BR112017013149A2 - formas de estado sólido de pirrolidinonas heteroaromáticas fundidas. - Google Patents
formas de estado sólido de pirrolidinonas heteroaromáticas fundidas.Info
- Publication number
- BR112017013149A2 BR112017013149A2 BR112017013149-8A BR112017013149A BR112017013149A2 BR 112017013149 A2 BR112017013149 A2 BR 112017013149A2 BR 112017013149 A BR112017013149 A BR 112017013149A BR 112017013149 A2 BR112017013149 A2 BR 112017013149A2
- Authority
- BR
- Brazil
- Prior art keywords
- solid state
- state forms
- fused heteroaromatic
- pyrrolidinones
- heteroaromatic pyrrolidinones
- Prior art date
Links
- -1 heteroaromatic pyrrolidinones Chemical class 0.000 title 1
- 239000007787 solid Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462093564P | 2014-12-18 | 2014-12-18 | |
| US62/093,564 | 2014-12-18 | ||
| US201562115223P | 2015-02-12 | 2015-02-12 | |
| US62/115,223 | 2015-02-12 | ||
| US201562180222P | 2015-06-16 | 2015-06-16 | |
| US62/180,222 | 2015-06-16 | ||
| PCT/IB2015/002489 WO2016097862A2 (en) | 2014-12-18 | 2015-12-17 | Solid state forms of fused heteroaromatic pyrrolidinones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112017013149A2 true BR112017013149A2 (pt) | 2018-04-10 |
| BR112017013149B1 BR112017013149B1 (pt) | 2022-10-11 |
Family
ID=55299676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017013149-8A BR112017013149B1 (pt) | 2014-12-18 | 2015-12-17 | Composto, composição farmacêutica e uso dos mesmos |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US10676473B2 (pt) |
| EP (2) | EP3233857B1 (pt) |
| JP (3) | JP6778195B2 (pt) |
| KR (1) | KR102037502B1 (pt) |
| CN (1) | CN107108609B (pt) |
| AU (1) | AU2015365580B2 (pt) |
| BR (1) | BR112017013149B1 (pt) |
| CA (1) | CA2970864C (pt) |
| CL (1) | CL2017001561A1 (pt) |
| CO (1) | CO2017005910A2 (pt) |
| CR (1) | CR20170249A (pt) |
| DK (1) | DK3233857T3 (pt) |
| DO (1) | DOP2017000130A (pt) |
| EA (1) | EA032291B1 (pt) |
| EC (1) | ECSP17038100A (pt) |
| ES (1) | ES2788454T3 (pt) |
| GE (1) | GEP20197050B (pt) |
| HK (1) | HK1243406A1 (pt) |
| IL (1) | IL252941B (pt) |
| MX (1) | MX2017007162A (pt) |
| NZ (1) | NZ732371A (pt) |
| PE (1) | PE20171179A1 (pt) |
| PH (1) | PH12017501123A1 (pt) |
| PL (1) | PL3233857T3 (pt) |
| SG (1) | SG11201701911QA (pt) |
| TN (1) | TN2017000080A1 (pt) |
| UA (1) | UA120632C2 (pt) |
| WO (1) | WO2016097862A2 (pt) |
| ZA (1) | ZA201701800B (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3233857B1 (en) * | 2014-12-18 | 2020-03-11 | Takeda Pharmaceutical Company Limited | Solid state forms of fused heteroaromatic pyrrolidinones |
| US20190231757A1 (en) * | 2016-07-13 | 2019-08-01 | Takeda Pharmaceutical Company Limited | Combination of spleen tyrosine kinase inhibitors and other therapeutic agents |
| JP2020537678A (ja) | 2017-10-19 | 2020-12-24 | バイエル・アニマル・ヘルス・ゲーエムベーハー | 動物における疾患の治療および予防のための縮合ヘテロ芳香族ピロリドンの使用 |
| WO2019088039A1 (en) | 2017-10-30 | 2019-05-09 | Takeda Pharmaceutical Company Limited | Treatment of acute myeloid leukemia |
| EP3896063B1 (en) * | 2018-12-14 | 2024-01-24 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Crystalline forms of the syk inhibitor 5-fluoro-1-methyl-3-[[5-[4-(3-oxetanyl)-1-piperazinyl]-2-pyridinyl]amino]-6-(1h-pyrazol-3-yl)-2(1h)-quinolinone hydrochloride salt (1:1) |
| WO2020161663A1 (en) | 2019-02-07 | 2020-08-13 | Janssen Biotech, Inc. | Dihydroorotate dehydrogenase inhibitors |
| TW202104207A (zh) | 2019-04-17 | 2021-02-01 | 美商健生生物科技公司 | 二氫乳清酸脫氫酶抑制劑 |
| EP4041714B1 (en) | 2019-10-10 | 2023-12-13 | Janssen Biotech, Inc. | Bi-aryl dihydroorotate dehydrogenase inhibitors |
