ZA981625B - N-hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted heteroarylamines as matrix metalloproteinase inhibitors. - Google Patents
N-hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted heteroarylamines as matrix metalloproteinase inhibitors.Info
- Publication number
- ZA981625B ZA981625B ZA9801625A ZA981625A ZA981625B ZA 981625 B ZA981625 B ZA 981625B ZA 9801625 A ZA9801625 A ZA 9801625A ZA 981625 A ZA981625 A ZA 981625A ZA 981625 B ZA981625 B ZA 981625B
- Authority
- ZA
- South Africa
- Prior art keywords
- heteroarylamines
- sulfinyl
- sulfonyl
- aryl
- hydroxy
- Prior art date
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- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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- C07D277/70—Sulfur atoms
- C07D277/74—Sulfur atoms substituted by carbon atoms
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
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US80672897A | 1997-02-27 | 1997-02-27 |
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ZA9801628A ZA981628B (en) | 1997-02-27 | 1998-02-26 | N-hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl or arylamides as matrix metalloproteinase inhibitors. |
ZA9801625A ZA981625B (en) | 1997-02-27 | 1998-02-26 | N-hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted heteroarylamines as matrix metalloproteinase inhibitors. |
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ZA9801628A ZA981628B (en) | 1997-02-27 | 1998-02-26 | N-hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl or arylamides as matrix metalloproteinase inhibitors. |
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EP (2) | EP0970046B1 (xx) |
JP (2) | JP2001513771A (xx) |
KR (2) | KR20000075809A (xx) |
CN (2) | CN1210263C (xx) |
AR (1) | AR011451A1 (xx) |
AT (2) | ATE263554T1 (xx) |
AU (2) | AU726204B2 (xx) |
BG (2) | BG103757A (xx) |
BR (2) | BR9807802A (xx) |
CA (2) | CA2282655A1 (xx) |
CY (1) | CY2477B1 (xx) |
DE (2) | DE69823019T2 (xx) |
DK (2) | DK0970046T3 (xx) |
EA (2) | EA003836B1 (xx) |
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ES (2) | ES2212274T3 (xx) |
GE (2) | GEP20022627B (xx) |
HK (1) | HK1024875A1 (xx) |
HU (2) | HUP0002092A3 (xx) |
IL (2) | IL131258A0 (xx) |
NO (2) | NO314302B1 (xx) |
NZ (2) | NZ337336A (xx) |
PL (2) | PL335401A1 (xx) |
PT (2) | PT973512E (xx) |
SK (2) | SK115899A3 (xx) |
TR (2) | TR199901901T2 (xx) |
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UA (1) | UA58543C2 (xx) |
WO (2) | WO1998037877A1 (xx) |
YU (2) | YU41099A (xx) |
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US7115632B1 (en) | 1999-05-12 | 2006-10-03 | G. D. Searle & Co. | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
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ID24417A (id) * | 1997-10-15 | 2000-07-20 | American Home Prod | Ariloksi-alkil-dialkilamina yang baru |
WO1999025687A1 (en) * | 1997-11-14 | 1999-05-27 | G.D. Searle & Co. | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
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US6946473B2 (en) | 1999-01-27 | 2005-09-20 | Wyeth Holdings Corporation | Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors |
US6753337B2 (en) | 1999-01-27 | 2004-06-22 | Wyeth Holdings Corporation | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors |
AR035312A1 (es) * | 1999-01-27 | 2004-05-12 | Wyeth Corp | Compuestos de acido hidroxamico que contienen alquinilo como inhibidores de metaloproteinasa de matriz/tace, composicion farmaceutica que los comprenden y el uso de los mismos para la manufactura de un medicamento |
AR035311A1 (es) * | 1999-01-27 | 2004-05-12 | Wyeth Corp | Derivados de acido hidroxamico que contienen alquinilo, como inhibidores de las metalloproteinasas de matriz y de la tace, composicion farmaceutica y el uso de los mismos para la manufactura de un medicamento |
WO2000044723A1 (en) * | 1999-01-27 | 2000-08-03 | American Cyanamid Company | Alkynyl containing hydroxamic acid derivatives, their preparation and their use as matrix metalloproteinase (mmp) inhibitors/tnf-alpha converting enzyme (tace) inhibitors |
