NO168826B - ANALOGY PROCEDURE FOR PREPARATION OF POLY-4-AMINOPYRROL-2-CARBOXAMIDODE DERIVATIVES - Google Patents
ANALOGY PROCEDURE FOR PREPARATION OF POLY-4-AMINOPYRROL-2-CARBOXAMIDODE DERIVATIVES Download PDFInfo
- Publication number
- NO168826B NO168826B NO862860A NO862860A NO168826B NO 168826 B NO168826 B NO 168826B NO 862860 A NO862860 A NO 862860A NO 862860 A NO862860 A NO 862860A NO 168826 B NO168826 B NO 168826B
- Authority
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- Norway
- Prior art keywords
- nickel
- alloy
- preparation
- carboxamidode
- aminopyrrol
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 9
- 238000002360 preparation method Methods 0.000 title claims description 3
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 16
- 229910045601 alloy Inorganic materials 0.000 claims description 12
- 239000000956 alloy Substances 0.000 claims description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- 229910001030 Iron–nickel alloy Inorganic materials 0.000 claims description 9
- 229910052759 nickel Inorganic materials 0.000 claims description 8
- 150000004767 nitrides Chemical class 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 229910052720 vanadium Inorganic materials 0.000 claims description 5
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 4
- 239000010936 titanium Substances 0.000 claims description 4
- 229910052719 titanium Inorganic materials 0.000 claims description 4
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 claims description 3
- 229910052758 niobium Inorganic materials 0.000 claims description 3
- 239000010955 niobium Substances 0.000 claims description 3
- GUCVJGMIXFAOAE-UHFFFAOYSA-N niobium atom Chemical compound [Nb] GUCVJGMIXFAOAE-UHFFFAOYSA-N 0.000 claims description 3
- 229910052726 zirconium Inorganic materials 0.000 claims description 3
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 description 9
- 239000002184 metal Substances 0.000 description 9
- 238000003466 welding Methods 0.000 description 6
- 239000010953 base metal Substances 0.000 description 4
- 238000002425 crystallisation Methods 0.000 description 4
- 230000008025 crystallization Effects 0.000 description 4
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 4
- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000004904 shortening Methods 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229910001374 Invar Inorganic materials 0.000 description 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 229910052770 Uranium Inorganic materials 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- -1 carbon Chemical compound 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- UGKDIUIOSMUOAW-UHFFFAOYSA-N iron nickel Chemical compound [Fe].[Ni] UGKDIUIOSMUOAW-UHFFFAOYSA-N 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 150000001247 metal acetylides Chemical class 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000000135 prohibitive effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 238000009864 tensile test Methods 0.000 description 1
- 230000008646 thermal stress Effects 0.000 description 1
- DNYWZCXLKNTFFI-UHFFFAOYSA-N uranium Chemical compound [U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U] DNYWZCXLKNTFFI-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polyamides (AREA)
Description
Fremgangsmåte til å bedre sveisbarheten av Method of improving the weldability of
jern-nikkellegeringer med nikkelinnhold iron-nickel alloys with nickel content
over 30 vektprosent. over 30 percent by weight.
Det er kjent at der for transport av flytendegjort gass, f.eks. metan, i sveisede beholdere kreves beholderkonstruksjoner med stort volum og bestående av materialer med spesielle egenskaper som dikteres av de teknologiske krav til slike beholderes konstruksjon,av de flytendegjorte gassers temperatur, som f.eks. kan være så lav som -160°C i det hyppigste tilfelle, nemlig metan, samt av arbeids-betingelsene for disse beholdere. It is known that for the transport of liquefied gas, e.g. methane, in welded containers, container constructions with a large volume and consisting of materials with special properties are required, which are dictated by the technological requirements for the construction of such containers, by the temperature of the liquefied gases, such as e.g. can be as low as -160°C in the most frequent case, namely methane, as well as of the working conditions for these containers.
Disse spesielle egenskaper, som de benyttede materialer absolutt må ha, er i forste rekke: Tilstrekkelig mekanisk fasthet ved meget lav temperatur, ingen skjorhet ved meget lav temperatur, meget lav utvidelseskoeffisient i området mellom omgivelses-temperaturen og arbeidstemperaturen, These special properties, which the materials used absolutely must have, are primarily: Sufficient mechanical strength at very low temperature, no brittleness at very low temperature, very low coefficient of expansion in the area between the ambient temperature and the working temperature,
god formbarhet, good formability,
god sveisbarhet ved de forskjellige metoder som kjele-produsentene kan anvende. good weldability by the different methods that the boiler manufacturers can use.