| WO2022074534A1 (en) | 2020-10-05 | 2022-04-14 | Janssen Biotech, Inc. | Combinations of dihydroorotate dehydrogenase inhibitors and hypomethylating agents |
| WO2022127753A1 (zh) * | 2020-12-18 | 2022-06-23 | 山东轩竹医药科技有限公司 | 稠环类AhR抑制剂 |
| EP4337216A1 (en) | 2021-05-11 | 2024-03-20 | JANSSEN Pharmaceutica NV | Combination therapies |
| WO2022237719A1 (en) | 2021-05-11 | 2022-11-17 | Janssen Pharmaceutica Nv | Combination therapies |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1960372B1 (en) * | 2005-12-15 | 2015-12-09 | Rigel Pharmaceuticals, Inc. | Kinase inhibitors and their uses |
| GEP20156243B (en) * | 2009-12-23 | 2015-02-10 | Takeda Pharmaceutical | Fused heteroaromatic pyrrolidinones as syk inhibitors |
| EP2723739B1 (en) * | 2011-06-22 | 2016-08-24 | Takeda Pharmaceutical Company Limited | Substituted 6-aza-isoindolin-1-one derivatives |
| TW201625263A (zh) * | 2014-09-24 | 2016-07-16 | 千禧製藥公司 | 利用ＰＩ３Ｋα抑制劑與紫杉烷之組合治療 |
| EP3233857B1 (en) * | 2014-12-18 | 2020-03-11 | Takeda Pharmaceutical Company Limited | Solid state forms of fused heteroaromatic pyrrolidinones |
-
2015
- 2015-12-17 EP EP15831150.6A patent/EP3233857B1/en active Active
- 2015-12-17 PL PL15831150T patent/PL3233857T3/pl unknown
- 2015-12-17 EP EP20156863.1A patent/EP3677582B1/en active Active
- 2015-12-17 NZ NZ732371A patent/NZ732371A/en unknown
- 2015-12-17 SG SG11201701911QA patent/SG11201701911QA/en unknown
- 2015-12-17 TN TN2017000080A patent/TN2017000080A1/en unknown
- 2015-12-17 MX MX2017007162A patent/MX2017007162A/es active IP Right Grant
- 2015-12-17 JP JP2017532678A patent/JP6778195B2/ja active Active
- 2015-12-17 PE PE2017000944A patent/PE20171179A1/es unknown
- 2015-12-17 CR CR20170249A patent/CR20170249A/es unknown
- 2015-12-17 CA CA2970864A patent/CA2970864C/en active Active
- 2015-12-17 US US14/973,180 patent/US10676473B2/en active Active
- 2015-12-17 ES ES15831150T patent/ES2788454T3/es active Active
- 2015-12-17 UA UAA201707489A patent/UA120632C2/uk unknown
- 2015-12-17 GE GEAP201514545A patent/GEP20197050B/en unknown
- 2015-12-17 WO PCT/IB2015/002489 patent/WO2016097862A2/en active Application Filing
- 2015-12-17 AU AU2015365580A patent/AU2015365580B2/en active Active
- 2015-12-17 EA EA201791369A patent/EA032291B1/ru unknown
- 2015-12-17 CN CN201580068971.2A patent/CN107108609B/zh active Active
- 2015-12-17 KR KR1020177019929A patent/KR102037502B1/ko active IP Right Grant
- 2015-12-17 BR BR112017013149-8A patent/BR112017013149B1/pt not_active IP Right Cessation
- 2015-12-17 DK DK15831150.6T patent/DK3233857T3/da active
-
2017
- 2017-03-13 ZA ZA2017/01800A patent/ZA201701800B/en unknown
- 2017-05-31 DO DO2017000130A patent/DOP2017000130A/es unknown
- 2017-06-15 CO CONC2017/0005910A patent/CO2017005910A2/es unknown
- 2017-06-15 CL CL2017001561A patent/CL2017001561A1/es unknown
- 2017-06-15 PH PH12017501123A patent/PH12017501123A1/en unknown
- 2017-06-15 IL IL252941A patent/IL252941B/en active IP Right Grant
- 2017-06-16 EC ECIEPI201738100A patent/ECSP17038100A/es unknown
-
2018
- 2018-02-27 HK HK18102803.3A patent/HK1243406A1/zh unknown
-
2020
- 2020-04-30 JP JP2020080282A patent/JP6974534B2/ja active Active
- 2020-05-08 US US16/870,653 patent/US11352355B2/en active Active
-
2021
- 2021-11-04 JP JP2021180105A patent/JP2022017477A/ja active Pending
-
2022
- 2022-12-23 US US18/088,286 patent/US20230348461A1/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/12/2015, OBSERVADAS AS CONDICOES LEGAIS |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 8A ANUIDADE. |
|
| B24D | Patent annual fee: restoration after fee payment |