EA199900768A1 - N-гидрокси-2- (алкил, арил или гетероарилсульфанил, сульфинил или сульфонил) -3-замещенный алкил, арил или гетероариламиды в качестве ингибиторов матричной металлопротеиназы - Google Patents

N-гидрокси-2- (алкил, арил или гетероарилсульфанил, сульфинил или сульфонил) -3-замещенный алкил, арил или гетероариламиды в качестве ингибиторов матричной металлопротеиназы

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Publication number
EA199900768A1
EA199900768A1 EA199900768A EA199900768A EA199900768A1 EA 199900768 A1 EA199900768 A1 EA 199900768A1 EA 199900768 A EA199900768 A EA 199900768A EA 199900768 A EA199900768 A EA 199900768A EA 199900768 A1 EA199900768 A1 EA 199900768A1
Authority
EA
Eurasian Patent Office
Prior art keywords
sulfonyl
tnf
aryl
matrix
tapp
Prior art date
Application number
EA199900768A
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English (en)
Other versions
EA003836B1 (ru
Inventor
Мудумбай Аранапакам Венкатесан
Джордж Теодор Гросу
Жами Мари Дэвис
Байхуа Ху
Мэтью Джеймс О'Делл
Дерек Сесил Коул
Жанни Леа Бэйкер
Мэрси Памела Джекобсон
Original Assignee
Американ Цианамид Компани
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Application filed by Американ Цианамид Компани filed Critical Американ Цианамид Компани
Publication of EA199900768A1 publication Critical patent/EA199900768A1/ru
Publication of EA003836B1 publication Critical patent/EA003836B1/ru

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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Матричные металлопротеиназы (ММП) представляют собой группу ферментов, вовлеченных в патологическую деструкцию соединительной ткани и базальных мембран. Эти цинксодержащие эндопептидазы содержат несколько ферментных субъединиц, состоящих из коллагеназ, стромелизинов и желатиназ. TNF-α превращающий фермент (ТАПФ), про-воспалительный цитокин, катализирует образование TNF-α из присоединенного к мембране TNF-α белкового предшественника. Предполагалось, что низкомолекулярные ингибиторы ММП и ТАПФ, таким образом, могут использоваться для лечения различных состояний заболевания. Настоящее изобретение представляет низкомолекулярные, непептидные ингибиторы матричных металлопротеиназ (ММП) и TNF-α превращающего фермента (ТАПФ) для лечения артрита, метастазов опухоли, карнеальной язвы, патологического ранозаживления, периодонтальных заболеваний, костных заболеваний, диабета (инсулин зависимого) и ВИЧ инфекции. Соединения по данному изобретению представлены формулой (I), где R, R, Rи Rздесь описаны.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900768A 1997-02-27 1998-02-17 N-гидрокси-2-(алкил, арил или гетероарилсульфанил, сульфинил или сульфонил)-3-замещенный алкил, арил или гетероариламиды в качестве ингибиторов матричной металлопротеиназы EA003836B1 (ru)

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US80672897A 1997-02-27 1997-02-27
PCT/US1998/003291 WO1998038163A1 (en) 1997-02-27 1998-02-17 N-hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors

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EA199900768A1 true EA199900768A1 (ru) 2000-08-28
EA003836B1 EA003836B1 (ru) 2003-10-30

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EA199900769A EA001742B1 (ru) 1997-02-27 1998-02-17 N-гидрокси-2-(алкил-, арил- или гетероарилсульфанил, -сульфинил или -сульфонил)-3-замещенные алкилов, арилов или гетероариламидов в качестве ингибиторов матриксных металлопротеиназ
EA199900768A EA003836B1 (ru) 1997-02-27 1998-02-17 N-гидрокси-2-(алкил, арил или гетероарилсульфанил, сульфинил или сульфонил)-3-замещенный алкил, арил или гетероариламиды в качестве ингибиторов матричной металлопротеиназы

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AU6168698A (en) 1998-09-18
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