Ett av de materialer som har vært anerkjent å representere One of the materials that has been recognized to represent
et godt kompromiss mellom disse forskjellige krav, er en jern-nikkellegering med 36% nikkel og markedsfort under patenthavernes varemerke a good compromise between these different requirements is an iron-nickel alloy with 36% nickel and marketed under the patentee's trademark
"IN VAR". "IN WAS".
Denne legering har allerede vært benyttet for bygging av tanker som utgjor integrerende deler av et fartoys skrog. Disse tanker er uteksperimentert og har gitt gode resultater. This alloy has already been used for the construction of tanks that form integral parts of a ship's hull. These thoughts have been experimented with and have produced good results.
Fabrikasjonsforsok har vist at en av vanskelighetene lå i å realisere gode sveiser som utmerker seg ved fravær av riss i sveiseskjoten, fravær av riss i de soner av legeringen som er utsatt for varmen under sveiseoperasjonen, altså sonene i nærheten av sveiseskjbten, og permanens - i sveiseskjoten og i den sone som er utsatt for varmen - av metallurgiske karakteristikker og fysikalske egenskaper som ligger nær grunnmetallets. Manufacturing trials have shown that one of the difficulties lies in realizing good welds that are distinguished by the absence of cracks in the weld joint, the absence of cracks in the zones of the alloy that are exposed to the heat during the welding operation, i.e. the zones near the welding job, and permanence - in the weld joint and in the zone exposed to the heat - of metallurgical characteristics and physical properties close to those of the base metal.
Fravær av riss i sveiseskjoten kan oppnås ved omhyggelig valg av sveisemetallet i tilfellet av et slikt anvendes, eller ved noyaktig fastleggelse av sveisebetingelsene når man ikke bruker noe slikt sveise-metall. Absence of cracks in the weld joint can be achieved by careful selection of the weld metal in the event that such is used, or by accurate determination of the welding conditions when no such weld metal is used.
Dannelsen av riss i de soner som påvirkes av varmen, er vanskeligere å unngå. Den skyldes ofte en sprohet av grunnmetallet ved temperaturer over 500°C. Under sveiseoperasjonen blir således grunnmetallet utsatt for betydelige spenninger. Er metallet duktilt, får disse ingen konsekvenser, men hvis metallet er sprott, kan de gi opphav til brudd. Imidlertid har en jern-nikkellegering med 36% nikkel, hvis den bearbeides uten særskilte forholdsregler, et sprohetsområde i varme, noe som ved rask strekkprbve ytrer seg ved en minimal brudd-forlengelse og -forkortelse. Dette minimum forekommer i temperatur-området mellom 600 og 1000°C. The formation of cracks in the zones affected by the heat is more difficult to avoid. It is often due to brittleness of the base metal at temperatures above 500°C. During the welding operation, the base metal is thus exposed to significant stresses. If the metal is ductile, these have no consequences, but if the metal is brittle, they can give rise to breakage. However, an iron-nickel alloy with 36% nickel, if processed without special precautions, has an area of embrittlement in heat, which is manifested in a rapid tensile test by minimal fracture elongation and shortening. This minimum occurs in the temperature range between 600 and 1000°C.
Tegningen viser to kurver, den ene for bruddforlengelsen og den annen for bruddforkortelsen, ved en jern-nikkellegering med 36% nikkel .som funksjon av temperaturen. Kurve A viser forlengelsen og kurve S forkortelsen i %. The drawing shows two curves, one for the fracture elongation and the other for the fracture shortening, for an iron-nickel alloy with 36% nickel as a function of temperature. Curve A shows the extension and curve S the shortening in %.
Sproheten,som ytrer seg ved et minimum i kurvene i området mellom 600 og 1000°C, kan gi opphav til forskjellige vanskeligheter under. The roughness, which manifests itself at a minimum in the curves in the range between 600 and 1000°C, can give rise to various difficulties below.
sveiseoperasjoner som forekommer ved fremstillingen av lagrings- eller transportbeholdere for flytende gasser. ■' welding operations occurring in the manufacture of storage or transport containers for liquefied gases. ■'
Denne sprohet i varme har vært tilskrevet metallets svovel-innhold når dette overstiger 0,02$. This volatility in heat has been attributed to the sulfur content of the metal when this exceeds 0.02$.
Det har vært foreslått å bote på den ved en vidtgående av-svovling, f.eks. ved den fremgangsmåte som sokerne har beskrevet i fransk patentskrift nr.. 1.465.578'It has been proposed to cure it by extensive desulphurisation, e.g. by the method described by the applicants in French patent document no. 1,465,578'
Ved denne fremgangsmåte gjor man bruk av den avsvovlende virkning av uran, som f.eks. i tilfellet av "INVAR" med 36$ nikkel tilsettes som en ganske liten andel for ikke å influere på legeringens utvidelseskoeffisient. In this method, use is made of the desulphurisation effect of uranium, which e.g. in the case of "INVAR" with 36$ nickel is added as a fairly small proportion so as not to influence the alloy's coefficient of expansion.
Et annet kjent botemiddel for det tilfelle at der benyttes tilskuddsmetall for sveisingen, er å lade dette metall med mangan og titan i en slik grad at der tilfoyes jern-nikkel-grunnlegeringen noen prosent av hvert av disse elementer. Imidlertid har denne losning den alvorlige ulempe å oke legeringens utvidelseskoeffisient i prohibitiv grad. Another known remedy for the case that filler metal is used for welding is to charge this metal with manganese and titanium to such an extent that a few percent of each of these elements is added to the iron-nickel base alloy. However, this solution has the serious disadvantage of increasing the alloy's coefficient of expansion to a prohibitive degree.
Uansett hvilken metode man anvender for å begrense virkningen av tilstedeværende svovel, gjenstår imidlertid det forhold at sproheten i varme også avhenger av metallets krystallisasjonstilstand: en grov-krystallinsk form begunstiger losning av intergranulære bindinger under virkningen av en varmespenning. Regardless of which method is used to limit the effect of sulfur present, however, the fact remains that the brittleness in heat also depends on the metal's state of crystallization: a coarse-crystalline form favors the loosening of intergranular bonds under the action of a thermal stress.
Oppfinnelsen går ut på en fremgangsmåte til å bedre sveisbarheten av jern-nikkellegeringer med nikkelinnhold over 30 vektprosent, hvor grov-krystallisasjon unngås, samtidig som legeringens egenskaper med hensyn til varmeutvidelse ikke blir vesentlig endret. The invention concerns a method for improving the weldability of iron-nickel alloys with a nickel content of more than 30% by weight, where coarse crystallization is avoided, while at the same time the properties of the alloy with regard to thermal expansion are not significantly changed.
Ifolge oppfinnelsen er denne fremgangsmåte karakterisert ved at der under tilberedningen av jern-nikkellegeringen innfores en tilsetning i en mengde av 0,02 - 0,1 vektprosent, av minst ett av elementene vanadium, titan, zirkonium og niob, egnet til å danne nitrider ved forbindelse med nitrogen som er tilstede eller innfores i legeringen. According to the invention, this method is characterized in that, during the preparation of the iron-nickel alloy, an addition is introduced in an amount of 0.02 - 0.1 percent by weight, of at least one of the elements vanadium, titanium, zirconium and niobium, suitable for forming nitrides by compound with nitrogen present or introduced into the alloy.
Grovkrystallisasjon blir dermed forhindret ved at rekrystallisasjonen ved oppvarmning blokkeres takket være at der på for-hånd er dispergert en uopploselig fase i legeringen. Ved en foretrukken utfSrelsesform av oppfinnelsen utgjores denne uopploselige fase av nitrider av vanadium. Coarse crystallization is thus prevented by recrystallization upon heating being blocked thanks to the fact that an insoluble phase has been dispersed in the alloy in advance. In a preferred embodiment of the invention, this insoluble phase is made of nitrides of vanadium.
Tilstedeværelsen av denne uopploselige fase forhindrer korn-veksten i legeringen og reduserer derfor den sprohet som skyldes det opprinnelige nærvær av svovel. The presence of this insoluble phase prevents grain growth in the alloy and therefore reduces the brittleness due to the original presence of sulphur.
I denne forbindelse ble det funnet at tilstedeværelsen av den nevnte uopploselige fase, når mengden av den er riktig innstilt, ikke endrer legeringens egenskaper med hensyn til varmeutvidelse. Andre elementer enn vanadium,^ nemlig titan, zirkonium og niob, kan benyttes med sammenlignbart resultat i de samme legeringer. Disse elementer bor tilsettes i mengder stort sett svarende til mengdene av vanadium, slik at de med nitrogenet danner uopploselige nitrider som er fint dispergert i grunnmetallet, og at mengden og arten av disse utfellinger ikke endrer metallets opprinnelige egenskaper med hensyn til varmeutvidelse. In this regard, it was found that the presence of said insoluble phase, when its amount is properly adjusted, does not change the properties of the alloy with regard to thermal expansion. Elements other than vanadium, namely titanium, zirconium and niobium, can be used with comparable results in the same alloys. These elements should be added in amounts largely corresponding to the amounts of vanadium, so that they form insoluble nitrides with the nitrogen that are finely dispersed in the base metal, and that the amount and nature of these precipitates do not change the original properties of the metal with regard to thermal expansion.