US6340691B1 (en) | 1999-01-27 | 2002-01-22 | American Cyanamid Company | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors |
US6448250B1 (en) | 1999-02-08 | 2002-09-10 | G. D. Searle & Company | Sulfamato hydroxamic acid metalloprotease inhibitor |
US6800646B1 (en) | 1999-02-08 | 2004-10-05 | Pharmacia Corporation | Sulfamato hydroxamic acid metalloprotease inhibitor |
SE9901572D0 (sv) | 1999-05-03 | 1999-05-03 | Astra Ab | New compounds |
US6511993B1 (en) | 1999-06-03 | 2003-01-28 | Kevin Neil Dack | Metalloprotease inhibitors |
MXPA02007291A (es) * | 2000-01-27 | 2002-11-29 | American Cyanamid Co | Metodo para preparar derivados de acido alfa-sulfonil hidroxamico. |
US6683093B2 (en) | 2000-05-12 | 2004-01-27 | Pharmacia Corporation | Aromatic sulfone hydroxamic acids and their use as protease inhibitors |
CZ20032913A3 (cs) | 2001-05-11 | 2004-05-12 | Pharmaciaácorporation | Aromatické sulfonhydroxamáty a jejich použití jako inhibitorů proteázy |
US6683078B2 (en) | 2001-07-19 | 2004-01-27 | Pharmacia Corporation | Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors |
CN101597262A (zh) | 2002-03-05 | 2009-12-09 | 特兰斯泰克制药公司 | 抑制配体与高级糖化终产物受体相互作用的单和双环吡咯衍生物 |
CA2483314A1 (en) | 2002-04-25 | 2003-11-06 | Pharmacia Corporation | Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
JP2006502980A (ja) * | 2002-06-25 | 2006-01-26 | ファルマシア・コーポレーション | アリールスルホニルヒドロキサム酸およびアミド誘導体、ならびにプロテアーゼ阻害薬としてのそれらの使用 |
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US7423176B2 (en) | 2004-04-13 | 2008-09-09 | Cephalon, Inc. | Bicyclic aromatic sulfinyl derivatives |
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JP5448164B2 (ja) | 2006-07-28 | 2014-03-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cb2受容体を変調する化合物 |
US7928123B2 (en) | 2006-09-25 | 2011-04-19 | Boehringer Ingelheim International Gmbh | Compounds which modulate the CB2 receptor |
MX2009003763A (es) | 2006-10-05 | 2009-04-22 | Janssen Pharmaceutica Nv | Inhibidores de metaloproteasa derivados de heterociclicos. |
US7879911B2 (en) | 2007-02-01 | 2011-02-01 | Johnson Alan T | Hydroxamic acid derivatives of phenoxy-acetic acids and analogs useful as therapeutic agents for treating anthrax poisoning |
WO2009061652A1 (en) | 2007-11-07 | 2009-05-14 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
JP5749162B2 (ja) | 2008-07-10 | 2015-07-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cb2受容体を調節するスルホン化合物 |
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US8299103B2 (en) | 2009-06-15 | 2012-10-30 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
WO2010147791A1 (en) | 2009-06-16 | 2010-12-23 | Boehringer Ingelheim International Gmbh | Azetidine 2 -carboxamide derivatives which modulate the cb2 receptor |
WO2011037795A1 (en) | 2009-09-22 | 2011-03-31 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the cb2 receptor |
EP2470510B1 (en) | 2009-09-30 | 2014-05-14 | TransTech Pharma, LLC | Substituted imidazole derivatives for treatment of alzheimers disease. |
CA2774250C (en) * | 2009-10-13 | 2013-12-17 | Pfizer Inc. | C-linked hydroxamic acid derivatives useful as antibacterial agents |
EP2523936A1 (en) | 2010-01-15 | 2012-11-21 | Boehringer Ingelheim International GmbH | Compounds which modulate the cb2 receptor |
US8329735B2 (en) | 2010-03-05 | 2012-12-11 | Boehringer Ingelheim International Gmbh | Tetrazole compounds which selectively modulate the CB2 receptor |
EP2595959B1 (en) | 2010-07-22 | 2015-11-04 | Boehringer Ingelheim International GmbH | Sulfonyl compounds which modulate the cb2 receptor |
RU2578607C2 (ru) * | 2010-09-17 | 2016-03-27 | Дзе Юниверсити Оф Токио | Композиция для поддержания функции тромбоцитов |
EP2877446B9 (en) * | 2012-07-18 | 2017-01-25 | Proyecto de Biomedicina Cima, S.L. | New antifibrinolytic compounds |
EP2803668A1 (en) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles |
US9796686B2 (en) | 2014-05-16 | 2017-10-24 | Idorsia Pharmaceuticals Ltd | Antibacterial quinazoline-4(3H)-one derivatives |
