) 1988-11-16
PT82984A (en) 1986-08-01
GB2178036A (en) 1987-02-04
HU205949B (en) 1992-07-28
FR2585018B1 (en) 1989-07-13
DE3623880A1 (en) 1987-01-29
AU587841B2 (en) 1989-08-31
FI83640B (en) 1991-04-30
FI83640C (en) 1991-08-12
IE59073B1 (en) 1994-01-12
CN1018825B (en) 1992-10-28
AT387013B (en) 1988-11-25
GB8617292D0 (en) 1986-08-20
KR930010496B1 (en) 1993-10-25
IL79402A (en) 1991-06-10
IE861875L (en) 1987-01-16
CS8605412A2 (en) 1991-03-12
SE8603098L (en) 1987-01-17
CN86104787A (en) 1987-02-18
CA1285934C (en) 1991-07-09
CS276981B6 (en) 1992-11-18
JPS6277362A (en) 1987-04-09
ES2000502A6 (en) 1988-03-01
FR2585018A1 (en) 1987-01-23
NL8601837A (en) 1987-02-16
DK335986D0 (en) 1986-07-15
SE8603098D0 (en) 1986-07-11
HUT43088A (en) 1987-09-28
IT8621125A0 (en) 1986-07-15
PH24714A (en) 1990-10-01
NO168826B (en) 1991-12-30
IT8621125A1 (en) 1988-01-15
SE468642B (en) 1993-02-22
PT82984B (en) 1989-01-30
KR870001201A (en) 1987-03-12
NZ216829A (en) 1989-03-29
NO862860L (en) 1987-01-19
NO862860D0 (en) 1986-07-15
FI862959A (en) 1987-01-17
DK335986A (en) 1987-01-17
CH674206A5 (en) 1990-05-15
GB2178036B (en) 1989-08-16
IL79402A0 (en) 1986-10-31
GR861841B (en) 1986-11-18
ATA188886A (en) 1988-04-15
NO168826C (en) 1992-04-08
AU6020286A (en) 1987-01-22
JPH0780843B2 (en) 1995-08-30
FI862959A0 (en) 1986-07-16

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Legal Events

Date Code Title Description
CA Change of address of the owner of the patent
CH Change of patent owner
CN Change of patent owner's name
RE Patent lapsed

Owner name: PHARMACIA & UPJOHN S.P.A.

Effective date: 19980731