I tilfellet av at disse tilsetninger har særlig stor affinitet til andre elementer enn nitrogen, f.eks. karbon, bor mengden av dem bestemmes slik at der stadig kan danne seg nitrider etter at en del av tilsetningen er bundet ved utfelling av karbider. In the event that these additives have a particularly high affinity for elements other than nitrogen, e.g. carbon, the amount of them should be determined so that nitrides can still form after part of the addition has been bound by precipitation of carbides.
Det kan nevnes at det fra forskjellige eldre publikasjoner It may be mentioned that from various older publications
i og for seg er kjent å sette ett eller flere av de omtalte elementer til jern-nikkellegeringer med over ^ Pfo nikkel. Imidlertid omtales ikke i noen av disse publikasjoner dannelse av nitrider eller i det hele tatt tilstedeværelse av nitrogen, <p>g tilsetningen skjer i stbrre vektmengder og ikke til det foreliggende formål å bedre sveisbarheten ved å blokkere rekrystallisasjonen under oppvarmningen og derved forhindre skadelig grovkrystallisasjon. In and of itself, it is known to add one or more of the mentioned elements to iron-nickel alloys with more than ^ Pfo nickel. However, the formation of nitrides or the presence of nitrogen at all is not mentioned in any of these publications, <p>g the addition takes place in greater amounts by weight and not for the present purpose of improving weldability by blocking recrystallization during heating and thereby preventing harmful coarse crystallization.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858517922A GB8517922D0 (en) | 1985-07-16 | 1985-07-16 | Carboxamido derivatives |
| GB868613594A GB8613594D0 (en) | 1986-06-04 | 1986-06-04 | Poly-4-aminopyrrole-2-carboxamido derivatives |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO862860D0 NO862860D0 (en) | 1986-07-15 |
| NO862860L NO862860L (en) | 1987-01-19 |
| NO168826B true NO168826B (en) | 1991-12-30 |
| NO168826C NO168826C (en) | 1992-04-08 |
Family
ID=26289538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO862860A NO168826C (en) | 1985-07-16 | 1986-07-15 | ANALOGY PROCEDURE FOR PREPARATION OF POLY-4-AMINOPYRROL-2-CARBOXAMIDODE DERIVATIVES |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPH0780843B2 (en) |
| KR (1) | KR930010496B1 (en) |
| CN (1) | CN1018825B (en) |
| AT (1) | AT387013B (en) |
| AU (1) | AU587841B2 (en) |
| BE (1) | BE905110A (en) |
| CA (1) | CA1285934C (en) |
| CH (1) | CH674206A5 (en) |
| CS (1) | CS276981B6 (en) |
| DE (1) | DE3623880A1 (en) |
| DK (1) | DK335986A (en) |
| ES (1) | ES2000502A6 (en) |
| FI (1) | FI83640C (en) |
| FR (1) | FR2585018B1 (en) |
| GB (1) | GB2178036B (en) |
| GR (1) | GR861841B (en) |
| HU (1) | HU205949B (en) |
| IE (1) | IE59073B1 (en) |
| IL (1) | IL79402A (en) |
| IT (1) | IT1196488B (en) |
| NL (1) | NL8601837A (en) |
| NO (1) | NO168826C (en) |
| NZ (1) | NZ216829A (en) |
| PH (1) | PH24714A (en) |
| PT (1) | PT82984B (en) |
| SE (1) | SE468642B (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN85103908A (en) * | 1985-07-16 | 1986-11-05 | 法米塔利·卡洛·埃尔巴有限公司 | Preparation 4 '-novel method of the red rhzomorph of Biao Duokesuo |
| GB8906709D0 (en) * | 1989-03-23 | 1989-05-10 | Creighton Andrew M | Acryloyl substituted pyrrole derivatives |
| IT1243389B (en) * | 1990-11-22 | 1994-06-10 | Menarini Farma Ind | POLYAMINE-PYRROLCARBOXIDE DERIVATIVES, PREPARATION PROCESSES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| WO1992013838A1 (en) * | 1991-02-06 | 1992-08-20 | Synphar Laboratories, Inc. | Oligopeptide antiretroviral agents |
| IT1247878B (en) * | 1991-02-15 | 1995-01-05 | Menarini Farma Ind | POLY-4-AMINOPYRROL-2-CARBOXYXID DERIVATIVES, PREPARATION PROCESSES AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM |
