EA199900792A1 - Сульфонильные двухвалентные арильные или гетероарильные соединения гидроксамовой кислоты - Google Patents

Сульфонильные двухвалентные арильные или гетероарильные соединения гидроксамовой кислоты

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Publication number
EA199900792A1
EA199900792A1 EA199900792A EA199900792A EA199900792A1 EA 199900792 A1 EA199900792 A1 EA 199900792A1 EA 199900792 A EA199900792 A EA 199900792A EA 199900792 A EA199900792 A EA 199900792A EA 199900792 A1 EA199900792 A1 EA 199900792A1
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EA
Eurasian Patent Office
Prior art keywords
hydroxamic acid
sulphonile
heteroaaryne
double
acid compounds
Prior art date
Application number
EA199900792A
Other languages
English (en)
Inventor
Джозеф Дж. Макдональд
Томас Э. Барта
Дэниел П. Бекер
Луис Дж. Беделл
Шашидхар Н. Рао
Джон Н. Фрескос
Брент В. Мишке
Original Assignee
Монсанто Компани
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Publication date
Application filed by Монсанто Компани filed Critical Монсанто Компани
Publication of EA199900792A1 publication Critical patent/EA199900792A1/ru

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Представлены сульфонильное двухвалентное ароматическое или гетероароматическое циклическое соединение гидроксамовой кислоты, которое, среди прочего, ингибирует активность матрикса металлопротеазы, и способ лечения, который включает введение хозяину, имеющему состояние, связанное с патологической активностью матрикса металлопротеазы, указанного сульфонильного двухвалентного ароматического или гетероароматического циклического соединения гидроксамовой кислоты в количестве, эффективном для ингибирования фермента ММР.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900792A 1997-03-04 1998-03-04 Сульфонильные двухвалентные арильные или гетероарильные соединения гидроксамовой кислоты EA199900792A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3518297P 1997-03-04 1997-03-04
PCT/US1998/004300 WO1998038859A1 (en) 1997-03-04 1998-03-04 Sulfonyl divalent aryl or heteroaryl hydroxamic acid compounds

Publications (1)

Publication Number Publication Date
EA199900792A1 true EA199900792A1 (ru) 2000-04-24

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EA199900792A EA199900792A1 (ru) 1997-03-04 1998-03-04 Сульфонильные двухвалентные арильные или гетероарильные соединения гидроксамовой кислоты

Country Status (20)

Country Link
US (3) US6380258B2 (ru)
EP (4) EP0984959B1 (ru)
JP (4) JP2002513407A (ru)
KR (3) KR20000075946A (ru)
CN (3) CN1253474A (ru)
AT (1) ATE254599T1 (ru)
AU (2) AU750303B2 (ru)
BR (2) BR9808214A (ru)
CA (4) CA2283272A1 (ru)
DE (1) DE69819878T2 (ru)
DK (1) DK0973392T3 (ru)
EA (1) EA199900792A1 (ru)
ES (2) ES2209122T3 (ru)
HK (1) HK1027806A1 (ru)
IL (3) IL131494A (ru)
NO (1) NO315647B1 (ru)
NZ (1) NZ337326A (ru)
PL (1) PL335732A1 (ru)
PT (1) PT973392E (ru)
WO (1) WO1998038859A1 (ru)

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