EA032291B1 - Твердые формы конденсированных гетероароматических пирролидинонов - Google Patents

Твердые формы конденсированных гетероароматических пирролидинонов Download PDF

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Publication number
EA032291B1
EA032291B1 EA201791369A EA201791369A EA032291B1 EA 032291 B1 EA032291 B1 EA 032291B1 EA 201791369 A EA201791369 A EA 201791369A EA 201791369 A EA201791369 A EA 201791369A EA 032291 B1 EA032291 B1 EA 032291B1
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EA
Eurasian Patent Office
Prior art keywords
compound
cancer
shows
mixture
temperature
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EA201791369A
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English (en)
Russian (ru)
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EA201791369A1 (ru
Inventor
Жунлян Чэнь
Томонори Итибакасе
Чуньжун Ма
Кристофер Мэттьюс
Хадзиме Мотойоси
Колин О'Брайан
Кентаро Ядзи
Наоки Йосикава
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Такеда Фармасьютикал Компани Лимитед
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Application filed by Такеда Фармасьютикал Компани Лимитед filed Critical Такеда Фармасьютикал Компани Лимитед
Publication of EA201791369A1 publication Critical patent/EA201791369A1/ru
Publication of EA032291B1 publication Critical patent/EA032291B1/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
EA201791369A 2014-12-18 2015-12-17 Твердые формы конденсированных гетероароматических пирролидинонов EA032291B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462093564P 2014-12-18 2014-12-18
US201562115223P 2015-02-12 2015-02-12
US201562180222P 2015-06-16 2015-06-16
PCT/IB2015/002489 WO2016097862A2 (en) 2014-12-18 2015-12-17 Solid state forms of fused heteroaromatic pyrrolidinones

Publications (2)

Publication Number Publication Date
EA201791369A1 EA201791369A1 (ru) 2017-10-31
EA032291B1 true EA032291B1 (ru) 2019-05-31

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ID=55299676

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201791369A EA032291B1 (ru) 2014-12-18 2015-12-17 Твердые формы конденсированных гетероароматических пирролидинонов

Country Status (29)

Country Link
US (3) US10676473B2 (OSRAM)
EP (2) EP3233857B1 (OSRAM)
JP (3) JP6778195B2 (OSRAM)
KR (1) KR102037502B1 (OSRAM)
CN (1) CN107108609B (OSRAM)
AU (1) AU2015365580B2 (OSRAM)
BR (1) BR112017013149B1 (OSRAM)
CA (1) CA2970864C (OSRAM)
CL (1) CL2017001561A1 (OSRAM)
CO (1) CO2017005910A2 (OSRAM)
CR (1) CR20170249A (OSRAM)
DK (1) DK3233857T3 (OSRAM)
DO (1) DOP2017000130A (OSRAM)
EA (1) EA032291B1 (OSRAM)
EC (1) ECSP17038100A (OSRAM)
ES (1) ES2788454T3 (OSRAM)
GE (1) GEP20197050B (OSRAM)
IL (1) IL252941B (OSRAM)
MX (1) MX373586B (OSRAM)
MY (1) MY199935A (OSRAM)
NZ (1) NZ732371A (OSRAM)
PE (1) PE20171179A1 (OSRAM)
PH (1) PH12017501123A1 (OSRAM)
PL (1) PL3233857T3 (OSRAM)
SG (1) SG11201701911QA (OSRAM)
TN (1) TN2017000080A1 (OSRAM)
UA (1) UA120632C2 (OSRAM)
WO (1) WO2016097862A2 (OSRAM)
ZA (1) ZA201701800B (OSRAM)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3233857T3 (pl) * 2014-12-18 2020-07-27 Takeda Pharmaceutical Company Limited Stałe postacie skondensowanych heteroaromatycznych pirolidynonów
CA3030630A1 (en) * 2016-07-13 2018-01-18 Takeda Pharmaceutical Company Limited Combination of spleen tyrosine kinase inhibitors and other therapeutic agents
JP2020537678A (ja) 2017-10-19 2020-12-24 バイエル・アニマル・ヘルス・ゲーエムベーハー 動物における疾患の治療および予防のための縮合ヘテロ芳香族ピロリドンの使用
WO2019088039A1 (en) 2017-10-30 2019-05-09 Takeda Pharmaceutical Company Limited Treatment of acute myeloid leukemia
ES2971892T3 (es) * 2018-12-14 2024-06-10 Chia Tai Tianqing Pharmaceutical Group Co Ltd Formas cristalinas del inhibidor de Syk sal hidrocloruro de 5-fluoro-1-metil-3-[[5-[4-(3-oxetanil)-1-piperazinil]-2-piridinil]amino]-6-(1H-pirazol-3-il)-2(1H)-quinolinona (1:1)
CN113453680A (zh) 2019-02-07 2021-09-28 詹森生物科技公司 二氢乳清酸脱氢酶抑制剂
TW202104207A (zh) 2019-04-17 2021-02-01 美商健生生物科技公司 二氫乳清酸脫氫酶抑制劑
WO2021070132A1 (en) 2019-10-10 2021-04-15 Janssen Biotech, Inc. Bi-aryl dihydroorotate dehydrogenase inhibitors
AU2020404305A1 (en) 2019-12-19 2022-08-04 Janssen Pharmaceutica Nv Substituted straight chain spiro derivatives
WO2022074534A1 (en) 2020-10-05 2022-04-14 Janssen Biotech, Inc. Combinations of dihydroorotate dehydrogenase inhibitors and hypomethylating agents
WO2022127753A1 (zh) * 2020-12-18 2022-06-23 山东轩竹医药科技有限公司 稠环类AhR抑制剂
JP2024518497A (ja) 2021-05-11 2024-05-01 ヤンセン ファーマシューティカ エヌ.ベー. 併用療法
KR20240006638A (ko) 2021-05-11 2024-01-15 얀센 파마슈티카 엔브이 조합 요법
CN120322230A (zh) 2022-11-30 2025-07-15 詹森药业有限公司 包含多发性内分泌癌蛋白-mll抑制剂和至少一种其他治疗剂的组合
WO2024114666A1 (en) 2022-11-30 2024-06-06 Janssen Pharmaceutica Nv Combinations comprising a menin-mll inhibitor and a bcl-2 inhibitor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2516434A1 (en) * 2009-12-23 2012-10-31 Takeda Pharmaceutical Company Limited Fused heteroaromatic pyrrolidinones as syk inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1960372B1 (en) * 2005-12-15 2015-12-09 Rigel Pharmaceuticals, Inc. Kinase inhibitors and their uses
EP2723739B1 (en) 2011-06-22 2016-08-24 Takeda Pharmaceutical Company Limited Substituted 6-aza-isoindolin-1-one derivatives
TW201625263A (zh) * 2014-09-24 2016-07-16 千禧製藥公司 利用PI3Kα抑制劑與紫杉烷之組合治療
PL3233857T3 (pl) * 2014-12-18 2020-07-27 Takeda Pharmaceutical Company Limited Stałe postacie skondensowanych heteroaromatycznych pirolidynonów

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2516434A1 (en) * 2009-12-23 2012-10-31 Takeda Pharmaceutical Company Limited Fused heteroaromatic pyrrolidinones as syk inhibitors

Also Published As

Publication number Publication date
PL3233857T3 (pl) 2020-07-27
JP2017537969A (ja) 2017-12-21
ES2788454T3 (es) 2020-10-21
PE20171179A1 (es) 2017-08-22
MY199935A (en) 2023-11-29
CA2970864C (en) 2020-04-14
HK1243406A1 (zh) 2018-07-13
CN107108609A (zh) 2017-08-29
BR112017013149A2 (pt) 2018-04-10
TN2017000080A1 (en) 2018-07-04
MX2017007162A (es) 2017-08-28
JP2020143081A (ja) 2020-09-10
PH12017501123A1 (en) 2017-11-27
EP3233857A2 (en) 2017-10-25
ECSP17038100A (es) 2017-12-01
JP6974534B2 (ja) 2021-12-01
CL2017001561A1 (es) 2018-01-12
JP2022017477A (ja) 2022-01-25
US20230348461A1 (en) 2023-11-02
IL252941A0 (en) 2017-08-31
GEP20197050B (en) 2019-12-10
AU2015365580A1 (en) 2017-07-06
KR20170095374A (ko) 2017-08-22
US11352355B2 (en) 2022-06-07
CA2970864A1 (en) 2016-06-23
NZ732371A (en) 2023-04-28
CN107108609B (zh) 2020-02-18
US10676473B2 (en) 2020-06-09
CO2017005910A2 (es) 2017-10-20
BR112017013149B1 (pt) 2022-10-11
MX373586B (es) 2020-05-05
IL252941B (en) 2020-11-30
ZA201701800B (en) 2020-05-27
EP3677582B1 (en) 2023-01-25
EP3233857B1 (en) 2020-03-11
UA120632C2 (uk) 2020-01-10
SG11201701911QA (en) 2017-04-27
WO2016097862A2 (en) 2016-06-23
KR102037502B1 (ko) 2019-10-28
CR20170249A (es) 2017-09-25
EA201791369A1 (ru) 2017-10-31
DOP2017000130A (es) 2017-07-15
JP6778195B2 (ja) 2020-10-28
WO2016097862A3 (en) 2016-08-11
DK3233857T3 (da) 2020-04-27
US20160176869A1 (en) 2016-06-23
AU2015365580B2 (en) 2020-04-02
US20200339573A1 (en) 2020-10-29
EP3677582A1 (en) 2020-07-08

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