| GB2260134A (en) * | 1991-10-04 | 1993-04-07 | Erba Carlo Spa | Derivatives of poly-5-amino-3-carboxy-1-methyl compounds |
| IT1262921B (en) * | 1992-01-10 | 1996-07-22 | Federico Arcamone | ANALOGUE AGENTS ANALOGUES OF PYROL-AMIDINE OLIGOPEPTIDES BACK TO PREPARATION PROCESSES AND PHARMACEUTICAL PRODUCTS CONTAINING THEM |
| GB9416005D0 (en) * | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Peptidic compounds analogous to distamycin a and process for their preparation |
| WO1997010208A1 (en) * | 1995-09-12 | 1997-03-20 | Kyowa Hakko Kogyo Co., Ltd. | Compounds uch 15 |
| CA2244139C (en) * | 1996-02-02 | 2005-06-07 | Pharmacia & Upjohn S.P.A. | Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
| GB9615692D0 (en) * | 1996-07-25 | 1996-09-04 | Pharmacia Spa | Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
| GB0011059D0 (en) | 2000-05-08 | 2000-06-28 | Pharmacia & Upjohn Spa | Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione |
| GB0015447D0 (en) | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents |
| GB0015446D0 (en) | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites |
| GB0016447D0 (en) | 2000-07-04 | 2000-08-23 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
| US6969592B2 (en) | 2001-09-26 | 2005-11-29 | Pharmacia Italia S.P.A. | Method for predicting the sensitivity to chemotherapy |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR86210E (en) | 1963-04-04 | 1966-03-23 | ||
| BR6461040D0 (en) * | 1963-07-26 | 1973-08-02 | Farmaceutici Italia | PROCESS TO PREPARE NEW PIRROL DERIVATIVES |
| DE1795539A1 (en) * | 1963-07-26 | 1972-01-13 | Farmaceutici Italia | Process for the production of new pyrrole derivatives and their salts |
| BE666612A (en) * | 1963-07-26 | 1965-11-03 | ||
| NL130086C (en) | 1964-07-14 | 1970-06-15 | ||
| CN85103908A (en) * | 1985-07-16 | 1986-11-05 | 法米塔利·卡洛·埃尔巴有限公司 | Preparation 4 '-novel method of the red rhzomorph of Biao Duokesuo |
-
1986
- 1986-07-11 AT AT0188886A patent/AT387013B/en not_active IP Right Cessation
- 1986-07-11 SE SE8603098A patent/SE468642B/en not_active IP Right Cessation
- 1986-07-14 NZ NZ216829A patent/NZ216829A/en unknown
- 1986-07-14 IE IE187586A patent/IE59073B1/en not_active IP Right Cessation
- 1986-07-14 HU HU862904A patent/HU205949B/en not_active IP Right Cessation
- 1986-07-14 NL NL8601837A patent/NL8601837A/en not_active Application Discontinuation
- 1986-07-14 ES ES8600290A patent/ES2000502A6/en not_active Expired
- 1986-07-14 IL IL79402A patent/IL79402A/en not_active IP Right Cessation
- 1986-07-14 AU AU60202/86A patent/AU587841B2/en not_active Ceased
- 1986-07-15 BE BE0/216924A patent/BE905110A/en not_active IP Right Cessation
- 1986-07-15 PH PH34014A patent/PH24714A/en unknown
- 1986-07-15 KR KR1019860005715A patent/KR930010496B1/en not_active IP Right Cessation
- 1986-07-15 CH CH2820/86A patent/CH674206A5/de not_active IP Right Cessation
- 1986-07-15 DE DE3623880A patent/DE3623880A1/en not_active Withdrawn
- 1986-07-15 NO NO862860A patent/NO168826C/en unknown
- 1986-07-15 DK DK335986A patent/DK335986A/en not_active Application Discontinuation
- 1986-07-15 CA CA000513760A patent/CA1285934C/en not_active Expired - Fee Related
- 1986-07-15 FR FR868610294A patent/FR2585018B1/en not_active Expired
- 1986-07-15 IT IT21125/86A patent/IT1196488B/en active
- 1986-07-15 GR GR861841A patent/GR861841B/en unknown
- 1986-07-15 JP JP61164879A patent/JPH0780843B2/en not_active Expired - Lifetime
- 1986-07-15 PT PT82984A patent/PT82984B/en not_active IP Right Cessation
- 1986-07-16 GB GB8617292A patent/GB2178036B/en not_active Expired
- 1986-07-16 CN CN86104787A patent/CN1018825B/en not_active Expired
- 1986-07-16 CS CS865412A patent/CS276981B6/en unknown
- 1986-07-16 FI FI862959A patent/FI83640C/en not_active IP Right Cessation
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