CN107188837B (zh) * | 2017-06-06 | 2019-05-28 | 温州大学 | 一种α-酰基高烯丙基硫醚类化合物的合成方法 |
CA3115038A1 (en) | 2018-10-04 | 2020-04-09 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Egfr inhibitors for treating keratodermas |
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GB1574822A (en) * | 1976-03-23 | 1980-09-10 | Lafon Labor | Acetohydroxamic acid derivatives and pharmaceutical compositions thereof |
FR2528041A1 (fr) * | 1982-06-04 | 1983-12-09 | Lafon Labor | Acides halogenobenzhydrylsulfinylacetohydroxamiques, procede de preparation et utilisation en therapeutique |
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GB9416897D0 (en) * | 1994-08-20 | 1994-10-12 | British Biotech Pharm | Metalloproteinase inhibitors |
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WO1997024117A1 (en) * | 1996-01-02 | 1997-07-10 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted (aryl, heteroaryl, arylmethyl or heteroarylmethyl) hydroxamic acid compounds |
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1998
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- 1998-02-17 GE GEAP19985007A patent/GEP20022627B/en unknown
- 1998-02-17 JP JP53772498A patent/JP2001513771A/ja not_active Withdrawn
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- 1998-02-17 WO PCT/US1998/002987 patent/WO1998037877A1/en not_active Application Discontinuation
- 1998-02-17 KR KR1019997007882A patent/KR20000075809A/ko not_active Application Discontinuation
- 1998-02-17 AT AT98906468T patent/ATE263554T1/de not_active IP Right Cessation
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- 1998-02-17 JP JP53770698A patent/JP2001519777A/ja not_active Withdrawn
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- 1998-02-17 PL PL98335286A patent/PL335286A1/xx unknown
- 1998-02-17 NZ NZ337336A patent/NZ337336A/en unknown
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- 1998-02-17 IL IL13125898A patent/IL131258A0/xx not_active IP Right Cessation
- 1998-02-17 DE DE69823019T patent/DE69823019T2/de not_active Expired - Fee Related
- 1998-02-17 IL IL13125798A patent/IL131257A0/xx unknown
- 1998-02-17 EE EEP199900371A patent/EE04295B1/xx not_active IP Right Cessation
- 1998-02-17 CA CA002282656A patent/CA2282656A1/en not_active Abandoned
- 1998-02-17 ES ES98906468T patent/ES2217540T3/es not_active Expired - Lifetime
- 1998-02-17 BR BR9807802A patent/BR9807802A/pt not_active IP Right Cessation
- 1998-02-17 HU HU0001463A patent/HUP0001463A3/hu unknown
- 1998-02-17 AT AT98910022T patent/ATE256107T1/de not_active IP Right Cessation
- 1998-02-17 YU YU40999A patent/YU40999A/sh unknown
- 1998-02-17 NZ NZ337298A patent/NZ337298A/xx unknown
- 1998-02-17 DE DE69820424T patent/DE69820424T2/de not_active Expired - Fee Related
- 1998-02-17 PT PT98910022T patent/PT970046E/pt unknown
- 1998-02-17 BR BR9807803-8A patent/BR9807803A/pt not_active IP Right Cessation
- 1998-02-17 EP EP98906468A patent/EP0973512B1/en not_active Expired - Lifetime
- 1998-02-17 AU AU61686/98A patent/AU726204B2/en not_active Ceased
- 1998-02-17 CN CN98804329A patent/CN1252790A/zh active Pending
- 1998-02-17 AU AU64368/98A patent/AU748998B2/en not_active Ceased
- 1998-02-17 EA EA199900769A patent/EA001742B1/ru not_active IP Right Cessation
- 1998-02-26 ZA ZA9801628A patent/ZA981628B/xx unknown
- 1998-02-26 ZA ZA9801625A patent/ZA981625B/xx unknown
- 1998-02-27 AR ARP980100909A patent/AR011451A1/es not_active Application Discontinuation
- 1998-03-17 TW TW087102853A patent/TW568900B/zh active
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1999
- 1999-08-26 NO NO19994125A patent/NO314302B1/no unknown
- 1999-08-26 NO NO19994124A patent/NO314258B1/no not_active IP Right Cessation
- 1999-09-24 BG BG103757A patent/BG103757A/bg unknown
- 1999-09-27 BG BG103760A patent/BG103760A/bg unknown
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2000
- 2000-07-07 HK HK00104181A patent/HK1024875A1/xx not_active IP Right Cessation
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2004
- 2004-09-08 CY CY0400069A patent/CY2477B1/xx unknown
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