ATE288922T1 - Bestimmte heteroaryl substituierte thiol inhibitoren von endothelin wechselnden enzymen - Google Patents
Bestimmte heteroaryl substituierte thiol inhibitoren von endothelin wechselnden enzymenInfo
- Publication number
- ATE288922T1 ATE288922T1 AT99923433T AT99923433T ATE288922T1 AT E288922 T1 ATE288922 T1 AT E288922T1 AT 99923433 T AT99923433 T AT 99923433T AT 99923433 T AT99923433 T AT 99923433T AT E288922 T1 ATE288922 T1 AT E288922T1
- Authority
- AT
- Austria
- Prior art keywords
- endothelin
- heteroaryl substituted
- substituted thiol
- certain heteroaryl
- thiol inhibitors
- Prior art date
Links
- 102000002045 Endothelin Human genes 0.000 title 1
- 108050009340 Endothelin Proteins 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
- 239000003774 sulfhydryl reagent Substances 0.000 title 1
- 125000003396 thiol group Chemical class [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6497998A | 1998-04-23 | 1998-04-23 | |
| PCT/EP1999/002694 WO1999055723A1 (en) | 1998-04-23 | 1999-04-21 | Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE288922T1 true ATE288922T1 (de) | 2005-02-15 |
Family
ID=22059547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99923433T ATE288922T1 (de) | 1998-04-23 | 1999-04-21 | Bestimmte heteroaryl substituierte thiol inhibitoren von endothelin wechselnden enzymen |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1080104B1 (de) |
| JP (1) | JP3646062B2 (de) |
| AT (1) | ATE288922T1 (de) |
| AU (1) | AU750048B2 (de) |
| CA (1) | CA2324251A1 (de) |
| DE (1) | DE69923676T2 (de) |
| ES (1) | ES2237917T3 (de) |
| IL (1) | IL138688A0 (de) |
| PT (1) | PT1080104E (de) |
| WO (1) | WO1999055723A1 (de) |
| ZA (1) | ZA200004679B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6423727B1 (en) | 1998-04-23 | 2002-07-23 | Novartis Ag | Certain thiol inhibitors of endothelin-converting enzyme |
| US6426354B1 (en) | 1998-04-23 | 2002-07-30 | Novartis Ag | Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme |
| JP4603646B2 (ja) * | 1999-11-15 | 2010-12-22 | 富士フイルムファインケミカルズ株式会社 | 新規なジピリジル誘導体 |
| NL1014353C2 (nl) * | 2000-02-11 | 2001-08-15 | Dsm Nv | Werkwijze voor de bereiding van (R) -2-broom-3-fenylpropaanzuur. |
| US20020028799A1 (en) * | 2000-07-06 | 2002-03-07 | Naylor Alasdair Mark | Treatment of male sexual dysfunction |
| US6670479B2 (en) * | 2001-03-07 | 2003-12-30 | Advanced Research And Technology Institute, Inc. | Amination process |
| US6777443B2 (en) | 2001-05-15 | 2004-08-17 | Novartis Ag | Dipeptide derivatives |
| CA2456281A1 (en) * | 2001-09-21 | 2003-04-03 | Novartis Ag | Pyrane derivatives as both ace- and nep- inhibitors |
| EP1481960A4 (de) * | 2002-02-04 | 2005-04-06 | Kaneka Corp | Verfahren zur herstellung optisch aktiver 2-halogencarbonsäuren |
| TWI259079B (en) | 2002-02-08 | 2006-08-01 | Merck & Co Inc | N-biphenyl(substituted methyl)aminocycloalkanecarboxamide derivatives |
| US7091380B2 (en) | 2002-02-08 | 2006-08-15 | Merck & Co., Inc. | N-biphenylmethyl aminocycloalkanecarboxamide derivatives |
| JP3975226B2 (ja) | 2006-01-11 | 2007-09-12 | 生化学工業株式会社 | シクロアルキルカルボニルアミノ酸誘導体及びその製造方法 |
| EP2036920B1 (de) | 2006-01-11 | 2011-05-18 | Seikagaku Corporation | Cycloalkylcarbonylaminosäureester-derivat und herstellungsverfahren dafür |
| JP4047365B2 (ja) | 2006-01-11 | 2008-02-13 | 生化学工業株式会社 | シクロアルカンカルボキサミド誘導体及びその製造方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5432186A (en) * | 1993-11-16 | 1995-07-11 | Ciba-Geigy Corporation | Cyclic amino acid derivatives |
| FR2745571B1 (fr) * | 1996-03-04 | 1998-06-19 | Inst Nat Sante Rech Med | Nouveaux derives soufres comportant une liaison amide, leur procede de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant |
| FR2745570B1 (fr) * | 1996-03-04 | 1998-06-19 | Roussel Uclaf | Nouveaux derives soufres comportant une liaison retroamide, leur procede et intermediaires de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant |
-
1999
- 1999-04-21 EP EP99923433A patent/EP1080104B1/de not_active Expired - Lifetime
- 1999-04-21 JP JP2000545881A patent/JP3646062B2/ja not_active Expired - Fee Related
- 1999-04-21 ES ES99923433T patent/ES2237917T3/es not_active Expired - Lifetime
- 1999-04-21 CA CA002324251A patent/CA2324251A1/en not_active Abandoned
- 1999-04-21 AT AT99923433T patent/ATE288922T1/de not_active IP Right Cessation
- 1999-04-21 AU AU40319/99A patent/AU750048B2/en not_active Ceased
- 1999-04-21 WO PCT/EP1999/002694 patent/WO1999055723A1/en not_active Ceased
- 1999-04-21 PT PT99923433T patent/PT1080104E/pt unknown
- 1999-04-21 DE DE69923676T patent/DE69923676T2/de not_active Expired - Fee Related
- 1999-04-21 IL IL13868899A patent/IL138688A0/xx unknown
-
2000
- 2000-09-06 ZA ZA200004679A patent/ZA200004679B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2237917T3 (es) | 2005-08-01 |
| CA2324251A1 (en) | 1999-11-04 |
| AU750048B2 (en) | 2002-07-11 |
| ZA200004679B (en) | 2002-04-24 |
| EP1080104B1 (de) | 2005-02-09 |
| WO1999055723A1 (en) | 1999-11-04 |
| DE69923676T2 (de) | 2006-01-12 |
| PT1080104E (pt) | 2005-06-30 |
| EP1080104A1 (de) | 2001-03-07 |
| IL138688A0 (en) | 2001-10-31 |
| DE69923676D1 (de) | 2005-03-17 |
| JP3646062B2 (ja) | 2005-05-11 |
| AU4031999A (en) | 1999-11-16 |
| JP2002513029A (ja) | 2002-05-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1080104 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |