YU41099A - N-hidroksi-2-(alkil,aril ili heteroaril sulfanil,sulfinil ili sulfonil)-3-substituisani alkil, aril ili heteroaril- amidi, kao inhibitori za metaloproteinaze - Google Patents

N-hidroksi-2-(alkil,aril ili heteroaril sulfanil,sulfinil ili sulfonil)-3-substituisani alkil, aril ili heteroaril- amidi, kao inhibitori za metaloproteinaze

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Publication number
YU41099A
YU41099A YU41099A YU41099A YU41099A YU 41099 A YU41099 A YU 41099A YU 41099 A YU41099 A YU 41099A YU 41099 A YU41099 A YU 41099A YU 41099 A YU41099 A YU 41099A
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Yugoslavia
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alpha
tnf
aryl
tace
mmps
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YU41099A
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English (en)
Inventor
Aranapakam Mudumbai Venkatesan
George Theodore Grosu
Jamie Marie Davis
Jannie Lea Baker
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American Cyanamid Company
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Publication of YU41099A publication Critical patent/YU41099A/sh

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    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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Abstract

Maticne metaloproteinaze (MMP) su grupa enzima koja ucestvuje u pataloskoj razgradnji vezivnog tkiva i osnovnih membrana. Ove endopeptidaze, koje sadrze cink, sastoje se od nekoliko podvrsta enzima, u koje dolaze kolagenaze, stromelizini i zelatinaze. Enzimi za konverziju TNF-α (TACE), proinflamatorni citokin, katalizuju stvaranje TNF-α- vezanog u membrani. Ocekuje sa da ce mali molekukli, kao inhibitori MMP i TACE, posedovati potencijal za lecenje niza bolesnih stanja. Sadasnji pronalazak daje ne-peptidne inhibitore matricnih metaloproteinaza (MMP) i enzima za konverziju TNF-α (TACE), niske molarne mase, za lecenje artritisa, metastaza tumora, ulceracije tkiva, abnomarlnog zarastanja rana, periodontalnih oboljenja, oboljenja kostiju, dijabetesa (rezistentnost prema insulinu) i HIV infekcije. Jedinjenja ovog pronalaska predstavlja formula (I) gde su R1, R2, R3 i R4 opisani u tekstu.
YU41099A 1997-02-27 1998-02-17 N-hidroksi-2-(alkil,aril ili heteroaril sulfanil,sulfinil ili sulfonil)-3-substituisani alkil, aril ili heteroaril- amidi, kao inhibitori za metaloproteinaze YU41099A (sh)

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YU40999A YU40999A (sh) 1997-02-27 1998-02-17 N-hidroksi-2-(alkil,aril ili heteroaril sulfanil,sulfinil ili sulfonil)-3-supstituisani alkil,aril ili heteroarilamidi, kao inhibitori za matrične metaloproteinaze

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EP0973512B1 (en) 2004-04-07
AU6168698A (en) 1998-09-18
GEP20022626B (en) 2002-02-25
AU726204B2 (en) 2000-11-02
NZ337336A (en) 2001-05-25
EE04150B1 (et) 2003-10-15
CN1252790A (zh) 2000-05-10
CN1252713A (zh) 2000-05-10
EE04295B1 (et) 2004-06-15
EE9900369A (et) 2000-04-17
EP0970046B1 (en) 2003-12-10
JP2001513771A (ja) 2001-09-04
IL131258A0 (en) 2001-01-28
BG103760A (bg) 2000-04-28
EP0973512A1 (en) 2000-01-26
UA58543C2 (uk) 2003-08-15
KR20000075809A (ko) 2000-12-26
ZA981625B (en) 1999-08-26
NO994124D0 (no) 1999-08-26
GEP20022627B (en) 2002-02-25
DE69820424D1 (en) 2004-01-22
EP0970046A1 (en) 2000-01-12
PL335286A1 (en) 2000-04-10
HUP0001463A3 (en) 2001-04-28
SK115799A3 (en) 2000-09-12
DK0973512T3 (da) 2004-07-12
TR199902095T2 (xx) 1999-12-21
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JP2001519777A (ja) 2001-10-23
IL131257A0 (en) 2001-01-28
KR20000075808A (ko) 2000-12-26
BR9807802A (pt) 2000-03-21
NO314258B1 (no) 2003-02-24
WO1998037877A1 (en) 1998-09-03
EA001742B1 (ru) 2001-08-27
WO1998038163A1 (en) 1998-09-03
HK1024875A1 (en) 2000-10-27
TW568900B (en) 2004-01-01
NO994124L (no) 1999-10-26
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BG103757A (bg) 2000-04-28
PL335401A1 (en) 2000-04-25

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